PubMed:10395645
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-24 | protein | denotes | NF-kappa B |
| T2 | 126-142 | protein | denotes | caspase-1 and -3 |
| T3 | 144-154 | protein | denotes | NF-kappa B |
| T4 | 201-214 | DNA | denotes | various genes |
| T5 | 272-279 | cell_type | denotes | T cells |
| T6 | 319-329 | protein | denotes | NF-kappa B |
| T7 | 422-440 | protein | denotes | NF-kappa B1 dimers |
| T8 | 503-527 | cell_type | denotes | resting normal human PBL |
| T9 | 543-553 | protein | denotes | NF-kappa B |
| T10 | 736-753 | protein | denotes | caspase inhibitor |
| T11 | 754-763 | protein | denotes | Z-VAD-fmk |
| T12 | 789-800 | protein | denotes | Ac-DEVD-fmk |
| T13 | 845-852 | protein | denotes | caspase |
| T14 | 900-910 | protein | denotes | NF-kappa B |
| T15 | 1017-1035 | protein | denotes | soluble Fas ligand |
| T16 | 1037-1041 | protein | denotes | CD95 |
| T17 | 1075-1106 | protein | denotes | active death effector proteases |
| T18 | 1107-1116 | protein | denotes | caspase-1 |
| T19 | 1123-1145 | protein | denotes | IL-1 converting enzyme |
| T20 | 1148-1157 | protein | denotes | caspase-3 |
| T21 | 1164-1182 | protein | denotes | CPP32/Yama/apopain |
| T22 | 1189-1198 | protein | denotes | caspase-6 |
| T23 | 1228-1248 | protein | denotes | caspase-3 substrates |
| T24 | 1249-1276 | protein | denotes | poly(ADP-ribose) polymerase |
| T25 | 1281-1308 | protein | denotes | DNA fragmentation factor-45 |
| T26 | 1394-1402 | protein | denotes | caspases |
| T27 | 1434-1441 | cell_type | denotes | T cells |
| T28 | 1455-1465 | protein | denotes | NF-kappa B |
| T29 | 1579-1589 | protein | denotes | NF-kappa B |
| T30 | 1605-1614 | cell_type | denotes | naive PBL |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 14-33 | NP | denotes | NF-kappa B activity |
| C2 | 37-56 | NP | denotes | human T lymphocytes |
| C3 | 144-154 | NP | denotes | NF-kappa B |
| C4 | 201-214 | NP | denotes | various genes |
| C5 | 215-219 | NP | denotes | that |
| C6 | 272-279 | NP | denotes | T cells |
| C7 | 281-293 | NP | denotes | Our findings |
| C9 | 319-338 | NP | denotes | NF-kappa B activity |
| C8 | 304-371 | NP | denotes | suppression of NF-kappa B activity with cell-permeable SN50 peptide |
| C10 | 373-378 | NP | denotes | which |
| C11 | 422-440 | NP | denotes | NF-kappa B1 dimers |
| C12 | 454-459 | NP | denotes | their |
| C13 | 543-553 | NP | denotes | NF-kappa B |
| C14 | 818-841 | NP | denotes | SN50-mediated apoptosis |
| C15 | 1310-1324 | NP | denotes | These findings |
| C16 | 1434-1441 | NP | denotes | T cells |
| C17 | 1509-1531 | NP | denotes | SN50-induced apoptosis |
| C18 | 1533-1545 | NP | denotes | Our findings |
| C19 | 1579-1589 | NP | denotes | NF-kappa B |
| R1 | C5 | C4 | coref-relat | that,various genes |
| R2 | C6 | C2 | coref-ident | T cells,human T lymphocytes |
| R3 | C9 | C1 | coref-ident | NF-kappa B activity,NF-kappa B activity |
| R4 | C10 | C8 | coref-relat | which,suppression of NF-kappa B activity with cell-permeable SN50 peptide |
| R5 | C12 | C11 | coref-pron | their,NF-kappa B1 dimers |
| R6 | C13 | C3 | coref-ident | NF-kappa B,NF-kappa B |
| R7 | C15 | C7 | coref-ident | These findings,Our findings |
| R8 | C16 | C6 | coref-ident | T cells,T cells |
| R9 | C17 | C14 | coref-ident | SN50-induced apoptosis,SN50-mediated apoptosis |
| R10 | C18 | C15 | coref-ident | Our findings,These findings |
| R11 | C19 | C13 | coref-ident | NF-kappa B,NF-kappa B |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-143 | Sentence | denotes | Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3. |
| S2 | 144-280 | Sentence | denotes | NF-kappa B is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells. |
| S3 | 281-528 | Sentence | denotes | Our findings show that suppression of NF-kappa B activity with cell-permeable SN50 peptide, which masks the nuclear localization sequence of NF-kappa B1 dimers and prevents their nuclear localization, induces apoptosis in resting normal human PBL. |
| S4 | 529-686 | Sentence | denotes | Inhibition of NF-kappa B resulted in the externalization of phosphatidylserine, induction of DNA breaks, and morphological changes consistent with apoptosis. |
| S5 | 687-863 | Sentence | denotes | DNA fragmentation was efficiently blocked by the caspase inhibitor Z-VAD-fmk and partially blocked by Ac-DEVD-fmk, suggesting that SN50-mediated apoptosis is caspase-dependent. |
| S6 | 864-1309 | Sentence | denotes | Interestingly, apoptosis induced by NF-kappa B suppression, in contrast to that induced by TPEN (N,N,N',N'-tetrakis [2-pyridylmethyl]ethylenediamine) or soluble Fas ligand (CD95), was observed in the absence of active death effector proteases caspase-1-like (IL-1 converting enzyme), caspase-3-like (CPP32/Yama/apopain), and caspase-6-like and without cleavage of caspase-3 substrates poly(ADP-ribose) polymerase and DNA fragmentation factor-45. |
| S7 | 1310-1416 | Sentence | denotes | These findings suggest either low level of activation is required or that different caspases are involved. |
| S8 | 1417-1532 | Sentence | denotes | Preactivation of T cells resulting in NF-kappa B nuclear translocation protected cells from SN50-induced apoptosis. |
| S9 | 1533-1615 | Sentence | denotes | Our findings demonstrate an essential role of NF-kappa B in survival of naive PBL. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-24 | protein_complex | denotes | NF-kappa B |
| T2 | 83-92 | other_name | denotes | apoptosis |
| T3 | 144-154 | protein_complex | denotes | NF-kappa B |
| T4 | 201-214 | DNA_family_or_group | denotes | various genes |
| T5 | 272-279 | cell_type | denotes | T cells |
| T6 | 319-329 | protein_complex | denotes | NF-kappa B |
| T7 | 344-358 | peptide | denotes | cell-permeable |
| T8 | 359-363 | peptide | denotes | SN50 |
| T9 | 422-433 | protein_complex | denotes | NF-kappa B1 |
| T10 | 460-480 | other_name | denotes | nuclear localization |
| T11 | 490-499 | other_name | denotes | apoptosis |
| T12 | 503-527 | cell_type | denotes | resting normal human PBL |
| T13 | 543-553 | protein_complex | denotes | NF-kappa B |
| T14 | 589-607 | amino_acid_monomer | denotes | phosphatidylserine |
| T15 | 676-685 | other_name | denotes | apoptosis |
| T16 | 687-704 | other_name | denotes | DNA fragmentation |
| T17 | 736-753 | protein_family_or_group | denotes | caspase inhibitor |
| T18 | 754-763 | protein_molecule | denotes | Z-VAD-fmk |
| T19 | 789-800 | protein_molecule | denotes | Ac-DEVD-fmk |
| T20 | 818-822 | peptide | denotes | SN50 |
| T21 | 832-841 | other_name | denotes | apoptosis |
| T22 | 845-852 | protein_family_or_group | denotes | caspase |
| T23 | 879-888 | other_name | denotes | apoptosis |
| T24 | 900-910 | protein_complex | denotes | NF-kappa B |
| T25 | 955-959 | other_organic_compound | denotes | TPEN |
| T26 | 961-1012 | other_organic_compound | denotes | N,N,N',N'-tetrakis [2-pyridylmethyl]ethylenediamine |
| T27 | 1017-1035 | protein_molecule | denotes | soluble Fas ligand |
| T28 | 1037-1041 | protein_molecule | denotes | CD95 |
| T29 | 1075-1106 | protein_family_or_group | denotes | active death effector proteases |
| T30 | 1107-1116 | protein_molecule | denotes | caspase-1 |
| T31 | 1123-1145 | protein_molecule | denotes | IL-1 converting enzyme |
| T32 | 1148-1157 | protein_molecule | denotes | caspase-3 |
| T33 | 1164-1182 | protein_molecule | denotes | CPP32/Yama/apopain |
| T34 | 1189-1198 | protein_molecule | denotes | caspase-6 |
| T35 | 1228-1237 | protein_molecule | denotes | caspase-3 |
| T36 | 1249-1254 | protein_molecule | denotes | poly( |
| T37 | 1254-1257 | nucleotide | denotes | ADP |
| T38 | 1281-1298 | other_name | denotes | DNA fragmentation |
| T39 | 1394-1402 | protein_family_or_group | denotes | caspases |
| T40 | 1434-1441 | cell_type | denotes | T cells |
| T41 | 1455-1465 | protein_complex | denotes | NF-kappa B |
| T42 | 1509-1513 | peptide | denotes | SN50 |
| T43 | 1522-1531 | other_name | denotes | apoptosis |
| T44 | 1579-1589 | protein_complex | denotes | NF-kappa B |
| T45 | 1605-1614 | cell_type | denotes | naive PBL |