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PubMed:10352247 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 48-58 cell_line denotes CTL clones
T2 117-120 protein denotes CD8
T3 175-178 protein denotes TCR
T4 243-246 protein denotes TCR
T5 301-315 cell_type denotes memory T cells
T6 641-659 cell_line denotes CD8+ T cell clones
T7 753-779 protein denotes single MHC/peptide complex
T8 806-816 protein denotes TCR chains
T9 1017-1020 protein denotes MHC
T10 1101-1104 protein denotes TCR
T11 1159-1162 protein denotes CD8
T12 1183-1195 protein denotes anti-CD8 mAb
T13 1222-1225 protein denotes TCR
T14 1392-1407 protein denotes TCR-CD8 complex
T15 1474-1477 protein denotes CD8
T16 1536-1539 protein denotes TCR

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-190 Sentence denotes Selection and long-term persistence of reactive CTL clones during an EBV chronic response are determined by avidity, CD8 variable contribution compensating for differences in TCR affinities.
S2 191-408 Sentence denotes Recent studies have suggested that the diversity of TCR repertoire after primary immunization is conserved in memory T cells and that a progressive narrowing of this repertoire may take place during recall infections.
S3 409-582 Sentence denotes It now remains to be investigated which parameters determine the repertoire of the memory response and possibly restrict its diversity after subsequent antigenic challenges.
S4 583-780 Sentence denotes To address this question, we took advantage of a panel of CD8+ T cell clones from the joint of a rheumatoid arthritis patient and selected for their reactivity against a single MHC/peptide complex.
S5 781-918 Sentence denotes Characterization of both TCR chains documented a great diversity among those clones and the persistence of clonotypes over a 2-yr period.
S6 919-1100 Sentence denotes Strikingly, despite the observed repertoire heterogeneity, all clones displayed a narrow range of MHC/peptide density requirements in cytotoxicity assays (ED50 between 9 and 36 nM).
S7 1101-1196 Sentence denotes TCR affinities were then indirectly estimated by blocking CD8 interaction with an anti-CD8 mAb.
S8 1197-1301 Sentence denotes We found a wide range of TCR affinities among the different clonotypes that segregated with Vbeta usage.
S9 1302-1578 Sentence denotes We thus propose that during an in vivo chronic response, a narrow range of avidity of the TCR-CD8 complex conditions long-term clonotype persistence, and that the level of CD8 contribution is adjusted to keep clonotypes with variable TCR affinities within this avidity window.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 175-189 NP denotes TCR affinities
C2 243-257 NP denotes TCR repertoire
C3 352-367 NP denotes this repertoire
C4 470-507 NP denotes the repertoire of the memory response
C5 530-533 NP denotes its
C6 630-708 NP denotes a panel of CD8+ T cell clones from the joint of a rheumatoid arthritis patient
C7 726-731 NP denotes their
C8 852-864 NP denotes those clones
C9 978-988 NP denotes all clones
C10 1101-1115 NP denotes TCR affinities
C11 1222-1236 NP denotes TCR affinities
C12 1243-1267 NP denotes the different clonotypes
C13 1268-1272 NP denotes that
R1 C3 C2 coref-ident this repertoire,TCR repertoire
R2 C5 C4 coref-pron its,the repertoire of the memory response
R3 C7 C6 coref-pron their,a panel of CD8+ T cell clones from the joint of a rheumatoid arthritis patient
R4 C8 C6 coref-ident those clones,a panel of CD8+ T cell clones from the joint of a rheumatoid arthritis patient
R5 C9 C8 coref-ident all clones,those clones
R6 C10 C1 coref-ident TCR affinities,TCR affinities
R7 C11 C10 coref-ident TCR affinities,TCR affinities
R8 C13 C12 coref-relat that,the different clonotypes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 48-58 cell_line denotes CTL clones
T2 69-89 other_name denotes EBV chronic response
T3 117-120 protein_molecule denotes CD8
T4 175-178 protein_family_or_group denotes TCR
T5 243-246 protein_family_or_group denotes TCR
T6 264-284 other_name denotes primary immunization
T7 301-315 cell_type denotes memory T cells
T8 390-407 other_name denotes recall infections
T9 561-581 other_name denotes antigenic challenges
T10 641-659 cell_line denotes CD8+ T cell clones
T11 680-708 multi_cell denotes rheumatoid arthritis patient
T12 753-779 protein_complex denotes single MHC/peptide complex
T13 806-809 protein_family_or_group denotes TCR
T14 888-898 other_name denotes clonotypes
T15 1017-1020 protein_complex denotes MHC
T16 1053-1072 other_name denotes cytotoxicity assays
T17 1074-1078 other_name denotes ED50
T18 1101-1104 protein_family_or_group denotes TCR
T19 1159-1162 protein_molecule denotes CD8
T20 1183-1195 protein_family_or_group denotes anti-CD8 mAb
T21 1222-1225 protein_family_or_group denotes TCR
T22 1392-1395 protein_family_or_group denotes TCR
T23 1474-1477 protein_molecule denotes CD8
T24 1536-1539 protein_family_or_group denotes TCR
T25 1563-1577 other_name denotes avidity window

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 680-700 HP_0001370 denotes rheumatoid arthritis
T2 691-700 HP_0001369 denotes arthritis