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PubMed:10381501 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-6 protein denotes GATA-1
T2 11-25 protein denotes erythropoietin
T3 85-91 protein denotes bcl-xL
T4 108-128 protein denotes transcription factor
T5 129-135 protein denotes GATA-1
T6 192-233 cell_line denotes vitro-differentiated embryonic stem cells
T7 279-285 protein denotes GATA-1
T8 287-317 cell_line denotes committed erythroid precursors
T9 401-407 protein denotes GATA-1
T10 467-482 cell_type denotes erythroid cells
T11 484-490 protein denotes GATA-1
T12 530-552 protein denotes anti-apoptotic protein
T13 553-559 protein denotes bcl-xL
T14 590-595 protein denotes bcl-2
T15 600-605 protein denotes mcl-1
T16 634-640 protein denotes bcl-xL
T17 654-660 protein denotes GATA-1
T18 697-748 cell_line denotes vitro-differentiated bcl-xL-/- embryonic stem cells
T19 791-806 cell_type denotes erythroid cells
T20 839-850 DNA denotes GATA-1 gene
T21 889-903 protein denotes erythropoietin
T22 973-979 protein denotes GATA-1
T23 993-999 protein denotes bcl-xL
T24 1114-1120 protein denotes bcl-xL
T25 1211-1217 protein denotes bcl-xL
T26 1255-1261 protein denotes GATA-1
T27 1266-1280 protein denotes erythropoietin

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-103 Sentence denotes GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
S2 104-175 Sentence denotes The transcription factor GATA-1 is essential for normal erythropoiesis.
S3 176-376 Sentence denotes By examining in vitro-differentiated embryonic stem cells, we showed previously that in the absence of GATA-1, committed erythroid precursors fail to complete maturation and instead undergo apoptosis.
S4 377-443 Sentence denotes The mechanisms by which GATA-1 controls cell survival are unknown.
S5 444-606 Sentence denotes Here we report that in erythroid cells, GATA-1 strongly induces the expression of the anti-apoptotic protein bcl-xL, but not the related proteins bcl-2 and mcl-1.
S6 607-862 Sentence denotes Consistent with a role for bcl-xL in mediating GATA-1-induced erythroid cell survival, in vitro-differentiated bcl-xL-/- embryonic stem cells fail to generate viable mature definitive erythroid cells, a phenotype resembling that of GATA-1 gene disruption.
S7 863-1084 Sentence denotes In addition, we show that erythropoietin, which is also required for erythroid cell survival, cooperates with GATA-1 to stimulate bcl-xL gene expression and to maintain erythroid cell viability during terminal maturation.
S8 1085-1298 Sentence denotes Together, our data show that bcl-xL is essential for normal erythroid development and suggest a regulatory hierarchy in which bcl-xL is a critical downstream effector of GATA-1 and erythropoietin-mediated signals.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-6 NP denotes GATA-1
C2 11-25 NP denotes erythropoietin
C3 47-70 NP denotes erythroid cell survival
C4 85-102 NP denotes bcl-xL expression
C5 104-135 NP denotes The transcription factor GATA-1
C6 279-285 NP denotes GATA-1
C7 377-391 NP denotes The mechanisms
C8 395-400 NP denotes which
C9 401-407 NP denotes GATA-1
C10 484-490 NP denotes GATA-1
C12 526-559 NP denotes the anti-apoptotic protein bcl-xL
C11 508-559 NP denotes the expression of the anti-apoptotic protein bcl-xL
C13 634-640 NP denotes bcl-xL
C14 766-806 NP denotes viable mature definitive erythroid cells
C16 808-819 NP denotes a phenotype
C17 831-835 NP denotes that
C15 808-861 NP denotes a phenotype resembling that of GATA-1 gene disruption
C18 889-903 NP denotes erythropoietin
C19 905-910 NP denotes which
C20 932-955 NP denotes erythroid cell survival
C21 973-979 NP denotes GATA-1
C22 1114-1120 NP denotes bcl-xL
C23 1179-1201 NP denotes a regulatory hierarchy
C24 1205-1210 NP denotes which
C25 1211-1217 NP denotes bcl-xL
C26 1255-1261 NP denotes GATA-1
R1 C5 C1 coref-ident The transcription factor GATA-1,GATA-1
R2 C6 C5 coref-ident GATA-1,The transcription factor GATA-1
R3 C8 C7 coref-relat which,The mechanisms
R4 C9 C6 coref-ident GATA-1,GATA-1
R5 C10 C9 coref-ident GATA-1,GATA-1
R6 C11 C4 coref-ident the expression of the anti-apoptotic protein bcl-xL,bcl-xL expression
R7 C13 C12 coref-ident bcl-xL,the anti-apoptotic protein bcl-xL
R8 C17 C16 coref-pron that,a phenotype
R9 C15 C14 coref-appos a phenotype resembling that of GATA-1 gene disruption,viable mature definitive erythroid cells
R10 C18 C2 coref-ident erythropoietin,erythropoietin
R11 C19 C18 coref-relat which,erythropoietin
R12 C20 C3 coref-ident erythroid cell survival,erythroid cell survival
R13 C21 C10 coref-ident GATA-1,GATA-1
R14 C22 C13 coref-ident bcl-xL,bcl-xL
R15 C24 C23 coref-relat which,a regulatory hierarchy
R16 C25 C22 coref-ident bcl-xL,bcl-xL
R17 C26 C21 coref-ident GATA-1,GATA-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-6 protein_molecule denotes GATA-1
T2 11-25 protein_family_or_group denotes erythropoietin
T3 47-70 other_name denotes erythroid cell survival
T4 85-91 protein_molecule denotes bcl-xL
T5 108-128 protein_family_or_group denotes transcription factor
T6 129-135 protein_molecule denotes GATA-1
T7 192-233 cell_line denotes vitro-differentiated embryonic stem cells
T8 279-285 protein_molecule denotes GATA-1
T9 287-317 cell_line denotes committed erythroid precursors
T10 366-375 other_name denotes apoptosis
T11 401-407 protein_molecule denotes GATA-1
T12 417-430 other_name denotes cell survival
T13 467-482 cell_type denotes erythroid cells
T14 484-490 protein_molecule denotes GATA-1
T15 530-552 protein_family_or_group denotes anti-apoptotic protein
T16 553-559 protein_molecule denotes bcl-xL
T17 590-595 protein_molecule denotes bcl-2
T18 600-605 protein_molecule denotes mcl-1
T19 634-640 protein_molecule denotes bcl-xL
T20 654-660 protein_molecule denotes GATA-1
T21 669-678 other_name denotes erythroid
T22 679-692 other_name denotes cell survival
T23 697-717 cell_line denotes vitro-differentiated
T24 718-724 protein_molecule denotes bcl-xL
T25 791-806 cell_type denotes erythroid cells
T26 839-850 DNA_domain_or_region denotes GATA-1 gene
T27 889-903 protein_family_or_group denotes erythropoietin
T28 932-941 other_name denotes erythroid
T29 942-955 other_name denotes cell survival
T30 973-979 protein_molecule denotes GATA-1
T31 993-999 protein_molecule denotes bcl-xL
T32 1064-1083 other_name denotes terminal maturation
T33 1114-1120 protein_molecule denotes bcl-xL
T34 1181-1201 other_name denotes regulatory hierarchy
T35 1211-1217 protein_molecule denotes bcl-xL
T36 1255-1261 protein_molecule denotes GATA-1
T37 1266-1280 protein_family_or_group denotes erythropoietin