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PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering.
T2 110-221 Sentence denotes The GTPase Rho is known to mediate the assembly of integrin-containing focal adhesions and actin stress fibers.
T3 222-382 Sentence denotes Here, we investigate the role of Rho in regulating the distribution of the monocyte-binding receptors E-selectin, ICAM-1, and VCAM-1 in human endothelial cells.
T4 383-570 Sentence denotes Inhibition of Rho activity with C3 transferase or N19RhoA, a dominant negative RhoA mutant, reduced the adhesion of monocytes to activated endothelial cells and inhibited their spreading.
T5 571-661 Sentence denotes Similar effects were observed after pretreatment of endothelial cells with cytochalasin D.
T6 662-762 Sentence denotes In contrast, dominant negative Rac and Cdc42 proteins did not affect monocyte adhesion or spreading.
T7 763-1023 Sentence denotes C3 transferase and cytochalasin D did not alter the expression levels of monocyte-binding receptors on endothelial cells, but did inhibit clustering of E-selectin, ICAM-1, and VCAM-1 on the cell surface induced by monocyte adhesion or cross-linking antibodies.
T8 1024-1073 Sentence denotes Similarly, N19RhoA inhibited receptor clustering.
T9 1074-1257 Sentence denotes Monocyte adhesion and receptor cross-linking induced stress fiber assembly, and inhibitors of myosin light chain kinase prevented this response but did not affect receptor clustering.
T10 1258-1333 Sentence denotes Finally, receptor clusters colocalized with ezrin/moesin/ radixin proteins.
T11 1334-1588 Sentence denotes These results suggest that Rho is required in endothelial cells for the assembly of stable adhesions with monocytes via the clustering of monocyte-binding receptors and their association with the actin cytoskeleton, independent of stress fiber formation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 35-58 cell_type denotes human endothelial cells
T2 75-78 protein denotes Rho
T3 114-120 protein denotes GTPase
T4 121-124 protein denotes Rho
T5 255-258 protein denotes Rho
T6 297-323 protein denotes monocyte-binding receptors
T7 324-334 protein denotes E-selectin
T8 336-342 protein denotes ICAM-1
T9 348-354 protein denotes VCAM-1
T10 358-381 cell_type denotes human endothelial cells
T11 397-400 protein denotes Rho
T12 415-429 protein denotes C3 transferase
T13 433-440 protein denotes N19RhoA
T14 462-473 protein denotes RhoA mutant
T15 499-508 cell_type denotes monocytes
T16 522-539 cell_type denotes endothelial cells
T17 623-640 cell_type denotes endothelial cells
T18 675-715 protein denotes dominant negative Rac and Cdc42 proteins
T19 836-862 protein denotes monocyte-binding receptors
T20 866-883 cell_type denotes endothelial cells
T21 915-925 protein denotes E-selectin
T22 927-933 protein denotes ICAM-1
T23 939-945 protein denotes VCAM-1
T24 998-1022 protein denotes cross-linking antibodies
T25 1035-1042 protein denotes N19RhoA
T26 1168-1193 protein denotes myosin light chain kinase
T27 1302-1332 protein denotes ezrin/moesin/ radixin proteins
T28 1361-1364 protein denotes Rho
T29 1380-1397 cell_type denotes endothelial cells
T30 1440-1449 cell_type denotes monocytes
T31 1472-1498 protein denotes monocyte-binding receptors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-109 Sentence denotes Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering.
S2 110-221 Sentence denotes The GTPase Rho is known to mediate the assembly of integrin-containing focal adhesions and actin stress fibers.
S3 222-382 Sentence denotes Here, we investigate the role of Rho in regulating the distribution of the monocyte-binding receptors E-selectin, ICAM-1, and VCAM-1 in human endothelial cells.
S4 383-570 Sentence denotes Inhibition of Rho activity with C3 transferase or N19RhoA, a dominant negative RhoA mutant, reduced the adhesion of monocytes to activated endothelial cells and inhibited their spreading.
S5 571-661 Sentence denotes Similar effects were observed after pretreatment of endothelial cells with cytochalasin D.
S6 662-762 Sentence denotes In contrast, dominant negative Rac and Cdc42 proteins did not affect monocyte adhesion or spreading.
S7 763-1023 Sentence denotes C3 transferase and cytochalasin D did not alter the expression levels of monocyte-binding receptors on endothelial cells, but did inhibit clustering of E-selectin, ICAM-1, and VCAM-1 on the cell surface induced by monocyte adhesion or cross-linking antibodies.
S8 1024-1073 Sentence denotes Similarly, N19RhoA inhibited receptor clustering.
S9 1074-1257 Sentence denotes Monocyte adhesion and receptor cross-linking induced stress fiber assembly, and inhibitors of myosin light chain kinase prevented this response but did not affect receptor clustering.
S10 1258-1333 Sentence denotes Finally, receptor clusters colocalized with ezrin/moesin/ radixin proteins.
S11 1334-1588 Sentence denotes These results suggest that Rho is required in endothelial cells for the assembly of stable adhesions with monocytes via the clustering of monocyte-binding receptors and their association with the actin cytoskeleton, independent of stress fiber formation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 35-58 NP denotes human endothelial cells
C2 255-258 NP denotes Rho
C3 293-354 NP denotes the monocyte-binding receptors E-selectin, ICAM-1, and VCAM-1
C4 358-381 NP denotes human endothelial cells
C5 415-429 NP denotes C3 transferase
C6 433-440 NP denotes N19RhoA
C7 442-473 NP denotes a dominant negative RhoA mutant
C8 499-508 NP denotes monocytes
C9 554-559 NP denotes their
C10 623-640 NP denotes endothelial cells
C11 646-660 NP denotes cytochalasin D
C12 763-777 NP denotes C3 transferase
C13 782-796 NP denotes cytochalasin D
C14 836-862 NP denotes monocyte-binding receptors
C15 866-883 NP denotes endothelial cells
C16 915-945 NP denotes E-selectin, ICAM-1, and VCAM-1
C17 977-994 NP denotes monocyte adhesion
C18 1035-1042 NP denotes N19RhoA
C19 1053-1072 NP denotes receptor clustering
C20 1074-1091 NP denotes Monocyte adhesion
C21 1237-1256 NP denotes receptor clustering
C22 1361-1364 NP denotes Rho
C23 1380-1397 NP denotes endothelial cells
C24 1440-1449 NP denotes monocytes
C26 1472-1498 NP denotes monocyte-binding receptors
C25 1454-1498 NP denotes the clustering of monocyte-binding receptors
C27 1503-1508 NP denotes their
R1 C4 C1 coref-ident human endothelial cells,human endothelial cells
R2 C7 C6 coref-appos a dominant negative RhoA mutant,N19RhoA
R3 C9 C8 coref-pron their,monocytes
R4 C10 C4 coref-ident endothelial cells,human endothelial cells
R5 C12 C5 coref-ident C3 transferase,C3 transferase
R6 C13 C11 coref-ident cytochalasin D,cytochalasin D
R7 C14 C3 coref-ident monocyte-binding receptors,"the monocyte-binding receptors E-selectin, ICAM-1, and VCAM-1"
R8 C15 C10 coref-ident endothelial cells,endothelial cells
R9 C16 C14 coref-ident "E-selectin, ICAM-1, and VCAM-1",monocyte-binding receptors
R10 C18 C6 coref-ident N19RhoA,N19RhoA
R11 C20 C17 coref-ident Monocyte adhesion,monocyte adhesion
R12 C21 C19 coref-ident receptor clustering,receptor clustering
R13 C22 C2 coref-ident Rho,Rho
R14 C23 C15 coref-ident endothelial cells,endothelial cells
R15 C24 C8 coref-ident monocytes,monocytes
R16 C26 C16 coref-ident monocyte-binding receptors,"E-selectin, ICAM-1, and VCAM-1"
R17 C25 C21 coref-ident the clustering of monocyte-binding receptors,receptor clustering
R18 C27 C26 coref-pron their,monocyte-binding receptors

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-17 other_name denotes Monocyte adhesion
T2 35-58 cell_type denotes human endothelial cells
T3 75-78 protein_molecule denotes Rho
T4 114-120 protein_family_or_group denotes GTPase
T5 121-124 protein_molecule denotes Rho
T6 161-196 cell_component denotes integrin-containing focal adhesions
T7 201-220 cell_component denotes actin stress fibers
T8 255-258 protein_molecule denotes Rho
T9 297-323 protein_family_or_group denotes monocyte-binding receptors
T10 324-334 protein_molecule denotes E-selectin
T11 336-342 protein_molecule denotes ICAM-1
T12 348-354 protein_molecule denotes VCAM-1
T13 358-381 cell_type denotes human endothelial cells
T14 397-400 protein_molecule denotes Rho
T15 415-429 protein_molecule denotes C3 transferase
T16 433-440 protein_molecule denotes N19RhoA
T17 462-473 protein_family_or_group denotes RhoA mutant
T18 499-508 cell_type denotes monocytes
T19 522-539 cell_type denotes endothelial cells
T20 623-640 cell_type denotes endothelial cells
T21 646-660 other_organic_compound denotes cytochalasin D
T22 731-748 other_name denotes monocyte adhesion
T23 782-796 other_organic_compound denotes cytochalasin D
T24 836-862 protein_family_or_group denotes monocyte-binding receptors
T25 866-883 cell_type denotes endothelial cells
T26 915-925 protein_molecule denotes E-selectin
T27 927-933 protein_molecule denotes ICAM-1
T28 939-945 protein_molecule denotes VCAM-1
T29 977-994 other_name denotes monocyte adhesion
T30 998-1022 protein_family_or_group denotes cross-linking antibodies
T31 1035-1042 protein_molecule denotes N19RhoA
T32 1074-1091 other_name denotes Monocyte adhesion
T33 1105-1126 other_name denotes cross-linking induced
T34 1127-1139 cell_component denotes stress fiber
T35 1168-1193 protein_molecule denotes myosin light chain kinase
T36 1237-1256 other_name denotes receptor clustering
T37 1361-1364 protein_molecule denotes Rho
T38 1380-1397 cell_type denotes endothelial cells
T39 1440-1449 cell_type denotes monocytes
T40 1472-1498 protein_family_or_group denotes monocyte-binding receptors
T41 1536-1548 cell_component denotes cytoskeleton
T42 1565-1577 cell_component denotes stress fiber