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PubMed:10377075 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 1714-1717 DiseaseOrPhenotypicFeature denotes can 0012833

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 46-79 protein denotes vascular cell adhesion molecule-1
T2 94-117 cell_type denotes human endothelial cells
T3 317-335 protein denotes adhesion molecules
T4 339-342 cell_type denotes ECs
T5 396-444 protein denotes Peroxisome proliferator-activated receptor-alpha
T6 446-455 protein denotes PPARalpha
T7 474-497 protein denotes nuclear receptor family
T8 620-629 protein denotes PPARalpha
T9 644-653 cell_type denotes human ECs
T10 678-711 protein denotes vascular cell adhesion molecule-1
T11 713-719 protein denotes VCAM-1
T12 778-802 cell_type denotes human carotid artery ECs
T13 811-820 protein denotes PPARalpha
T14 838-856 cell_type denotes cultured human ECs
T15 866-875 protein denotes PPARalpha
T16 920-944 protein denotes TNF-alpha-induced VCAM-1
T17 1016-1025 protein denotes PPARgamma
T18 1043-1052 protein denotes PPARalpha
T19 1091-1097 protein denotes VCAM-1
T20 1188-1214 DNA denotes VCAM-1 promoter constructs
T21 1291-1297 protein denotes VCAM-1
T22 1334-1343 protein denotes NF-kappaB
T23 1354-1363 protein denotes PPARalpha
T24 1409-1419 cell_line denotes U937 cells
T25 1423-1441 cell_type denotes cultured human ECs
T26 1456-1465 cell_type denotes Human ECs
T27 1474-1483 protein denotes PPARalpha
T28 1575-1581 protein denotes VCAM-1
T29 1727-1736 protein denotes PPARalpha

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-118 Sentence denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells.
S2 119-262 Sentence denotes BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions.
S3 263-395 Sentence denotes Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation.
S4 396-588 Sentence denotes Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives.
S5 589-721 Sentence denotes The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).
S6 722-821 Sentence denotes METHODS AND RESULTS: Immunohistochemistry revealed that human carotid artery ECs express PPARalpha.
S7 822-1037 Sentence denotes Pretreatment of cultured human ECs with the PPARalpha activators fenofibrate or WY14643 inhibited TNF-alpha-induced VCAM-1 in a time- and concentration-dependent manner, an effect not seen with PPARgamma activators.
S8 1038-1150 Sentence denotes Both PPARalpha activators decreased cytokine-induced VCAM-1 mRNA expression without altering its mRNA half-life.
S9 1151-1344 Sentence denotes Transient transfection of deletional VCAM-1 promoter constructs and electrophoretic mobility shift assays suggest that fenofibrate inhibits VCAM-1 transcription in part by inhibiting NF-kappaB.
S10 1345-1442 Sentence denotes Finally, PPARalpha activators significantly reduced adhesion of U937 cells to cultured human ECs.
S11 1443-1598 Sentence denotes CONCLUSIONS: Human ECs express PPARalpha, a potentially important regulator of atherogenesis through its transcriptional control of VCAM-1 gene expression.
S12 1599-1737 Sentence denotes Such findings also have implications regarding the clinical use of lipid-lowering agents, like fibric acids, which can activate PPARalpha.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-20 NP denotes PPARalpha activators
C2 94-117 NP denotes human endothelial cells
C3 339-342 NP denotes ECs
C4 396-456 NP denotes Peroxisome proliferator-activated receptor-alpha (PPARalpha)
C5 458-497 NP denotes a member of the nuclear receptor family
C6 644-653 NP denotes human ECs
C7 658-663 NP denotes their
C8 811-820 NP denotes PPARalpha
C9 838-856 NP denotes cultured human ECs
C10 862-909 NP denotes the PPARalpha activators fenofibrate or WY14643
C11 1038-1063 NP denotes Both PPARalpha activators
C12 1354-1374 NP denotes PPARalpha activators
C13 1423-1441 NP denotes cultured human ECs
C14 1456-1465 NP denotes Human ECs
C15 1474-1483 NP denotes PPARalpha
C16 1485-1535 NP denotes a potentially important regulator of atherogenesis
C17 1544-1547 NP denotes its
C18 1666-1706 NP denotes lipid-lowering agents, like fibric acids
C19 1708-1713 NP denotes which
C20 1727-1736 NP denotes PPARalpha
R1 C3 C2 coref-ident ECs,human endothelial cells
R2 C5 C4 coref-appos a member of the nuclear receptor family,Peroxisome proliferator-activated receptor-alpha (PPARalpha)
R3 C6 C3 coref-ident human ECs,ECs
R4 C7 C4 coref-pron their,Peroxisome proliferator-activated receptor-alpha (PPARalpha)
R5 C8 C4 coref-ident PPARalpha,Peroxisome proliferator-activated receptor-alpha (PPARalpha)
R6 C10 C1 coref-ident the PPARalpha activators fenofibrate or WY14643,PPARalpha activators
R7 C11 C10 coref-ident Both PPARalpha activators,the PPARalpha activators fenofibrate or WY14643
R8 C12 C11 coref-ident PPARalpha activators,Both PPARalpha activators
R9 C13 C9 coref-ident cultured human ECs,cultured human ECs
R10 C14 C6 coref-ident Human ECs,human ECs
R11 C15 C8 coref-ident PPARalpha,PPARalpha
R12 C16 C15 coref-appos a potentially important regulator of atherogenesis,PPARalpha
R13 C17 C15 coref-pron its,PPARalpha
R14 C19 C18 coref-relat which,"lipid-lowering agents, like fibric acids"
R15 C20 C15 coref-ident PPARalpha,PPARalpha

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_organic_compound denotes PPARalpha activators
T2 29-45 other_name denotes cytokine-induced
T3 46-79 protein_molecule denotes vascular cell adhesion molecule-1
T4 94-117 cell_type denotes human endothelial cells
T5 131-159 other_name denotes Adhesion molecule expression
T6 167-196 cell_component denotes endothelial cell (EC) surface
T7 213-234 other_name denotes leukocyte recruitment
T8 238-261 other_name denotes atherosclerotic lesions
T9 287-313 other_name denotes transcriptional regulation
T10 317-335 protein_family_or_group denotes adhesion molecules
T11 339-342 cell_type denotes ECs
T12 378-394 other_name denotes plaque formation
T13 396-406 cell_type denotes Peroxisome
T14 446-455 protein_molecule denotes PPARalpha
T15 474-497 protein_family_or_group denotes nuclear receptor family
T16 509-524 other_name denotes gene expression
T17 548-559 lipid denotes fatty acids
T18 620-629 protein_molecule denotes PPARalpha
T19 644-649 cell_type denotes human
T20 650-653 cell_type denotes ECs
T21 678-711 protein_molecule denotes vascular cell adhesion molecule-1
T22 713-719 protein_molecule denotes VCAM-1
T23 743-763 other_name denotes Immunohistochemistry
T24 778-798 cell_type denotes human carotid artery
T25 799-802 cell_type denotes ECs
T26 811-820 protein_molecule denotes PPARalpha
T27 838-852 cell_type denotes cultured human
T28 853-856 cell_type denotes ECs
T29 866-875 protein_molecule denotes PPARalpha
T30 887-898 other_artificial_source denotes fenofibrate
T31 902-909 other_artificial_source denotes WY14643
T32 920-937 protein_molecule denotes TNF-alpha-induced
T33 938-944 protein_molecule denotes VCAM-1
T34 1016-1025 protein_molecule denotes PPARgamma
T35 1043-1052 protein_molecule denotes PPARalpha
T36 1091-1097 protein_molecule denotes VCAM-1
T37 1135-1149 other_name denotes mRNA half-life
T38 1188-1194 protein_molecule denotes VCAM-1
T39 1219-1256 other_name denotes electrophoretic mobility shift assays
T40 1270-1281 other_artificial_source denotes fenofibrate
T41 1291-1297 protein_molecule denotes VCAM-1
T42 1334-1343 protein_complex denotes NF-kappaB
T43 1354-1363 protein_molecule denotes PPARalpha
T44 1389-1405 other_name denotes reduced adhesion
T45 1409-1419 cell_line denotes U937 cells
T46 1423-1441 cell_type denotes cultured human ECs
T47 1456-1465 cell_type denotes Human ECs
T48 1474-1483 protein_molecule denotes PPARalpha
T49 1522-1535 other_name denotes atherogenesis
T50 1575-1581 protein_molecule denotes VCAM-1
T51 1666-1687 other_name denotes lipid-lowering agents
T52 1694-1706 other_organic_compound denotes fibric acids
T53 1727-1736 protein_molecule denotes PPARalpha

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20066350 0-549 tscript(p(HGNC:PPARA)) decreases r(HGNC:VCAM1) denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain f
BEL:20066350 0-549 tscript(p(HGNC:PPARA)) decreases r(HGNC:VCAM1) denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain f
BEL:20045996 0-721 p(HGNC:VCAM1) increases bp(GOBP:"cell adhesion") denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives. The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).
BEL:20045756 0-720 p(HGNC:TNF) increases r(HGNC:VCAM1) denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives. The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1)
BEL:20045632 2-720 p(HGNC:TNF) increases p(HGNC:VCAM1) denotes ARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives. The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1)
BEL:20044882 0-721 p(HGNC:SELP) increases bp(GOBP:"cell adhesion") denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives. The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).
BEL:20044874 0-721 p(HGNC:SELE) increases bp(GOBP:"cell adhesion") denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives. The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).
BEL:20042314 0-721 p(HGNC:ICAM1) increases bp(GOBP:"cell adhesion") denotes PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. BACKGROUND: Adhesion molecule expression on the endothelial cell (EC) surface is critical for leukocyte recruitment to atherosclerotic lesions. Better understanding of transcriptional regulation of adhesion molecules in ECs may provide important insight into plaque formation. Peroxisome proliferator-activated receptor-alpha (PPARalpha), a member of the nuclear receptor family, regulates gene expression in response to certain fatty acids and fibric acid derivatives. The present study investigated PPARalpha expression in human ECs and their regulation of vascular cell adhesion molecule-1 (VCAM-1).