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PubMed:10359457 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 11-17 protein denotes CYP1A1
T2 89-108 protein denotes cytochrome P-4501A1
T3 110-116 protein denotes CYP1A1
T4 426-444 protein denotes cytochrome P4501A1
T5 490-501 RNA denotes CYP1A1 mRNA
T6 523-551 cell_line denotes cultured human keratinocytes
T7 553-568 cell_line denotes HaCaT cell line
T8 571-602 cell_type denotes primary human blood lymphocytes
T9 607-625 cell_line denotes mouse Hepa-1 cells
T10 813-834 protein denotes reverse transcriptase
T11 925-938 cell_type denotes treated cells
T12 966-977 RNA denotes CYP1A1 mRNA
T13 1077-1088 cell_line denotes HaCaT cells
T14 1093-1104 cell_type denotes lymphocytes
T15 1244-1301 cell_line denotes Hepa-1 wild-type and Ah receptor deficient c12 cell lines
T16 1316-1336 cell_line denotes Wild-type (wt) cells
T17 1506-1515 cell_type denotes c12 cells
T18 1584-1595 protein denotes Ah receptor
T19 1656-1662 protein denotes CYP1A1
T20 1682-1697 cell_type denotes mammalian cells
T21 1716-1727 protein denotes Ah receptor
T22 1855-1866 protein denotes Ah receptor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-75 Sentence denotes UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan.
S2 76-224 Sentence denotes Induction of cytochrome P-4501A1 (CYP1A1) activity by UV has been observed earlier in animal studies via a mechanism that has not yet been resolved.
S3 225-387 Sentence denotes Our previous data have indicated that formylated indolocarbazoles which are formed by UV irradiation of tryptophan solutions are very potent Ah-receptor agonists.
S4 388-626 Sentence denotes To evaluate the effect of UV light on cytochrome P4501A1 gene expression, we studied the induction of CYP1A1 mRNA by UV irradiation of cultured human keratinocytes (HaCaT cell line), primary human blood lymphocytes and mouse Hepa-1 cells.
S5 627-793 Sentence denotes The cells were exposed to UV light delivered by a bank of 6 Philips TL20/12RS sun lamps emitting primarily in the UVB range in the absence and presence of tryptophan.
S6 794-939 Sentence denotes A semiquantitative reverse transcriptase-linked polymerase chain reaction (RT-PCR) was used for analysis of gene expression in the treated cells.
S7 940-1149 Sentence denotes The results show that the CYP1A1 mRNA level induced by UV in the presence of tryptophan was higher than that induced by UV alone in both HaCaT cells and lymphocytes after 3 h of incubation post-UV irradiation.
S8 1150-1315 Sentence denotes To find out if the induction by UV light is caused by the formation of an Ah receptor ligand, Hepa-1 wild-type and Ah receptor deficient c12 cell lines were applied.
S9 1316-1516 Sentence denotes Wild-type (wt) cells were inducible either by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) or by UV-irradiation but very low or undetectable levels were observed in the c12 cells.
S10 1517-1606 Sentence denotes This shows that the induction of gene expression by FICZ and UV is Ah receptor dependent.
S11 1607-1758 Sentence denotes Together, these results indicate that UV-induced CYP1A1 gene expression in mammalian cells is mediated by an Ah receptor ligand formed from tryptophan.
S12 1759-1940 Sentence denotes Thus, the photoproducts of tryptophan are suggested to be mediators of light via binding to the Ah receptor and as such also could have a role in light-regulated biological rhythms.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 64-74 NP denotes tryptophan
C2 130-132 NP denotes UV
C3 181-192 NP denotes a mechanism
C4 193-197 NP denotes that
C5 263-290 NP denotes formylated indolocarbazoles
C6 291-296 NP denotes which
C7 414-422 NP denotes UV light
C8 523-625 NP denotes cultured human keratinocytes (HaCaT cell line), primary human blood lymphocytes and mouse Hepa-1 cells
C9 627-636 NP denotes The cells
C10 782-792 NP denotes tryptophan
C11 902-917 NP denotes gene expression
C12 962-983 NP denotes the CYP1A1 mRNA level
C13 995-997 NP denotes UV
C14 1017-1027 NP denotes tryptophan
C15 1044-1048 NP denotes that
C16 1060-1068 NP denotes UV alone
C17 1182-1190 NP denotes UV light
C18 1265-1301 NP denotes Ah receptor deficient c12 cell lines
C19 1362-1427 NP denotes the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ)
C20 1502-1515 NP denotes the c12 cells
C21 1550-1565 NP denotes gene expression
C22 1569-1573 NP denotes FICZ
C23 1578-1580 NP denotes UV
C24 1747-1757 NP denotes tryptophan
C25 1786-1796 NP denotes tryptophan
R1 C4 C3 coref-relat that,a mechanism
R2 C6 C5 coref-relat which,formylated indolocarbazoles
R3 C9 C8 coref-ident The cells,"cultured human keratinocytes (HaCaT cell line), primary human blood lymphocytes and mouse Hepa-1 cells"
R4 C10 C1 coref-ident tryptophan,tryptophan
R5 C13 C2 coref-ident UV,UV
R6 C14 C10 coref-ident tryptophan,tryptophan
R7 C15 C12 coref-pron that,the CYP1A1 mRNA level
R8 C16 C13 coref-ident UV alone,UV
R9 C17 C7 coref-ident UV light,UV light
R10 C20 C18 coref-ident the c12 cells,Ah receptor deficient c12 cell lines
R11 C21 C11 coref-ident gene expression,gene expression
R12 C22 C19 coref-ident FICZ,"the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ)"
R13 C23 C16 coref-ident UV,UV alone
R14 C24 C14 coref-ident tryptophan,tryptophan
R15 C25 C24 coref-ident tryptophan,tryptophan

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-10 other_name denotes UV-induced
T2 11-17 protein_molecule denotes CYP1A1
T3 18-33 other_name denotes gene expression
T4 64-74 amino_acid_monomer denotes tryptophan
T5 89-108 protein_molecule denotes cytochrome P-4501A1
T6 110-116 protein_molecule denotes CYP1A1
T7 130-132 other_name denotes UV
T8 162-176 other_name denotes animal studies
T9 263-290 other_organic_compound denotes formylated indolocarbazoles
T10 311-313 other_name denotes UV
T11 329-339 amino_acid_monomer denotes tryptophan
T12 366-386 other_organic_compound denotes Ah-receptor agonists
T13 414-416 other_name denotes UV
T14 426-444 protein_molecule denotes cytochrome P4501A1
T15 445-460 other_name denotes gene expression
T16 490-496 protein_molecule denotes CYP1A1
T17 505-507 other_name denotes UV
T18 523-551 cell_line denotes cultured human keratinocytes
T19 553-568 cell_line denotes HaCaT cell line
T20 571-602 cell_type denotes primary human blood lymphocytes
T21 607-625 cell_line denotes mouse Hepa-1 cells
T22 653-655 other_name denotes UV
T23 687-714 other_name denotes Philips TL20/12RS sun lamps
T24 741-750 other_name denotes UVB range
T25 782-792 amino_acid_monomer denotes tryptophan
T26 796-812 other_name denotes semiquantitative
T27 813-834 protein_molecule denotes reverse transcriptase
T28 869-875 other_name denotes RT-PCR
T29 902-917 other_name denotes gene expression
T30 925-938 cell_type denotes treated cells
T31 966-972 protein_molecule denotes CYP1A1
T32 995-997 other_name denotes UV
T33 1017-1027 amino_acid_monomer denotes tryptophan
T34 1060-1062 other_name denotes UV
T35 1077-1088 cell_line denotes HaCaT cells
T36 1093-1104 cell_type denotes lymphocytes
T37 1134-1136 other_name denotes UV
T38 1182-1184 other_name denotes UV
T39 1316-1336 cell_line denotes Wild-type (wt) cells
T40 1366-1376 amino_acid_monomer denotes tryptophan
T41 1390-1420 other_organic_compound denotes 6-formylindolo[3,2-b]carbazole
T42 1422-1426 other_organic_compound denotes FICZ
T43 1434-1436 other_name denotes UV
T44 1506-1515 cell_type denotes c12 cells
T45 1550-1565 other_name denotes gene expression
T46 1569-1573 other_organic_compound denotes FICZ
T47 1578-1580 other_name denotes UV
T48 1584-1595 protein_molecule denotes Ah receptor
T49 1645-1647 other_name denotes UV
T50 1656-1662 protein_molecule denotes CYP1A1
T51 1663-1678 other_name denotes gene expression
T52 1682-1697 cell_type denotes mammalian cells
T53 1716-1727 protein_molecule denotes Ah receptor
T54 1747-1757 amino_acid_monomer denotes tryptophan
T55 1769-1782 other_organic_compound denotes photoproducts
T56 1786-1796 amino_acid_monomer denotes tryptophan
T57 1855-1866 protein_molecule denotes Ah receptor
T58 1905-1939 other_name denotes light-regulated biological rhythms