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bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 24-28 Gene_or_gene_product denotes Myt1
T2 90-103 Cellular_component denotes intracellular
T3 119-133 Complex denotes Cdc2-cyclin B1
T4 149-153 Gene_or_gene_product denotes Myt1
T5 202-215 Complex denotes Cdc2-cyclin B
T6 245-249 Gene_or_gene_product denotes Cdc2
T7 253-265 Simple_chemical denotes threonine 14
T8 270-281 Simple_chemical denotes tyrosine 15
T9 312-316 Gene_or_gene_product denotes Myt1
T10 334-355 Cellular_component denotes endoplasmic reticulum
T11 360-373 Cellular_component denotes Golgi complex
T12 383-397 Complex denotes Cdc2-cyclin B1
T13 428-435 Cellular_component denotes nucleus
T14 444-453 Cellular_component denotes cytoplasm
T15 542-546 Gene_or_gene_product denotes Myt1
T16 559-566 Cellular_component denotes nuclear
T17 567-578 Cellular_component denotes cytoplasmic
T18 592-601 Gene_or_gene_product denotes cyclin B1
T19 699-703 Gene_or_gene_product denotes Myt1
T20 725-739 Complex denotes Cdc2-cyclin B1
T21 760-764 Gene_or_gene_product denotes Myt1
T22 809-818 Gene_or_gene_product denotes cyclin B1
T23 857-871 Complex denotes Cdc2-cyclin B1
T24 941-945 Gene_or_gene_product denotes Myt1
T25 1009-1018 Gene_or_gene_product denotes cyclin B1
T26 1101-1115 Complex denotes Cdc2-cyclin B1
T27 1150-1154 Gene_or_gene_product denotes Myt1
T28 1190-1194 Gene_or_gene_product denotes Cdc2
T29 1198-1202 Gene_or_gene_product denotes Myt1
T30 1230-1234 Gene_or_gene_product denotes Myt1
T31 1283-1297 Complex denotes Cdc2-cyclin B1
T32 1315-1324 Cellular_component denotes cytoplasm

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes.
T2 145-282 Sentence denotes The Myt1 protein kinase functions to negatively regulate Cdc2-cyclin B complexes by phosphorylating Cdc2 on threonine 14 and tyrosine 15.
T3 283-454 Sentence denotes Throughout interphase, human Myt1 localizes to the endoplasmic reticulum and Golgi complex, whereas Cdc2-cyclin B1 complexes shuttle between the nucleus and the cytoplasm.
T4 455-662 Sentence denotes Here we report that overproduction of either kinase-active or kinase-inactive forms of Myt1 blocked the nuclear-cytoplasmic shuttling of cyclin B1 and caused cells to delay in the G2 phase of the cell cycle.
T5 663-759 Sentence denotes The COOH-terminal 63 amino acids of Myt1 were identified as a Cdc2-cyclin B1 interaction domain.
T6 760-891 Sentence denotes Myt1 mutants lacking this domain no longer bound cyclin B1 and did not efficiently phosphorylate Cdc2-cyclin B1 complexes in vitro.
T7 892-1058 Sentence denotes In addition, cells overproducing mutant forms of Myt1 lacking the interaction domain exhibited normal trafficking of cyclin B1 and unperturbed cell cycle progression.
T8 1059-1325 Sentence denotes These results suggest that the docking of Cdc2-cyclin B1 complexes to the COOH terminus of Myt1 facilitates the phosphorylation of Cdc2 by Myt1 and that overproduction of Myt1 perturbs cell cycle progression by sequestering Cdc2-cyclin B1 complexes in the cytoplasm.