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PubMed:10369419 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 19-53 protein denotes interleukin-4 receptor alpha chain
T2 88-111 protein denotes phagocyte NADPH oxidase
T3 115-122 cell_type denotes B cells
T4 124-142 protein denotes Interleukin (IL)-4
T5 170-173 protein denotes IgE
T6 187-194 cell_type denotes B cells
T7 225-232 cell_line denotes T cells
T8 234-238 protein denotes IL-4
T9 297-310 protein denotes IL-4 receptor
T10 312-317 protein denotes IL-4R
T11 337-349 cell_type denotes target cells
T12 351-356 protein denotes IL-4R
T13 391-408 protein denotes IL-4R alpha chain
T14 410-421 protein denotes IL-4R alpha
T15 438-455 protein denotes IL-2R gamma chain
T16 463-481 protein denotes IL-13R alpha chain
T17 517-542 protein denotes membrane-proximal portion
T18 550-568 protein denotes cytoplasmic domain
T19 576-593 protein denotes human IL-4R alpha
T20 595-607 protein denotes hIL-4R alpha
T21 701-706 protein denotes STAT6
T22 729-752 protein denotes truncated hIL-4R alphas
T23 812-835 protein denotes phagocyte NADPH oxidase
T24 946-958 protein denotes hIL-4R alpha
T25 962-969 cell_type denotes B cells
T26 1076-1080 protein denotes IL-4
T27 1084-1091 cell_type denotes B cells
T28 1116-1121 protein denotes STAT6
T29 1123-1127 protein denotes CD23
T30 1144-1147 protein denotes IgE
T31 1169-1173 protein denotes IL-4
T32 1323-1330 cell_type denotes B cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-123 Sentence denotes Association of the interleukin-4 receptor alpha chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells.
S2 124-233 Sentence denotes Interleukin (IL)-4 plays an important role in IgE synthesis in B cells and in Th2 differentiation in T cells.
S3 234-350 Sentence denotes IL-4 conducts its biological activities through binding to the IL-4 receptor (IL-4R) on the surface of target cells.
S4 351-482 Sentence denotes IL-4R are thought to be composed of the IL-4R alpha chain (IL-4R alpha) and either the IL-2R gamma chain or the IL-13R alpha chain.
S5 483-753 Sentence denotes We have previously shown that the membrane-proximal portion in the cytoplasmic domain of the human IL-4R alpha (hIL-4R alpha) is critical for proliferation, generation of germline epsilon transcript, and activation of STAT6, based on analyses of truncated hIL-4R alphas.
S6 754-884 Sentence denotes In this study, we found that p47phox, an activator of the phagocyte NADPH oxidase, binds to this portion by the two-hybrid system.
S7 885-998 Sentence denotes Furthermore, we observed the association of p47phox with the hIL-4R alpha in B cells derived from a normal donor.
S8 999-1092 Sentence denotes These results suggest that p47phox is involved in the signal transduction of IL-4 in B cells.
S9 1093-1331 Sentence denotes However, activation of STAT6, CD23 expression, and IgE synthesis induced by IL-4 were not affected in p47phox-deficient patients, which raises the possibility that p47phox may be important in other signaling activities as well in B cells.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 15-53 NP denotes the interleukin-4 receptor alpha chain
C2 59-66 NP denotes p47phox
C3 68-111 NP denotes an activator of the phagocyte NADPH oxidase
C4 115-122 NP denotes B cells
C5 124-142 NP denotes Interleukin (IL)-4
C6 187-194 NP denotes B cells
C7 234-238 NP denotes IL-4
C8 248-251 NP denotes its
C9 293-318 NP denotes the IL-4 receptor (IL-4R)
C10 351-356 NP denotes IL-4R
C11 387-422 NP denotes the IL-4R alpha chain (IL-4R alpha)
C13 572-608 NP denotes the human IL-4R alpha (hIL-4R alpha)
C12 513-608 NP denotes the membrane-proximal portion in the cytoplasmic domain of the human IL-4R alpha (hIL-4R alpha)
C14 687-706 NP denotes activation of STAT6
C15 783-790 NP denotes p47phox
C16 792-835 NP denotes an activator of the phagocyte NADPH oxidase
C17 846-858 NP denotes this portion
C18 929-936 NP denotes p47phox
C19 942-958 NP denotes the hIL-4R alpha
C20 1026-1033 NP denotes p47phox
C21 1076-1080 NP denotes IL-4
C22 1084-1091 NP denotes B cells
C23 1102-1121 NP denotes activation of STAT6
C24 1169-1173 NP denotes IL-4
C25 1236-1251 NP denotes the possibility
C26 1252-1256 NP denotes that
C27 1257-1264 NP denotes p47phox
C28 1323-1330 NP denotes B cells
R1 C3 C2 coref-appos an activator of the phagocyte NADPH oxidase,p47phox
R2 C6 C4 coref-ident B cells,B cells
R3 C7 C5 coref-ident IL-4,Interleukin (IL)-4
R4 C8 C7 coref-pron its,IL-4
R5 C10 C9 coref-ident IL-4R,the IL-4 receptor (IL-4R)
R6 C11 C1 coref-ident the IL-4R alpha chain (IL-4R alpha),the interleukin-4 receptor alpha chain
R7 C15 C2 coref-ident p47phox,p47phox
R8 C16 C15 coref-appos an activator of the phagocyte NADPH oxidase,p47phox
R9 C17 C12 coref-ident this portion,the membrane-proximal portion in the cytoplasmic domain of the human IL-4R alpha (hIL-4R alpha)
R10 C18 C15 coref-ident p47phox,p47phox
R11 C19 C13 coref-ident the hIL-4R alpha,the human IL-4R alpha (hIL-4R alpha)
R12 C20 C18 coref-ident p47phox,p47phox
R13 C21 C7 coref-ident IL-4,IL-4
R14 C22 C6 coref-ident B cells,B cells
R15 C23 C14 coref-ident activation of STAT6,activation of STAT6
R16 C24 C21 coref-ident IL-4,IL-4
R17 C26 C25 coref-relat that,the possibility
R18 C27 C20 coref-ident p47phox,p47phox
R19 C28 C22 coref-ident B cells,B cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 19-53 protein_subunit denotes interleukin-4 receptor alpha chain
T2 59-66 other_organic_compound denotes p47phox
T3 88-111 protein_molecule denotes phagocyte NADPH oxidase
T4 115-122 cell_type denotes B cells
T5 124-142 protein_molecule denotes Interleukin (IL)-4
T6 170-173 protein_family_or_group denotes IgE
T7 187-194 cell_type denotes B cells
T8 202-221 other_name denotes Th2 differentiation
T9 225-232 cell_line denotes T cells
T10 234-238 protein_molecule denotes IL-4
T11 297-301 protein_molecule denotes IL-4
T12 312-317 protein_family_or_group denotes IL-4R
T13 337-349 cell_type denotes target cells
T14 351-356 protein_family_or_group denotes IL-4R
T15 391-408 protein_subunit denotes IL-4R alpha chain
T16 410-421 protein_subunit denotes IL-4R alpha
T17 438-455 protein_subunit denotes IL-2R gamma chain
T18 463-481 protein_subunit denotes IL-13R alpha chain
T19 517-542 protein_domain_or_region denotes membrane-proximal portion
T20 550-568 protein_domain_or_region denotes cytoplasmic domain
T21 576-581 protein_subunit denotes human
T22 582-593 protein_subunit denotes IL-4R alpha
T23 595-607 protein_subunit denotes hIL-4R alpha
T24 701-706 protein_molecule denotes STAT6
T25 729-752 protein_subunit denotes truncated hIL-4R alphas
T26 783-790 other_organic_compound denotes p47phox
T27 812-835 protein_molecule denotes phagocyte NADPH oxidase
T28 866-883 other_name denotes two-hybrid system
T29 929-936 other_organic_compound denotes p47phox
T30 946-958 protein_subunit denotes hIL-4R alpha
T31 962-969 cell_type denotes B cells
T32 985-997 multi_cell denotes normal donor
T33 1026-1033 other_organic_compound denotes p47phox
T34 1076-1080 protein_molecule denotes IL-4
T35 1084-1091 cell_type denotes B cells
T36 1116-1121 protein_molecule denotes STAT6
T37 1123-1127 protein_molecule denotes CD23
T38 1144-1147 protein_family_or_group denotes IgE
T39 1169-1173 protein_molecule denotes IL-4
T40 1195-1202 other_organic_compound denotes p47phox
T41 1213-1221 multi_cell denotes patients
T42 1257-1264 other_organic_compound denotes p47phox
T43 1323-1330 cell_type denotes B cells