PubMed:10352258 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	22-32	protein	denotes	NF-kappa B
T2	36-51	cell_type	denotes	T-lineage cells
T3	107-115	protein	denotes	cytokine
T4	253-263	protein	denotes	NF-kappa B
T5	355-359	protein	denotes	RelA
T6	364-379	protein	denotes	c-Rel complexes
T7	414-429	cell_type	denotes	T-lineage cells
T8	481-496	protein	denotes	I kappa B alpha
T9	596-603	cell_type	denotes	T cells
T10	672-693	cell_type	denotes	splenic T lymphocytes
T11	707-711	protein	denotes	IL-2
T12	716-727	protein	denotes	IL-2R alpha
T13	894-898	protein	denotes	IL-4
T14	900-905	protein	denotes	IL-10
T15	911-920	protein	denotes	IFN-gamma
T16	951-969	cell_type	denotes	transgenic T cells
T17	1007-1025	cell_type	denotes	transgenic T cells
T18	1113-1143	protein	denotes	NF-kappa B/Rel family proteins
T19	1183-1202	protein	denotes	regulating proteins
T20	1219-1223	protein	denotes	IL-2

Id	Subject	Object	Predicate	Lexical cue
S1	0-226	Sentence	denotes	In vivo inhibition of NF-kappa B in T-lineage cells leads to a dramatic decrease in cell proliferation and cytokine production and to increased cell apoptosis in response to mitogenic stimuli, but not to abnormal thymopoiesis.
S2	227-497	Sentence	denotes	To understand the role of NF-kappa B complexes in T cell development and activation, we have generated transgenic mice in which RelA and c-Rel complexes were selectively inhibited in the T-lineage cells by specific expression of a trans-dominant form of I kappa B alpha.
S3	498-694	Sentence	denotes	Transgene expression did not affect the thymic development, but led to lowered numbers of splenic T cells and to a dramatic decrease in the ex vivo proliferative response of splenic T lymphocytes.
S4	695-866	Sentence	denotes	Analysis of IL-2 and IL-2R alpha expression demonstrated that the perturbation of the proliferation response was not attributable to an abnormal expression of these genes.
S5	867-970	Sentence	denotes	In contrast, expression of IL-4, IL-10, and IFN-gamma was strongly inhibited in the transgenic T cells.
S6	971-1069	Sentence	denotes	The proliferative deficiency of the transgenic T cells was associated with an increased apoptosis.
S7	1070-1297	Sentence	denotes	These results point out the involvement of NF-kappa B/Rel family proteins in growth signaling pathways by either regulating proteins involved in the IL-2 signaling or by functionally interfering with the cell cycle progression.

Id	Subject	Object	Predicate	Lexical cue
C1	36-51	NP	denotes	T-lineage cells
C2	134-158	NP	denotes	increased cell apoptosis
C3	330-345	NP	denotes	transgenic mice
C4	349-354	NP	denotes	which
C5	410-429	NP	denotes	the T-lineage cells
C6	947-969	NP	denotes	the transgenic T cells
C7	1003-1025	NP	denotes	the transgenic T cells
C8	1046-1068	NP	denotes	an increased apoptosis
R1	C4	C3	coref-relat	which,transgenic mice
R2	C5	C1	coref-ident	the T-lineage cells,T-lineage cells
R3	C7	C6	coref-ident	the transgenic T cells,the transgenic T cells
R4	C8	C2	coref-ident	an increased apoptosis,increased cell apoptosis

Id	Subject	Object	Predicate	Lexical cue
T1	22-32	protein_complex	denotes	NF-kappa B
T2	36-51	cell_type	denotes	T-lineage cells
T3	84-102	other_name	denotes	cell proliferation
T4	107-115	protein_family_or_group	denotes	cytokine
T5	149-158	other_name	denotes	apoptosis
T6	174-191	other_name	denotes	mitogenic stimuli
T7	204-225	other_name	denotes	abnormal thymopoiesis
T8	253-263	protein_complex	denotes	NF-kappa B
T9	330-345	other_artificial_source	denotes	transgenic mice
T10	355-359	protein_molecule	denotes	RelA
T11	364-379	protein_complex	denotes	c-Rel complexes
T12	414-429	cell_type	denotes	T-lineage cells
T13	481-496	protein_molecule	denotes	I kappa B alpha
T14	498-518	other_name	denotes	Transgene expression
T15	538-556	other_name	denotes	thymic development
T16	596-603	cell_type	denotes	T cells
T17	638-668	other_name	denotes	ex vivo proliferative response
T18	672-679	cell_type	denotes	splenic
T19	680-693	cell_type	denotes	T lymphocytes
T20	707-711	protein_molecule	denotes	IL-2
T21	716-727	protein_molecule	denotes	IL-2R alpha
T22	781-803	other_name	denotes	proliferation response
T23	894-898	protein_molecule	denotes	IL-4
T24	900-905	protein_molecule	denotes	IL-10
T25	911-920	protein_molecule	denotes	IFN-gamma
T26	951-961	cell_type	denotes	transgenic
T27	962-969	cell_type	denotes	T cells
T28	1007-1025	cell_type	denotes	transgenic T cells
T29	1059-1068	other_name	denotes	apoptosis
T30	1113-1123	protein_complex	denotes	NF-kappa B
T31	1147-1172	other_name	denotes	growth signaling pathways
T32	1183-1202	protein_family_or_group	denotes	regulating proteins
T33	1219-1223	protein_molecule	denotes	IL-2
T34	1274-1296	other_name	denotes	cell cycle progression