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PubMed:10378895 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 18-35 DNA denotes Wilms' tumor gene
T2 37-40 DNA denotes WT1
T3 119-142 cell_line denotes leukemic cell line K562
T4 148-165 DNA denotes Wilms' tumor gene
T5 167-170 DNA denotes WT1
T6 182-202 protein denotes transcription factor
T7 210-226 protein denotes zinc finger type
T8 249-252 DNA denotes WT1
T9 306-309 DNA denotes WT1
T10 366-385 cell_line denotes leukemic cell lines
T11 405-408 DNA denotes WT1
T12 417-435 cell_line denotes myeloid cell lines
T13 524-527 DNA denotes WT1
T14 542-561 cell_type denotes hematopoietic cells
T15 654-657 DNA denotes WT1
T16 698-721 cell_line denotes leukemic cell line K562
T17 723-733 cell_line denotes K562 cells
T18 753-756 DNA denotes WT1
T19 959-962 DNA denotes WT1
T20 966-970 cell_line denotes K562
T21 1046-1056 protein denotes hemoglobin
T22 1072-1077 protein denotes hemin
T23 1099-1134 protein denotes megakaryocytic cell surface markers
T24 1229-1232 DNA denotes WT1
T25 1267-1277 cell_line denotes K562 cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-143 Sentence denotes Downregulation of Wilms' tumor gene (WT1) is not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562.
S2 144-227 Sentence denotes The Wilms' tumor gene (WT1) encodes a transcription factor of the zinc finger type.
S3 228-386 Sentence denotes A high expression of WT1 has been detected in a range of acute leukemias, and WT1 is downregulated during induced differentiation of some leukemic cell lines.
S4 387-484 Sentence denotes Overexpression of WT1 in some myeloid cell lines confers resistance to differentiation induction.
S5 485-599 Sentence denotes These observations suggest that a high WT1 expression in hematopoietic cells is incompatible with differentiation.
S6 600-722 Sentence denotes In this study, each of the four different isoforms of WT1 was constitutively overexpressed in the leukemic cell line K562.
S7 723-870 Sentence denotes K562 cells express endogenous WT1, which is downregulated as a response to induced differentiation along the erythroid and megakaryocytic pathways.
S8 871-1193 Sentence denotes We now demonstrate that a forced exogenous expression of the four different isoforms of WT1 in K562 does not affect the differentiation response, as judged by accumulation of hemoglobin in response to hemin or the expression of megakaryocytic cell surface markers in response to 12-O-tetradecanoylphorbol-13-acetate (TPA).
S9 1194-1363 Sentence denotes We conclude that downregulation of WT1 during induced differentiation of K562 cells is not a prerequisite for erythroid or megakaryocytic differentiation of these cells.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 18-41 NP denotes Wilms' tumor gene (WT1)
C3 115-142 NP denotes the leukemic cell line K562
C2 45-142 NP denotes not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562
C4 144-171 NP denotes The Wilms' tumor gene (WT1)
C5 249-252 NP denotes WT1
C6 306-309 NP denotes WT1
C7 405-408 NP denotes WT1
C9 654-657 NP denotes WT1
C8 623-657 NP denotes the four different isoforms of WT1
C10 694-721 NP denotes the leukemic cell line K562
C11 723-733 NP denotes K562 cells
C12 742-756 NP denotes endogenous WT1
C13 758-763 NP denotes which
C15 959-962 NP denotes WT1
C14 928-962 NP denotes the four different isoforms of WT1
C16 966-970 NP denotes K562
C17 1229-1232 NP denotes WT1
C18 1267-1277 NP denotes K562 cells
C20 1351-1362 NP denotes these cells
C19 1281-1362 NP denotes not a prerequisite for erythroid or megakaryocytic differentiation of these cells
R1 C4 C1 coref-ident The Wilms' tumor gene (WT1),Wilms' tumor gene (WT1)
R2 C5 C4 coref-ident WT1,The Wilms' tumor gene (WT1)
R3 C6 C5 coref-ident WT1,WT1
R4 C7 C6 coref-ident WT1,WT1
R5 C9 C7 coref-ident WT1,WT1
R6 C10 C3 coref-ident the leukemic cell line K562,the leukemic cell line K562
R7 C11 C10 coref-ident K562 cells,the leukemic cell line K562
R8 C13 C12 coref-relat which,endogenous WT1
R9 C15 C9 coref-ident WT1,WT1
R10 C14 C8 coref-ident the four different isoforms of WT1,the four different isoforms of WT1
R11 C16 C11 coref-ident K562,K562 cells
R12 C17 C15 coref-ident WT1,WT1
R13 C18 C16 coref-ident K562 cells,K562
R14 C20 C18 coref-ident these cells,K562 cells
R15 C19 C2 coref-ident not a prerequisite for erythroid or megakaryocytic differentiation of these cells,not a prerequisite for erythroid or megakaryocytic differentiation of the leukemic cell line K562

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 18-35 DNA_domain_or_region denotes Wilms' tumor gene
T2 37-40 DNA_domain_or_region denotes WT1
T3 81-111 other_name denotes megakaryocytic differentiation
T4 119-142 cell_line denotes leukemic cell line K562
T5 148-165 DNA_domain_or_region denotes Wilms' tumor gene
T6 167-170 DNA_domain_or_region denotes WT1
T7 182-202 protein_family_or_group denotes transcription factor
T8 210-226 protein_family_or_group denotes zinc finger type
T9 249-252 DNA_domain_or_region denotes WT1
T10 285-300 other_name denotes acute leukemias
T11 306-309 DNA_domain_or_region denotes WT1
T12 366-385 cell_line denotes leukemic cell lines
T13 405-408 DNA_domain_or_region denotes WT1
T14 417-435 cell_line denotes myeloid cell lines
T15 458-483 other_name denotes differentiation induction
T16 519-523 other_name denotes high
T17 524-527 DNA_domain_or_region denotes WT1
T18 542-561 cell_type denotes hematopoietic cells
T19 654-657 DNA_domain_or_region denotes WT1
T20 698-721 cell_line denotes leukemic cell line K562
T21 723-733 cell_line denotes K562 cells
T22 753-756 DNA_domain_or_region denotes WT1
T23 904-924 other_name denotes exogenous expression
T24 959-962 DNA_domain_or_region denotes WT1
T25 966-970 cell_line denotes K562
T26 991-1015 other_name denotes differentiation response
T27 1046-1056 protein_complex denotes hemoglobin
T28 1072-1077 protein_molecule denotes hemin
T29 1099-1134 protein_family_or_group denotes megakaryocytic cell surface markers
T30 1150-1186 other_organic_compound denotes 12-O-tetradecanoylphorbol-13-acetate
T31 1188-1191 other_organic_compound denotes TPA
T32 1229-1232 DNA_domain_or_region denotes WT1
T33 1267-1277 cell_line denotes K562 cells
T34 1317-1347 other_name denotes megakaryocytic differentiation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 148-160 HP_0002667 denotes Wilms' tumor
T2 155-160 HP_0002664 denotes tumor
T3 285-300 HP_0002488 denotes acute leukemias
T4 291-300 HP_0001909 denotes leukemias