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PubMed:10400640 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator.
T2 134-432 Sentence denotes Although the linkage of polyglutamine (poly-Q) repeat expansion in the androgen receptor (AR) to Kennedy's disease (X-linked spinal and bulbar muscular atrophy) was a major step forward, the detailed molecular mechanism of how the change in poly-Q length contributes to the disease remains unclear.
T3 433-626 Sentence denotes Here we report the identification of a nuclear G-protein, Ras-related nuclear protein/ARA24, as the first AR coactivator that can bind differentially with different lengths of poly-Q within AR.
T4 627-797 Sentence denotes In the yeast and mammalian reciprocal interacting assays, our data suggested the interaction of AR N-terminal domain with ARA24 diminishes as the poly-Q length increases.
T5 798-876 Sentence denotes The coactivation of ARA24 also diminishes with the poly-Q expansion within AR.
T6 877-985 Sentence denotes Deletion of the acidic hexapeptide (DEDDDL) at the C terminus of ARA24 further enhances its AR coactivation.
T7 986-1201 Sentence denotes Together, our data suggest that poor interaction and weaker coactivation of ARA24 to the longer poly-Q AR in the X-linked spinal and bulbar muscular atrophied AR could contribute to the weaker transactivation of AR.
T8 1202-1362 Sentence denotes The consequence of poor interaction and weak coactivation may eventually lead to the partial androgen insensitivity during the development of Kennedy's disease.

relna

Id Subject Object Predicate Lexical cue
T1 43-48 Protein denotes ARA24
T2 71-88 DNA denotes androgen receptor
T3 205-222 DNA denotes androgen receptor
T4 224-226 DNA denotes AR
T5 519-524 Protein denotes ARA24
T6 539-541 DNA denotes AR
T7 623-625 DNA denotes AR
T8 723-725 DNA denotes AR
T9 749-754 Protein denotes ARA24
T10 818-823 Protein denotes ARA24
T11 873-875 DNA denotes AR
T12 942-947 Protein denotes ARA24
T13 969-971 DNA denotes AR
T14 1062-1067 Protein denotes ARA24
T15 1089-1091 DNA denotes AR
T16 1145-1147 DNA denotes AR
T17 1198-1200 DNA denotes AR
R0 T5 T6 linked ARA24,AR

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 250-258 HP_0001417 denotes X-linked
T2 277-293 HP_0003202 denotes muscular atrophy
T3 1099-1107 HP_0001417 denotes X-linked
T4 1126-1144 HP_0003202 denotes muscular atrophied

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10400640-1#71#88#gene367 205-222 gene367 denotes androgen receptor
10400640-1#90#92#gene367 224-226 gene367 denotes AR
10400640-1#97#114#diseaseC1839259 231-248 diseaseC1839259 denotes Kennedy's disease
10400640-1#116#159#diseaseC1839259 250-293 diseaseC1839259 denotes X-linked spinal and bulbar muscular atrophy
10400640-1#97#114#diseaseC1839259 231-248 diseaseC1839259 denotes Kennedy's disease
10400640-1#116#159#diseaseC1839259 250-293 diseaseC1839259 denotes X-linked spinal and bulbar muscular atrophy
71#88#gene36797#114#diseaseC1839259 10400640-1#71#88#gene367 10400640-1#97#114#diseaseC1839259 associated_with androgen receptor,Kennedy's disease
71#88#gene367116#159#diseaseC1839259 10400640-1#71#88#gene367 10400640-1#116#159#diseaseC1839259 associated_with androgen receptor,X-linked spinal and bulbar muscular atrophy
71#88#gene36797#114#diseaseC1839259 10400640-1#71#88#gene367 10400640-1#97#114#diseaseC1839259 associated_with androgen receptor,Kennedy's disease
71#88#gene367116#159#diseaseC1839259 10400640-1#71#88#gene367 10400640-1#116#159#diseaseC1839259 associated_with androgen receptor,X-linked spinal and bulbar muscular atrophy
90#92#gene36797#114#diseaseC1839259 10400640-1#90#92#gene367 10400640-1#97#114#diseaseC1839259 associated_with AR,Kennedy's disease
90#92#gene367116#159#diseaseC1839259 10400640-1#90#92#gene367 10400640-1#116#159#diseaseC1839259 associated_with AR,X-linked spinal and bulbar muscular atrophy
90#92#gene36797#114#diseaseC1839259 10400640-1#90#92#gene367 10400640-1#97#114#diseaseC1839259 associated_with AR,Kennedy's disease
90#92#gene367116#159#diseaseC1839259 10400640-1#90#92#gene367 10400640-1#116#159#diseaseC1839259 associated_with AR,X-linked spinal and bulbar muscular atrophy

DisGeNET

Id Subject Object Predicate Lexical cue
T0 205-222 gene:367 denotes androgen receptor
T1 250-293 disease:C1839259 denotes X-linked spinal and bulbar muscular atrophy
T2 224-226 gene:367 denotes AR
T3 250-293 disease:C1839259 denotes X-linked spinal and bulbar muscular atrophy
R1 T0 T1 associated_with androgen receptor,X-linked spinal and bulbar muscular atrophy
R2 T2 T3 associated_with AR,X-linked spinal and bulbar muscular atrophy

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 277-293 Phenotype denotes muscular atrophy HP:0003202
T2 1126-1144 Phenotype denotes muscular atrophied HP:0003202

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 231-248 Disease denotes Kennedy's disease http://purl.obolibrary.org/obo/MONDO_0010735
T2 259-293 Disease denotes spinal and bulbar muscular atrophy http://purl.obolibrary.org/obo/MONDO_0010735
T3 1108-1144 Disease denotes spinal and bulbar muscular atrophied http://purl.obolibrary.org/obo/MONDO_0010735
T4 1344-1361 Disease denotes Kennedy's disease http://purl.obolibrary.org/obo/MONDO_0010735

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 25-31 Body_part denotes neuron http://purl.obolibrary.org/obo/CL_0000540
T2 270-276 Body_part denotes bulbar http://purl.obolibrary.org/obo/UBERON_0022272
T3 1119-1125 Body_part denotes bulbar http://purl.obolibrary.org/obo/UBERON_0022272

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 25-31 Cell denotes neuron http://purl.obolibrary.org/obo/CL:0000540
T2 173-177 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T4 375-379 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T6 609-613 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T8 773-777 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T10 849-853 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T12 1082-1086 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775