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PubMed:10380915 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 45-49 protein denotes JAK3
T2 49-58 protein denotes /STAT5a/b
T3 133-140 cell_type denotes T cells
T4 142-163 protein denotes Janus kinase 3 (JAK3)
T5 169-196 protein denotes cytoplasmic tyrosine kinase
T6 210-216 cell_type denotes T cell
T7 246-255 protein denotes cytokines
T8 273-332 protein denotes interleukin-2 (IL-2) receptor common gamma chain (gamma(c))
T9 358-362 protein denotes JAK3
T10 483-487 protein denotes JAK3
T11 658-662 protein denotes JAK3
T12 711-780 protein denotes signal transducer and activator of transcription 5a and 5b (STAT5a/b)
T13 834-843 protein denotes cytokines
T14 853-861 protein denotes gamma(c)
T15 885-889 protein denotes IL-2
T16 929-936 cell_type denotes T cells
T17 1151-1156 protein denotes Zap70
T18 1160-1166 protein denotes p56Lck
T19 1173-1181 protein denotes anti-CD3
T20 1203-1210 cell_type denotes T cells
T21 1276-1280 protein denotes JAK3
T22 1328-1334 cell_type denotes T cell
T23 1407-1413 cell_type denotes T cell

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-141 Sentence denotes Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
S2 142-333 Sentence denotes Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase required for T cell development and activated by cytokines that utilize the interleukin-2 (IL-2) receptor common gamma chain (gamma(c)).
S3 334-447 Sentence denotes Genetic inactivation of JAK3 is manifested as severe combined immunodeficiency disease (SCID) in humans and mice.
S4 448-569 Sentence denotes These findings have suggested that JAK3 represents a pharmacological target to control certain lymphoid-derived diseases.
S5 570-781 Sentence denotes Here we provide novel evidence that AG-490 potently inhibits the autokinase activity of JAK3 and tyrosine phosphorylation and DNA binding of signal transducer and activator of transcription 5a and 5b (STAT5a/b).
S6 782-862 Sentence denotes Similar inhibitory effects were observed with other cytokines that use gamma(c).
S7 863-994 Sentence denotes AG-490 also inhibited IL-2-mediated proliferative growth in human T cells with an IC50) = 25 microM that was partially recoverable.
S8 995-1211 Sentence denotes Moreover, we demonstrate that this inhibitor prevented tetanus toxoid antigen-specific T cell proliferation and expansion but failed to block activation of Zap70 or p56Lck after anti-CD3 stimulation of human T cells.
S9 1212-1503 Sentence denotes Taken together, these findings suggest that AG-490 inhibits the JAK3-mediated Type II signaling pathway but not the T cell receptor-derived Type I pathway and possesses therapeutic potential for T cell-derived pathologies such as graft-versus-host disease, allergy, and autoimmune disorders.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-17 NP denotes Tyrphostin AG-490
C2 142-163 NP denotes Janus kinase 3 (JAK3)
C3 246-255 NP denotes cytokines
C4 256-260 NP denotes that
C5 269-332 NP denotes the interleukin-2 (IL-2) receptor common gamma chain (gamma(c))
C6 358-362 NP denotes JAK3
C7 483-487 NP denotes JAK3
C8 586-600 NP denotes novel evidence
C9 601-605 NP denotes that
C10 606-612 NP denotes AG-490
C11 658-662 NP denotes JAK3
C12 828-843 NP denotes other cytokines
C13 844-848 NP denotes that
C14 853-861 NP denotes gamma(c)
C15 863-869 NP denotes AG-490
C16 923-936 NP denotes human T cells
C17 942-962 NP denotes an IC50) = 25 microM
C18 963-967 NP denotes that
C19 1025-1039 NP denotes this inhibitor
C20 1197-1210 NP denotes human T cells
C21 1256-1262 NP denotes AG-490
R1 C4 C3 coref-relat that,cytokines
R2 C6 C2 coref-ident JAK3,Janus kinase 3 (JAK3)
R3 C7 C6 coref-ident JAK3,JAK3
R4 C9 C8 coref-relat that,novel evidence
R5 C10 C1 coref-ident AG-490,Tyrphostin AG-490
R6 C11 C7 coref-ident JAK3,JAK3
R7 C13 C12 coref-relat that,other cytokines
R8 C14 C5 coref-ident gamma(c),the interleukin-2 (IL-2) receptor common gamma chain (gamma(c))
R9 C15 C10 coref-ident AG-490,AG-490
R10 C18 C17 coref-relat that,an IC50) = 25 microM
R11 C19 C15 coref-ident this inhibitor,AG-490
R12 C20 C16 coref-ident human T cells,human T cells
R13 C21 C19 coref-ident AG-490,this inhibitor

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-10 other_artificial_source denotes Tyrphostin
T2 11-17 other_artificial_source denotes AG-490
T3 27-44 other_name denotes cytokine-mediated
T4 45-49 protein_molecule denotes JAK3
T5 49-58 protein_family_or_group denotes /STAT5a/b
T6 83-105 other_name denotes cellular proliferation
T7 109-132 other_name denotes antigen-activated human
T8 133-140 cell_type denotes T cells
T9 142-158 protein_molecule denotes Janus kinase 3 (
T10 158-162 protein_molecule denotes JAK3
T11 169-196 protein_family_or_group denotes cytoplasmic tyrosine kinase
T12 210-216 cell_type denotes T cell
T13 246-255 protein_family_or_group denotes cytokines
T14 273-293 protein_molecule denotes interleukin-2 (IL-2)
T15 323-331 protein_subunit denotes gamma(c)
T16 358-362 protein_molecule denotes JAK3
T17 380-427 other_name denotes severe combined immunodeficiency disease (SCID)
T18 431-437 multi_cell denotes humans
T19 442-446 multi_cell denotes mice
T20 483-487 protein_molecule denotes JAK3
T21 543-568 other_name denotes lymphoid-derived diseases
T22 606-612 other_artificial_source denotes AG-490
T23 635-654 other_name denotes autokinase activity
T24 658-662 protein_molecule denotes JAK3
T25 667-691 other_name denotes tyrosine phosphorylation
T26 696-707 other_name denotes DNA binding
T27 711-771 protein_family_or_group denotes signal transducer and activator of transcription 5a and 5b (
T28 771-779 protein_family_or_group denotes STAT5a/b
T29 834-843 protein_family_or_group denotes cytokines
T30 853-861 protein_subunit denotes gamma(c)
T31 863-869 other_artificial_source denotes AG-490
T32 885-889 protein_molecule denotes IL-2
T33 929-936 cell_type denotes T cells
T34 945-962 other_name denotes IC50) = 25 microM
T35 1151-1156 protein_molecule denotes Zap70
T36 1160-1166 protein_molecule denotes p56Lck
T37 1173-1181 protein_molecule denotes anti-CD3
T38 1203-1210 cell_type denotes T cells
T39 1256-1262 other_artificial_source denotes AG-490
T40 1276-1280 protein_molecule denotes JAK3
T41 1328-1334 cell_type denotes T cell
T42 1407-1413 cell_type denotes T cell
T43 1442-1467 other_name denotes graft-versus-host disease
T44 1469-1476 other_name denotes allergy
T45 1482-1502 other_name denotes autoimmune disorders

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 380-412 HP_0004430 denotes severe combined immunodeficiency
T2 387-412 HP_0005387 denotes combined immunodeficiency
T3 396-412 HP_0002721 denotes immunodeficiency
T4 1469-1476 HP_0012393 denotes allergy
T5 1482-1492 HP_0002960 denotes autoimmune
T6 1482-1502 HP_0002960 denotes autoimmune disorders