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PubMed:10383940 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes STAT1
T2 67-85 protein denotes adhesion molecules
T3 87-102 cell_type denotes Human monocytes
T4 195-206 cell_type denotes macrophages
T5 423-488 protein denotes signal transducers and activators of transcription (STAT) factors
T6 565-570 protein denotes STAT1
T7 648-653 protein denotes STAT1
T8 682-704 DNA denotes STAT binding sequences
T9 706-709 DNA denotes SBE
T10 726-735 DNA denotes promoters
T11 817-826 DNA denotes FcgammaRI
T12 831-837 DNA denotes ICAM-1
T13 866-910 DNA denotes transcription factor IFN regulatory factor-1
T14 1026-1031 protein denotes STAT1
T15 1058-1067 cell_type denotes monocytes
T16 1210-1215 protein denotes STAT1
T17 1256-1279 cell_line denotes IFN-gamma-treated cells
T18 1322-1327 protein denotes STAT1
T19 1343-1351 protein denotes cytokine
T20 1382-1386 protein denotes Y701
T21 1391-1401 protein denotes S727 STAT1
T22 1441-1472 protein denotes transforming growth factor-beta
T23 1516-1549 protein denotes monocytic differentiation markers
T24 1608-1613 protein denotes STAT1
T25 1675-1680 protein denotes STAT1
T26 1747-1756 cell_type denotes monocytes
T27 1769-1789 protein denotes transcription factor
T28 1867-1883 DNA denotes functional genes
T29 1893-1899 protein denotes ICAM-1
T30 1904-1913 protein denotes FcgammaRI

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 36-57 NP denotes macrophage maturation
C1 24-57 NP denotes monocyte to macrophage maturation
C3 87-151 NP denotes Human monocytes isolated from peripheral blood of healthy donors
C4 252-257 NP denotes their
C5 565-578 NP denotes STAT1 protein
C6 739-744 NP denotes genes
C7 745-750 NP denotes which
C9 787-808 NP denotes macrophage maturation
C8 775-808 NP denotes monocyte to macrophage maturation
C10 817-837 NP denotes FcgammaRI and ICAM-1
C11 1441-1472 NP denotes transforming growth factor-beta
C12 1474-1479 NP denotes which
C13 1561-1582 NP denotes macrophage maturation
C14 1675-1680 NP denotes STAT1
C15 1893-1913 NP denotes ICAM-1 and FcgammaRI
R1 C4 C3 coref-pron their,Human monocytes isolated from peripheral blood of healthy donors
R2 C7 C6 coref-relat which,genes
R3 C9 C2 coref-ident macrophage maturation,macrophage maturation
R4 C8 C1 coref-ident monocyte to macrophage maturation,monocyte to macrophage maturation
R5 C12 C11 coref-relat which,transforming growth factor-beta
R6 C13 C9 coref-ident macrophage maturation,macrophage maturation
R7 C14 C5 coref-ident STAT1,STAT1 protein
R8 C15 C10 coref-ident ICAM-1 and FcgammaRI,FcgammaRI and ICAM-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-86 Sentence denotes STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules.
S2 87-318 Sentence denotes Human monocytes isolated from peripheral blood of healthy donors show a time-dependent differentiation into macrophages upon in vitro cultivation, closely mimicking their in vivo migration and maturation into extravascular tissues.
S3 319-387 Sentence denotes The mediator(s) of this maturation process has not been yet defined.
S4 388-647 Sentence denotes We investigated the involvement of signal transducers and activators of transcription (STAT) factors in this phenomenon and reported the specific, time-dependent, activation of STAT1 protein starting at day 0/1 of cultivation and maximally expressed at day 5.
S5 648-911 Sentence denotes STAT1 activity was evident on the STAT binding sequences (SBE) present in the promoters of genes which are up-regulated during monocyte to macrophage maturation such as FcgammaRI and ICAM-1, and in the promoter of the transcription factor IFN regulatory factor-1.
S6 912-1043 Sentence denotes Moreover, the effect of cell adhesion to fibronectin or laminin was studied to investigate mechanisms involved in STAT1 activation.
S7 1044-1280 Sentence denotes Compared with monocytes adherent on plastic surfaces, freshly isolated cells allowed to adhere either to fibronectin- or laminin-coated flasks exhibited an increased STAT1 binding activity both in control and in IFN-gamma-treated cells.
S8 1281-1418 Sentence denotes The molecular events leading to enhanced STAT1 activation and cytokine responsiveness concerned both Y701 and S727 STAT1 phosphorylation.
S9 1419-1631 Sentence denotes Exogenous addition of transforming growth factor-beta, which exerts an inhibitory effect on some monocytic differentiation markers, inhibited macrophage maturation, integrin expression and STAT1 binding activity.
S10 1632-1914 Sentence denotes Taken together these results indicate that STAT1 plays a pivotal role in the differentiation/maturation process of monocytes as an early transcription factor initially activated by adherence and then able to modulate the expression of functional genes, such as ICAM-1 and FcgammaRI.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 protein_molecule denotes STAT1
T2 24-57 other_name denotes monocyte to macrophage maturation
T3 67-85 protein_family_or_group denotes adhesion molecules
T4 87-102 cell_type denotes Human monocytes
T5 117-133 tissue denotes peripheral blood
T6 137-151 body_part denotes healthy donors
T7 195-206 cell_type denotes macrophages
T8 261-275 other_name denotes vivo migration
T9 280-290 other_name denotes maturation
T10 296-317 tissue denotes extravascular tissues
T11 423-488 protein_family_or_group denotes signal transducers and activators of transcription (STAT) factors
T12 565-570 protein_molecule denotes STAT1
T13 648-653 protein_molecule denotes STAT1
T14 682-704 DNA_domain_or_region denotes STAT binding sequences
T15 706-709 DNA_domain_or_region denotes SBE
T16 726-735 DNA_family_or_group denotes promoters
T17 817-826 DNA_domain_or_region denotes FcgammaRI
T18 831-837 DNA_domain_or_region denotes ICAM-1
T19 866-886 protein_family_or_group denotes transcription factor
T20 1026-1031 protein_molecule denotes STAT1
T21 1058-1067 cell_type denotes monocytes
T22 1080-1096 other_organic_compound denotes plastic surfaces
T23 1210-1215 protein_molecule denotes STAT1
T24 1256-1279 cell_line denotes IFN-gamma-treated cells
T25 1322-1327 protein_molecule denotes STAT1
T26 1343-1351 protein_family_or_group denotes cytokine
T27 1382-1386 protein_molecule denotes Y701
T28 1391-1395 protein_molecule denotes S727
T29 1396-1401 protein_molecule denotes STAT1
T30 1441-1472 protein_molecule denotes transforming growth factor-beta
T31 1516-1549 protein_family_or_group denotes monocytic differentiation markers
T32 1608-1613 protein_molecule denotes STAT1
T33 1675-1680 protein_molecule denotes STAT1
T34 1709-1743 other_name denotes differentiation/maturation process
T35 1747-1756 cell_type denotes monocytes
T36 1769-1789 protein_family_or_group denotes transcription factor
T37 1867-1883 DNA_family_or_group denotes functional genes
T38 1893-1899 DNA_domain_or_region denotes ICAM-1
T39 1904-1913 DNA_domain_or_region denotes FcgammaRI