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sentences

Id Subject Object Predicate Lexical cue
T1 0-89 Sentence denotes Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription.
T2 90-281 Sentence denotes Ubc9, a homologue of the class E2 ubiquitin-conjugating enzymes, has recently been shown to catalyze conjugation of a small ubiquitin-like molecule-1 (SUMO-1) to a variety of target proteins.
T3 282-484 Sentence denotes SUMO-1 modifications have been implicated in the targeting of proteins to the nuclear envelope and certain intranuclear structures and in converting proteins resistant to ubiquitin-mediated degradation.
T4 485-649 Sentence denotes In the present work, we find that Ubc9 interacts with the androgen receptor (AR), a member of the steroid receptor family of ligand-activated transcription factors.
T5 650-771 Sentence denotes In transiently transfected COS-1 cells, AR-dependent but not basal transcription is enhanced by the coexpression of Ubc9.
T6 772-934 Sentence denotes The N-terminal half of the AR hinge region containing the C-terminal part of the bipartite nuclear localization signal is essential for the interaction with Ubc9.
T7 935-1162 Sentence denotes Deletion of this part of the nuclear localization signal, which does not completely prevent the transfer of AR to the nucleus, abolishes the AR-Ubc9 interaction and attenuates the transcriptional response to cotransfected Ubc9.
T8 1163-1513 Sentence denotes The C93S substitution of Ubc9, which prevents SUMO-1 conjugation by abrogating the formation of a thiolester bond between SUMO-1 and Ubc9, does not influence the capability of Ubc9 to stimulate AR-dependent transactivation, implying that Ubc9 is able to act as an AR coregulator in a fashion independent of its ability to catalyze SUMO-1 conjugation.

relna

Id Subject Object Predicate Lexical cue
T1 0-4 Protein denotes Ubc9
T2 24-41 DNA denotes androgen receptor
T3 90-94 Protein denotes Ubc9
T4 208-239 Protein denotes small ubiquitin-like molecule-1
T5 241-247 Protein denotes SUMO-1
T6 282-288 Protein denotes SUMO-1
T7 519-523 Protein denotes Ubc9
T8 543-560 DNA denotes androgen receptor
T9 562-564 DNA denotes AR
T10 690-692 DNA denotes AR
T11 766-770 Protein denotes Ubc9
T12 799-801 DNA denotes AR
T13 929-933 Protein denotes Ubc9
T14 1043-1045 DNA denotes AR
T15 1076-1078 DNA denotes AR
T16 1079-1083 Protein denotes Ubc9
T17 1157-1161 Protein denotes Ubc9
T18 1188-1192 Protein denotes Ubc9
T19 1209-1215 Protein denotes SUMO-1
T20 1285-1291 Protein denotes SUMO-1
T21 1296-1300 Protein denotes Ubc9
T22 1339-1343 Protein denotes Ubc9
T23 1357-1359 DNA denotes AR
T24 1401-1405 Protein denotes Ubc9
T25 1427-1429 DNA denotes AR
T26 1494-1500 Protein denotes SUMO-1
R0 T1 T2 linked Ubc9,androgen receptor
R1 T7 T8 linked Ubc9,androgen receptor
R2 T15 T16 linked AR,Ubc9

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 863-890 Disease denotes nuclear localization signal http://purl.obolibrary.org/obo/MONDO_0000179
T2 964-991 Disease denotes nuclear localization signal http://purl.obolibrary.org/obo/MONDO_0000179

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 360-376 Body_part denotes nuclear envelope http://purl.obolibrary.org/obo/GO_0005635
T2 1053-1060 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 711-716 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324