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PubMed:10349513 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 156-184 DNA denotes human beta-globin gene locus
T2 236-251 cell_type denotes erythroid cells
T3 318-346 DNA denotes DNase 1 hypersensitive sites
T4 365-393 DNA denotes active globin gene promoters
T5 428-455 DNA denotes globin locus control region
T6 504-526 DNA denotes beta-like globin genes
T7 632-660 DNA denotes minimal beta-globin promoter
T8 681-743 DNA denotes erythroid-specific DNase 1 hypersensitive site-forming element
T9 745-749 DNA denotes HSFE
T10 779-808 DNA denotes beta-globin promoter and gene
T11 850-855 protein denotes NF-E2
T12 857-861 protein denotes AP-1
T13 863-869 protein denotes GATA-1
T14 874-878 protein denotes Sp-1
T15 920-948 cell_type denotes murine erythroleukemia cells
T16 1021-1025 DNA denotes HSFE
T17 1054-1061 protein denotes DNase 1
T18 1142-1161 DNA denotes artificial promoter
T19 1208-1229 DNA denotes beta-globin promoters
T20 1346-1362 DNA denotes beta-globin gene
T21 1416-1432 DNA denotes beta-globin gene
T22 1491-1509 DNA denotes cis-acting element
T23 1595-1611 DNA denotes beta-globin gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-124 Sentence denotes Targeted remodeling of human beta-globin promoter chromatin structure produces increased expression and decreased silencing.
S2 125-252 Sentence denotes The chromatin structure of the human beta-globin gene locus assumes a transcriptionally-active conformation in erythroid cells.
S3 253-394 Sentence denotes One feature of this chromatin reorganization is the formation of DNase 1 hypersensitive sites in the regions of active globin gene promoters.
S4 395-527 Sentence denotes This reorganization requires the globin locus control region and is associated with normal expression of the beta-like globin genes.
S5 528-809 Sentence denotes To determine whether it is possible to artificially enhance the opening of the chromatin structure of a minimal beta-globin promoter, we placed a 101bp, erythroid-specific DNase 1 hypersensitive site-forming element (HSFE) immediately upstream of the beta-globin promoter and gene.
S6 810-879 Sentence denotes This element includes binding sites for NF-E2, AP-1, GATA-1 and Sp-1.
S7 880-1016 Sentence denotes Constructs were stably transfected into murine erythroleukemia cells and promoter chromatin structure and gene expression were analyzed.
S8 1017-1265 Sentence denotes The HSFE induced an area of enhanced DNase 1 hypersensitivity extending from the transcriptional start site to -300bp of the artificial promoter and significantly increased the proportion of beta-globin promoters in an open chromatin configuration.
S9 1266-1443 Sentence denotes This remodeling of promoter chromatin structure resulted in 3-fold increases in beta-globin gene transcription and induction, and inhibited long-term beta-globin gene silencing.
S10 1444-1623 Sentence denotes These results indicate that a relatively small cis-acting element is able to enhance remodeling of promoter chromatin structure resulting in increased beta-globin gene expression.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 23-69 NP denotes human beta-globin promoter chromatin structure
C2 268-297 NP denotes this chromatin reorganization
C3 395-414 NP denotes This reorganization
C4 672-750 NP denotes a 101bp, erythroid-specific DNase 1 hypersensitive site-forming element (HSFE)
C5 810-822 NP denotes This element
C6 953-981 NP denotes promoter chromatin structure
C7 1017-1025 NP denotes The HSFE
C8 1285-1313 NP denotes promoter chromatin structure
C9 1543-1571 NP denotes promoter chromatin structure
R1 C3 C2 coref-ident This reorganization,this chromatin reorganization
R2 C5 C4 coref-ident This element,"a 101bp, erythroid-specific DNase 1 hypersensitive site-forming element (HSFE)"
R3 C6 C1 coref-ident promoter chromatin structure,human beta-globin promoter chromatin structure
R4 C7 C5 coref-ident The HSFE,This element
R5 C8 C6 coref-ident promoter chromatin structure,promoter chromatin structure
R6 C9 C8 coref-ident promoter chromatin structure,promoter chromatin structure

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-19 other_name denotes Targeted remodeling
T2 156-184 DNA_domain_or_region denotes human beta-globin gene locus
T3 195-232 other_name denotes transcriptionally-active conformation
T4 236-251 cell_type denotes erythroid cells
T5 318-346 DNA_domain_or_region denotes DNase 1 hypersensitive sites
T6 365-393 DNA_family_or_group denotes active globin gene promoters
T7 428-455 DNA_domain_or_region denotes globin locus control region
T8 504-526 DNA_family_or_group denotes beta-like globin genes
T9 632-660 DNA_family_or_group denotes minimal beta-globin promoter
T10 681-743 DNA_domain_or_region denotes erythroid-specific DNase 1 hypersensitive site-forming element
T11 745-749 DNA_domain_or_region denotes HSFE
T12 850-855 protein_molecule denotes NF-E2
T13 857-861 protein_molecule denotes AP-1
T14 863-869 protein_molecule denotes GATA-1
T15 874-878 protein_molecule denotes Sp-1
T16 920-948 cell_type denotes murine erythroleukemia cells
T17 953-981 DNA_substructure denotes promoter chromatin structure
T18 1021-1025 DNA_domain_or_region denotes HSFE
T19 1045-1053 other_name denotes enhanced
T20 1054-1061 protein_molecule denotes DNase 1
T21 1142-1161 DNA_molecule denotes artificial promoter
T22 1208-1229 DNA_domain_or_region denotes beta-globin promoters
T23 1236-1264 DNA_substructure denotes open chromatin configuration
T24 1285-1313 DNA_substructure denotes promoter chromatin structure
T25 1346-1362 DNA_domain_or_region denotes beta-globin gene
T26 1406-1415 other_name denotes long-term
T27 1416-1432 DNA_domain_or_region denotes beta-globin gene
T28 1491-1509 DNA_domain_or_region denotes cis-acting element
T29 1543-1571 DNA_substructure denotes promoter chromatin structure
T30 1595-1611 DNA_family_or_group denotes beta-globin gene