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PubMed:10356629 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-24 protein denotes Glucocorticoid receptors
T2 642-664 cell_type denotes mononuclear leukocytes
T3 835-859 protein denotes glucocorticoid receptors
T4 863-885 cell_type denotes mononuclear leukocytes
T5 887-890 cell_type denotes MNL
T6 1098-1121 protein denotes glucocorticoid receptor
T7 1460-1463 cell_type denotes MNL
T8 1841-1844 cell_type denotes MNL

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-24 protein_family_or_group denotes Glucocorticoid receptors
T2 94-110 other_name denotes anorexia nervosa
T3 167-175 lipid denotes cortisol
T4 201-209 lipid denotes cortisol
T5 254-274 other_organic_compound denotes metabolic substrates
T6 310-325 lipid denotes glucocorticoids
T7 396-404 multi_cell denotes patients
T8 429-445 other_name denotes anorexia nervosa
T9 450-458 multi_cell denotes patients
T10 464-488 other_name denotes active Cushing's disease
T11 497-515 multi_cell denotes healthy volunteers
T12 642-664 cell_type denotes mononuclear leukocytes
T13 678-695 lipid denotes [3H]dexamethasone
T14 722-735 lipid denotes dexamethasone
T15 739-752 nucleotide denotes [3H]thymidine
T16 835-859 protein_family_or_group denotes glucocorticoid receptors
T17 863-885 cell_type denotes mononuclear leukocytes
T18 887-890 cell_type denotes MNL
T19 910-918 multi_cell denotes patients
T20 924-940 other_name denotes anorexia nervosa
T21 942-950 multi_cell denotes patients
T22 956-980 other_name denotes active Cushing's disease
T23 1098-1121 protein_family_or_group denotes glucocorticoid receptor
T24 1162-1178 other_name denotes anorexia nervosa
T25 1193-1202 multi_cell denotes Cushing's
T26 1203-1211 multi_cell denotes patients
T27 1224-1240 multi_cell denotes control subjects
T28 1373-1394 lipid denotes urinary free cortisol
T29 1413-1421 multi_cell denotes patients
T30 1429-1442 nucleotide denotes [3H]thymidine
T31 1460-1463 cell_type denotes MNL
T32 1493-1509 other_name denotes anorexia nervosa
T33 1524-1533 multi_cell denotes Cushing's
T34 1534-1542 multi_cell denotes patients
T35 1555-1571 multi_cell denotes control subjects
T36 1605-1618 lipid denotes dexamethasone
T37 1643-1659 multi_cell denotes control subjects
T38 1663-1671 multi_cell denotes patients
T39 1677-1693 other_name denotes anorexia nervosa
T40 1743-1760 other_name denotes Cushing's disease
T41 1765-1773 multi_cell denotes patients
T42 1779-1795 other_name denotes anorexia nervosa
T43 1818-1831 nucleotide denotes [3H]thymidine
T44 1841-1844 cell_type denotes MNL
T45 1875-1896 lipid denotes urinary free cortisol
T46 1955-1974 other_name denotes cushingoid features
T47 1978-1986 multi_cell denotes patients
T48 1992-2008 other_name denotes anorexia nervosa
T49 2055-2070 lipid denotes glucocorticoids
T50 2112-2132 other_organic_compound denotes metabolic substrates

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-67 Sentence denotes Glucocorticoid receptors in anorexia nervosa and Cushing's disease.
S2 68-190 Sentence denotes BACKGROUND: Patients with anorexia nervosa do not display cushingoid features in spite of elevated cortisol plasma levels.
S3 191-375 Sentence denotes Whether a cortisol resistance or a reduced availability of the metabolic substrates necessary to develop the effect of glucocorticoids is responsible for this has not been established.
S4 376-584 Sentence denotes METHODS: Twenty-two patients with severe restrictive anorexia nervosa, 10 patients with active Cushing's disease, and 24 healthy volunteers without psychiatric disorders or mood alterations were investigated.
S5 585-811 Sentence denotes Glucocorticoid receptor characteristics were examined on mononuclear leukocytes by measuring [3H]dexamethasone binding and the effect of dexamethasone on [3H]thymidine incorporation, which represents an index of DNA synthesis.
S6 812-1085 Sentence denotes RESULTS: The number of glucocorticoid receptors on mononuclear leukocytes (MNL) was comparable in patients with anorexia nervosa, patients with active Cushing's disease, and normal subjects (binding capacity 3.3 +/- 0.23 vs. 3.7 +/- 0.30 and 3.5 +/- 0.20 fmol/10(6) cells).
S7 1086-1422 Sentence denotes Conversely, glucocorticoid receptor affinity was significantly decreased in anorexia nervosa as well as in Cushing's patients compared to control subjects (dissociation constant 4.0 +/- 0.31 and 4.1 +/- 0.34 vs. 2.9 +/- 0.29 nmol/L, p < .001) and inversely correlated with the levels of urinary free cortisol in both groups of patients.
S8 1423-1761 Sentence denotes Basal [3H]thymidine incorporation in MNL was significantly reduced in anorexia nervosa as well as in Cushing's patients compared to control subjects (p < .001) and was diminished by dexamethasone to an extent similar to control subjects in patients with anorexia nervosa, but significantly (p < .001) less in those with Cushing's disease.
S9 1762-1904 Sentence denotes In patients with anorexia nervosa, the incorporation of [3H]thymidine into the MNL was inversely correlated with urinary free cortisol levels.
S10 1905-2133 Sentence denotes CONCLUSIONS: These data indicate that the lack of cushingoid features in patients with anorexia nervosa is not ascribable to a reduced sensitivity to glucocorticoids but is more likely due to the paucity of metabolic substrates.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 28-44 NP denotes anorexia nervosa
C2 49-66 NP denotes Cushing's disease
C4 94-110 NP denotes anorexia nervosa
C3 80-110 NP denotes Patients with anorexia nervosa
C5 126-145 NP denotes cushingoid features
C6 250-274 NP denotes the metabolic substrates
C7 310-325 NP denotes glucocorticoids
C8 642-664 NP denotes mononuclear leukocytes
C10 722-735 NP denotes dexamethasone
C9 708-766 NP denotes the effect of dexamethasone on [3H]thymidine incorporation
C11 768-773 NP denotes which
C12 863-891 NP denotes mononuclear leukocytes (MNL)
C14 924-940 NP denotes anorexia nervosa
C13 910-940 NP denotes patients with anorexia nervosa
C15 942-980 NP denotes patients with active Cushing's disease
C16 986-1001 NP denotes normal subjects
C17 1224-1240 NP denotes control subjects
C18 1460-1463 NP denotes MNL
C19 1555-1571 NP denotes control subjects
C20 1605-1618 NP denotes dexamethasone
C21 1643-1659 NP denotes control subjects
C23 1663-1671 NP denotes patients
C24 1677-1693 NP denotes anorexia nervosa
C22 1663-1693 NP denotes patients with anorexia nervosa
C26 1732-1737 NP denotes those
C27 1743-1760 NP denotes Cushing's disease
C25 1732-1760 NP denotes those with Cushing's disease
C29 1779-1795 NP denotes anorexia nervosa
C28 1765-1795 NP denotes patients with anorexia nervosa
C30 1837-1844 NP denotes the MNL
C31 1955-1974 NP denotes cushingoid features
C33 1992-2008 NP denotes anorexia nervosa
C32 1978-2008 NP denotes patients with anorexia nervosa
C34 2055-2070 NP denotes glucocorticoids
C35 2112-2132 NP denotes metabolic substrates
R1 C4 C1 coref-ident anorexia nervosa,anorexia nervosa
R2 C11 C9 coref-relat which,the effect of dexamethasone on [3H]thymidine incorporation
R3 C12 C8 coref-ident mononuclear leukocytes (MNL),mononuclear leukocytes
R4 C14 C4 coref-ident anorexia nervosa,anorexia nervosa
R5 C13 C3 coref-ident patients with anorexia nervosa,Patients with anorexia nervosa
R6 C17 C16 coref-ident control subjects,normal subjects
R7 C18 C12 coref-ident MNL,mononuclear leukocytes (MNL)
R8 C19 C17 coref-ident control subjects,control subjects
R9 C20 C10 coref-ident dexamethasone,dexamethasone
R10 C21 C19 coref-ident control subjects,control subjects
R11 C24 C14 coref-ident anorexia nervosa,anorexia nervosa
R12 C22 C13 coref-ident patients with anorexia nervosa,patients with anorexia nervosa
R13 C26 C23 coref-pron those,patients
R14 C27 C2 coref-ident Cushing's disease,Cushing's disease
R15 C25 C15 coref-ident those with Cushing's disease,patients with active Cushing's disease
R16 C29 C24 coref-ident anorexia nervosa,anorexia nervosa
R17 C28 C22 coref-ident patients with anorexia nervosa,patients with anorexia nervosa
R18 C30 C18 coref-ident the MNL,MNL
R19 C31 C5 coref-ident cushingoid features,cushingoid features
R20 C33 C29 coref-ident anorexia nervosa,anorexia nervosa
R21 C32 C28 coref-ident patients with anorexia nervosa,patients with anorexia nervosa
R22 C34 C7 coref-ident glucocorticoids,glucocorticoids
R23 C35 C6 coref-ident metabolic substrates,the metabolic substrates

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 94-102 HP_0002039 denotes anorexia