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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells.
T2 98-109 Sentence denotes BACKGROUND:
T3 110-236 Sentence denotes Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs) are found in the atmospheric urban pollution.
T4 237-348 Sentence denotes Such compounds have been shown to favor IgE production, bronchial hyperresponsiveness, and airway inflammation.
T5 349-447 Sentence denotes Chemokines are a group of chemotactic cytokines involved in the recruitment of inflammatory cells.
T6 448-458 Sentence denotes OBJECTIVE:
T7 459-600 Sentence denotes We investigated the effect of DEP-PAHs on the release and mRNA expression of IL-8, MCP-1, and RANTES by PBMCs obtained from healthy subjects.
T8 601-609 Sentence denotes METHODS:
T9 610-729 Sentence denotes Protein production in supernatants was assessed by ELISA, and mRNA expression was evaluated by semiquantitative RT-PCR.
T10 730-738 Sentence denotes RESULTS:
T11 739-876 Sentence denotes Secretion of IL-8 and RANTES increased in a dose-dependent manner with increasing concentrations of DEP-PAHs (range, 0.5 ng to 50 ng/mL).
T12 877-976 Sentence denotes On the contrary, the release of MCP-1 was significantly inhibited, also in a dose-dependent manner.
T13 977-1112 Sentence denotes Messenger RNA production coding for IL-8, RANTES, and MCP-1 showed parallel variations to the production of the correspondent proteins.
T14 1113-1258 Sentence denotes Effects of DEP-PAHs became significant at 7 hours and up to 48 hours time culture for MCP-1, and up to 24 hours time culture for IL-8 and RANTES.
T15 1259-1553 Sentence denotes Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.
T16 1554-1565 Sentence denotes CONCLUSION:
T17 1566-1786 Sentence denotes These findings suggest that the chemokine pathways are modulated by DEP-PAHs at the transcriptional level, reinforcing the idea that the development of inflammatory reactions might be affected by diesel exhaust emission.
T1 0-97 Sentence denotes Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells.
T2 98-109 Sentence denotes BACKGROUND:
T3 110-236 Sentence denotes Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs) are found in the atmospheric urban pollution.
T4 237-348 Sentence denotes Such compounds have been shown to favor IgE production, bronchial hyperresponsiveness, and airway inflammation.
T5 349-447 Sentence denotes Chemokines are a group of chemotactic cytokines involved in the recruitment of inflammatory cells.
T6 448-458 Sentence denotes OBJECTIVE:
T7 459-600 Sentence denotes We investigated the effect of DEP-PAHs on the release and mRNA expression of IL-8, MCP-1, and RANTES by PBMCs obtained from healthy subjects.
T8 601-609 Sentence denotes METHODS:
T9 610-729 Sentence denotes Protein production in supernatants was assessed by ELISA, and mRNA expression was evaluated by semiquantitative RT-PCR.
T10 730-738 Sentence denotes RESULTS:
T11 739-876 Sentence denotes Secretion of IL-8 and RANTES increased in a dose-dependent manner with increasing concentrations of DEP-PAHs (range, 0.5 ng to 50 ng/mL).
T12 877-976 Sentence denotes On the contrary, the release of MCP-1 was significantly inhibited, also in a dose-dependent manner.
T13 977-1112 Sentence denotes Messenger RNA production coding for IL-8, RANTES, and MCP-1 showed parallel variations to the production of the correspondent proteins.
T14 1113-1258 Sentence denotes Effects of DEP-PAHs became significant at 7 hours and up to 48 hours time culture for MCP-1, and up to 24 hours time culture for IL-8 and RANTES.
T15 1259-1553 Sentence denotes Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.
T16 1554-1565 Sentence denotes CONCLUSION:
T17 1566-1786 Sentence denotes These findings suggest that the chemokine pathways are modulated by DEP-PAHs at the transcriptional level, reinforcing the idea that the development of inflammatory reactions might be affected by diesel exhaust emission.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 38-47 protein denotes chemokine
T2 62-96 cell_type denotes peripheral blood mononuclear cells
T3 277-280 protein denotes IgE
T4 375-396 protein denotes chemotactic cytokines
T5 428-446 cell_type denotes inflammatory cells
T6 517-521 RNA denotes mRNA
T7 536-540 protein denotes IL-8
T8 542-547 protein denotes MCP-1
T9 553-559 protein denotes RANTES
T10 563-568 cell_type denotes PBMCs
T11 672-676 RNA denotes mRNA
T12 752-756 protein denotes IL-8
T13 761-767 protein denotes RANTES
T14 909-914 protein denotes MCP-1
T15 977-990 RNA denotes Messenger RNA
T16 1013-1017 protein denotes IL-8
T17 1019-1025 protein denotes RANTES
T18 1031-1036 protein denotes MCP-1
T19 1089-1111 protein denotes correspondent proteins
T20 1199-1204 protein denotes MCP-1
T21 1242-1246 protein denotes IL-8
T22 1251-1257 protein denotes RANTES
T23 1287-1310 cell_type denotes DEP-PAH-activated cells
T24 1405-1416 cell_type denotes neutrophils
T25 1421-1432 cell_type denotes eosinophils
T26 1489-1498 protein denotes anti-IL-8
T27 1503-1514 protein denotes anti-RANTES
T28 1598-1607 protein denotes chemokine

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-97 Sentence denotes Effects of diesel organic extracts on chemokine production by peripheral blood mononuclear cells.
S2 98-236 Sentence denotes BACKGROUND: Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs) are found in the atmospheric urban pollution.
S3 237-348 Sentence denotes Such compounds have been shown to favor IgE production, bronchial hyperresponsiveness, and airway inflammation.
S4 349-447 Sentence denotes Chemokines are a group of chemotactic cytokines involved in the recruitment of inflammatory cells.
S5 448-600 Sentence denotes OBJECTIVE: We investigated the effect of DEP-PAHs on the release and mRNA expression of IL-8, MCP-1, and RANTES by PBMCs obtained from healthy subjects.
S6 601-729 Sentence denotes METHODS: Protein production in supernatants was assessed by ELISA, and mRNA expression was evaluated by semiquantitative RT-PCR.
S7 730-876 Sentence denotes RESULTS: Secretion of IL-8 and RANTES increased in a dose-dependent manner with increasing concentrations of DEP-PAHs (range, 0.5 ng to 50 ng/mL).
S8 877-976 Sentence denotes On the contrary, the release of MCP-1 was significantly inhibited, also in a dose-dependent manner.
S9 977-1112 Sentence denotes Messenger RNA production coding for IL-8, RANTES, and MCP-1 showed parallel variations to the production of the correspondent proteins.
S10 1113-1258 Sentence denotes Effects of DEP-PAHs became significant at 7 hours and up to 48 hours time culture for MCP-1, and up to 24 hours time culture for IL-8 and RANTES.
S11 1259-1553 Sentence denotes Moreover, supernatants from DEP-PAH-activated cells, compared with those of controls, exhibited a significantly enhanced chemotactic activity for neutrophils and eosinophils, which was significantly inhibited by pretreatment with anti-IL-8 and anti-RANTES neutralizing antibodies, respectively.
S12 1554-1786 Sentence denotes CONCLUSION: These findings suggest that the chemokine pathways are modulated by DEP-PAHs at the transcriptional level, reinforcing the idea that the development of inflammatory reactions might be affected by diesel exhaust emission.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 110-190 NP denotes Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs)
C2 237-251 NP denotes Such compounds
C3 489-497 NP denotes DEP-PAHs
C5 536-540 NP denotes IL-8
C6 542-547 NP denotes MCP-1
C7 553-559 NP denotes RANTES
C4 536-559 NP denotes IL-8, MCP-1, and RANTES
C9 752-756 NP denotes IL-8
C10 761-767 NP denotes RANTES
C8 752-767 NP denotes IL-8 and RANTES
C11 781-804 NP denotes a dose-dependent manner
C12 839-847 NP denotes DEP-PAHs
C13 909-914 NP denotes MCP-1
C14 952-975 NP denotes a dose-dependent manner
C16 1013-1017 NP denotes IL-8
C17 1019-1025 NP denotes RANTES
C18 1031-1036 NP denotes MCP-1
C15 1013-1036 NP denotes IL-8, RANTES, and MCP-1
C19 1124-1132 NP denotes DEP-PAHs
C20 1199-1204 NP denotes MCP-1
C22 1242-1246 NP denotes IL-8
C23 1251-1257 NP denotes RANTES
C21 1242-1257 NP denotes IL-8 and RANTES
C24 1269-1281 NP denotes supernatants
C25 1326-1331 NP denotes those
C26 1355-1432 NP denotes a significantly enhanced chemotactic activity for neutrophils and eosinophils
C27 1434-1439 NP denotes which
C28 1634-1642 NP denotes DEP-PAHs
C29 1685-1693 NP denotes the idea
C30 1694-1698 NP denotes that
R1 C2 C1 coref-ident Such compounds,Polyaromatic hydrocarbons (PAHs) associated with diesel exhaust particles (DEPs)
R2 C3 C2 coref-ident DEP-PAHs,Such compounds
R3 C9 C5 coref-ident IL-8,IL-8
R4 C10 C7 coref-ident RANTES,RANTES
R5 C12 C3 coref-ident DEP-PAHs,DEP-PAHs
R6 C13 C6 coref-ident MCP-1,MCP-1
R7 C14 C11 coref-ident a dose-dependent manner,a dose-dependent manner
R8 C16 C9 coref-ident IL-8,IL-8
R9 C17 C10 coref-ident RANTES,RANTES
R10 C18 C13 coref-ident MCP-1,MCP-1
R11 C15 C4 coref-ident "IL-8, RANTES, and MCP-1","IL-8, MCP-1, and RANTES"
R12 C19 C12 coref-ident DEP-PAHs,DEP-PAHs
R13 C20 C18 coref-ident MCP-1,MCP-1
R14 C22 C16 coref-ident IL-8,IL-8
R15 C23 C17 coref-ident RANTES,RANTES
R16 C21 C8 coref-ident IL-8 and RANTES,IL-8 and RANTES
R17 C25 C24 coref-pron those,supernatants
R18 C27 C26 coref-relat which,a significantly enhanced chemotactic activity for neutrophils and eosinophils
R19 C28 C19 coref-ident DEP-PAHs,DEP-PAHs
R20 C30 C29 coref-relat that,the idea

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 11-34 other_organic_compound denotes diesel organic extracts
T2 38-47 protein_family_or_group denotes chemokine
T3 62-96 cell_type denotes peripheral blood mononuclear cells
T4 110-135 other_organic_compound denotes Polyaromatic hydrocarbons
T5 137-141 other_organic_compound denotes PAHs
T6 159-183 other_organic_compound denotes diesel exhaust particles
T7 185-189 other_organic_compound denotes DEPs
T8 208-235 other_organic_compound denotes atmospheric urban pollution
T9 277-280 protein_family_or_group denotes IgE
T10 293-322 other_name denotes bronchial hyperresponsiveness
T11 328-347 other_name denotes airway inflammation
T12 375-396 protein_family_or_group denotes chemotactic cytokines
T13 428-446 cell_type denotes inflammatory cells
T14 489-493 other_organic_compound denotes DEP-
T15 493-497 other_organic_compound denotes PAHs
T16 517-521 RNA_family_or_group denotes mRNA
T17 536-540 protein_molecule denotes IL-8
T18 542-547 protein_molecule denotes MCP-1
T19 553-559 protein_molecule denotes RANTES
T20 563-568 cell_type denotes PBMCs
T21 583-599 multi_cell denotes healthy subjects
T22 610-628 other_name denotes Protein production
T23 661-666 other_name denotes ELISA
T24 672-676 RNA_family_or_group denotes mRNA
T25 725-728 other_name denotes PCR
T26 752-756 protein_molecule denotes IL-8
T27 761-767 protein_molecule denotes RANTES
T28 783-804 other_name denotes dose-dependent manner
T29 839-843 other_organic_compound denotes DEP-
T30 843-847 other_organic_compound denotes PAHs
T31 909-914 protein_molecule denotes MCP-1
T32 954-975 other_name denotes dose-dependent manner
T33 977-990 RNA_family_or_group denotes Messenger RNA
T34 1013-1017 protein_molecule denotes IL-8
T35 1019-1025 protein_molecule denotes RANTES
T36 1031-1036 protein_molecule denotes MCP-1
T37 1089-1111 protein_family_or_group denotes correspondent proteins
T38 1128-1132 other_organic_compound denotes PAHs
T39 1199-1204 protein_molecule denotes MCP-1
T40 1242-1246 protein_molecule denotes IL-8
T41 1251-1257 protein_molecule denotes RANTES
T42 1287-1310 cell_type denotes DEP-PAH-activated cells
T43 1380-1400 other_name denotes chemotactic activity
T44 1405-1416 cell_type denotes neutrophils
T45 1421-1432 cell_type denotes eosinophils
T46 1489-1494 protein_family_or_group denotes anti-
T47 1494-1498 protein_molecule denotes IL-8
T48 1503-1508 protein_family_or_group denotes anti-
T49 1508-1514 protein_molecule denotes RANTES
T50 1598-1607 protein_family_or_group denotes chemokine
T51 1638-1642 other_organic_compound denotes PAHs
T52 1650-1671 other_name denotes transcriptional level
T53 1718-1740 other_name denotes inflammatory reactions
T54 1762-1785 other_name denotes diesel exhaust emission