PubMed:10358775 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10358775","sourcedb":"PubMed","sourceid":"10358775","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10358775","text":"Selection of the T cell repertoire.\nAdvances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.","tracks":[{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":13,"end":34},"obj":"NP"},{"id":"C2","span":{"begin":97,"end":119},"obj":"NP"},{"id":"C3","span":{"begin":120,"end":124},"obj":"NP"},{"id":"C4","span":{"begin":131,"end":152},"obj":"NP"},{"id":"C5","span":{"begin":573,"end":613},"obj":"NP"},{"id":"C6","span":{"begin":614,"end":618},"obj":"NP"},{"id":"C7","span":{"begin":626,"end":647},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-relat","subj":"C3","obj":"C2"},{"id":"R2","pred":"coref-ident","subj":"C4","obj":"C1"},{"id":"R3","pred":"coref-relat","subj":"C6","obj":"C5"},{"id":"R4","pred":"coref-ident","subj":"C7","obj":"C4"}],"attributes":[{"subj":"C1","pred":"source","obj":"genia-medco-coref"},{"subj":"C2","pred":"source","obj":"genia-medco-coref"},{"subj":"C3","pred":"source","obj":"genia-medco-coref"},{"subj":"C4","pred":"source","obj":"genia-medco-coref"},{"subj":"C5","pred":"source","obj":"genia-medco-coref"},{"subj":"C6","pred":"source","obj":"genia-medco-coref"},{"subj":"C7","pred":"source","obj":"genia-medco-coref"}]},{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":200,"end":212},"obj":"cell_type"},{"id":"T2","span":{"begin":398,"end":423},"obj":"cell_type"},{"id":"T3","span":{"begin":525,"end":548},"obj":"cell_type"},{"id":"T4","span":{"begin":593,"end":602},"obj":"cell_type"}],"attributes":[{"subj":"T1","pred":"source","obj":"jnlpba-st-training"},{"subj":"T2","pred":"source","obj":"jnlpba-st-training"},{"subj":"T3","pred":"source","obj":"jnlpba-st-training"},{"subj":"T4","pred":"source","obj":"jnlpba-st-training"}]},{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":35},"obj":"Sentence"},{"id":"S2","span":{"begin":36,"end":153},"obj":"Sentence"},{"id":"S3","span":{"begin":154,"end":337},"obj":"Sentence"},{"id":"S4","span":{"begin":338,"end":451},"obj":"Sentence"},{"id":"S5","span":{"begin":452,"end":549},"obj":"Sentence"},{"id":"S6","span":{"begin":550,"end":713},"obj":"Sentence"}],"attributes":[{"subj":"S1","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S2","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S3","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S4","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S5","pred":"source","obj":"pubmed-sentences-benchmark"},{"subj":"S6","pred":"source","obj":"pubmed-sentences-benchmark"}]},{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":17,"end":34},"obj":"other_name"},{"id":"T2","span":{"begin":48,"end":63},"obj":"other_name"},{"id":"T3","span":{"begin":81,"end":93},"obj":"other_name"},{"id":"T4","span":{"begin":97,"end":119},"obj":"other_name"},{"id":"T5","span":{"begin":135,"end":152},"obj":"other_name"},{"id":"T6","span":{"begin":200,"end":212},"obj":"cell_type"},{"id":"T7","span":{"begin":270,"end":278},"obj":"other_name"},{"id":"T8","span":{"begin":283,"end":301},"obj":"other_name"},{"id":"T9","span":{"begin":338,"end":356},"obj":"other_name"},{"id":"T10","span":{"begin":398,"end":401},"obj":"protein_complex"},{"id":"T11","span":{"begin":429,"end":450},"obj":"other_name"},{"id":"T12","span":{"begin":452,"end":470},"obj":"other_name"},{"id":"T13","span":{"begin":525,"end":548},"obj":"cell_type"},{"id":"T14","span":{"begin":593,"end":602},"obj":"cell_type"},{"id":"T15","span":{"begin":630,"end":647},"obj":"other_name"}],"attributes":[{"subj":"T1","pred":"source","obj":"GENIAcorpus"},{"subj":"T2","pred":"source","obj":"GENIAcorpus"},{"subj":"T3","pred":"source","obj":"GENIAcorpus"},{"subj":"T4","pred":"source","obj":"GENIAcorpus"},{"subj":"T5","pred":"source","obj":"GENIAcorpus"},{"subj":"T6","pred":"source","obj":"GENIAcorpus"},{"subj":"T7","pred":"source","obj":"GENIAcorpus"},{"subj":"T8","pred":"source","obj":"GENIAcorpus"},{"subj":"T9","pred":"source","obj":"GENIAcorpus"},{"subj":"T10","pred":"source","obj":"GENIAcorpus"},{"subj":"T11","pred":"source","obj":"GENIAcorpus"},{"subj":"T12","pred":"source","obj":"GENIAcorpus"},{"subj":"T13","pred":"source","obj":"GENIAcorpus"},{"subj":"T14","pred":"source","obj":"GENIAcorpus"},{"subj":"T15","pred":"source","obj":"GENIAcorpus"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"genia-medco-coref","color":"#eca793","default":true},{"id":"jnlpba-st-training","color":"#9398ec"},{"id":"pubmed-sentences-benchmark","color":"#b2ec93"},{"id":"GENIAcorpus","color":"#ec93cc"}]}]}}