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PubMed:10362842 JSONTXT

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GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
55 1043-1048 Species denotes human 9606

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 55-70 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 158-173 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T3 249-264 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T4 375-390 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T5 512-527 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T6 667-682 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T7 1004-1019 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T8 1055-1070 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T9 1175-1190 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T10 1359-1374 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-78 Sentence denotes Characterization of fibroblast growth factor 1 binding heparan sulfate domain.
TextSentencer_T2 79-229 Sentence denotes Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors.
TextSentencer_T3 230-439 Sentence denotes While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1.
TextSentencer_T4 440-655 Sentence denotes In the current study we present evidence that the minimal FGF-1 binding heparan sulfate sequence comprises 5-7 monosaccharide units and contains a critical trisulfated IdoA(2-OSO3)-GlcNSO3(6-OSO3) disaccharide unit.
TextSentencer_T5 656-786 Sentence denotes N-Sulfated heparan sulfate decasaccharides depleted of FGF-1 binding domains showed dose-dependent and saturable binding to FGF-2.
TextSentencer_T6 787-964 Sentence denotes These data indicate that the FGF-1 binding domain is distinct from the minimal FGF-2 binding site, previously shown to contain an IdoA(2-OSO3) residue but no 6-O-sulfate groups.
TextSentencer_T7 965-1161 Sentence denotes We further show that the FGF-1 binding heparan sulfate domain is expressed in human aorta heparan sulfate in an age-related manner in contrast to the constitutively expressed FGF-2 binding domain.
TextSentencer_T8 1162-1271 Sentence denotes Reduction of heparan sulfate O-sulfation by chlorate treatment of cells selectively impedes binding to FGF-1.
TextSentencer_T9 1272-1426 Sentence denotes The present data implicate the 6-O-sulfation of IdoA(2-OSO3)-GlcNSO3 units in cellular heparan sulfate in the control of the biological activity of FGF-1.
T1 0-78 Sentence denotes Characterization of fibroblast growth factor 1 binding heparan sulfate domain.
T2 79-229 Sentence denotes Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors.
T3 230-439 Sentence denotes While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1.
T4 440-655 Sentence denotes In the current study we present evidence that the minimal FGF-1 binding heparan sulfate sequence comprises 5-7 monosaccharide units and contains a critical trisulfated IdoA(2-OSO3)-GlcNSO3(6-OSO3) disaccharide unit.
T5 656-786 Sentence denotes N-Sulfated heparan sulfate decasaccharides depleted of FGF-1 binding domains showed dose-dependent and saturable binding to FGF-2.
T6 787-964 Sentence denotes These data indicate that the FGF-1 binding domain is distinct from the minimal FGF-2 binding site, previously shown to contain an IdoA(2-OSO3) residue but no 6-O-sulfate groups.
T7 965-1161 Sentence denotes We further show that the FGF-1 binding heparan sulfate domain is expressed in human aorta heparan sulfate in an age-related manner in contrast to the constitutively expressed FGF-2 binding domain.
T8 1162-1271 Sentence denotes Reduction of heparan sulfate O-sulfation by chlorate treatment of cells selectively impedes binding to FGF-1.
T9 1272-1426 Sentence denotes The present data implicate the 6-O-sulfation of IdoA(2-OSO3)-GlcNSO3 units in cellular heparan sulfate in the control of the biological activity of FGF-1.
T1 0-78 Sentence denotes Characterization of fibroblast growth factor 1 binding heparan sulfate domain.
T2 79-229 Sentence denotes Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors.
T3 230-439 Sentence denotes While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1.
T4 440-655 Sentence denotes In the current study we present evidence that the minimal FGF-1 binding heparan sulfate sequence comprises 5-7 monosaccharide units and contains a critical trisulfated IdoA(2-OSO3)-GlcNSO3(6-OSO3) disaccharide unit.
T5 656-786 Sentence denotes N-Sulfated heparan sulfate decasaccharides depleted of FGF-1 binding domains showed dose-dependent and saturable binding to FGF-2.
T6 787-964 Sentence denotes These data indicate that the FGF-1 binding domain is distinct from the minimal FGF-2 binding site, previously shown to contain an IdoA(2-OSO3) residue but no 6-O-sulfate groups.
T7 965-1161 Sentence denotes We further show that the FGF-1 binding heparan sulfate domain is expressed in human aorta heparan sulfate in an age-related manner in contrast to the constitutively expressed FGF-2 binding domain.
T8 1162-1271 Sentence denotes Reduction of heparan sulfate O-sulfation by chlorate treatment of cells selectively impedes binding to FGF-1.
T9 1272-1426 Sentence denotes The present data implicate the 6-O-sulfation of IdoA(2-OSO3)-GlcNSO3 units in cellular heparan sulfate in the control of the biological activity of FGF-1.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1049-1054 http://purl.obolibrary.org/obo/MAT_0000035 denotes aorta

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 20-30 FMAID:63877 denotes fibroblast
_T2 20-30 FMAID:162340 denotes fibroblast
_T3 55-62 FMAID:67110 denotes heparan
_T4 55-62 FMAID:165191 denotes heparan
_T5 55-70 FMAID:63023 denotes heparan sulfate
_T6 55-70 FMAID:167405 denotes heparan sulfate
_T7 79-89 FMAID:162340 denotes Fibroblast
_T8 79-89 FMAID:63877 denotes Fibroblast
_T9 158-165 FMAID:67110 denotes heparan
_T10 158-165 FMAID:165191 denotes heparan
_T11 158-173 FMAID:167405 denotes heparan sulfate
_T12 158-173 FMAID:63023 denotes heparan sulfate
_T13 202-214 FMAID:212684 denotes cell surface
_T14 202-214 FMAID:200942 denotes cell surface
_T15 207-214 FMAID:50594 denotes surface
_T16 207-214 FMAID:146300 denotes surface
_T17 249-256 FMAID:67110 denotes heparan
_T18 249-256 FMAID:165191 denotes heparan
_T19 249-264 FMAID:167405 denotes heparan sulfate
_T20 249-264 FMAID:63023 denotes heparan sulfate
_T21 375-382 FMAID:165191 denotes heparan
_T22 375-382 FMAID:67110 denotes heparan
_T23 375-390 FMAID:63023 denotes heparan sulfate
_T24 375-390 FMAID:167405 denotes heparan sulfate
_T25 512-519 FMAID:67110 denotes heparan
_T26 512-519 FMAID:165191 denotes heparan
_T27 512-527 FMAID:63023 denotes heparan sulfate
_T28 512-527 FMAID:167405 denotes heparan sulfate
_T29 551-565 FMAID:196730 denotes monosaccharide
_T30 551-565 FMAID:82741 denotes monosaccharide
_T31 637-649 FMAID:82744 denotes disaccharide
_T32 637-649 FMAID:196733 denotes disaccharide
_T33 667-674 FMAID:67110 denotes heparan
_T34 667-674 FMAID:165191 denotes heparan
_T35 667-682 FMAID:63023 denotes heparan sulfate
_T36 667-682 FMAID:167405 denotes heparan sulfate
_T37 1004-1011 FMAID:67110 denotes heparan
_T38 1004-1011 FMAID:165191 denotes heparan
_T39 1004-1019 FMAID:63023 denotes heparan sulfate
_T40 1004-1019 FMAID:167405 denotes heparan sulfate
_T41 1049-1054 FMAID:90119 denotes aorta
_T42 1049-1054 FMAID:3734 denotes aorta
_T43 1055-1062 FMAID:67110 denotes heparan
_T44 1055-1062 FMAID:165191 denotes heparan
_T45 1055-1070 FMAID:167405 denotes heparan sulfate
_T46 1055-1070 FMAID:63023 denotes heparan sulfate
_T47 1077-1080 FMAID:276692 denotes age
_T48 1175-1182 FMAID:67110 denotes heparan
_T49 1175-1182 FMAID:165191 denotes heparan
_T50 1175-1190 FMAID:63023 denotes heparan sulfate
_T51 1175-1190 FMAID:167405 denotes heparan sulfate
_T52 1228-1233 FMAID:169002 denotes cells
_T53 1228-1233 FMAID:68646 denotes cells
_T54 1359-1366 FMAID:67110 denotes heparan
_T55 1359-1366 FMAID:165191 denotes heparan
_T56 1359-1374 FMAID:63023 denotes heparan sulfate
_T57 1359-1374 FMAID:167405 denotes heparan sulfate

uniprot-human

Id Subject Object Predicate Lexical cue
T1 31-46 http://www.uniprot.org/uniprot/P13385 denotes growth factor 1
T2 31-46 http://www.uniprot.org/uniprot/Q99684 denotes growth factor 1
T3 31-54 http://www.uniprot.org/uniprot/P05230 denotes growth factor 1 binding
T4 105-110 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T5 433-438 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T6 498-503 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T7 711-716 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T8 816-821 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T9 990-995 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T10 1265-1270 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T11 1420-1425 http://www.uniprot.org/uniprot/P05230 denotes FGF-1
T12 31-46 http://www.uniprot.org/uniprot/P28069 denotes growth factor 1
T13 31-54 http://www.uniprot.org/uniprot/Q14512 denotes growth factor 1 binding
T14 498-511 http://www.uniprot.org/uniprot/Q14512 denotes FGF-1 binding
T15 711-724 http://www.uniprot.org/uniprot/Q14512 denotes FGF-1 binding
T16 816-829 http://www.uniprot.org/uniprot/Q14512 denotes FGF-1 binding
T17 990-1003 http://www.uniprot.org/uniprot/Q14512 denotes FGF-1 binding
T18 1254-1270 http://www.uniprot.org/uniprot/Q14512 denotes binding to FGF-1
T19 38-54 http://www.uniprot.org/uniprot/P17480 denotes factor 1 binding
T20 38-54 http://www.uniprot.org/uniprot/Q16633 denotes factor 1 binding
T21 38-54 http://www.uniprot.org/uniprot/O95248 denotes factor 1 binding
T22 38-54 http://www.uniprot.org/uniprot/P15976 denotes factor 1 binding
T23 38-54 http://www.uniprot.org/uniprot/O95365 denotes factor 1 binding
T24 38-54 http://www.uniprot.org/uniprot/O75626 denotes factor 1 binding
T25 38-54 http://www.uniprot.org/uniprot/Q8TES7 denotes factor 1 binding
T26 38-54 http://www.uniprot.org/uniprot/Q9UIV1 denotes factor 1 binding
T27 115-120 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T28 283-288 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T29 780-785 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T30 866-871 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T31 1140-1145 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T32 272-288 http://www.uniprot.org/uniprot/Q9BYJ0 denotes binding to FGF-2
T33 769-785 http://www.uniprot.org/uniprot/Q9BYJ0 denotes binding to FGF-2
T34 866-879 http://www.uniprot.org/uniprot/Q9BYJ0 denotes FGF-2 binding
T35 1140-1153 http://www.uniprot.org/uniprot/Q9BYJ0 denotes FGF-2 binding
T36 715-732 http://www.uniprot.org/uniprot/Q6PD62 denotes 1 binding domains
T37 820-836 http://www.uniprot.org/uniprot/Q6PD62 denotes 1 binding domain
T38 715-732 http://www.uniprot.org/uniprot/Q86U70 denotes 1 binding domains
T39 820-836 http://www.uniprot.org/uniprot/Q86U70 denotes 1 binding domain
T40 715-732 http://www.uniprot.org/uniprot/Q9Y3L3 denotes 1 binding domains
T41 820-836 http://www.uniprot.org/uniprot/Q9Y3L3 denotes 1 binding domain
T42 715-732 http://www.uniprot.org/uniprot/Q9H299 denotes 1 binding domains
T43 820-836 http://www.uniprot.org/uniprot/Q9H299 denotes 1 binding domain
T44 715-732 http://www.uniprot.org/uniprot/Q9NWI9 denotes 1 binding domains
T45 820-836 http://www.uniprot.org/uniprot/Q9NWI9 denotes 1 binding domain
T46 715-732 http://www.uniprot.org/uniprot/Q96G27 denotes 1 binding domains
T47 820-836 http://www.uniprot.org/uniprot/Q96G27 denotes 1 binding domain
T48 1144-1160 http://www.uniprot.org/uniprot/Q969T9 denotes 2 binding domain
T49 1144-1160 http://www.uniprot.org/uniprot/O43679 denotes 2 binding domain
T50 1144-1160 http://www.uniprot.org/uniprot/P78315 denotes 2 binding domain

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 105-110 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T2 433-438 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T3 498-503 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T4 711-716 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T5 816-821 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T6 990-995 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T7 1265-1270 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T8 1420-1425 http://www.uniprot.org/uniprot/P61148 denotes FGF-1
T9 115-120 http://www.uniprot.org/uniprot/P15655 denotes FGF-2
T10 283-288 http://www.uniprot.org/uniprot/P15655 denotes FGF-2
T11 780-785 http://www.uniprot.org/uniprot/P15655 denotes FGF-2
T12 866-871 http://www.uniprot.org/uniprot/P15655 denotes FGF-2
T13 1140-1145 http://www.uniprot.org/uniprot/P15655 denotes FGF-2
T14 498-511 http://www.uniprot.org/uniprot/O70514 denotes FGF-1 binding
T15 711-724 http://www.uniprot.org/uniprot/O70514 denotes FGF-1 binding
T16 816-829 http://www.uniprot.org/uniprot/O70514 denotes FGF-1 binding
T17 990-1003 http://www.uniprot.org/uniprot/O70514 denotes FGF-1 binding
T18 1254-1270 http://www.uniprot.org/uniprot/O70514 denotes binding to FGF-1

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 219-228 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T2 957-963 http://purl.bioontology.org/ontology/STY/T096 denotes groups
T3 1081-1088 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T4 1228-1233 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 31-37 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T2 90-96 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3 63-70 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T4 166-173 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T5 257-264 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T6 383-390 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T7 520-527 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T8 675-682 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T9 949-956 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T10 1012-1019 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T11 1063-1070 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T12 1183-1190 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T13 658-666 http://purl.obolibrary.org/obo/GO_0051923 denotes Sulfated
T14 1193-1202 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T15 1307-1316 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation
T16 1077-1080 http://purl.obolibrary.org/obo/GO_0007568 denotes age
T17 1350-1358 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular

GO-MF

Id Subject Object Predicate Lexical cue
T33 504-511 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T34 717-724 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T35 769-776 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T36 822-829 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T37 872-879 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T38 996-1003 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T39 1146-1153 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T40 1254-1261 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T41 47-70 http://purl.obolibrary.org/obo/GO_0008201 denotes binding heparan sulfate
T42 47-70 http://purl.obolibrary.org/obo/GO_1904399 denotes binding heparan sulfate
T43 504-527 http://purl.obolibrary.org/obo/GO_0008201 denotes binding heparan sulfate
T44 504-527 http://purl.obolibrary.org/obo/GO_1904399 denotes binding heparan sulfate
T45 996-1019 http://purl.obolibrary.org/obo/GO_0008201 denotes binding heparan sulfate
T46 996-1019 http://purl.obolibrary.org/obo/GO_1904399 denotes binding heparan sulfate
T47 47-70 http://purl.obolibrary.org/obo/GO_0043395 denotes binding heparan sulfate
T48 504-527 http://purl.obolibrary.org/obo/GO_0043395 denotes binding heparan sulfate
T49 996-1019 http://purl.obolibrary.org/obo/GO_0043395 denotes binding heparan sulfate
T50 272-286 http://purl.obolibrary.org/obo/GO_0017134 denotes binding to FGF
T51 769-783 http://purl.obolibrary.org/obo/GO_0017134 denotes binding to FGF
T52 1254-1268 http://purl.obolibrary.org/obo/GO_0017134 denotes binding to FGF
T53 272-288 http://purl.obolibrary.org/obo/GO_0017134 denotes binding to FGF-2
T54 769-785 http://purl.obolibrary.org/obo/GO_0017134 denotes binding to FGF-2
T55 866-879 http://purl.obolibrary.org/obo/GO_0017134 denotes FGF-2 binding
T56 1140-1153 http://purl.obolibrary.org/obo/GO_0017134 denotes FGF-2 binding
T57 498-511 http://purl.obolibrary.org/obo/GO_0017134 denotes FGF-1 binding
T58 711-724 http://purl.obolibrary.org/obo/GO_0017134 denotes FGF-1 binding
T59 816-829 http://purl.obolibrary.org/obo/GO_0017134 denotes FGF-1 binding
T60 990-1003 http://purl.obolibrary.org/obo/GO_0017134 denotes FGF-1 binding
T61 1254-1270 http://purl.obolibrary.org/obo/GO_0017134 denotes binding to FGF-1
T62 715-732 http://purl.obolibrary.org/obo/GO_0050683 denotes 1 binding domains
T63 820-836 http://purl.obolibrary.org/obo/GO_0050683 denotes 1 binding domain
T64 1144-1160 http://purl.obolibrary.org/obo/GO_0050682 denotes 2 binding domain
T1 47-54 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 272-279 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 504-511 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 717-724 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 769-776 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 822-829 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 872-879 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T8 996-1003 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T9 1146-1153 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T10 1254-1261 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T11 47-54 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 272-279 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T13 504-511 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T14 717-724 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T15 769-776 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T16 822-829 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T17 872-879 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T18 996-1003 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T19 1146-1153 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T20 1254-1261 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T21 47-54 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T22 272-279 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T23 504-511 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T24 717-724 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T25 769-776 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T26 822-829 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T27 872-879 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T28 996-1003 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T29 1146-1153 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T30 1254-1261 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T31 47-54 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T32 272-279 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 202-206 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 1228-1233 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 202-214 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 1049-1054 http://purl.obolibrary.org/obo/UBERON_0000947 denotes aorta

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1049-1054 http://purl.obolibrary.org/obo/MAT_0000035 denotes aorta

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 55-70 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T2 158-173 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T3 249-264 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T4 375-390 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T5 512-527 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T6 667-682 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T7 1004-1019 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T8 1055-1070 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T9 1175-1190 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
PD-GlycoEpitope-B_T10 1359-1374 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 608-612 "http://rdf.glycoinfo.org/glycan/G93013RN" denotes IdoA
GlycanIUPAC_T2 917-921 "http://rdf.glycoinfo.org/glycan/G93013RN" denotes IdoA
GlycanIUPAC_T3 1320-1324 "http://rdf.glycoinfo.org/glycan/G93013RN" denotes IdoA
GlycanIUPAC_T4 608-612 "http://rdf.glycoinfo.org/glycan/G40820ST" denotes IdoA
GlycanIUPAC_T5 917-921 "http://rdf.glycoinfo.org/glycan/G40820ST" denotes IdoA
GlycanIUPAC_T6 1320-1324 "http://rdf.glycoinfo.org/glycan/G40820ST" denotes IdoA
GlycanIUPAC_T7 608-612 "http://rdf.glycoinfo.org/glycan/G55034GQ" denotes IdoA
GlycanIUPAC_T8 917-921 "http://rdf.glycoinfo.org/glycan/G55034GQ" denotes IdoA
GlycanIUPAC_T9 1320-1324 "http://rdf.glycoinfo.org/glycan/G55034GQ" denotes IdoA

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1049-1054 http://purl.obolibrary.org/obo/UBERON_0000947 denotes aorta

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1049-1054 Body_part denotes aorta http://purl.obolibrary.org/obo/MAT_0000035

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Characterization of fibroblast growth factor 1 binding heparan sulfate domain.
T2 79-229 Sentence denotes Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors.
T3 230-439 Sentence denotes While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1.
T4 440-655 Sentence denotes In the current study we present evidence that the minimal FGF-1 binding heparan sulfate sequence comprises 5-7 monosaccharide units and contains a critical trisulfated IdoA(2-OSO3)-GlcNSO3(6-OSO3) disaccharide unit.
T5 656-786 Sentence denotes N-Sulfated heparan sulfate decasaccharides depleted of FGF-1 binding domains showed dose-dependent and saturable binding to FGF-2.
T6 787-964 Sentence denotes These data indicate that the FGF-1 binding domain is distinct from the minimal FGF-2 binding site, previously shown to contain an IdoA(2-OSO3) residue but no 6-O-sulfate groups.
T7 965-1161 Sentence denotes We further show that the FGF-1 binding heparan sulfate domain is expressed in human aorta heparan sulfate in an age-related manner in contrast to the constitutively expressed FGF-2 binding domain.
T8 1162-1271 Sentence denotes Reduction of heparan sulfate O-sulfation by chlorate treatment of cells selectively impedes binding to FGF-1.
T9 1272-1426 Sentence denotes The present data implicate the 6-O-sulfation of IdoA(2-OSO3)-GlcNSO3 units in cellular heparan sulfate in the control of the biological activity of FGF-1.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 55-70 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 158-173 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 249-264 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T4 375-390 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T5 512-527 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T6 667-682 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T7 1004-1019 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T8 1055-1070 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T9 1175-1190 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T10 1359-1374 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1043-1048 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 20-30 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T2 79-89 Body_part denotes Fibroblast http://purl.obolibrary.org/obo/CL_0000057
T3 1049-1054 Body_part denotes aorta http://purl.obolibrary.org/obo/UBERON_0000947

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 20-30 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T2 79-89 Cell denotes Fibroblast http://purl.obolibrary.org/obo/CL:0000057