PubMed:10384094
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10384094","sourcedb":"PubMed","sourceid":"10384094","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10384094","text":"Cutting edge: expression of the NF of activated T cells in eosinophils: regulation by IL-4 and IL-5.\nWe report that NF-AT1 and NF-AT4 are expressed cytoplasmically in resting eosinophils, whereas NF-AT2 and NF-AT3 have not been seen. Likewise, NF-AT1 mRNA and NF-AT4 mRNA have been detected in resting eosinophils, and their levels can be significantly up-regulated by the Th2-associated cytokines IL-4 and IL-5. There is no detectable NF-AT protein expression in the nuclei of resting eosinophils. However NF-ATs appear in the nuclei of IL-4-, IL-5-, or ionomycin-stimulated eosinophils. Only NF-AT1 and NF-AT4, but not NF-AT2 and NF-AT3, have translocated into the nuclei in IL-4- or IL-5-stimulated eosinophils. These findings delineate a novel pathway in the cytokine network in which Th2 lymphocytes \"control\" eosinophils via the release of IL-4 and IL-5, and activation of NF-AT in eosinophils. The findings also suggest that a later feedback \"talking\" may exist between eosinophils and Th2 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