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PubMed:10373548 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 170-173 DiseaseOrPhenotypicFeature denotes CIS 0004647
T2 679-682 DiseaseOrPhenotypicFeature denotes CIS 0004647
T3 729-732 DiseaseOrPhenotypicFeature denotes CIS 0004647
T4 1321-1324 DiseaseOrPhenotypicFeature denotes CIS 0004647

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-6 protein denotes SOCS-3
T2 49-62 protein denotes interleukin-2
T3 78-83 protein denotes STAT5
T4 165-184 protein denotes SOCS/CIS/SSI family
T5 221-229 protein denotes cytokine
T6 388-401 protein denotes SOCS proteins
T7 439-452 protein denotes interleukin-2
T8 454-458 protein denotes IL-2
T9 473-480 cell_type denotes T cells
T10 497-503 protein denotes SOCS-3
T11 530-534 protein denotes IL-2
T12 543-555 cell_line denotes T-cell lines
T13 560-594 cell_type denotes human peripheral blood lymphocytes
T14 596-602 protein denotes SOCS-3
T15 655-659 protein denotes IL-2
T16 679-682 protein denotes CIS
T17 729-732 protein denotes CIS
T18 734-740 protein denotes SOCS-3
T19 792-796 protein denotes IL-2
T20 826-832 protein denotes SOCS-3
T21 869-873 protein denotes Jak1
T22 878-882 protein denotes Jak2
T23 904-908 protein denotes Jak3
T24 932-938 protein denotes SOCS-3
T25 955-959 protein denotes Jak1
T26 974-978 protein denotes Jak1
T27 1057-1081 protein denotes IL-2 receptor beta chain
T28 1083-1092 protein denotes IL-2Rbeta
T29 1115-1119 protein denotes IL-2
T30 1135-1142 cell_type denotes T cells
T31 1144-1150 protein denotes SOCS-3
T32 1181-1202 protein denotes IL-2 receptor complex
T33 1222-1250 protein denotes tyrosine phosphorylated Jak1
T34 1255-1264 protein denotes IL-2Rbeta
T35 1283-1294 cell_type denotes lymphocytes
T36 1306-1312 protein denotes SOCS-3
T37 1321-1324 protein denotes CIS
T38 1326-1330 protein denotes IL-2
T39 1367-1373 protein denotes STAT5b
T40 1434-1454 protein denotes IL-3-mediated STAT5b
T41 1520-1524 protein denotes IL-2
T42 1530-1534 protein denotes IL-3
T43 1582-1588 protein denotes SOCS-3
T44 1621-1627 protein denotes SOCS-3
T45 1650-1654 protein denotes IL-2
T46 1658-1665 cell_type denotes T cells
T47 1686-1690 protein denotes IL-2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-129 Sentence denotes SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.
S2 130-376 Sentence denotes Members of the recently discovered SOCS/CIS/SSI family have been proposed as regulators of cytokine signaling, and while targets and mechanisms have been suggested for some family members, the precise role of these proteins remains to be defined.
S3 377-481 Sentence denotes To date no SOCS proteins have been specifically implicated in interleukin-2 (IL-2) signaling in T cells.
S4 482-595 Sentence denotes Here we report SOCS-3 expression in response to IL-2 in both T-cell lines and human peripheral blood lymphocytes.
S5 596-721 Sentence denotes SOCS-3 protein was detectable as early as 30 min following IL-2 stimulation, while CIS was seen only at low levels after 2 h.
S6 722-797 Sentence denotes Unlike CIS, SOCS-3 was rapidly tyrosine phosphorylated in response to IL-2.
S7 798-909 Sentence denotes Tyrosine phosphorylation of SOCS-3 was observed upon coexpression with Jak1 and Jak2 but only weakly with Jak3.
S8 910-1094 Sentence denotes In these experiments, SOCS-3 associated with Jak1 and inhibited Jak1 phosphorylation, and this inhibition was markedly enhanced by the presence of IL-2 receptor beta chain (IL-2Rbeta).
S9 1095-1265 Sentence denotes Moreover, following IL-2 stimulation of T cells, SOCS-3 was able to interact with the IL-2 receptor complex, and in particular tyrosine phosphorylated Jak1 and IL-2Rbeta.
S10 1266-1480 Sentence denotes Additionally, in lymphocytes expressing SOCS-3 but not CIS, IL-2-induced tyrosine phosphorylation of STAT5b was markedly reduced, while there was only a weak effect on IL-3-mediated STAT5b tyrosine phosphorylation.
S11 1481-1589 Sentence denotes Finally, proliferation induced by both IL-2- and IL-3 was significantly inhibited in the presence of SOCS-3.
S12 1590-1739 Sentence denotes The findings suggest that when SOCS-3 is rapidly induced by IL-2 in T cells, it acts to inhibit IL-2 responses in a classical negative feedback loop.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-6 NP denotes SOCS-3
C2 49-62 NP denotes interleukin-2
C3 298-317 NP denotes some family members
C4 339-353 NP denotes these proteins
C5 473-480 NP denotes T cells
C6 596-610 NP denotes SOCS-3 protein
C7 679-682 NP denotes CIS
C8 729-732 NP denotes CIS
C9 734-740 NP denotes SOCS-3
C10 792-796 NP denotes IL-2
C11 826-832 NP denotes SOCS-3
C12 869-873 NP denotes Jak1
C13 932-938 NP denotes SOCS-3
C14 955-959 NP denotes Jak1
C15 1135-1142 NP denotes T cells
C16 1144-1150 NP denotes SOCS-3
C17 1306-1312 NP denotes SOCS-3
C18 1582-1588 NP denotes SOCS-3
C19 1621-1627 NP denotes SOCS-3
C20 1650-1654 NP denotes IL-2
C21 1658-1665 NP denotes T cells
C22 1667-1669 NP denotes it
R1 C4 C3 coref-ident these proteins,some family members
R2 C6 C1 coref-ident SOCS-3 protein,SOCS-3
R3 C8 C7 coref-ident CIS,CIS
R4 C9 C6 coref-ident SOCS-3,SOCS-3 protein
R5 C10 C2 coref-ident IL-2,interleukin-2
R6 C11 C9 coref-ident SOCS-3,SOCS-3
R7 C13 C11 coref-ident SOCS-3,SOCS-3
R8 C14 C12 coref-ident Jak1,Jak1
R9 C15 C5 coref-ident T cells,T cells
R10 C16 C13 coref-ident SOCS-3,SOCS-3
R11 C17 C16 coref-ident SOCS-3,SOCS-3
R12 C18 C17 coref-ident SOCS-3,SOCS-3
R13 C19 C18 coref-ident SOCS-3,SOCS-3
R14 C20 C10 coref-ident IL-2,IL-2
R15 C21 C15 coref-ident T cells,T cells
R16 C22 C19 coref-pron it,SOCS-3

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-6 protein_molecule denotes SOCS-3
T2 49-62 protein_molecule denotes interleukin-2
T3 78-83 protein_molecule denotes STAT5
T4 104-128 other_name denotes lymphocyte proliferation
T5 165-184 protein_family_or_group denotes SOCS/CIS/SSI family
T6 221-229 protein_family_or_group denotes cytokine
T7 388-401 protein_family_or_group denotes SOCS proteins
T8 439-452 protein_molecule denotes interleukin-2
T9 454-458 protein_molecule denotes IL-2
T10 473-480 cell_type denotes T cells
T11 497-503 protein_molecule denotes SOCS-3
T12 530-534 protein_molecule denotes IL-2
T13 543-555 cell_line denotes T-cell lines
T14 560-594 cell_type denotes human peripheral blood lymphocytes
T15 596-602 protein_molecule denotes SOCS-3
T16 655-659 protein_molecule denotes IL-2
T17 679-682 protein_molecule denotes CIS
T18 729-732 protein_molecule denotes CIS
T19 734-740 protein_molecule denotes SOCS-3
T20 753-761 amino_acid_monomer denotes tyrosine
T21 792-796 protein_molecule denotes IL-2
T22 826-832 protein_molecule denotes SOCS-3
T23 869-873 protein_molecule denotes Jak1
T24 878-882 protein_molecule denotes Jak2
T25 904-908 protein_molecule denotes Jak3
T26 932-938 protein_molecule denotes SOCS-3
T27 955-959 protein_molecule denotes Jak1
T28 974-978 protein_molecule denotes Jak1
T29 1057-1061 protein_molecule denotes IL-2
T30 1083-1092 protein_subunit denotes IL-2Rbeta
T31 1115-1119 protein_molecule denotes IL-2
T32 1135-1142 cell_type denotes T cells
T33 1144-1150 protein_molecule denotes SOCS-3
T34 1181-1185 protein_molecule denotes IL-2
T35 1222-1230 amino_acid_monomer denotes tyrosine
T36 1246-1250 protein_molecule denotes Jak1
T37 1255-1264 protein_subunit denotes IL-2Rbeta
T38 1283-1294 cell_type denotes lymphocytes
T39 1306-1312 protein_molecule denotes SOCS-3
T40 1321-1324 protein_molecule denotes CIS
T41 1326-1330 protein_molecule denotes IL-2
T42 1339-1347 amino_acid_monomer denotes tyrosine
T43 1367-1373 protein_molecule denotes STAT5b
T44 1434-1447 protein_molecule denotes IL-3-mediated
T45 1448-1454 protein_molecule denotes STAT5b
T46 1455-1463 amino_acid_monomer denotes tyrosine
T47 1520-1524 protein_molecule denotes IL-2
T48 1530-1534 protein_molecule denotes IL-3
T49 1582-1588 protein_molecule denotes SOCS-3
T50 1621-1627 protein_molecule denotes SOCS-3
T51 1650-1654 protein_molecule denotes IL-2
T52 1658-1665 cell_type denotes T cells
T53 1686-1690 protein_molecule denotes IL-2
T54 1716-1738 other_name denotes negative feedback loop