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PubMed:10362840 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 231-257 Cell denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139
T2 1123-1145 Cell denotes vein endothelial cells http://purl.obolibrary.org/obo/CL:0002543

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 23-30 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 23-30 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 173-180 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 173-180 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 293-300 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 293-300 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 437-444 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 437-444 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 474-481 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 474-481 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 556-563 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 556-563 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 594-601 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 594-601 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 640-647 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 640-647 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T17 727-734 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T18 727-734 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T19 829-836 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T20 829-836 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T21 1012-1019 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T22 1012-1019 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T23 1031-1038 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T24 1031-1038 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T25 1230-1237 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T26 1230-1237 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 23-30 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 173-180 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 293-300 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T7 437-444 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T9 474-481 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T11 556-563 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T13 594-601 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T15 640-647 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T17 727-734 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T19 829-836 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T21 1012-1019 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T23 1031-1038 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T25 1230-1237 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-95 Sentence denotes Structural features in heparin that interact with VEGF165 and modulate its biological activity.
TextSentencer_T2 96-258 Sentence denotes The 165 amino acid form of vascular endothelial growth factor (VEGF165) is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells.
TextSentencer_T3 259-466 Sentence denotes We examined activities of various heparin derivatives toward their interactions with VEGF165 using an enzyme-linked immunosorbent assay and elucidated the structural features in heparin for the interactions.
TextSentencer_T4 467-610 Sentence denotes Native heparin interacted with VEGF165, whereas N-desulfated, N-acetylated (N-DS, N-Ac-) heparin, and 6-O-desulfated (6-O-DS-) heparin did not.
TextSentencer_T5 611-702 Sentence denotes The 2-O-desulfated (2-O-DS-) heparin retained the ability for the interaction with VEGF165.
TextSentencer_T6 703-795 Sentence denotes In contrast, the 2-O-DS-heparin exhibited no ability for the interaction with FGF-2 and HGF.
TextSentencer_T7 796-973 Sentence denotes Thus, structural requirements in heparin for the specific interaction with VEGF165 are distinct from those with FGF-2 and HGF which require a high content of 2-O-sulfate groups.
TextSentencer_T8 974-1300 Sentence denotes In a cell proliferation assay, native heparin and 2-O-DS-heparin exhibited inhibitory abilities for VEGF165-induced proliferation of human umbilical vein endothelial cells (HUVECs) with their high concentrations (more than 64 microg/ml), while only native heparin could enhance the proliferation of the chlorate-treated cells.
TextSentencer_T9 1301-1504 Sentence denotes These results suggested that a high content of 2-O-sulfate groups is not required for the specific interaction with VEGF165alone, although it is essential for the mitogenic activity of the growth factor.
T1 0-95 Sentence denotes Structural features in heparin that interact with VEGF165 and modulate its biological activity.
T2 96-258 Sentence denotes The 165 amino acid form of vascular endothelial growth factor (VEGF165) is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells.
T3 259-466 Sentence denotes We examined activities of various heparin derivatives toward their interactions with VEGF165 using an enzyme-linked immunosorbent assay and elucidated the structural features in heparin for the interactions.
T4 467-610 Sentence denotes Native heparin interacted with VEGF165, whereas N-desulfated, N-acetylated (N-DS, N-Ac-) heparin, and 6-O-desulfated (6-O-DS-) heparin did not.
T5 611-702 Sentence denotes The 2-O-desulfated (2-O-DS-) heparin retained the ability for the interaction with VEGF165.
T6 703-795 Sentence denotes In contrast, the 2-O-DS-heparin exhibited no ability for the interaction with FGF-2 and HGF.
T7 796-973 Sentence denotes Thus, structural requirements in heparin for the specific interaction with VEGF165 are distinct from those with FGF-2 and HGF which require a high content of 2-O-sulfate groups.
T8 974-1300 Sentence denotes In a cell proliferation assay, native heparin and 2-O-DS-heparin exhibited inhibitory abilities for VEGF165-induced proliferation of human umbilical vein endothelial cells (HUVECs) with their high concentrations (more than 64 microg/ml), while only native heparin could enhance the proliferation of the chlorate-treated cells.
T9 1301-1504 Sentence denotes These results suggested that a high content of 2-O-sulfate groups is not required for the specific interaction with VEGF165alone, although it is essential for the mitogenic activity of the growth factor.
T1 0-95 Sentence denotes Structural features in heparin that interact with VEGF165 and modulate its biological activity.
T2 96-258 Sentence denotes The 165 amino acid form of vascular endothelial growth factor (VEGF165) is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells.
T3 259-466 Sentence denotes We examined activities of various heparin derivatives toward their interactions with VEGF165 using an enzyme-linked immunosorbent assay and elucidated the structural features in heparin for the interactions.
T4 467-610 Sentence denotes Native heparin interacted with VEGF165, whereas N-desulfated, N-acetylated (N-DS, N-Ac-) heparin, and 6-O-desulfated (6-O-DS-) heparin did not.
T5 611-702 Sentence denotes The 2-O-desulfated (2-O-DS-) heparin retained the ability for the interaction with VEGF165.
T6 703-795 Sentence denotes In contrast, the 2-O-DS-heparin exhibited no ability for the interaction with FGF-2 and HGF.
T7 796-973 Sentence denotes Thus, structural requirements in heparin for the specific interaction with VEGF165 are distinct from those with FGF-2 and HGF which require a high content of 2-O-sulfate groups.
T8 974-1300 Sentence denotes In a cell proliferation assay, native heparin and 2-O-DS-heparin exhibited inhibitory abilities for VEGF165-induced proliferation of human umbilical vein endothelial cells (HUVECs) with their high concentrations (more than 64 microg/ml), while only native heparin could enhance the proliferation of the chlorate-treated cells.
T9 1301-1504 Sentence denotes These results suggested that a high content of 2-O-sulfate groups is not required for the specific interaction with VEGF165alone, although it is essential for the mitogenic activity of the growth factor.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 23-30 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 23-30 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 173-180 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 173-180 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 293-300 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 293-300 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 437-444 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 437-444 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 474-481 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T10 474-481 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T11 556-563 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T12 556-563 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T13 594-601 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T14 594-601 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T15 640-647 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T16 640-647 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T17 727-734 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T18 727-734 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T19 829-836 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T20 829-836 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T21 1012-1019 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T22 1012-1019 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T23 1031-1038 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T24 1031-1038 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T25 1230-1237 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T26 1230-1237 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1123-1127 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 23-30 FMAID:82839 denotes heparin
_T2 23-30 FMAID:167420 denotes heparin
_T3 104-114 FMAID:82739 denotes amino acid
_T4 104-114 FMAID:196728 denotes amino acid
_T5 132-143 FMAID:63916 denotes endothelial
_T6 132-143 FMAID:162384 denotes endothelial
_T7 173-180 FMAID:82839 denotes heparin
_T8 173-180 FMAID:167420 denotes heparin
_T9 240-251 FMAID:162384 denotes endothelial
_T10 240-251 FMAID:63916 denotes endothelial
_T11 240-257 FMAID:69075 denotes endothelial cells
_T12 240-257 FMAID:164926 denotes endothelial cells
_T13 240-257 FMAID:66772 denotes endothelial cells
_T14 240-257 FMAID:169653 denotes endothelial cells
_T15 252-257 FMAID:169002 denotes cells
_T16 252-257 FMAID:68646 denotes cells
_T17 293-300 FMAID:167420 denotes heparin
_T18 293-300 FMAID:82839 denotes heparin
_T19 437-444 FMAID:167420 denotes heparin
_T20 437-444 FMAID:82839 denotes heparin
_T21 474-481 FMAID:167420 denotes heparin
_T22 474-481 FMAID:82839 denotes heparin
_T23 556-563 FMAID:167420 denotes heparin
_T24 556-563 FMAID:82839 denotes heparin
_T25 594-601 FMAID:82839 denotes heparin
_T26 594-601 FMAID:167420 denotes heparin
_T27 640-647 FMAID:82839 denotes heparin
_T28 640-647 FMAID:167420 denotes heparin
_T29 727-734 FMAID:167420 denotes heparin
_T30 727-734 FMAID:82839 denotes heparin
_T31 829-836 FMAID:167420 denotes heparin
_T32 829-836 FMAID:82839 denotes heparin
_T33 1012-1019 FMAID:167420 denotes heparin
_T34 1012-1019 FMAID:82839 denotes heparin
_T35 1031-1038 FMAID:167420 denotes heparin
_T36 1031-1038 FMAID:82839 denotes heparin
_T37 1113-1127 FMAID:171155 denotes umbilical vein
_T38 1113-1127 FMAID:70317 denotes umbilical vein
_T39 1123-1127 FMAID:185470 denotes vein
_T40 1123-1127 FMAID:171667 denotes vein
_T41 1123-1127 FMAID:50723 denotes vein
_T42 1123-1127 FMAID:217490 denotes vein
_T43 1123-1127 FMAID:217063 denotes vein
_T44 1128-1139 FMAID:63916 denotes endothelial
_T45 1128-1139 FMAID:162384 denotes endothelial
_T46 1128-1145 FMAID:66772 denotes endothelial cells
_T47 1128-1145 FMAID:164926 denotes endothelial cells
_T48 1128-1145 FMAID:169653 denotes endothelial cells
_T49 1128-1145 FMAID:69075 denotes endothelial cells
_T50 1140-1145 FMAID:68646 denotes cells
_T51 1140-1145 FMAID:169002 denotes cells
_T52 1230-1237 FMAID:167420 denotes heparin
_T53 1230-1237 FMAID:82839 denotes heparin
_T54 1294-1299 FMAID:169002 denotes cells
_T55 1294-1299 FMAID:68646 denotes cells

uniprot-human

Id Subject Object Predicate Lexical cue
T1 545-547 http://www.uniprot.org/uniprot/P49366 denotes DS
T2 589-591 http://www.uniprot.org/uniprot/P49366 denotes DS
T3 635-637 http://www.uniprot.org/uniprot/P49366 denotes DS
T4 724-726 http://www.uniprot.org/uniprot/P49366 denotes DS
T5 1028-1030 http://www.uniprot.org/uniprot/P49366 denotes DS
T6 781-786 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T7 908-913 http://www.uniprot.org/uniprot/Q9UC54 denotes FGF-2
T8 791-794 http://www.uniprot.org/uniprot/Q9BYM0 denotes HGF
T9 918-921 http://www.uniprot.org/uniprot/Q9BYM0 denotes HGF

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 781-786 http://www.uniprot.org/uniprot/P15655 denotes FGF-2
T2 908-913 http://www.uniprot.org/uniprot/P15655 denotes FGF-2

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 252-257 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 966-972 http://purl.bioontology.org/ontology/STY/T096 denotes groups
T3 1140-1145 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 1294-1299 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1360-1366 http://purl.bioontology.org/ontology/STY/T096 denotes groups

GO-BP

Id Subject Object Predicate Lexical cue
T1 144-150 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T2 189-195 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3 1490-1496 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4 208-226 http://purl.obolibrary.org/obo/GO_0045840 denotes mitogenic activity
T5 1464-1482 http://purl.obolibrary.org/obo/GO_0045840 denotes mitogenic activity
T6 551-553 http://purl.obolibrary.org/obo/GO_0003987 denotes Ac
T7 551-553 http://purl.obolibrary.org/obo/GO_0043884 denotes Ac
T8 958-965 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T9 1352-1359 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfate
T10 979-997 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T11 1474-1496 http://purl.obolibrary.org/obo/GO_0045927 denotes activity of the growth

GO-MF

Id Subject Object Predicate Lexical cue
T1 173-188 http://purl.obolibrary.org/obo/GO_0008201 denotes heparin-binding
T2 181-188 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 181-188 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T4 181-188 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T5 181-188 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6 181-202 http://purl.obolibrary.org/obo/GO_0019838 denotes binding growth factor
T7 181-202 http://purl.obolibrary.org/obo/GO_0048408 denotes binding growth factor
T8 181-202 http://purl.obolibrary.org/obo/GO_0036458 denotes binding growth factor
T9 181-202 http://purl.obolibrary.org/obo/GO_0017134 denotes binding growth factor
T10 181-202 http://purl.obolibrary.org/obo/GO_0048406 denotes binding growth factor
T11 181-202 http://purl.obolibrary.org/obo/GO_0070851 denotes binding growth factor
T12 1474-1503 http://purl.obolibrary.org/obo/GO_0008083 denotes activity of the growth factor

GO-CC

Id Subject Object Predicate Lexical cue
T1 252-257 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 1140-1145 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 979-983 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 1113-1127 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
T2 1113-1139 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
T3 1123-1127 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1123-1127 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 23-30 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T2 173-180 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T3 293-300 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T4 437-444 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T5 474-481 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T6 556-563 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T7 594-601 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T8 640-647 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T9 727-734 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T10 829-836 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T11 1012-1019 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T12 1031-1038 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin
T13 1230-1237 http://rdf.glycoinfo.org/glycan/G54161DR denotes heparin

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1113-1127 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
PD-UBERON-AE-B_T2 1113-1139 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
PD-UBERON-AE-B_T3 1123-1127 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1123-1127 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 545-550 Disease denotes DS, N http://purl.obolibrary.org/obo/MONDO_0007790

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1107-1112 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 231-257 Body_part denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T2 1113-1127 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T3 1128-1145 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115