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PubMed:10384153 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes Altered memory T cell differentiation in patients with early rheumatoid arthritis.
T2 83-253 Sentence denotes The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
T3 254-548 Sentence denotes To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
T4 549-672 Sentence denotes No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
T5 673-814 Sentence denotes A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
T6 815-868 Sentence denotes Marked differences were found in response to priming.
T7 869-977 Sentence denotes Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
T8 978-1082 Sentence denotes By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
T9 1083-1226 Sentence denotes Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
T10 1227-1437 Sentence denotes In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
T11 1438-1732 Sentence denotes The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.
T1 0-82 Sentence denotes Altered memory T cell differentiation in patients with early rheumatoid arthritis.
T2 83-253 Sentence denotes The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
T3 254-548 Sentence denotes To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
T4 549-672 Sentence denotes No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
T5 673-814 Sentence denotes A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
T6 815-868 Sentence denotes Marked differences were found in response to priming.
T7 869-977 Sentence denotes Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
T8 978-1082 Sentence denotes By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
T9 1083-1226 Sentence denotes Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
T10 1227-1437 Sentence denotes In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
T11 1438-1732 Sentence denotes The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 8-21 cell_type denotes memory T cell
T2 281-294 cell_type denotes memory T cell
T3 414-441 cell_type denotes resting CD4+ memory T cells
T4 566-574 protein denotes cytokine
T5 597-628 cell_type denotes freshly isolated memory T cells
T6 675-694 cell_line denotes cell culture system
T7 751-763 protein denotes Th effectors
T8 769-791 cell_type denotes resting memory T cells
T9 869-878 cell_line denotes Th2 cells
T10 936-945 protein denotes anti-CD28
T11 964-967 protein denotes TCR
T12 1093-1097 protein denotes IL-4
T13 1264-1284 cell_type denotes IL-2-producing cells
T14 1335-1344 cell_type denotes Th1 cells
T15 1359-1368 protein denotes IFN-gamma
T16 1377-1381 protein denotes IL-2
T17 1414-1422 protein denotes anti-CD3
T18 1427-1436 protein denotes anti-CD28
T19 1460-1479 cell_type denotes CD4+ memory T cells
T20 1600-1633 cell_type denotes cytokine-producing effector cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 114-139 NP denotes rheumatoid arthritis (RA)
C2 198-222 NP denotes Th2 cell differentiation
C3 376-378 NP denotes RA
C4 445-493 NP denotes patients with early (6 wk to 12 mo) untreated RA
C5 501-538 NP denotes age- and sex-matched healthy controls
C6 650-658 NP denotes patients
C7 663-671 NP denotes controls
C8 673-694 NP denotes A cell culture system
C9 713-717 NP denotes that
C10 899-919 NP denotes all healthy controls
C11 936-945 NP denotes anti-CD28
C12 1034-1053 NP denotes Th2 differentiation
C13 1230-1242 NP denotes all patients
C14 1315-1344 NP denotes well-differentiated Th1 cells
C15 1345-1349 NP denotes that
C16 1427-1436 NP denotes anti-CD28
C18 1485-1517 NP denotes patients with early untreated RA
C17 1460-1517 NP denotes CD4+ memory T cells from patients with early untreated RA
C19 1555-1560 NP denotes their
C20 1591-1633 NP denotes specific cytokine-producing effector cells
C21 1634-1638 NP denotes that
C22 1729-1731 NP denotes RA
R1 C3 C1 coref-ident RA,rheumatoid arthritis (RA)
R2 C6 C4 coref-ident patients,patients with early (6 wk to 12 mo) untreated RA
R3 C7 C5 coref-ident controls,age- and sex-matched healthy controls
R4 C9 C8 coref-pron that,A cell culture system
R5 C10 C7 coref-ident all healthy controls,controls
R6 C12 C2 coref-ident Th2 differentiation,Th2 cell differentiation
R7 C13 C6 coref-ident all patients,patients
R8 C15 C14 coref-relat that,well-differentiated Th1 cells
R9 C16 C11 coref-ident anti-CD28,anti-CD28
R10 C18 C13 coref-ident patients with early untreated RA,all patients
R11 C19 C17 coref-relat their,CD4+ memory T cells from patients with early untreated RA
R12 C21 C20 coref-relat that,specific cytokine-producing effector cells
R13 C22 C3 coref-ident RA,RA

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-82 Sentence denotes Altered memory T cell differentiation in patients with early rheumatoid arthritis.
S2 83-253 Sentence denotes The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
S3 254-548 Sentence denotes To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
S4 549-672 Sentence denotes No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
S5 673-814 Sentence denotes A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
S6 815-868 Sentence denotes Marked differences were found in response to priming.
S7 869-977 Sentence denotes Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
S8 978-1082 Sentence denotes By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
S9 1083-1226 Sentence denotes Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
S10 1227-1437 Sentence denotes In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
S11 1438-1732 Sentence denotes The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-7 other_name denotes Altered
T2 8-21 cell_type denotes memory T cell
T3 55-81 other_name denotes early rheumatoid arthritis
T4 114-134 other_name denotes rheumatoid arthritis
T5 136-138 other_name denotes RA
T6 281-294 cell_type denotes memory T cell
T7 376-378 other_name denotes RA
T8 414-441 cell_type denotes resting CD4+ memory T cells
T9 445-453 multi_cell denotes patients
T10 491-493 other_name denotes RA
T11 510-538 multi_cell denotes sex-matched healthy controls
T12 566-574 protein_family_or_group denotes cytokine
T13 597-628 cell_type denotes freshly isolated memory T cells
T14 650-658 multi_cell denotes patients
T15 675-694 cell_line denotes cell culture system
T16 751-763 protein_family_or_group denotes Th effectors
T17 769-791 cell_type denotes resting memory T cells
T18 869-878 cell_line denotes Th2 cells
T19 936-945 protein_family_or_group denotes anti-CD28
T20 964-967 protein_family_or_group denotes TCR
T21 1034-1053 other_name denotes Th2 differentiation
T22 1070-1072 other_name denotes RA
T23 1073-1081 multi_cell denotes patients
T24 1093-1097 protein_molecule denotes IL-4
T25 1126-1145 other_name denotes Th2 differentiation
T26 1162-1170 multi_cell denotes patients
T27 1217-1225 multi_cell denotes patients
T28 1234-1242 multi_cell denotes patients
T29 1264-1268 protein_molecule denotes IL-2
T30 1335-1344 cell_type denotes Th1 cells
T31 1359-1368 protein_molecule denotes IFN-gamma
T32 1377-1381 protein_molecule denotes IL-2
T33 1414-1422 protein_family_or_group denotes anti-CD3
T34 1427-1436 protein_family_or_group denotes anti-CD28
T35 1460-1479 cell_type denotes CD4+ memory T cells
T36 1485-1493 multi_cell denotes patients
T37 1515-1517 other_name denotes RA
T38 1530-1551 other_name denotes intrinsic abnormality
T39 1600-1633 cell_type denotes cytokine-producing effector cells
T40 1678-1725 other_name denotes Th1-dominated chronic (auto)immune inflammation
T41 1729-1731 other_name denotes RA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 114-134 HP_0001370 denotes rheumatoid arthritis
T2 125-134 HP_0001369 denotes arthritis