PubMed:10357820
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 83-210 | DRI_Approach | denotes | Here we show that the lymphoid lineage-determining factors Ikaros and Aiolos can function as strong transcriptional repressors. |
| T2 | 211-325 | DRI_Background | denotes | This function is mediated through two repression domains and is dependent upon the promoter context and cell type. |
| T3 | 326-474 | DRI_Background | denotes | Repression by Ikaros proteins correlates with hypo-acetylation of core histones at promoter sites and is relieved by histone deacetylase inhibitors. |
| T4 | 475-649 | DRI_Outcome | denotes | Consistent with these findings, Ikaros and its repression domains can interact in vivo and in vitro with the mSin3 family of co-repressors which bind to histone deacetylases. |
| T5 | 650-903 | DRI_Approach | denotes | Based on these and our recent findings of associations between Ikaros and Mi-2-HDAC, we propose that Ikaros family members modulate gene expression during lymphocyte development by recruiting distinct histone deacetylase complexes to specific promoters. |
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 160-163 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T2 | 541-544 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-20 | protein | denotes | Ikaros |
| T2 | 25-31 | protein | denotes | Aiolos |
| T3 | 52-81 | protein | denotes | histone deacetylase complexes |
| T4 | 105-141 | protein | denotes | lymphoid lineage-determining factors |
| T5 | 142-148 | protein | denotes | Ikaros |
| T6 | 153-159 | protein | denotes | Aiolos |
| T7 | 176-209 | protein | denotes | strong transcriptional repressors |
| T8 | 249-267 | protein | denotes | repression domains |
| T9 | 340-355 | protein | denotes | Ikaros proteins |
| T10 | 392-405 | protein | denotes | core histones |
| T11 | 409-423 | DNA | denotes | promoter sites |
| T12 | 443-462 | protein | denotes | histone deacetylase |
| T13 | 507-513 | protein | denotes | Ikaros |
| T14 | 522-540 | protein | denotes | repression domains |
| T15 | 584-596 | protein | denotes | mSin3 family |
| T16 | 628-648 | protein | denotes | histone deacetylases |
| T17 | 713-719 | protein | denotes | Ikaros |
| T18 | 724-733 | protein | denotes | Mi-2-HDAC |
| T19 | 751-772 | protein | denotes | Ikaros family members |
| T20 | 851-880 | protein | denotes | histone deacetylase complexes |
| T21 | 884-902 | DNA | denotes | specific promoters |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-82 | Sentence | denotes | Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |
| S2 | 83-210 | Sentence | denotes | Here we show that the lymphoid lineage-determining factors Ikaros and Aiolos can function as strong transcriptional repressors. |
| S3 | 211-325 | Sentence | denotes | This function is mediated through two repression domains and is dependent upon the promoter context and cell type. |
| S4 | 326-474 | Sentence | denotes | Repression by Ikaros proteins correlates with hypo-acetylation of core histones at promoter sites and is relieved by histone deacetylase inhibitors. |
| S5 | 475-649 | Sentence | denotes | Consistent with these findings, Ikaros and its repression domains can interact in vivo and in vitro with the mSin3 family of co-repressors which bind to histone deacetylases. |
| S6 | 650-903 | Sentence | denotes | Based on these and our recent findings of associations between Ikaros and Mi-2-HDAC, we propose that Ikaros family members modulate gene expression during lymphocyte development by recruiting distinct histone deacetylase complexes to specific promoters. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 14-20 | NP | denotes | Ikaros |
| C1 | 14-31 | NP | denotes | Ikaros and Aiolos |
| C3 | 101-159 | NP | denotes | the lymphoid lineage-determining factors Ikaros and Aiolos |
| C4 | 340-355 | NP | denotes | Ikaros proteins |
| C5 | 518-521 | NP | denotes | its |
| C6 | 580-613 | NP | denotes | the mSin3 family of co-repressors |
| C7 | 614-619 | NP | denotes | which |
| C8 | 713-719 | NP | denotes | Ikaros |
| R1 | C3 | C1 | coref-ident | the lymphoid lineage-determining factors Ikaros and Aiolos,Ikaros and Aiolos |
| R2 | C4 | C2 | coref-ident | Ikaros proteins,Ikaros |
| R3 | C5 | C4 | coref-pron | its,Ikaros proteins |
| R4 | C7 | C6 | coref-relat | which,the mSin3 family of co-repressors |
| R5 | C8 | C4 | coref-ident | Ikaros,Ikaros proteins |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-20 | protein_molecule | denotes | Ikaros |
| T2 | 25-31 | protein_molecule | denotes | Aiolos |
| T3 | 52-81 | protein_complex | denotes | histone deacetylase complexes |
| T4 | 105-141 | protein_family_or_group | denotes | lymphoid lineage-determining factors |
| T5 | 142-148 | protein_molecule | denotes | Ikaros |
| T6 | 153-159 | protein_molecule | denotes | Aiolos |
| T7 | 176-209 | protein_family_or_group | denotes | strong transcriptional repressors |
| T8 | 249-267 | protein_family_or_group | denotes | repression domains |
| T9 | 294-310 | other_name | denotes | promoter context |
| T10 | 315-324 | other_name | denotes | cell type |
| T11 | 340-346 | protein_molecule | denotes | Ikaros |
| T12 | 392-405 | protein_family_or_group | denotes | core histones |
| T13 | 409-423 | DNA_domain_or_region | denotes | promoter sites |
| T14 | 443-462 | protein_molecule | denotes | histone deacetylase |
| T15 | 507-513 | protein_molecule | denotes | Ikaros |
| T16 | 522-540 | protein_domain_or_region | denotes | repression domains |
| T17 | 584-596 | protein_family_or_group | denotes | mSin3 family |
| T18 | 628-648 | protein_family_or_group | denotes | histone deacetylases |
| T19 | 713-719 | protein_molecule | denotes | Ikaros |
| T20 | 724-733 | protein_molecule | denotes | Mi-2-HDAC |
| T21 | 751-757 | protein_molecule | denotes | Ikaros |
| T22 | 782-797 | other_name | denotes | gene expression |
| T23 | 805-827 | other_name | denotes | lymphocyte development |
| T24 | 851-870 | protein_molecule | denotes | histone deacetylase |
| T25 | 884-902 | DNA_domain_or_region | denotes | specific promoters |