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PubMed:10369255 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 28-33 protein denotes OCT-1
T2 49-68 DNA denotes TNF promoter region
T3 125-150 DNA denotes cytokine promoter regions
T4 500-520 protein denotes transcription factor
T5 619-634 cell_type denotes human monocytes
T6 914-925 DNA denotes HLA alleles

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10369255-0#28#33#gene5451 28-33 gene5451 denotes OCT-1
10369255-0#28#33#gene6580 28-33 gene6580 denotes OCT-1
10369255-0#49#52#gene7124 49-52 gene7124 denotes TNF
10369255-0#95#102#diseaseC0024530 95-102 diseaseC0024530 denotes malaria
10369255-0#95#102#diseaseC0024530 95-102 diseaseC0024530 denotes malaria
10369255-3#4#9#gene5451 640-645 gene5451 denotes OCT-1
10369255-3#4#9#gene6580 640-645 gene6580 denotes OCT-1
10369255-3#249#252#gene7124 885-888 gene7124 denotes TNF
10369255-3#123#139#diseaseC0024534 759-775 diseaseC0024534 denotes cerebral malaria
10369255-3#123#139#diseaseC0024534 759-775 diseaseC0024534 denotes cerebral malaria
28#33#gene545195#102#diseaseC0024530 10369255-0#28#33#gene5451 10369255-0#95#102#diseaseC0024530 associated_with OCT-1,malaria
28#33#gene545195#102#diseaseC0024530 10369255-0#28#33#gene5451 10369255-0#95#102#diseaseC0024530 associated_with OCT-1,malaria
28#33#gene658095#102#diseaseC0024530 10369255-0#28#33#gene6580 10369255-0#95#102#diseaseC0024530 associated_with OCT-1,malaria
28#33#gene658095#102#diseaseC0024530 10369255-0#28#33#gene6580 10369255-0#95#102#diseaseC0024530 associated_with OCT-1,malaria
49#52#gene712495#102#diseaseC0024530 10369255-0#49#52#gene7124 10369255-0#95#102#diseaseC0024530 associated_with TNF,malaria
49#52#gene712495#102#diseaseC0024530 10369255-0#49#52#gene7124 10369255-0#95#102#diseaseC0024530 associated_with TNF,malaria
4#9#gene5451123#139#diseaseC0024534 10369255-3#4#9#gene5451 10369255-3#123#139#diseaseC0024534 associated_with OCT-1,cerebral malaria
4#9#gene5451123#139#diseaseC0024534 10369255-3#4#9#gene5451 10369255-3#123#139#diseaseC0024534 associated_with OCT-1,cerebral malaria
4#9#gene6580123#139#diseaseC0024534 10369255-3#4#9#gene6580 10369255-3#123#139#diseaseC0024534 associated_with OCT-1,cerebral malaria
4#9#gene6580123#139#diseaseC0024534 10369255-3#4#9#gene6580 10369255-3#123#139#diseaseC0024534 associated_with OCT-1,cerebral malaria
249#252#gene7124123#139#diseaseC0024534 10369255-3#249#252#gene7124 10369255-3#123#139#diseaseC0024534 associated_with TNF,cerebral malaria
249#252#gene7124123#139#diseaseC0024534 10369255-3#249#252#gene7124 10369255-3#123#139#diseaseC0024534 associated_with TNF,cerebral malaria

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-103 Sentence denotes A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.
S2 104-305 Sentence denotes Genetic variation in cytokine promoter regions is postulated to influence susceptibility to infection, but the molecular mechanisms by which such polymorphisms might affect gene regulation are unknown.
S3 306-635 Sentence denotes Through systematic DNA footprinting of the TNF (encoding tumour necrosis factor, TNF) promoter region, we have identified a single nucleotide polymorphism (SNP) that causes the helix-turn-helix transcription factor OCT-1 to bind to a novel region of complex protein-DNA interactions and alters gene expression in human monocytes.
S4 636-926 Sentence denotes The OCT-1-binding genotype, found in approximately 5% of Africans, is associated with fourfold increased susceptibility to cerebral malaria in large case-control studies of West African and East African populations, after correction for other known TNF polymorphisms and linked HLA alleles.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-14 NP denotes A polymorphism
C2 15-19 NP denotes that
C3 45-68 NP denotes the TNF promoter region
C4 211-235 NP denotes the molecular mechanisms
C5 239-244 NP denotes which
C6 345-407 NP denotes the TNF (encoding tumour necrosis factor, TNF) promoter region
C7 428-466 NP denotes a single nucleotide polymorphism (SNP)
C8 467-471 NP denotes that
R1 C2 C1 coref-relat that,A polymorphism
R2 C5 C4 coref-relat which,the molecular mechanisms
R3 C6 C3 coref-ident "the TNF (encoding tumour necrosis factor, TNF) promoter region",the TNF promoter region
R4 C8 C7 coref-relat that,a single nucleotide polymorphism (SNP)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 2-14 other_name denotes polymorphism
T2 28-33 protein_molecule denotes OCT-1
T3 49-61 DNA_domain_or_region denotes TNF promoter
T4 88-102 other_name denotes severe malaria
T5 104-121 other_name denotes Genetic variation
T6 125-150 DNA_family_or_group denotes cytokine promoter regions
T7 215-235 other_name denotes molecular mechanisms
T8 250-263 other_name denotes polymorphisms
T9 500-520 protein_family_or_group denotes transcription factor
T10 556-588 other_name denotes complex protein-DNA interactions
T11 600-615 other_name denotes gene expression
T12 619-634 cell_type denotes human monocytes
T13 640-662 other_name denotes OCT-1-binding genotype
T14 693-701 multi_cell denotes Africans
T15 759-775 other_name denotes cerebral malaria
T16 885-888 other_name denotes TNF
T17 889-902 other_name denotes polymorphisms
T18 914-925 DNA_domain_or_region denotes HLA alleles

DisGeNET

Id Subject Object Predicate Lexical cue
T0 28-33 gene:5451 denotes OCT-1
T1 95-102 disease:C0024530 denotes malaria
T2 28-33 gene:6580 denotes OCT-1
T3 95-102 disease:C0024530 denotes malaria
T4 49-52 gene:7124 denotes TNF
T5 95-102 disease:C0024530 denotes malaria
R1 T0 T1 associated_with OCT-1,malaria
R2 T2 T3 associated_with OCT-1,malaria
R3 T4 T5 associated_with TNF,malaria

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 178-205 HP_0002719 denotes susceptibility to infection
T2 363-369 HP_0002664 denotes tumour