PubMed:10364157
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 387-390 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T2 | 598-613 | DiseaseOrPhenotypicFeature | denotes | erythroleukemia | 0017858 |
| T3 | 688-691 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 22-73 | protein | denotes | hematopoietic transcription factors PU.1 and GATA-1 |
| T2 | 100-115 | cell_type | denotes | erythroid cells |
| T3 | 245-249 | protein | denotes | PU.1 |
| T4 | 255-309 | protein | denotes | hematopoietic-specific Ets family transcription factor |
| T5 | 351-380 | cell_type | denotes | lymphoid and myeloid lineages |
| T6 | 382-386 | protein | denotes | PU.1 |
| T7 | 406-417 | protein | denotes | oncoprotein |
| T8 | 592-625 | cell_line | denotes | mouse erythroleukemia (MEL) cells |
| T9 | 661-665 | protein | denotes | PU.1 |
| T10 | 683-687 | protein | denotes | PU.1 |
| T11 | 768-772 | protein | denotes | PU.1 |
| T12 | 829-833 | protein | denotes | PU.1 |
| T13 | 858-864 | protein | denotes | GATA-1 |
| T14 | 868-900 | protein | denotes | zinc finger transcription factor |
| T15 | 961-965 | protein | denotes | PU.1 |
| T16 | 970-976 | protein | denotes | GATA-1 |
| T17 | 993-1012 | protein | denotes | DNA-binding domains |
| T18 | 1031-1035 | protein | denotes | PU.1 |
| T19 | 1046-1052 | protein | denotes | GATA-1 |
| T20 | 1099-1110 | protein | denotes | DNA binding |
| T21 | 1115-1138 | protein | denotes | transactivation domains |
| T22 | 1142-1146 | protein | denotes | PU.1 |
| T23 | 1245-1254 | cell_line | denotes | MEL cells |
| T24 | 1296-1300 | protein | denotes | PU.1 |
| T25 | 1424-1430 | protein | denotes | GATA-1 |
| T26 | 1439-1448 | cell_line | denotes | MEL cells |
| T27 | 1541-1545 | protein | denotes | PU.1 |
| T28 | 1628-1649 | protein | denotes | transcription factors |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 7-18 | cui:C0687133 | denotes | interaction |
| E2-ti-1 | 22-35 | cui:C0018957 | denotes | hematopoietic |
| E3-ti-1 | 36-62 | cui:C0246120 | denotes | transcription factors PU.1 |
| E4-ti-1 | 67-73 | cui:C1530719 | denotes | GATA-1 |
| E5-ti-1 | 75-85 | cui:C0205245 | denotes | functional |
| E6-ti-1 | 86-96 | cui:C0680242 | denotes | antagonism |
| E7-ti-1 | 100-115 | cui:C1257751 | denotes | erythroid cells |
| T1 | 97-99 | LOCATION_OF | denotes | in |
| E1-ab-1 | 117-141 | cui:C1608408 | denotes | Malignant transformation |
| E2-ab-1 | 159-167 | cui:C0205088 | denotes | terminal |
| E3-ab-1 | 168-172 | cui:C0007634 | denotes | cell |
| E4-ab-1 | 205-215 | cui:C0441712 | denotes | mechanisms |
| E5-ab-1 | 229-232 | cui:C1518422 | denotes | not |
| E1-ab-2 | 255-268 | cui:C0018957 | denotes | hematopoietic |
| E2-ab-2 | 282-288 | cui:C0015576 | denotes | family |
| E3-ab-2 | 278-309 | cui:C0072461 | denotes | Ets family transcription factor |
| E4-ab-2 | 331-342 | cui:C1527148 | denotes | development |
| E5-ab-2 | 351-359 | cui:C1518071 | denotes | lymphoid |
| E6-ab-2 | 364-371 | cui:C0439677 | denotes | myeloid |
| E1-ab-3 | 406-417 | cui:C0029005 | denotes | oncoprotein |
| E2-ab-3 | 439-449 | cui:C0185117 | denotes | expression |
| E3-ab-3 | 453-462 | cui:C1516960 | denotes | erythroid |
| E4-ab-3 | 486-495 | cui:C0021107 | denotes | insertion |
| E5-ab-3 | 499-511 | cui:C0886519 | denotes | transgenesis |
| E6-ab-3 | 519-535 | cui:C0023440 | denotes | erythroleukemias |
| E7-ab-3 | 539-543 | cui:C0026809 | denotes | mice |
| T2 | 474-476 | METHOD_OF | denotes | by |
| T3 | 512-518 | CAUSES | denotes | causes |
| T4 | 536-538 | PROCESS_OF | denotes | in |
| E1-ab-4 | 560-568 | cui:C0205088 | denotes | terminal |
| E2-ab-4 | 592-597 | cui:C0025914 | denotes | mouse |
| E3-ab-4 | 598-613 | cui:C0023440 | denotes | erythroleukemia |
| E4-ab-4 | 620-625 | cui:C0007634 | denotes | cells |
| E5-ab-4 | 698-707 | cui:C1516960 | denotes | erythroid |
| E1-ab-5 | 749-758 | cui:C0441712 | denotes | mechanism |
| E2-ab-5 | 789-798 | cui:C1516960 | denotes | erythroid |
| E1-ab-6 | 858-864 | cui:C1530719 | denotes | GATA-1 |
| E2-ab-6 | 868-879 | cui:C0080347 | denotes | zinc finger |
| E3-ab-6 | 880-900 | cui:C0040648 | denotes | transcription factor |
| E4-ab-6 | 914-923 | cui:C1516960 | denotes | erythroid |
| E1-ab-7 | 941-952 | cui:C0687133 | denotes | Interaction |
| E2-ab-7 | 970-976 | cui:C1530719 | denotes | GATA-1 |
| E3-ab-7 | 986-992 | cui:C0205266 | denotes | intact |
| E4-ab-7 | 993-1012 | cui:C1511662 | denotes | DNA-binding domains |
| E5-ab-7 | 1021-1029 | cui:C0033684 | denotes | proteins |
| T5 | 1013-1015 | COEXISTS_WITH | denotes | in |
| E1-ab-8 | 1046-1052 | cui:C1530719 | denotes | GATA-1 |
| E2-ab-8 | 1053-1061 | cui:C0086597 | denotes | mediated |
| E3-ab-8 | 1062-1088 | cui:C0162493 | denotes | transcriptional activation |
| E1-ab-9 | 1099-1110 | cui:C1148673 | denotes | DNA binding |
| E2-ab-9 | 1115-1130 | cui:C0040624 | denotes | transactivation |
| E3-ab-9 | 1164-1174 | cui:C0035143 | denotes | repression |
| E4-ab-9 | 1217-1225 | cui:C0205088 | denotes | terminal |
| E5-ab-9 | 1245-1248 | cui:C0025914 | denotes | MEL |
| E6-ab-9 | 1245-1248 | cui:C0023440 | denotes | MEL |
| E7-ab-9 | 1249-1254 | cui:C0007634 | denotes | cells |
| E1-ab-10 | 1274-1292 | cui:C1512167 | denotes | ectopic expression |
| E2-ab-10 | 1304-1311 | cui:C0043342 | denotes | Xenopus |
| E3-ab-10 | 1312-1319 | cui:C0013935 | denotes | embryos |
| E4-ab-10 | 1323-1333 | cui:C0205410 | denotes | sufficient |
| E5-ab-10 | 1343-1357 | cui:C0014819 | denotes | erythropoiesis |
| E6-ab-10 | 1365-1371 | cui:C0205307 | denotes | normal |
| E7-ab-10 | 1372-1383 | cui:C1527148 | denotes | development |
| T6 | 1304-1319 | PART_OF | denotes | Xenopus embryos |
| T7 | 1337-1342 | AFFECTS | denotes | block |
| E1-ab-11 | 1398-1410 | cui:C1293116 | denotes | introduction |
| E2-ab-11 | 1414-1423 | cui:C0205228 | denotes | exogenous |
| E3-ab-11 | 1424-1430 | cui:C1530719 | denotes | GATA-1 |
| E4-ab-11 | 1439-1442 | cui:C0025914 | denotes | MEL |
| E5-ab-11 | 1439-1442 | cui:C0023440 | denotes | MEL |
| E6-ab-11 | 1443-1448 | cui:C0007634 | denotes | cells |
| E7-ab-11 | 1453-1460 | cui:C0043342 | denotes | Xenopus |
| E8-ab-11 | 1461-1468 | cui:C0013935 | denotes | embryos |
| E9-ab-11 | 1495-1500 | cui:C0028778 | denotes | block |
| E10-ab-11 | 1504-1513 | cui:C1516960 | denotes | erythroid |
| T8 | 1431-1433 | LOCATION_OF | denotes | in |
| T9 | 1431-1433 | LOCATION_OF | denotes | in |
| T10 | 1453-1468 | PART_OF | denotes | Xenopus embryos |
| T11 | 1482-1490 | TREATS | denotes | relieves |
| E1-ab-12 | 1551-1558 | cui:C1274040 | denotes | results |
| E2-ab-12 | 1577-1590 | cui:C0597526 | denotes | stoichiometry |
| E3-ab-12 | 1628-1649 | cui:C0040648 | denotes | transcription factors |
| E4-ab-12 | 1689-1698 | cui:C1522240 | denotes | processes |
| E5-ab-12 | 1702-1708 | cui:C0205307 | denotes | normal |
| E6-ab-12 | 1729-1753 | cui:C1608408 | denotes | malignant transformation |
| R1 | E7-ti-1 | T1 | subjectOf | erythroid cells,in |
| R2 | E4-ti-1 | T1 | objectOf | GATA-1,in |
| R3 | E4-ab-3 | T2 | subjectOf | insertion,by |
| R4 | E2-ab-3 | T2 | objectOf | expression,by |
| R5 | E1-ab-3 | T3 | subjectOf | oncoprotein,causes |
| R6 | E6-ab-3 | T3 | objectOf | erythroleukemias,causes |
| R7 | E6-ab-3 | T4 | subjectOf | erythroleukemias,in |
| R8 | E7-ab-3 | T4 | objectOf | mice,in |
| R9 | E2-ab-7 | T5 | subjectOf | GATA-1,in |
| R10 | E5-ab-7 | T5 | objectOf | proteins,in |
| R11 | E3-ab-10 | T6 | subjectOf | embryos,Xenopus embryos |
| R12 | E2-ab-10 | T6 | objectOf | Xenopus,Xenopus embryos |
| R13 | E1-ab-10 | T7 | subjectOf | ectopic expression,block |
| R14 | E5-ab-10 | T7 | objectOf | erythropoiesis,block |
| R15 | E6-ab-11 | T8 | subjectOf | cells,in |
| R16 | E3-ab-11 | T8 | objectOf | GATA-1,in |
| R17 | E8-ab-11 | T9 | subjectOf | embryos,in |
| R18 | E3-ab-11 | T9 | objectOf | GATA-1,in |
| R19 | E8-ab-11 | T10 | subjectOf | embryos,Xenopus embryos |
| R20 | E7-ab-11 | T10 | objectOf | Xenopus,Xenopus embryos |
| R21 | E1-ab-11 | T11 | subjectOf | introduction,relieves |
| R22 | E9-ab-11 | T11 | objectOf | block,relieves |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-116 | Sentence | denotes | Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. |
| S2 | 117-244 | Sentence | denotes | Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood. |
| S3 | 245-381 | Sentence | denotes | PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages. |
| S4 | 382-544 | Sentence | denotes | PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice. |
| S5 | 545-724 | Sentence | denotes | Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation. |
| S6 | 725-815 | Sentence | denotes | Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation. |
| S7 | 816-940 | Sentence | denotes | We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation. |
| S8 | 941-1030 | Sentence | denotes | Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins. |
| S9 | 1031-1089 | Sentence | denotes | PU.1 represses GATA-1-mediated transcriptional activation. |
| S10 | 1090-1255 | Sentence | denotes | Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells. |
| S11 | 1256-1384 | Sentence | denotes | We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development. |
| S12 | 1385-1546 | Sentence | denotes | Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1. |
| S13 | 1547-1754 | Sentence | denotes | Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 22-73 | NP | denotes | hematopoietic transcription factors PU.1 and GATA-1 |
| C2 | 117-141 | NP | denotes | Malignant transformation |
| C3 | 245-249 | NP | denotes | PU.1 |
| C4 | 253-309 | NP | denotes | a hematopoietic-specific Ets family transcription factor |
| C5 | 310-314 | NP | denotes | that |
| C6 | 382-386 | NP | denotes | PU.1 |
| C7 | 435-438 | NP | denotes | its |
| C8 | 560-625 | NP | denotes | terminal differentiation in the mouse erythroleukemia (MEL) cells |
| C9 | 661-665 | NP | denotes | PU.1 |
| C10 | 683-687 | NP | denotes | PU.1 |
| C11 | 698-723 | NP | denotes | erythroid differentiation |
| C12 | 745-758 | NP | denotes | the mechanism |
| C13 | 762-767 | NP | denotes | which |
| C14 | 768-772 | NP | denotes | PU.1 |
| C15 | 789-814 | NP | denotes | erythroid differentiation |
| C16 | 829-833 | NP | denotes | PU.1 |
| C17 | 858-864 | NP | denotes | GATA-1 |
| C19 | 914-939 | NP | denotes | erythroid differentiation |
| C18 | 866-939 | NP | denotes | a zinc finger transcription factor required for erythroid differentiation |
| C21 | 961-965 | NP | denotes | PU.1 |
| C22 | 970-976 | NP | denotes | GATA-1 |
| C20 | 961-976 | NP | denotes | PU.1 and GATA-1 |
| C23 | 1016-1029 | NP | denotes | both proteins |
| C24 | 1031-1035 | NP | denotes | PU.1 |
| C26 | 1142-1146 | NP | denotes | PU.1 |
| C25 | 1090-1146 | NP | denotes | Both the DNA binding and transactivation domains of PU.1 |
| C27 | 1179-1191 | NP | denotes | both domains |
| C28 | 1217-1254 | NP | denotes | terminal differentiation in MEL cells |
| C29 | 1296-1300 | NP | denotes | PU.1 |
| C30 | 1541-1545 | NP | denotes | PU.1 |
| C31 | 1729-1753 | NP | denotes | malignant transformation |
| R1 | C5 | C4 | coref-relat | that,a hematopoietic-specific Ets family transcription factor |
| R2 | C6 | C3 | coref-ident | PU.1,PU.1 |
| R3 | C7 | C6 | coref-pron | its,PU.1 |
| R4 | C9 | C6 | coref-ident | PU.1,PU.1 |
| R5 | C10 | C9 | coref-ident | PU.1,PU.1 |
| R6 | C13 | C12 | coref-relat | which,the mechanism |
| R7 | C14 | C10 | coref-ident | PU.1,PU.1 |
| R8 | C15 | C11 | coref-ident | erythroid differentiation,erythroid differentiation |
| R9 | C16 | C14 | coref-ident | PU.1,PU.1 |
| R10 | C19 | C15 | coref-ident | erythroid differentiation,erythroid differentiation |
| R11 | C18 | C17 | coref-appos | a zinc finger transcription factor required for erythroid differentiation,GATA-1 |
| R12 | C21 | C16 | coref-ident | PU.1,PU.1 |
| R13 | C22 | C17 | coref-ident | GATA-1,GATA-1 |
| R14 | C20 | C1 | coref-ident | PU.1 and GATA-1,hematopoietic transcription factors PU.1 and GATA-1 |
| R15 | C23 | C20 | coref-ident | both proteins,PU.1 and GATA-1 |
| R16 | C24 | C21 | coref-ident | PU.1,PU.1 |
| R17 | C26 | C24 | coref-ident | PU.1,PU.1 |
| R18 | C27 | C25 | coref-ident | both domains,Both the DNA binding and transactivation domains of PU.1 |
| R19 | C28 | C8 | coref-ident | terminal differentiation in MEL cells,terminal differentiation in the mouse erythroleukemia (MEL) cells |
| R20 | C29 | C26 | coref-ident | PU.1,PU.1 |
| R21 | C30 | C29 | coref-ident | PU.1,PU.1 |
| R22 | C31 | C2 | coref-ident | malignant transformation,Malignant transformation |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 100-115 | cell_type | denotes | erythroid cells |
| T2 | 117-141 | other_name | denotes | Malignant transformation |
| T3 | 159-188 | other_name | denotes | terminal cell differentiation |
| T4 | 245-249 | protein_molecule | denotes | PU.1 |
| T5 | 255-309 | protein_molecule | denotes | hematopoietic-specific Ets family transcription factor |
| T6 | 382-386 | protein_molecule | denotes | PU.1 |
| T7 | 406-417 | protein_family_or_group | denotes | oncoprotein |
| T8 | 453-473 | other_name | denotes | erythroid precursors |
| T9 | 477-495 | other_name | denotes | proviral insertion |
| T10 | 499-511 | other_name | denotes | transgenesis |
| T11 | 519-535 | other_name | denotes | erythroleukemias |
| T12 | 539-543 | multi_cell | denotes | mice |
| T13 | 560-584 | other_name | denotes | terminal differentiation |
| T14 | 592-615 | cell_line | denotes | mouse erythroleukemia ( |
| T15 | 615-618 | cell_line | denotes | MEL |
| T16 | 661-665 | protein_molecule | denotes | PU.1 |
| T17 | 683-687 | protein_molecule | denotes | PU.1 |
| T18 | 698-723 | other_name | denotes | erythroid differentiation |
| T19 | 768-772 | protein_molecule | denotes | PU.1 |
| T20 | 789-814 | other_name | denotes | erythroid differentiation |
| T21 | 829-833 | protein_molecule | denotes | PU.1 |
| T22 | 858-864 | protein_molecule | denotes | GATA-1 |
| T23 | 868-900 | protein_family_or_group | denotes | zinc finger transcription factor |
| T24 | 914-939 | other_name | denotes | erythroid differentiation |
| T25 | 961-965 | protein_molecule | denotes | PU.1 |
| T26 | 970-976 | protein_molecule | denotes | GATA-1 |
| T27 | 993-1012 | protein_domain_or_region | denotes | DNA-binding domains |
| T28 | 1031-1035 | protein_molecule | denotes | PU.1 |
| T29 | 1046-1052 | protein_molecule | denotes | GATA-1 |
| T30 | 1099-1110 | protein_domain_or_region | denotes | DNA binding |
| T31 | 1115-1138 | protein_domain_or_region | denotes | transactivation domains |
| T32 | 1142-1146 | protein_molecule | denotes | PU.1 |
| T33 | 1217-1241 | other_name | denotes | terminal differentiation |
| T34 | 1245-1254 | cell_line | denotes | MEL cells |
| T35 | 1274-1292 | other_name | denotes | ectopic expression |
| T36 | 1296-1300 | protein_molecule | denotes | PU.1 |
| T37 | 1304-1319 | multi_cell | denotes | Xenopus embryos |
| T38 | 1343-1357 | other_name | denotes | erythropoiesis |
| T39 | 1424-1430 | protein_molecule | denotes | GATA-1 |
| T40 | 1439-1448 | cell_line | denotes | MEL cells |
| T41 | 1453-1468 | multi_cell | denotes | Xenopus embryos |
| T42 | 1504-1529 | other_name | denotes | erythroid differentiation |
| T43 | 1541-1545 | protein_molecule | denotes | PU.1 |
| T44 | 1628-1649 | protein_family_or_group | denotes | transcription factors |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1425-1431 | C1530719 | denotes | ATA-1 |
| T2 | 1047-1053 | C1530719 | denotes | ATA-1- |
| T3 | 971-977 | C1530719 | denotes | ATA-1 |
| T4 | 859-865 | C1530719 | denotes | ATA-1, |
| T5 | 68-74 | C1530719 | denotes | ATA-1: |
| T6 | 101-116 | C1257751 | denotes | rythroid cells. |
| T7 | 1440-1443 | C0026809 | denotes | EL |
| T8 | 1246-1249 | C0026809 | denotes | EL |
| T9 | 593-597 | C0026809 | denotes | ouse |
| T10 | 540-544 | C0026809 | denotes | ice. |
| T11 | 87-97 | C0680242 | denotes | ntagonism |
| T12 | 942-953 | C1704675 | denotes | nteraction |
| T13 | 8-19 | C1704675 | denotes | nteraction |
| T14 | 23-63 | C0919490 | denotes | ematopoietic transcription factors PU.1 |
| T15 | 76-86 | C2700217 | denotes | unctional |
| T16 | 1-7 | C0439851 | denotes | irect |
| T17 | 1440-1443 | C0023440 | denotes | EL |
| T18 | 1246-1249 | C0023440 | denotes | EL |
| T19 | 599-614 | C0023440 | denotes | rythroleukemia |
| T20 | 520-536 | C0023440 | denotes | rythroleukemias |
| T21 | 1710-1725 | C0007589 | denotes | ifferentiation |
| T22 | 1515-1529 | C0007589 | denotes | ifferentiation |
| T23 | 925-940 | C0007589 | denotes | ifferentiation. |
| T24 | 800-815 | C0007589 | denotes | ifferentiation. |
| T25 | 709-724 | C0007589 | denotes | ifferentiation. |
| T26 | 169-189 | C0007589 | denotes | ell differentiation |
| T27 | 1454-1461 | C0043343 | denotes | enopus |
| T28 | 1305-1312 | C0043343 | denotes | enopus |
| T29 | 1542-1546 | C1705644 | denotes | U.1. |
| T30 | 1297-1301 | C1705644 | denotes | U.1 |
| T31 | 1143-1147 | C1705644 | denotes | U.1 |
| T32 | 1032-1036 | C1705644 | denotes | U.1 |
| T33 | 962-966 | C1705644 | denotes | U.1 |
| T34 | 830-833 | C1705644 | denotes | U.1 |
| T35 | 769-773 | C1705644 | denotes | U.1 |
| T36 | 684-688 | C1705644 | denotes | U.1 |
| T37 | 383-387 | C1705644 | denotes | U.1 |
| T38 | 246-250 | C1705644 | denotes | U.1 |
| T39 | 1629-1650 | C0040648 | denotes | ranscription factors |
| T40 | 881-901 | C0040648 | denotes | ranscription factor |
| T41 | 290-310 | C0040648 | denotes | ranscription factor |
| T42 | 397-400 | C0079613 | denotes | ct |
| T43 | 869-880 | C0080347 | denotes | inc finger |
| T44 | 1505-1514 | C1516960 | denotes | rythroid |
| T45 | 915-924 | C1516960 | denotes | rythroid |
| T46 | 790-799 | C1516960 | denotes | rythroid |
| T47 | 699-708 | C1516960 | denotes | rythroid |
| T48 | 454-463 | C1516960 | denotes | rythroid |
| T49 | 487-496 | C1512796 | denotes | nsertion |
| T50 | 1344-1358 | C0014819 | denotes | rythropoiesis |
| T51 | 1496-1501 | C2828370 | denotes | lock |
| T52 | 1338-1343 | C2828370 | denotes | lock |
| T53 | 1212-1216 | C2828370 | denotes | lock |
| T54 | 693-698 | C2828370 | denotes | lock |
| T55 | 513-518 | C1314792 | denotes | auses |
| T56 | 1202-1208 | C0027552 | denotes | eeded |
| T57 | 234-244 | C0162340 | denotes | nderstood. |
| T58 | 1063-1089 | C0162493 | denotes | ranscriptional activation. |
| T59 | 290-303 | C0040649 | denotes | ranscription |
| T60 | 407-418 | C0029005 | denotes | ncoprotein |
| T61 | 1116-1131 | C0040624 | denotes | ransactivation |
| T62 | 500-512 | C0886519 | denotes | ransgenesis |
| T63 | 1006-1013 | C1883221 | denotes | omains |
| T64 | 1218-1242 | C2752630 | denotes | erminal differentiation |
| T65 | 561-585 | C2752630 | denotes | erminal differentiation |
| T66 | 1152-1160 | C1514873 | denotes | equired |
| T67 | 902-910 | C1514873 | denotes | equired |
| T68 | 319-327 | C1514873 | denotes | equired |
| T69 | 1444-1449 | C0007634 | denotes | ells |
| T70 | 1250-1255 | C0007634 | denotes | ells. |
| T71 | 621-626 | C0007634 | denotes | ells |
| T72 | 151-159 | C0018790 | denotes | nhibits |
| T73 | 1165-1175 | C0035143 | denotes | epression |
| T74 | 283-289 | C0015576 | denotes | amily |
| T75 | 1462-1469 | C0013935 | denotes | mbryos |
| T76 | 1313-1320 | C0013935 | denotes | mbryos |
| T77 | 1740-1754 | C0040682 | denotes | ransformation. |
| T78 | 128-142 | C0040682 | denotes | ransformation |
| T79 | 750-759 | C0441712 | denotes | echanism |
| T80 | 206-216 | C0441712 | denotes | echanisms |
| T81 | 1595-1602 | C1947931 | denotes | irectly |
| T82 | 845-853 | C1947931 | denotes | irectly |
| T83 | 1373-1384 | C0678723 | denotes | evelopment. |
| T84 | 332-343 | C0678723 | denotes | evelopment |
| T85 | 1730-1739 | C0205282 | denotes | alignant |
| T86 | 118-127 | C0205282 | denotes | alignant |
| T87 | 1218-1226 | C0205088 | denotes | erminal |
| T88 | 160-168 | C0205088 | denotes | erminal |
| T89 | 422-432 | C1879547 | denotes | ctivation |
| T90 | 1100-1111 | C1148673 | denotes | NA binding |
| T91 | 440-450 | C0185117 | denotes | xpression |
| T92 | 820-824 | C0243095 | denotes | ind |
| T93 | 734-745 | C1292732 | denotes | nvestigate |
| T94 | 217-225 | C1314939 | denotes | nvolved |
| T95 | 230-233 | C1518422 | denotes | ot |
| T96 | 1483-1491 | C1301676 | denotes | elieves |
| T97 | 1265-1269 | C1547282 | denotes | how |
| T98 | 1209-1211 | C1883351 | denotes | o |
| T99 | 1552-1559 | C2825142 | denotes | esults |
| T100 | 1324-1334 | C0205410 | denotes | ufficient |
| T101 | 774-789 | C0521102 | denotes | nterferes with |
| T102 | 373-381 | C1881379 | denotes | ineages. |
| T103 | 464-474 | C1709634 | denotes | recursors |
| T104 | 1275-1293 | C1512167 | denotes | ctopic expression |
| T105 | 546-557 | C0449982 | denotes | estoration |
| T106 | 1399-1411 | C1293116 | denotes | ntroduction |
| T107 | 1578-1591 | C0597526 | denotes | toichiometry |
| T108 | 352-359 | C1518071 | denotes | ymphoid |
| T109 | 1690-1699 | C1522240 | denotes | rocesses |
| T110 | 365-372 | C0439677 | denotes | yeloid |
| T111 | 198-205 | C2939802 | denotes | recise |
| T112 | 169-173 | C1269647 | denotes | ell |
| T113 | 1054-1061 | C0086597 | denotes | ediated |
| T114 | 256-269 | C0229601 | denotes | ematopoietic- |
| T115 | 270-278 | C0205369 | denotes | pecific |
| T116 | 1415-1424 | C0205101 | denotes | xogenous |
| T117 | 987-992 | C0205266 | denotes | ntact |
| T118 | 1668-1678 | C1521761 | denotes | eterminant |
| T119 | 1703-1709 | C0439166 | denotes | ormal |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20045098 | 117-1753 | p(HGNC:SP1) increases r(HGNC:GATA1) | denotes | Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood. PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages. PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice. Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation. Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation. We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation. Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins. PU.1 represses GATA-1-mediated transcriptional activation. Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells. We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development. Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1. Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation |
| BEL:20068226 | 0-1753 | tscript(p(MGI:Gata1)) directlyIncreases r(MGI:Nfe2) | denotes | Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood. PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages. PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice. Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation. Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation. We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation. Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins. PU.1 represses GATA-1-mediated transcriptional activation. Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells. We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development. Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1. Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation |
| BEL:20068226 | 0-1753 | tscript(p(MGI:Gata1)) directlyIncreases r(MGI:Nfe2) | denotes | Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood. PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages. PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice. Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation. Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation. We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation. Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins. PU.1 represses GATA-1-mediated transcriptional activation. Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells. We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development. Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1. Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation |
| BEL:20065868 | 0-1753 | tscript(p(HGNC:GATA1)) directlyIncreases r(HGNC:NFE2) | denotes | Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood. PU.1 is a hematopoietic-specific Ets family transcription factor that is required for development of some lymphoid and myeloid lineages. PU.1 can also act as an oncoprotein as activation of its expression in erythroid precursors by proviral insertion or transgenesis causes erythroleukemias in mice. Restoration of terminal differentiation in the mouse erythroleukemia (MEL) cells requires a decline in the level of PU.1, indicating that PU.1 can block erythroid differentiation. Here we investigate the mechanism by which PU.1 interferes with erythroid differentiation. We find that PU.1 interacts directly with GATA-1, a zinc finger transcription factor required for erythroid differentiation. Interaction between PU.1 and GATA-1 requires intact DNA-binding domains in both proteins. PU.1 represses GATA-1-mediated transcriptional activation. Both the DNA binding and transactivation domains of PU.1 are required for repression and both domains are also needed to block terminal differentiation in MEL cells. We also show that ectopic expression of PU.1 in Xenopus embryos is sufficient to block erythropoiesis during normal development. Furthermore, introduction of exogenous GATA-1 in both MEL cells and Xenopus embryos and explants relieves the block to erythroid differentiation imposed by PU.1. Our results indicate that the stoichiometry of directly interacting but opposing transcription factors may be a crucial determinant governing processes of normal differentiation and malignant transformation |