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PubMed:10364168 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 798-809 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 0-13 Glycan_Motif denotes Peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T2 519-532 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2.
T2 98-232 Sentence denotes The life-threatening complications of sepsis in humans are elicited by infection with Gram-negative as well as Gram-positive bacteria.
T3 233-450 Sentence denotes Recently, lipopolysaccharide (LPS), a major biologically active agent of Gram-negative bacteria, was shown to mediate cellular activation by a member of the human Toll-like receptor family, Toll-like receptor (TLR) 2.
T4 451-623 Sentence denotes Here we investigate the mechanism of cellular activation by soluble peptidoglycan (sPGN) and lipoteichoic acid (LTA), main stimulatory components of Gram-positive bacteria.
T5 624-810 Sentence denotes Like LPS, sPGN and LTA bind to the glycosylphosphatidylinositol-anchored membrane protein CD14 and induce activation of the transcription factor NF-kappaB in host cells like macrophages.
T6 811-975 Sentence denotes We show that whole Gram-positive bacteria, sPGN and LTA induce the activation of NF-kappaB in HEK293 cells expressing TLR2 but not in cells expressing TLR1 or TLR4.
T7 976-1102 Sentence denotes The sPGN- and LTA-induced NF-kappaB activation was not inhibited by polymyxin B, an antibiotic that binds and neutralizes LPS.
T8 1103-1191 Sentence denotes Coexpression together with membrane CD14 enhances sPGN signal transmission through TLR2.
T9 1192-1280 Sentence denotes In contrast to LPS signaling, activation of TLR2 by sPGN and LTA does not require serum.
T10 1281-1369 Sentence denotes These findings identify TLR2 as a signal transducer for sPGN and LTA in addition to LPS.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 0-13 https://glytoucan.org/Structures/Glycans/G00023MO denotes Peptidoglycan
T2 519-532 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 0-13 Simple_chemical denotes Peptidoglycan
T2 19-36 Simple_chemical denotes lipoteichoic acid
T3 76-96 Gene_or_gene_product denotes toll-like receptor 2
T4 243-261 Simple_chemical denotes lipopolysaccharide
T5 263-266 Simple_chemical denotes LPS
T6 396-414 Gene_or_gene_product denotes Toll-like receptor
T7 423-449 Gene_or_gene_product denotes Toll-like receptor (TLR) 2
T8 519-532 Simple_chemical denotes peptidoglycan
T9 534-538 Simple_chemical denotes sPGN
T10 544-561 Simple_chemical denotes lipoteichoic acid
T11 563-566 Simple_chemical denotes LTA
T12 629-632 Simple_chemical denotes LPS
T13 634-638 Simple_chemical denotes sPGN
T14 643-646 Simple_chemical denotes LTA
T15 659-687 Simple_chemical denotes glycosylphosphatidylinositol
T16 697-705 Cellular_component denotes membrane
T17 714-718 Gene_or_gene_product denotes CD14
T18 769-778 Complex denotes NF-kappaB
T19 854-858 Simple_chemical denotes sPGN
T20 863-866 Simple_chemical denotes LTA
T21 892-901 Complex denotes NF-kappaB
T22 929-933 Gene_or_gene_product denotes TLR2
T23 962-966 Gene_or_gene_product denotes TLR1
T24 970-974 Gene_or_gene_product denotes TLR4
T25 980-984 Simple_chemical denotes sPGN
T26 990-993 Simple_chemical denotes LTA
T27 1002-1011 Complex denotes NF-kappaB
T28 1044-1055 Simple_chemical denotes polymyxin B
T29 1098-1101 Simple_chemical denotes LPS
T30 1130-1138 Cellular_component denotes membrane
T31 1139-1143 Gene_or_gene_product denotes CD14
T32 1153-1157 Simple_chemical denotes sPGN
T33 1186-1190 Gene_or_gene_product denotes TLR2
T34 1207-1210 Simple_chemical denotes LPS
T35 1236-1240 Gene_or_gene_product denotes TLR2
T36 1244-1248 Simple_chemical denotes sPGN
T37 1253-1256 Simple_chemical denotes LTA
T38 1305-1309 Gene_or_gene_product denotes TLR2
T39 1337-1341 Simple_chemical denotes sPGN
T40 1346-1349 Simple_chemical denotes LTA
T41 1365-1368 Simple_chemical denotes LPS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 136-142 HP_0100806 denotes sepsis

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 169-178 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 136-142 Phenotype denotes sepsis HP:0100806

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 136-142 OrganismTaxon denotes sepsis 137507
T2 223-231 OrganismTaxon denotes bacteria 2|629395
T4 320-328 OrganismTaxon denotes bacteria 2|629395
T6 390-395 OrganismTaxon denotes human 9606
T7 614-622 OrganismTaxon denotes bacteria 2|629395
T9 844-852 OrganismTaxon denotes bacteria 2|629395

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 697-705 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 798-809 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T5 1130-1138 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158