> top > docs > PubMed:10383126 > annotations

PubMed:10383126 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay.
TextSentencer_T2 112-277 Sentence denotes MYC gene overexpression was identified recently as a downstream step at the end of the Wnt/APC/beta-catenin pathway dysregulation observed in colorectal cancer (T-C.
TextSentencer_T3 278-318 Sentence denotes He et al., Science (Washington DC), 281:
TextSentencer_T4 319-336 Sentence denotes 1509-1512, 1998).
TextSentencer_T5 337-424 Sentence denotes It thus appears that an excess of c-myc protein is a primary cause of numerous cancers.
TextSentencer_T6 425-568 Sentence denotes In breast cancer, MYC has been studied mostly at the DNA level because of the poor quality of available antibodies against the protein product.
TextSentencer_T7 569-689 Sentence denotes The renewed interest in MYC calls for a sensitive and accurate method for analyzing MYC overexpression in breast tumors.
TextSentencer_T8 690-843 Sentence denotes We have developed a real-time quantitative reverse transcription-PCR assay based on TaqMan fluorescence methodology to quantify the MYC mRNA copy number.
TextSentencer_T9 844-903 Sentence denotes We validated the method on a large series of breast tumors.
TextSentencer_T10 904-1043 Sentence denotes MYC gene overexpression was observed in 29 of 134 (22%) breast tumor RNAs, ranging from 3.2 to 19 times the level in normal breast tissues.
TextSentencer_T11 1044-1209 Sentence denotes These data imply that dysregulated MYC gene expression is potentially involved in the pathogenesis of breast cancer, especially by favoring local cell proliferation.
TextSentencer_T12 1210-1322 Sentence denotes We also found that MYC gene overexpression was rarely due to an increased MYC gene copy number in breast cancer.
TextSentencer_T13 1323-1569 Sentence denotes This new, simple, rapid, and semiautomated method will be useful for screening cancer patients for MYC overexpression and will prove a powerful tool in large, randomized, prospective, cooperative group trials and in the MYC-based therapy project.
T1 0-111 Sentence denotes Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription-PCR assay.
T2 112-277 Sentence denotes MYC gene overexpression was identified recently as a downstream step at the end of the Wnt/APC/beta-catenin pathway dysregulation observed in colorectal cancer (T-C.
T3 278-318 Sentence denotes He et al., Science (Washington DC), 281:
T4 319-336 Sentence denotes 1509-1512, 1998).
T5 337-424 Sentence denotes It thus appears that an excess of c-myc protein is a primary cause of numerous cancers.
T6 425-568 Sentence denotes In breast cancer, MYC has been studied mostly at the DNA level because of the poor quality of available antibodies against the protein product.
T7 569-689 Sentence denotes The renewed interest in MYC calls for a sensitive and accurate method for analyzing MYC overexpression in breast tumors.
T8 690-843 Sentence denotes We have developed a real-time quantitative reverse transcription-PCR assay based on TaqMan fluorescence methodology to quantify the MYC mRNA copy number.
T9 844-903 Sentence denotes We validated the method on a large series of breast tumors.
T10 904-1043 Sentence denotes MYC gene overexpression was observed in 29 of 134 (22%) breast tumor RNAs, ranging from 3.2 to 19 times the level in normal breast tissues.
T11 1044-1209 Sentence denotes These data imply that dysregulated MYC gene expression is potentially involved in the pathogenesis of breast cancer, especially by favoring local cell proliferation.
T12 1210-1322 Sentence denotes We also found that MYC gene overexpression was rarely due to an increased MYC gene copy number in breast cancer.
T13 1323-1569 Sentence denotes This new, simple, rapid, and semiautomated method will be useful for screening cancer patients for MYC overexpression and will prove a powerful tool in large, randomized, prospective, cooperative group trials and in the MYC-based therapy project.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10383126-0#16#19#gene4609 16-19 gene4609 denotes MYC
10383126-0#48#61#diseaseC1458155 48-61 diseaseC1458155 denotes breast tumors
10383126-1#0#3#gene4609 112-115 gene4609 denotes MYC
10383126-1#91#94#gene324 203-206 gene324 denotes APC
10383126-1#142#159#diseaseC0009402 254-271 diseaseC0009402 denotes colorectal cancer
10383126-1#142#159#diseaseC1527249 254-271 diseaseC1527249 denotes colorectal cancer
10383126-1#142#159#diseaseC0009402 254-271 diseaseC0009402 denotes colorectal cancer
10383126-1#142#159#diseaseC1527249 254-271 diseaseC1527249 denotes colorectal cancer
10383126-10#19#22#gene4609 1229-1232 gene4609 denotes MYC
10383126-10#74#77#gene4609 1284-1287 gene4609 denotes MYC
10383126-10#98#111#diseaseC0006142 1308-1321 diseaseC0006142 denotes breast cancer
10383126-10#98#111#diseaseC0678222 1308-1321 diseaseC0678222 denotes breast cancer
10383126-10#98#111#diseaseC0006142 1308-1321 diseaseC0006142 denotes breast cancer
10383126-10#98#111#diseaseC0678222 1308-1321 diseaseC0678222 denotes breast cancer
16#19#gene460948#61#diseaseC1458155 10383126-0#16#19#gene4609 10383126-0#48#61#diseaseC1458155 associated_with MYC,breast tumors
0#3#gene4609142#159#diseaseC0009402 10383126-1#0#3#gene4609 10383126-1#142#159#diseaseC0009402 associated_with MYC,colorectal cancer
0#3#gene4609142#159#diseaseC1527249 10383126-1#0#3#gene4609 10383126-1#142#159#diseaseC1527249 associated_with MYC,colorectal cancer
0#3#gene4609142#159#diseaseC0009402 10383126-1#0#3#gene4609 10383126-1#142#159#diseaseC0009402 associated_with MYC,colorectal cancer
0#3#gene4609142#159#diseaseC1527249 10383126-1#0#3#gene4609 10383126-1#142#159#diseaseC1527249 associated_with MYC,colorectal cancer
91#94#gene324142#159#diseaseC0009402 10383126-1#91#94#gene324 10383126-1#142#159#diseaseC0009402 associated_with APC,colorectal cancer
91#94#gene324142#159#diseaseC1527249 10383126-1#91#94#gene324 10383126-1#142#159#diseaseC1527249 associated_with APC,colorectal cancer
91#94#gene324142#159#diseaseC0009402 10383126-1#91#94#gene324 10383126-1#142#159#diseaseC0009402 associated_with APC,colorectal cancer
91#94#gene324142#159#diseaseC1527249 10383126-1#91#94#gene324 10383126-1#142#159#diseaseC1527249 associated_with APC,colorectal cancer
19#22#gene460998#111#diseaseC0006142 10383126-10#19#22#gene4609 10383126-10#98#111#diseaseC0006142 associated_with MYC,breast cancer
19#22#gene460998#111#diseaseC0678222 10383126-10#19#22#gene4609 10383126-10#98#111#diseaseC0678222 associated_with MYC,breast cancer
19#22#gene460998#111#diseaseC0006142 10383126-10#19#22#gene4609 10383126-10#98#111#diseaseC0006142 associated_with MYC,breast cancer
19#22#gene460998#111#diseaseC0678222 10383126-10#19#22#gene4609 10383126-10#98#111#diseaseC0678222 associated_with MYC,breast cancer
74#77#gene460998#111#diseaseC0006142 10383126-10#74#77#gene4609 10383126-10#98#111#diseaseC0006142 associated_with MYC,breast cancer
74#77#gene460998#111#diseaseC0678222 10383126-10#74#77#gene4609 10383126-10#98#111#diseaseC0678222 associated_with MYC,breast cancer
74#77#gene460998#111#diseaseC0006142 10383126-10#74#77#gene4609 10383126-10#98#111#diseaseC0006142 associated_with MYC,breast cancer
74#77#gene460998#111#diseaseC0678222 10383126-10#74#77#gene4609 10383126-10#98#111#diseaseC0678222 associated_with MYC,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1397 1229-1232 gene:4609 denotes MYC
T1398 1308-1321 disease:C0006142 denotes breast cancer
T1399 1284-1287 gene:4609 denotes MYC
R1 T1397 T1398 associated_with MYC,breast cancer
R2 T1397 T1398 associated_with MYC,breast cancer
R3 T1399 T1398 associated_with MYC,breast cancer
R4 T1399 T1398 associated_with MYC,breast cancer

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1035-1042 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 48-54 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 428-434 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 675-681 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 889-895 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 960-966 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1028-1034 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1146-1152 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1308-1314 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 48-54 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 428-434 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 675-681 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 889-895 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 960-966 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1028-1034 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1146-1152 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1308-1314 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1035-1042 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

DisGeNET

Id Subject Object Predicate Lexical cue
T0 112-115 gene:4609 denotes MYC
T1 254-271 disease:C0009402 denotes colorectal cancer
T2 112-115 gene:4609 denotes MYC
T3 254-271 disease:C1527249 denotes colorectal cancer
T4 203-206 gene:5624 denotes APC
T5 254-271 disease:C0009402 denotes colorectal cancer
T6 203-206 gene:324 denotes APC
T7 254-271 disease:C1527249 denotes colorectal cancer
T8 203-206 gene:324 denotes APC
T9 254-271 disease:C0009402 denotes colorectal cancer
T10 203-206 gene:5624 denotes APC
T11 254-271 disease:C1527249 denotes colorectal cancer
T12 904-907 gene:4609 denotes MYC
T13 960-972 disease:C1458155 denotes breast tumor
R1 T0 T1 associated_with MYC,colorectal cancer
R2 T2 T3 associated_with MYC,colorectal cancer
R3 T4 T5 associated_with APC,colorectal cancer
R4 T6 T7 associated_with APC,colorectal cancer
R5 T8 T9 associated_with APC,colorectal cancer
R6 T10 T11 associated_with APC,colorectal cancer
R7 T12 T13 associated_with MYC,breast tumor

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 265-271 HP_0002664 denotes cancer
T2 416-423 HP_0002664 denotes cancers
T3 428-441 HP_0003002 denotes breast cancer
T4 428-441 HP_0100013 denotes breast cancer
T5 435-441 HP_0002664 denotes cancer
T6 675-688 HP_0003002 denotes breast tumors
T7 675-688 HP_0100013 denotes breast tumors
T8 682-688 HP_0002664 denotes tumors
T9 889-902 HP_0003002 denotes breast tumors
T10 889-902 HP_0100013 denotes breast tumors
T11 896-902 HP_0002664 denotes tumors
T12 960-972 HP_0003002 denotes breast tumor
T13 960-972 HP_0100013 denotes breast tumor
T14 967-972 HP_0002664 denotes tumor
T15 1146-1159 HP_0003002 denotes breast cancer
T16 1146-1159 HP_0100013 denotes breast cancer
T17 1153-1159 HP_0002664 denotes cancer
T18 1308-1321 HP_0003002 denotes breast cancer
T19 1308-1321 HP_0100013 denotes breast cancer
T20 1315-1321 HP_0002664 denotes cancer
T21 1402-1408 HP_0002664 denotes cancer