PubMed:10383454 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	714-718	Body_part	denotes	cell	http://purl.obolibrary.org/obo/CL_0000000

Id	Subject	Object	Predicate	Lexical cue
T1	0-93	Sentence	denotes	IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
T2	94-317	Sentence	denotes	The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of other members of the Toll/IL-1 receptor family.
T3	318-402	Sentence	denotes	We now report the identification and characterization of a novel IRAK-like molecule.
T4	403-574	Sentence	denotes	In contrast to the ubiquitously expressed IRAK and IRAK-2, this new IRAK-like molecule is found mainly in cells of monomyeloic origin and is, therefore, designated IRAK-M.
T5	575-737	Sentence	denotes	Although IRAK-M and IRAK-2 exhibit only a negligible autophosphorylation activity, they can reconstitute the IL-1 response in a 293 mutant cell line lacking IRAK.
T6	738-879	Sentence	denotes	In addition, we show for the first time that members of the IRAK family are indispensable elements of lipopolysaccharide signal transduction.
T7	880-1015	Sentence	denotes	The discovery of IRAK-M adds another level of complexity to our understanding of signaling by members of the Toll/IL-1 receptor family.

Id	Subject	Object	Predicate	Lexical cue
T1	222-227	http://purl.obolibrary.org/obo/MAT_0000488	denotes	later

Id	Subject	Object	Predicate	Lexical cue
T1	509-514	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2	648-656	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity
T3	714-718	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell

Id	Subject	Object	Predicate	Lexical cue
T1	0-6	Gene_or_gene_product	denotes	IRAK-M
T2	32-37	Gene_or_gene_product	denotes	Pelle
T3	38-78	Gene_or_gene_product	denotes	interleukin-1 receptor-associated kinase
T4	80-84	Gene_or_gene_product	denotes	IRAK
T5	98-138	Gene_or_gene_product	denotes	interleukin-1 receptor-associated kinase
T6	140-144	Gene_or_gene_product	denotes	IRAK
T7	193-206	Gene_or_gene_product	denotes	interleukin-1
T8	208-212	Gene_or_gene_product	denotes	IL-1
T9	291-309	Gene_or_gene_product	denotes	Toll/IL-1 receptor
T10	383-387	Gene_or_gene_product	denotes	IRAK
T11	445-449	Gene_or_gene_product	denotes	IRAK
T12	454-460	Gene_or_gene_product	denotes	IRAK-2
T13	471-475	Gene_or_gene_product	denotes	IRAK
T14	567-573	Gene_or_gene_product	denotes	IRAK-M
T15	584-590	Gene_or_gene_product	denotes	IRAK-M
T16	595-601	Gene_or_gene_product	denotes	IRAK-2
T17	684-688	Gene_or_gene_product	denotes	IL-1
T18	732-736	Gene_or_gene_product	denotes	IRAK
T19	798-802	Gene_or_gene_product	denotes	IRAK
T20	840-858	Simple_chemical	denotes	lipopolysaccharide
T21	897-903	Gene_or_gene_product	denotes	IRAK-M
T22	989-1007	Gene_or_gene_product	denotes	Toll/IL-1 receptor