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PubMed:10395652 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 28-77 protein denotes lipopolysaccharide-activated toll-like receptor 2
T2 79-112 protein denotes Human Toll-like receptor 2 (TLR2)
T3 118-136 protein denotes signaling receptor
T4 172-181 protein denotes NF-kappaB
T5 236-240 protein denotes TLR2
T6 274-278 protein denotes TLR2
T7 299-332 protein denotes high-affinity LPS binding protein
T8 342-346 protein denotes CD14
T9 362-382 protein denotes LPS receptor complex
T10 439-443 protein denotes TLR2
T11 492-522 protein denotes IL-1R-associated kinase (IRAK)
T12 543-547 protein denotes TLR2
T13 592-596 protein denotes TLR2
T14 645-649 protein denotes IRAK
T15 807-821 protein denotes wild-type TLR2
T16 875-879 protein denotes TLR2
T17 927-958 protein denotes myeloid differentiation protein
T18 960-964 protein denotes IRAK
T19 966-998 protein denotes TNF receptor-associated factor 6
T20 1004-1029 protein denotes NF-kappaB-inducing kinase
T21 1053-1057 protein denotes TLR2
T22 1068-1072 protein denotes TLR2
T23 1082-1091 protein denotes NF-kappaB
T24 1159-1163 protein denotes TLR2
T25 1168-1174 protein denotes IL-1Rs
T26 1231-1235 protein denotes TLR2

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 79-112 NP denotes Human Toll-like receptor 2 (TLR2)
C2 116-136 NP denotes a signaling receptor
C3 137-141 NP denotes that
C4 154-157 NP denotes LPS
C5 236-240 NP denotes TLR2
C6 256-259 NP denotes LPS
C7 274-278 NP denotes TLR2
C8 439-443 NP denotes TLR2
C9 488-522 NP denotes the IL-1R-associated kinase (IRAK)
C11 592-596 NP denotes TLR2
C10 557-628 NP denotes Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa
C12 645-649 NP denotes IRAK
C13 693-706 NP denotes these mutants
C14 960-964 NP denotes IRAK
C15 1053-1057 NP denotes TLR2
C16 1159-1163 NP denotes TLR2
C17 1231-1235 NP denotes TLR2
R1 C3 C2 coref-relat that,a signaling receptor
R2 C5 C1 coref-ident TLR2,Human Toll-like receptor 2 (TLR2)
R3 C6 C4 coref-ident LPS,LPS
R4 C7 C5 coref-ident TLR2,TLR2
R5 C8 C7 coref-ident TLR2,TLR2
R6 C11 C8 coref-ident TLR2,TLR2
R7 C12 C9 coref-ident IRAK,the IL-1R-associated kinase (IRAK)
R8 C13 C10 coref-ident these mutants,Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa
R9 C14 C12 coref-ident IRAK,IRAK
R10 C15 C11 coref-ident TLR2,TLR2
R11 C16 C15 coref-ident TLR2,TLR2
R12 C17 C16 coref-ident TLR2,TLR2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-78 Sentence denotes Signaling events induced by lipopolysaccharide-activated toll-like receptor 2.
S2 79-182 Sentence denotes Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB.
S3 183-260 Sentence denotes Here, we investigate further the events triggered by TLR2 in response to LPS.
S4 261-444 Sentence denotes We show that TLR2 associates with the high-affinity LPS binding protein membrane CD14 to serve as an LPS receptor complex, and that LPS treatment enhances the oligomerization of TLR2.
S5 445-556 Sentence denotes Concomitant with receptor oligomerization, the IL-1R-associated kinase (IRAK) is recruited to the TLR2 complex.
S6 557-742 Sentence denotes Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa fail to recruit IRAK, which is consistent with the inability of these mutants to transmit LPS cellular signaling.
S7 743-909 Sentence denotes Moreover, both deletion mutants could still form complexes with wild-type TLR2 and act in a dominant-negative (DN) fashion to block TLR2-mediated signal transduction.
S8 910-1103 Sentence denotes DN constructs of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing kinase, when coexpressed with TLR2, abrogate TLR2-mediated NF-kappaB activation.
S9 1104-1251 Sentence denotes These results reveal a conserved signaling pathway for TLR2 and IL-1Rs and suggest a molecular mechanism for the inhibition of TLR2 by DN variants.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-16 other_name denotes Signaling events
T2 28-77 protein_molecule denotes lipopolysaccharide-activated toll-like receptor 2
T3 79-107 protein_molecule denotes Human Toll-like receptor 2 (
T4 107-111 protein_molecule denotes TLR2
T5 118-136 protein_family_or_group denotes signaling receptor
T6 154-157 lipid denotes LPS
T7 172-181 protein_complex denotes NF-kappaB
T8 236-240 protein_molecule denotes TLR2
T9 256-259 lipid denotes LPS
T10 274-278 protein_molecule denotes TLR2
T11 299-332 protein_molecule denotes high-affinity LPS binding protein
T12 342-346 protein_molecule denotes CD14
T13 362-365 lipid denotes LPS
T14 393-396 lipid denotes LPS
T15 420-435 other_name denotes oligomerization
T16 439-443 protein_molecule denotes TLR2
T17 462-486 other_name denotes receptor oligomerization
T18 492-517 protein_molecule denotes IL-1R-associated kinase (
T19 517-521 protein_molecule denotes IRAK
T20 543-547 protein_molecule denotes TLR2
T21 592-596 protein_molecule denotes TLR2
T22 605-618 peptide denotes C-terminal 13
T23 622-628 peptide denotes 141 aa
T24 645-649 protein_molecule denotes IRAK
T25 719-722 lipid denotes LPS
T26 807-816 protein_molecule denotes wild-type
T27 817-821 protein_molecule denotes TLR2
T28 835-854 other_name denotes dominant-negative (
T29 854-856 other_name denotes DN
T30 875-879 protein_molecule denotes TLR2
T31 910-912 other_name denotes DN
T32 927-958 protein_molecule denotes myeloid differentiation protein
T33 960-964 protein_molecule denotes IRAK
T34 966-969 protein_family_or_group denotes TNF
T35 1004-1013 protein_complex denotes NF-kappaB
T36 1053-1057 protein_molecule denotes TLR2
T37 1068-1072 protein_molecule denotes TLR2
T38 1082-1091 protein_complex denotes NF-kappaB
T39 1127-1154 other_name denotes conserved signaling pathway
T40 1159-1163 protein_molecule denotes TLR2
T41 1168-1174 protein_family_or_group denotes IL-1Rs
T42 1231-1235 protein_molecule denotes TLR2
T43 1239-1241 other_name denotes DN