PubMed:10390665 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10390665","sourcedb":"PubMed","sourceid":"10390665","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10390665","text":"Anti-emetic efficacy of prophylactic granisetron compared with perphenazine for the prevention of post-operative vomiting in children.\nWe have compared the efficacy of granisetron with perphenazine in the prevention of vomiting after tonsillectomy with or without adenoidectomy in children. In a prospective, randomized, double-blind study, 90 paediatric patients, ASA I, aged 4-10 years, received granisetron 40 mg kg-1 or perphenazine 70 mg kg-1 (n = 45 each) intravenously immediately after an inhalation induction of anaesthesia. A standard general anaesthetic technique was employed throughout. A complete response, defined as no emesis with no need for another rescue antiemetic, during the first 3 h (0-3 h) after anesthesia was 87% with granisetron and 78% with perphenazine (P = 0.204). The corresponding incidence during the next 21 h (3-24 h) after anaesthesia was 87% and 62% (P = 0.007). No clinically serious adverse events were observed in any of the groups. We conclude that granisetron is a better anti-emetic than perphenazine for the long-term prevention of post-operative vomiting in children undergoing general anaesthesia for tonsillectomy.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":328,"end":333},"obj":"HP_0000618"},{"id":"T2","span":{"begin":635,"end":641},"obj":"HP_0002013"},{"id":"T3","span":{"begin":1092,"end":1100},"obj":"HP_0002013"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93c2ec","default":true}]}]}}