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sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes 20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.
T2 136-356 Sentence denotes 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays a major role in the stimulation of bone growth, mineralization, and intestinal calcium and phosphate absorption; it also acts as a general inhibitor of cellular proliferation.
T3 357-534 Sentence denotes Several new, clinically relevant compounds dissociate antiproliferative and calcemic activities of 1,25(OH)2D3, but the molecular basis for this has not been clearly elucidated.
T4 535-723 Sentence denotes Here, we tested whether the potency of one class of compounds, 20-epi analogues, to induce myeloid cell differentiation, is because of direct molecular effects on vitamin D receptor (VDR).
T5 724-953 Sentence denotes We report that two 20-epi analogues, MC1627 and MC1288, induced differentiation and transcription of p21(Waf1,Cip1), a key VDR target gene involved in growth inhibition, at a concentration 100-fold lower than that of 1,25(OH)2D3.
T6 954-1100 Sentence denotes We compared this sensitivity to analogue effects on VDR interacting proteins: RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex.
T7 1101-1374 Sentence denotes Compared with the interaction of VDR with RXR or GRIP-1, the differentiation dose-response most closely correlated to the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of the receptor to activate transcription in a cell-free system.
T8 1375-1581 Sentence denotes These results provide compelling links between the efficiency of the 20-epi analogue in inducing VDR/DRIP interactions, transactivation in vitro, and its enhanced ability to induce cellular differentiation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 216-220 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 249-259 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 75-99 protein denotes DRIP coactivator complex
T2 115-134 protein denotes vitamin D3 receptor
T3 698-716 protein denotes vitamin D receptor
T4 718-721 protein denotes VDR
T5 825-828 DNA denotes p21
T6 829-833 DNA denotes Waf1
T7 834-838 DNA denotes Cip1
T8 847-862 DNA denotes VDR target gene
T9 1006-1009 protein denotes VDR
T10 1032-1035 protein denotes RXR
T11 1037-1043 protein denotes GRIP-1
T12 1049-1056 protein denotes DRIP205
T13 1075-1099 protein denotes DRIP coactivator complex
T14 1134-1137 protein denotes VDR
T15 1143-1146 protein denotes RXR
T16 1150-1156 protein denotes GRIP-1
T17 1259-1283 protein denotes DRIP coactivator complex
T18 1287-1290 protein denotes VDR
T19 1472-1475 protein denotes VDR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-135 Sentence denotes 20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.
S2 136-356 Sentence denotes 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays a major role in the stimulation of bone growth, mineralization, and intestinal calcium and phosphate absorption; it also acts as a general inhibitor of cellular proliferation.
S3 357-534 Sentence denotes Several new, clinically relevant compounds dissociate antiproliferative and calcemic activities of 1,25(OH)2D3, but the molecular basis for this has not been clearly elucidated.
S4 535-723 Sentence denotes Here, we tested whether the potency of one class of compounds, 20-epi analogues, to induce myeloid cell differentiation, is because of direct molecular effects on vitamin D receptor (VDR).
S5 724-953 Sentence denotes We report that two 20-epi analogues, MC1627 and MC1288, induced differentiation and transcription of p21(Waf1,Cip1), a key VDR target gene involved in growth inhibition, at a concentration 100-fold lower than that of 1,25(OH)2D3.
S6 954-1100 Sentence denotes We compared this sensitivity to analogue effects on VDR interacting proteins: RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex.
S7 1101-1374 Sentence denotes Compared with the interaction of VDR with RXR or GRIP-1, the differentiation dose-response most closely correlated to the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of the receptor to activate transcription in a cell-free system.
S8 1375-1581 Sentence denotes These results provide compelling links between the efficiency of the 20-epi analogue in inducing VDR/DRIP interactions, transactivation in vitro, and its enhanced ability to induce cellular differentiation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 20-44 NP denotes 1,25-dihydroxyvitamin D3
C2 111-134 NP denotes the vitamin D3 receptor
C3 136-174 NP denotes 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)
C4 294-296 NP denotes it
C5 456-467 NP denotes 1,25(OH)2D3
C6 574-596 NP denotes one class of compounds
C7 598-614 NP denotes 20-epi analogues
C8 698-722 NP denotes vitamin D receptor (VDR)
C9 739-759 NP denotes two 20-epi analogues
C10 761-778 NP denotes MC1627 and MC1288
C11 825-839 NP denotes p21(Waf1,Cip1)
C12 841-892 NP denotes a key VDR target gene involved in growth inhibition
C13 941-952 NP denotes 1,25(OH)2D3
C14 1006-1030 NP denotes VDR interacting proteins
C16 1032-1035 NP denotes RXR
C17 1037-1043 NP denotes GRIP-1
C18 1049-1056 NP denotes DRIP205
C20 1071-1099 NP denotes the DRIP coactivator complex
C19 1058-1099 NP denotes a subunit of the DRIP coactivator complex
C15 1032-1099 NP denotes RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex
C21 1134-1137 NP denotes VDR
C22 1143-1146 NP denotes RXR
C23 1150-1156 NP denotes GRIP-1
C24 1255-1283 NP denotes the DRIP coactivator complex
C25 1287-1290 NP denotes VDR
C26 1313-1325 NP denotes the receptor
C27 1440-1459 NP denotes the 20-epi analogue
C28 1525-1528 NP denotes its
R1 C3 C1 coref-ident "1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)","1,25-dihydroxyvitamin D3"
R2 C4 C3 coref-pron it,"1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)"
R3 C5 C3 coref-ident "1,25(OH)2D3","1,25-Dihydroxyvitamin D3 (1,25(OH)2D3)"
R4 C7 C6 coref-appos 20-epi analogues,one class of compounds
R5 C8 C2 coref-ident vitamin D receptor (VDR),the vitamin D3 receptor
R6 C10 C9 coref-appos MC1627 and MC1288,two 20-epi analogues
R7 C12 C11 coref-appos a key VDR target gene involved in growth inhibition,"p21(Waf1,Cip1)"
R8 C13 C5 coref-ident "1,25(OH)2D3","1,25(OH)2D3"
R9 C19 C18 coref-appos a subunit of the DRIP coactivator complex,DRIP205
R10 C15 C14 coref-appos "RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex",VDR interacting proteins
R11 C21 C8 coref-ident VDR,vitamin D receptor (VDR)
R12 C22 C16 coref-ident RXR,RXR
R13 C23 C17 coref-ident GRIP-1,GRIP-1
R14 C24 C20 coref-ident the DRIP coactivator complex,the DRIP coactivator complex
R15 C25 C21 coref-ident VDR,VDR
R16 C26 C25 coref-ident the receptor,VDR
R17 C28 C27 coref-pron its,the 20-epi analogue

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-16 other_organic_compound denotes 20-Epi analogues
T2 20-44 lipid denotes 1,25-dihydroxyvitamin D3
T3 75-99 protein_complex denotes DRIP coactivator complex
T4 115-134 protein_family_or_group denotes vitamin D3 receptor
T5 136-160 lipid denotes 1,25-Dihydroxyvitamin D3
T6 162-173 lipid denotes 1,25(OH)2D3
T7 216-227 other_name denotes bone growth
T8 229-243 other_name denotes mineralization
T9 333-355 other_name denotes cellular proliferation
T10 433-452 other_name denotes calcemic activities
T11 456-467 lipid denotes 1,25(OH)2D3
T12 598-614 other_organic_compound denotes 20-epi analogues
T13 698-716 protein_family_or_group denotes vitamin D receptor
T14 718-721 protein_family_or_group denotes VDR
T15 743-759 other_organic_compound denotes 20-epi analogues
T16 761-767 other_organic_compound denotes MC1627
T17 772-778 other_organic_compound denotes MC1288
T18 825-828 DNA_domain_or_region denotes p21
T19 829-833 DNA_domain_or_region denotes Waf1
T20 834-838 DNA_domain_or_region denotes Cip1
T21 847-850 protein_family_or_group denotes VDR
T22 941-952 lipid denotes 1,25(OH)2D3
T23 1006-1009 protein_family_or_group denotes VDR
T24 1032-1035 protein_molecule denotes RXR
T25 1037-1043 protein_molecule denotes GRIP-1
T26 1049-1056 protein_molecule denotes DRIP205
T27 1075-1099 protein_complex denotes DRIP coactivator complex
T28 1134-1137 protein_family_or_group denotes VDR
T29 1143-1146 protein_molecule denotes RXR
T30 1150-1156 protein_molecule denotes GRIP-1
T31 1162-1191 other_name denotes differentiation dose-response
T32 1223-1251 other_name denotes ligand-dependent recruitment
T33 1259-1283 protein_complex denotes DRIP coactivator complex
T34 1287-1290 protein_family_or_group denotes VDR
T35 1357-1373 other_name denotes cell-free system
T36 1444-1459 other_organic_compound denotes 20-epi analogue
T37 1472-1475 protein_family_or_group denotes VDR
T38 1556-1580 other_name denotes cellular differentiation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 863-881 HP_0001507 denotes involved in growth

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 216-220 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 249-259 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 216-220 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T3 626-638 Body_part denotes myeloid cell http://purl.obolibrary.org/obo/CL_0000763

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 626-638 Cell denotes myeloid cell http://purl.obolibrary.org/obo/CL:0000763