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PubMed:10373522 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 960-969 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T2 1361-1370 DiseaseOrPhenotypicFeature denotes sensitive 0000605

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-8 protein denotes p70(s6k)
T2 20-49 protein denotes phosphatidylinositol 3-kinase
T3 86-89 protein denotes E2F
T4 104-117 cell_type denotes T lymphocytes
T5 122-135 cell_type denotes T lymphocytes
T6 141-163 protein denotes hematopoietic cytokine
T7 164-177 protein denotes interleukin-2
T8 179-183 protein denotes IL-2
T9 190-219 protein denotes phosphatidylinositol 3-kinase
T10 221-232 protein denotes PI 3-kinase
T11 273-276 protein denotes E2F
T12 337-348 protein denotes PI 3-kinase
T13 380-388 protein denotes p70(s6k)
T14 394-425 protein denotes 40S ribosomal protein S6 kinase
T15 711-719 protein denotes p70(s6k)
T16 724-728 protein denotes IL-2
T17 733-744 protein denotes PI 3-kinase
T18 759-763 protein denotes E2Fs
T19 823-827 protein denotes IL-2
T20 833-844 protein denotes PI 3-kinase
T21 884-887 protein denotes E2F
T22 998-1024 protein denotes rapamycin-resistant mutant
T23 1028-1036 protein denotes p70(s6k)
T24 1040-1047 cell_type denotes T cells
T25 1083-1086 protein denotes E2F
T26 1151-1154 protein denotes E2F
T27 1191-1199 protein denotes p70(s6k)
T28 1214-1242 protein denotes rapamycin-resistant p70(s6k)
T29 1459-1467 protein denotes p70(s6k)
T30 1488-1491 protein denotes E2F
T31 1583-1587 protein denotes IL-2
T32 1599-1610 protein denotes PI 3-kinase
T33 1616-1624 protein denotes p70(s6k)
T34 1667-1680 cell_type denotes T lymphocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-118 Sentence denotes p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes.
S2 119-336 Sentence denotes In T lymphocytes, the hematopoietic cytokine interleukin-2 (IL-2) uses phosphatidylinositol 3-kinase (PI 3-kinase)-induced signaling pathways to regulate E2F transcriptional activity, a critical cell cycle checkpoint.
S3 337-483 Sentence denotes PI 3-kinase also regulates the activity of p70(s6k), the 40S ribosomal protein S6 kinase, a response that is abrogated by the macrolide rapamycin.
S4 484-655 Sentence denotes This immunosuppressive drug is known to prevent T-cell proliferation, but the precise point at which rapamycin regulates T-cell cycle progression has yet to be elucidated.
S5 656-792 Sentence denotes Moreover, the effects of rapamycin on, and the role of p70(s6k) in, IL-2 and PI 3-kinase activation of E2Fs have not been characterized.
S6 793-981 Sentence denotes Our present results show that IL-2- and PI 3-kinase-induced pathways for the regulation of E2F transcriptional activity include both rapamycin-resistant and rapamycin-sensitive components.
S7 982-1097 Sentence denotes Expression of a rapamycin-resistant mutant of p70(s6k) in T cells could restore rapamycin-suppressed E2F responses.
S8 1098-1200 Sentence denotes Thus, the rapamycin-controlled processes involved in E2F regulation appear to be mediated by p70(s6k).
S9 1201-1423 Sentence denotes However, the rapamycin-resistant p70(s6k) could not rescue rapamycin inhibition of T-cell cycle entry, consistent with the involvement of additional, rapamycin-sensitive pathways in the control of T-cell cycle progression.
S10 1424-1681 Sentence denotes The present results thus show that p70(s6k) is able to regulate E2F transcriptional activity and provide direct evidence for the first time for a link between IL-2 receptors, PI 3-kinase, and p70(s6k) that regulates a crucial G1 checkpoint in T lymphocytes.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-8 NP denotes p70(s6k)
C2 20-49 NP denotes phosphatidylinositol 3-kinase
C3 86-100 NP denotes E2F regulation
C4 104-117 NP denotes T lymphocytes
C5 122-135 NP denotes T lymphocytes
C6 273-301 NP denotes E2F transcriptional activity
C7 303-335 NP denotes a critical cell cycle checkpoint
C8 337-348 NP denotes PI 3-kinase
C9 380-388 NP denotes p70(s6k)
C10 390-425 NP denotes the 40S ribosomal protein S6 kinase
C11 427-437 NP denotes a response
C12 438-442 NP denotes that
C13 459-482 NP denotes the macrolide rapamycin
C14 484-511 NP denotes This immunosuppressive drug
C15 558-575 NP denotes the precise point
C16 579-584 NP denotes which
C17 585-594 NP denotes rapamycin
C18 605-629 NP denotes T-cell cycle progression
C19 681-690 NP denotes rapamycin
C20 711-719 NP denotes p70(s6k)
C22 884-912 NP denotes E2F transcriptional activity
C21 866-912 NP denotes the regulation of E2F transcriptional activity
C23 1028-1036 NP denotes p70(s6k)
C24 1040-1047 NP denotes T cells
C25 1151-1165 NP denotes E2F regulation
C26 1191-1199 NP denotes p70(s6k)
C27 1398-1422 NP denotes T-cell cycle progression
C28 1459-1467 NP denotes p70(s6k)
C29 1488-1516 NP denotes E2F transcriptional activity
C31 1599-1610 NP denotes PI 3-kinase
C32 1616-1624 NP denotes p70(s6k)
C30 1568-1624 NP denotes a link between IL-2 receptors, PI 3-kinase, and p70(s6k)
C33 1625-1629 NP denotes that
C34 1667-1680 NP denotes T lymphocytes
R1 C5 C4 coref-ident T lymphocytes,T lymphocytes
R2 C7 C6 coref-appos a critical cell cycle checkpoint,E2F transcriptional activity
R3 C8 C2 coref-ident PI 3-kinase,phosphatidylinositol 3-kinase
R4 C9 C1 coref-ident p70(s6k),p70(s6k)
R5 C10 C9 coref-appos the 40S ribosomal protein S6 kinase,p70(s6k)
R6 C12 C11 coref-relat that,a response
R7 C14 C13 coref-ident This immunosuppressive drug,the macrolide rapamycin
R8 C16 C15 coref-relat which,the precise point
R9 C17 C14 coref-ident rapamycin,This immunosuppressive drug
R10 C19 C17 coref-ident rapamycin,rapamycin
R11 C20 C9 coref-ident p70(s6k),p70(s6k)
R12 C22 C6 coref-ident E2F transcriptional activity,E2F transcriptional activity
R13 C21 C3 coref-ident the regulation of E2F transcriptional activity,E2F regulation
R14 C23 C20 coref-ident p70(s6k),p70(s6k)
R15 C24 C5 coref-ident T cells,T lymphocytes
R16 C25 C21 coref-ident E2F regulation,the regulation of E2F transcriptional activity
R17 C26 C23 coref-ident p70(s6k),p70(s6k)
R18 C27 C18 coref-ident T-cell cycle progression,T-cell cycle progression
R19 C28 C26 coref-ident p70(s6k),p70(s6k)
R20 C29 C22 coref-ident E2F transcriptional activity,E2F transcriptional activity
R21 C31 C8 coref-ident PI 3-kinase,PI 3-kinase
R22 C32 C28 coref-ident p70(s6k),p70(s6k)
R23 C33 C30 coref-relat that,"a link between IL-2 receptors, PI 3-kinase, and p70(s6k)"
R24 C34 C24 coref-ident T lymphocytes,T cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-8 protein_molecule denotes p70(s6k)
T2 20-49 protein_molecule denotes phosphatidylinositol 3-kinase
T3 54-81 other_name denotes rapamycin-regulated signals
T4 86-89 protein_molecule denotes E2F
T5 104-117 cell_type denotes T lymphocytes
T6 122-135 cell_type denotes T lymphocytes
T7 141-163 protein_family_or_group denotes hematopoietic cytokine
T8 164-177 protein_molecule denotes interleukin-2
T9 179-183 protein_molecule denotes IL-2
T10 190-219 protein_molecule denotes phosphatidylinositol 3-kinase
T11 221-232 protein_molecule denotes PI 3-kinase
T12 273-276 protein_molecule denotes E2F
T13 314-335 other_name denotes cell cycle checkpoint
T14 337-348 protein_molecule denotes PI 3-kinase
T15 380-388 protein_molecule denotes p70(s6k)
T16 394-425 protein_molecule denotes 40S ribosomal protein S6 kinase
T17 463-472 other_organic_compound denotes macrolide
T18 473-482 other_organic_compound denotes rapamycin
T19 489-511 other_organic_compound denotes immunosuppressive drug
T20 532-552 other_name denotes T-cell proliferation
T21 585-594 other_organic_compound denotes rapamycin
T22 605-629 other_name denotes T-cell cycle progression
T23 681-690 other_organic_compound denotes rapamycin
T24 711-719 protein_molecule denotes p70(s6k)
T25 724-728 protein_molecule denotes IL-2
T26 733-744 protein_molecule denotes PI 3-kinase
T27 759-763 protein_family_or_group denotes E2Fs
T28 823-827 protein_molecule denotes IL-2
T29 833-844 protein_molecule denotes PI 3-kinase
T30 884-887 protein_molecule denotes E2F
T31 998-1007 other_organic_compound denotes rapamycin
T32 1028-1036 protein_molecule denotes p70(s6k)
T33 1040-1047 cell_type denotes T cells
T34 1062-1071 other_organic_compound denotes rapamycin
T35 1083-1086 protein_molecule denotes E2F
T36 1108-1117 other_organic_compound denotes rapamycin
T37 1151-1154 protein_molecule denotes E2F
T38 1191-1199 protein_molecule denotes p70(s6k)
T39 1214-1223 other_organic_compound denotes rapamycin
T40 1234-1242 protein_molecule denotes p70(s6k)
T41 1260-1269 other_organic_compound denotes rapamycin
T42 1351-1360 other_organic_compound denotes rapamycin
T43 1398-1422 other_name denotes T-cell cycle progression
T44 1459-1467 protein_molecule denotes p70(s6k)
T45 1488-1491 protein_molecule denotes E2F
T46 1583-1587 protein_molecule denotes IL-2
T47 1599-1610 protein_molecule denotes PI 3-kinase
T48 1616-1624 protein_molecule denotes p70(s6k)
T49 1650-1663 other_name denotes G1 checkpoint
T50 1667-1680 cell_type denotes T lymphocytes