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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 92-103 Cell denotes lymphocytes http://purl.obolibrary.org/obo/CL:0000542
T2 371-382 Cell denotes lymphocytes http://purl.obolibrary.org/obo/CL:0000542
T3 809-819 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542

sentences

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.
T2 105-257 Sentence denotes Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury.
T3 258-443 Sentence denotes In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited.
T4 444-685 Sentence denotes H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2.
T5 686-840 Sentence denotes Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2.
T6 841-1025 Sentence denotes Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation.
T7 1026-1201 Sentence denotes Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3.
T8 1202-1417 Sentence denotes Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus.
T9 1418-1624 Sentence denotes These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 26-31 protein denotes STAT3
T2 86-103 cell_type denotes human lymphocytes
T3 207-230 DNA denotes cytokine-encoding genes
T4 294-299 protein denotes STAT3
T5 305-325 protein denotes transcription factor
T6 365-382 cell_type denotes human lymphocytes
T7 404-412 protein denotes catalase
T8 482-487 protein denotes STAT3
T9 496-533 protein denotes sequence-specific DNA-bound complexes
T10 701-717 protein denotes STAT3 antibodies
T11 757-763 protein denotes 92 kDa
T12 997-1002 protein denotes STAT3
T13 1195-1200 protein denotes STAT3
T14 1284-1318 protein denotes intracellular tyrosine phosphatase
T15 1343-1348 protein denotes STAT3
T16 1477-1482 protein denotes STAT3
T17 1597-1600 protein denotes JAK
T18 1600-1605 protein denotes -STAT

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-104 Sentence denotes Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.
S2 105-257 Sentence denotes Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury.
S3 258-443 Sentence denotes In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited.
S4 444-685 Sentence denotes H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2.
S5 686-840 Sentence denotes Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2.
S6 841-1025 Sentence denotes Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation.
S7 1026-1201 Sentence denotes Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3.
S8 1202-1417 Sentence denotes Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus.
S9 1418-1624 Sentence denotes These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-16 NP denotes Oxidative stress
C2 86-103 NP denotes human lymphocytes
C3 105-121 NP denotes Oxidizing agents
C4 294-299 NP denotes STAT3
C5 303-325 NP denotes a transcription factor
C6 326-331 NP denotes whose
C8 365-382 NP denotes human lymphocytes
C7 357-382 NP denotes H2O2 in human lymphocytes
C9 387-392 NP denotes which
C10 482-487 NP denotes STAT3
C11 634-642 NP denotes vanadate
C12 680-684 NP denotes H2O2
C13 744-763 NP denotes a protein of 92 kDa
C14 764-768 NP denotes that
C15 835-839 NP denotes H2O2
C16 841-859 NP denotes Phenylarsine oxide
C17 861-893 NP denotes a tyrosine phosphatase inhibitor
C18 899-908 NP denotes genistein
C19 910-937 NP denotes a tyrosine kinase inhibitor
C20 1099-1103 NP denotes H2O2
C21 1195-1200 NP denotes STAT3
C22 1228-1232 NP denotes H2O2
C23 1237-1245 NP denotes vanadate
C24 1384-1387 NP denotes its
C25 1477-1482 NP denotes STAT3
C26 1503-1519 NP denotes oxidizing agents
C27 1573-1589 NP denotes oxidative stress
R1 C6 C5 coref-relat whose,a transcription factor
R2 C8 C2 coref-ident human lymphocytes,human lymphocytes
R3 C9 C7 coref-relat which,H2O2 in human lymphocytes
R4 C10 C4 coref-ident STAT3,STAT3
R5 C14 C13 coref-relat that,a protein of 92 kDa
R6 C15 C12 coref-ident H2O2,H2O2
R7 C17 C16 coref-appos a tyrosine phosphatase inhibitor,Phenylarsine oxide
R8 C19 C18 coref-appos a tyrosine kinase inhibitor,genistein
R9 C20 C15 coref-ident H2O2,H2O2
R10 C21 C10 coref-ident STAT3,STAT3
R11 C22 C20 coref-ident H2O2,H2O2
R12 C23 C11 coref-ident vanadate,vanadate
R13 C24 C21 coref-pron its,STAT3
R14 C25 C21 coref-ident STAT3,STAT3
R15 C26 C3 coref-ident oxidizing agents,Oxidizing agents
R16 C27 C1 coref-ident oxidative stress,Oxidative stress

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-16 other_name denotes Oxidative stress
T2 26-31 protein_molecule denotes STAT3
T3 32-40 amino_acid_monomer denotes tyrosine
T4 61-82 other_name denotes nuclear translocation
T5 86-103 cell_type denotes human lymphocytes
T6 105-121 other_organic_compound denotes Oxidizing agents
T7 177-203 other_name denotes transcriptional activation
T8 207-230 DNA_family_or_group denotes cytokine-encoding genes
T9 243-256 other_name denotes tissue injury
T10 294-299 protein_molecule denotes STAT3
T11 305-325 protein_family_or_group denotes transcription factor
T12 357-361 inorganic denotes H2O2
T13 365-382 cell_type denotes human lymphocytes
T14 404-412 protein_family_or_group denotes catalase
T15 444-448 inorganic denotes H2O2
T16 457-478 other_name denotes nuclear translocation
T17 482-487 protein_molecule denotes STAT3
T18 496-533 protein_complex denotes sequence-specific DNA-bound complexes
T19 551-565 other_name denotes immunoblotting
T20 569-586 cell_component denotes nuclear fractions
T21 591-628 other_name denotes electrophoretic mobility shift assays
T22 680-684 inorganic denotes H2O2
T23 701-706 protein_molecule denotes STAT3
T24 757-763 protein_molecule denotes 92 kDa
T25 795-803 amino_acid_monomer denotes tyrosine
T26 809-829 other_name denotes lymphocyte treatment
T27 835-839 inorganic denotes H2O2
T28 841-859 other_organic_compound denotes Phenylarsine oxide
T29 863-871 amino_acid_monomer denotes tyrosine
T30 899-908 other_organic_compound denotes genistein
T31 912-920 amino_acid_monomer denotes tyrosine
T32 983-987 inorganic denotes H2O2
T33 997-1002 protein_molecule denotes STAT3
T34 1003-1024 other_name denotes nuclear translocation
T35 1081-1083 inorganic denotes OH
T36 1099-1103 inorganic denotes H2O2
T37 1112-1128 other_name denotes Fenton reactions
T38 1150-1173 inorganic denotes oxygen reactive species
T39 1195-1200 protein_molecule denotes STAT3
T40 1228-1232 inorganic denotes H2O2
T41 1284-1297 protein_family_or_group denotes intracellular
T42 1298-1306 amino_acid_monomer denotes tyrosine
T43 1343-1348 protein_molecule denotes STAT3
T44 1349-1357 amino_acid_monomer denotes tyrosine
T45 1453-1473 other_name denotes DNA binding activity
T46 1477-1482 protein_molecule denotes STAT3
T47 1597-1600 protein_family_or_group denotes JAK
T48 1600-1605 protein_family_or_group denotes -STAT

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 0-16 Phenotype denotes Oxidative stress HP:0025464
T2 1573-1589 Phenotype denotes oxidative stress HP:0025464

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 250-256 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 86-91 OrganismTaxon denotes human 9606
T2 365-370 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 92-103 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T2 243-249 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 371-382 Body_part denotes lymphocytes http://purl.obolibrary.org/obo/CL_0000542
T4 809-819 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T5 1284-1297 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T6 1409-1416 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125