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PubMed:10358011 JSONTXT

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GGDB-2020

Id Subject Object Predicate Lexical cue
T1 132-163 https://acgg.asia/db/ggdb/info/gg077 denotes beta1,4-galactosyltransferase I
T2 282-289 https://acgg.asia/db/ggdb/info/gg004 denotes Lewis X
T3 282-289 https://acgg.asia/db/ggdb/info/gg005 denotes Lewis X
T4 282-289 https://acgg.asia/db/ggdb/info/gg006 denotes Lewis X
T5 282-289 https://acgg.asia/db/ggdb/info/gg007 denotes Lewis X
T6 282-289 https://acgg.asia/db/ggdb/info/gg008 denotes Lewis X
T7 282-289 https://acgg.asia/db/ggdb/info/gg003 denotes Lewis X
T8 647-651 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T9 647-651 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T10 1085-1089 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T11 1085-1089 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T12 1628-1632 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T13 1628-1632 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T14 2062-2066 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T15 2062-2066 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT

ggdb-test

Id Subject Object Predicate Lexical cue
T1 132-163 https://acgg.asia/db/ggdb/info/gg077 denotes beta1,4-galactosyltransferase I
T2 282-289 https://acgg.asia/db/ggdb/info/gg003 denotes Lewis X
T3 282-289 https://acgg.asia/db/ggdb/info/gg004 denotes Lewis X
T4 282-289 https://acgg.asia/db/ggdb/info/gg005 denotes Lewis X
T5 282-289 https://acgg.asia/db/ggdb/info/gg006 denotes Lewis X
T6 282-289 https://acgg.asia/db/ggdb/info/gg007 denotes Lewis X
T7 282-289 https://acgg.asia/db/ggdb/info/gg008 denotes Lewis X
T8 647-651 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T9 647-651 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T10 1085-1089 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T11 1085-1089 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T12 1628-1632 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T13 1628-1632 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
T14 2062-2066 https://acgg.asia/db/ggdb/info/gg111 denotes iGnT
T15 2062-2066 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 5-24 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T2 170-189 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T3 275-289 Glycan_Motif denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T4 333-352 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T5 539-559 Glycan_Motif denotes N-acetyllactosamines https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T6 711-730 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T7 815-835 Glycan_Motif denotes N-acetyllactosamines https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T8 904-923 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T9 1391-1410 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T10 1690-1709 Glycan_Motif denotes N-acetyllactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Poly-N-acetyllactosamine synthesis in branched N-glycans is controlled by complemental branch specificity of I-extension enzyme and beta1,4-galactosyltransferase I.
T2 165-290 Sentence denotes Poly-N-acetyllactosamine is a unique carbohydrate that can carry various functional oligosaccharides, such as sialyl Lewis X.
T3 291-488 Sentence denotes It has been shown that the amount of poly-N-acetyllactosamine is increased in N-glycans, when they contain Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->4GlcNAcbeta1 -->2)Manalpha1-->6 branched structure.
T4 489-703 Sentence denotes To determine how this increased synthesis of poly-N-acetyllactosamines takes place, the branched acceptor was incubated with a mixture of i-extension enzyme (iGnT) and beta1, 4galactosyltransferase I (beta4Gal-TI).
T5 704-884 Sentence denotes First, N-acetyllactosamine repeats were more readily added to the branched acceptor than the summation of poly-N-acetyllactosamines formed individually on each unbranched acceptor.
T6 885-1144 Sentence denotes Surprisingly, poly-N-acetyllactosamine was more efficiently formed on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain than in Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R, due to preferential action of iGnT on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain.
T7 1145-1351 Sentence denotes On the other hand, galactosylation was much more efficient on beta1,6-linked GlcNAc than beta1,2-linked GlcNAc, preferentially forming Galbeta1-->4GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalph a1-->6Manbeta -->R.
T8 1352-1544 Sentence denotes Starting with this preformed acceptor, N-acetyllactosamine repeats were added almost equally to Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R and Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chains.
T9 1545-1866 Sentence denotes Taken together, these results indicate that the complemental branch specificity of iGnT and beta4Gal-TI leads to efficient and equal addition of N-acetyllactosamine repeats on both side chains of GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalpha1-->6Manbet a-->R structure, which is consistent with the structures found in nature.
T10 1867-2083 Sentence denotes The results also suggest that the addition of Galbeta1-->4GlcNAcbeta1-->6 side chain on Galbeta1-->4GlcNAcbeta1-->2Man-->R side chain converts the acceptor to one that is much more favorable for iGnT and beta4Gal-TI.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 5-24 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T2 170-189 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T3 275-289 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis X
T4 282-289 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X
T5 333-352 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T6 539-559 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamines
T7 711-730 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T8 815-835 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamines
T9 904-923 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T10 1391-1410 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine
T11 1690-1709 https://glytoucan.org/Structures/Glycans/G00055MO denotes N-acetyllactosamine

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 275-289 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis X

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1158-1162 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand

glycogenes

Id Subject Object Predicate Lexical cue
PD-GlycoGenes20190927-B_T1 294-297 https://acgg.asia/db/ggdb/info/gg135 denotes has
PD-GlycoGenes20190927-B_T2 647-651 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
PD-GlycoGenes20190927-B_T3 1085-1089 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
PD-GlycoGenes20190927-B_T4 1628-1632 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT
PD-GlycoGenes20190927-B_T5 2062-2066 https://acgg.asia/db/ggdb/info/gg115 denotes iGnT

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 1222-1228 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 1249-1255 chem:24139 denotes GlcNAc

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 275-289 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 275-289 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 0-4 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T3 165-169 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T5 328-332 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T7 534-538 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T9 810-814 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T11 899-903 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 111-120 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T2 629-638 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T3 1158-1162 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Poly-N-acetyllactosamine synthesis in branched N-glycans is controlled by complemental branch specificity of I-extension enzyme and beta1,4-galactosyltransferase I.
T2 165-290 Sentence denotes Poly-N-acetyllactosamine is a unique carbohydrate that can carry various functional oligosaccharides, such as sialyl Lewis X.
T3 291-488 Sentence denotes It has been shown that the amount of poly-N-acetyllactosamine is increased in N-glycans, when they contain Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->4GlcNAcbeta1 -->2)Manalpha1-->6 branched structure.
T4 489-703 Sentence denotes To determine how this increased synthesis of poly-N-acetyllactosamines takes place, the branched acceptor was incubated with a mixture of i-extension enzyme (iGnT) and beta1, 4galactosyltransferase I (beta4Gal-TI).
T5 704-884 Sentence denotes First, N-acetyllactosamine repeats were more readily added to the branched acceptor than the summation of poly-N-acetyllactosamines formed individually on each unbranched acceptor.
T6 885-1144 Sentence denotes Surprisingly, poly-N-acetyllactosamine was more efficiently formed on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain than in Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R, due to preferential action of iGnT on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain.
T7 1145-1351 Sentence denotes On the other hand, galactosylation was much more efficient on beta1,6-linked GlcNAc than beta1,2-linked GlcNAc, preferentially forming Galbeta1-->4GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalph a1-->6Manbeta -->R.
T8 1352-1544 Sentence denotes Starting with this preformed acceptor, N-acetyllactosamine repeats were added almost equally to Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R and Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chains.
T9 1545-1866 Sentence denotes Taken together, these results indicate that the complemental branch specificity of iGnT and beta4Gal-TI leads to efficient and equal addition of N-acetyllactosamine repeats on both side chains of GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalpha1-->6Manbet a-->R structure, which is consistent with the structures found in nature.
T10 1867-2083 Sentence denotes The results also suggest that the addition of Galbeta1-->4GlcNAcbeta1-->6 side chain on Galbeta1-->4GlcNAcbeta1-->2Man-->R side chain converts the acceptor to one that is much more favorable for iGnT and beta4Gal-TI.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Poly-N-acetyllactosamine synthesis in branched N-glycans is controlled by complemental branch specificity of I-extension enzyme and beta1,4-galactosyltransferase I.
T2 165-488 Sentence denotes Poly-N-acetyllactosamine is a unique carbohydrate that can carry various functional oligosaccharides, such as sialyl Lewis X. It has been shown that the amount of poly-N-acetyllactosamine is increased in N-glycans, when they contain Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->4GlcNAcbeta1 -->2)Manalpha1-->6 branched structure.
T3 489-703 Sentence denotes To determine how this increased synthesis of poly-N-acetyllactosamines takes place, the branched acceptor was incubated with a mixture of i-extension enzyme (iGnT) and beta1, 4galactosyltransferase I (beta4Gal-TI).
T4 704-884 Sentence denotes First, N-acetyllactosamine repeats were more readily added to the branched acceptor than the summation of poly-N-acetyllactosamines formed individually on each unbranched acceptor.
T5 885-1144 Sentence denotes Surprisingly, poly-N-acetyllactosamine was more efficiently formed on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain than in Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R, due to preferential action of iGnT on Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chain.
T6 1145-1544 Sentence denotes On the other hand, galactosylation was much more efficient on beta1,6-linked GlcNAc than beta1,2-linked GlcNAc, preferentially forming Galbeta1-->4GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalph a1-->6Manbeta -->R. Starting with this preformed acceptor, N-acetyllactosamine repeats were added almost equally to Galbeta1-->4GlcNAcbeta1-->6Manalpha-->R and Galbeta1-->4GlcNAcbeta1-->2Manalpha-->R side chains.
T7 1545-1866 Sentence denotes Taken together, these results indicate that the complemental branch specificity of iGnT and beta4Gal-TI leads to efficient and equal addition of N-acetyllactosamine repeats on both side chains of GlcNAcbeta1-->6(GlcNAcbeta1-->2)Manalpha1-->6Manbet a-->R structure, which is consistent with the structures found in nature.
T8 1867-2083 Sentence denotes The results also suggest that the addition of Galbeta1-->4GlcNAcbeta1-->6 side chain on Galbeta1-->4GlcNAcbeta1-->2Man-->R side chain converts the acceptor to one that is much more favorable for iGnT and beta4Gal-TI.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 275-289 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 1158-1162 Body_part denotes hand FMA:9712

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1158-1162 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 275-289 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 111-120 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T2 629-638 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T3 1158-1162 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1158-1162 Body_part denotes hand http://purl.obolibrary.org/obo/MAT_0000091

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-4 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T3 165-169 Cell denotes Poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T5 328-332 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T7 534-538 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T9 810-814 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T11 899-903 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775