PubMed:10339482
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-16 | protein | denotes | Protein kinase B |
| T2 | 18-23 | protein | denotes | c-Akt |
| T3 | 26-55 | protein | denotes | phosphatidylinositol 3-kinase |
| T4 | 61-66 | protein | denotes | STAT5 |
| T5 | 84-98 | protein | denotes | erythropoietin |
| T6 | 100-103 | protein | denotes | EPO |
| T7 | 108-129 | cell_line | denotes | HCD57 erythroid cells |
| T8 | 166-211 | cell_line | denotes | EPO-independent, apoptosis-resistant subclone |
| T9 | 213-229 | cell_line | denotes | HCD57-SREI cells |
| T10 | 246-260 | protein | denotes | erythropoietin |
| T11 | 262-265 | protein | denotes | EPO |
| T12 | 271-287 | protein | denotes | stem cell factor |
| T13 | 289-292 | protein | denotes | SCF |
| T14 | 294-320 | protein | denotes | activated protein kinase B |
| T15 | 322-329 | protein | denotes | PKB/Akt |
| T16 | 334-369 | cell_line | denotes | EPO-dependent HCD57 erythroid cells |
| T17 | 497-500 | protein | denotes | EPO |
| T18 | 535-551 | cell_line | denotes | HCD57-SREI cells |
| T19 | 582-589 | protein | denotes | PKB/Akt |
| T20 | 591-597 | protein | denotes | STAT5a |
| T21 | 603-609 | protein | denotes | STAT5b |
| T22 | 630-651 | cell_line | denotes | EPO-independent cells |
| T23 | 653-663 | protein | denotes | PI3-kinase |
| T24 | 702-709 | protein | denotes | PKB/Akt |
| T25 | 722-732 | protein | denotes | PI3-kinase |
| T26 | 778-785 | protein | denotes | PKB/Akt |
| T27 | 807-814 | protein | denotes | PKB/Akt |
| T28 | 892-902 | cell_line | denotes | HCD57-SREI |
| T29 | 907-918 | cell_line | denotes | HCD57 cells |
| T30 | 951-958 | protein | denotes | PKB/Akt |
| T31 | 969-976 | protein | denotes | PKB/Akt |
| T32 | 1049-1060 | cell_line | denotes | HCD57 cells |
| T33 | 1066-1069 | protein | denotes | SCF |
| T34 | 1085-1092 | protein | denotes | PKB/Akt |
| T35 | 1157-1171 | protein | denotes | PKB/PI3-kinase |
| T36 | 1269-1274 | protein | denotes | STAT5 |
| T37 | 1336-1340 | protein | denotes | JAK2 |
| T38 | 1344-1348 | protein | denotes | EPOR |
| T39 | 1391-1401 | protein | denotes | PI3-kinase |
| T40 | 1401-1409 | protein | denotes | /PKB/Akt |
| T41 | 1433-1465 | cell_line | denotes | EPO-independent HCD57-SREI cells |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-231 | Sentence | denotes | Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). |
| S2 | 232-370 | Sentence | denotes | We found that erythropoietin (EPO) and stem cell factor (SCF) activated protein kinase B (PKB/Akt) in EPO-dependent HCD57 erythroid cells. |
| S3 | 371-553 | Sentence | denotes | To better understand signals controlling proliferation and viability, erythroid cells that resist apoptosis in the absence of EPO were subcloned and characterized (HCD57-SREI cells). |
| S4 | 554-652 | Sentence | denotes | Constitutive activations of PKB/Akt, STAT5a, and STAT5b were noted in these EPO-independent cells. |
| S5 | 653-824 | Sentence | denotes | PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. |
| S6 | 825-1035 | Sentence | denotes | The LY294002 study showed that proliferation and viability of both HCD57-SREI and HCD57 cells correlated with the activity of PKB/Akt; however, PKB/Akt activity alone did not protect these cells from apoptosis. |
| S7 | 1036-1129 | Sentence | denotes | Treatment of HCD57 cells with SCF also activated PKB/Akt, but did not protect from apoptosis. |
| S8 | 1130-1255 | Sentence | denotes | This result suggested that PKB/PI3-kinase activity is necessary but not sufficient to promote viability and/or proliferation. |
| S9 | 1256-1515 | Sentence | denotes | Constitutive STAT5 activity, activated through an unknown pathway not including JAK2 or EPOR, may act in concert with the constitutive PI3-kinase/PKB/Akt pathway to protect the EPO-independent HCD57-SREI cells from apoptosis and promote limited proliferation. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-24 | NP | denotes | Protein kinase B (c-Akt) |
| C2 | 108-129 | NP | denotes | HCD57 erythroid cells |
| C3 | 163-230 | NP | denotes | an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells) |
| C4 | 246-266 | NP | denotes | erythropoietin (EPO) |
| C5 | 271-293 | NP | denotes | stem cell factor (SCF) |
| C6 | 412-425 | NP | denotes | proliferation |
| C7 | 430-439 | NP | denotes | viability |
| C8 | 441-456 | NP | denotes | erythroid cells |
| C9 | 457-461 | NP | denotes | that |
| C10 | 469-478 | NP | denotes | apoptosis |
| C11 | 497-500 | NP | denotes | EPO |
| C12 | 582-589 | NP | denotes | PKB/Akt |
| C13 | 624-651 | NP | denotes | these EPO-independent cells |
| C14 | 702-709 | NP | denotes | PKB/Akt |
| C15 | 887-918 | NP | denotes | both HCD57-SREI and HCD57 cells |
| C17 | 951-959 | NP | denotes | PKB/Akt; |
| C16 | 935-959 | NP | denotes | the activity of PKB/Akt; |
| C18 | 969-991 | NP | denotes | PKB/Akt activity alone |
| C19 | 1008-1019 | NP | denotes | these cells |
| C20 | 1025-1034 | NP | denotes | apoptosis |
| C21 | 1049-1060 | NP | denotes | HCD57 cells |
| C22 | 1066-1069 | NP | denotes | SCF |
| C23 | 1085-1092 | NP | denotes | PKB/Akt |
| C24 | 1119-1128 | NP | denotes | apoptosis |
| C25 | 1224-1233 | NP | denotes | viability |
| C26 | 1241-1254 | NP | denotes | proliferation |
| C27 | 1429-1465 | NP | denotes | the EPO-independent HCD57-SREI cells |
| C28 | 1471-1480 | NP | denotes | apoptosis |
| R1 | C9 | C8 | coref-relat | that,erythroid cells |
| R2 | C11 | C4 | coref-ident | EPO,erythropoietin (EPO) |
| R3 | C12 | C1 | coref-ident | PKB/Akt,Protein kinase B (c-Akt) |
| R4 | C13 | C3 | coref-ident | these EPO-independent cells,"an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells)" |
| R5 | C14 | C12 | coref-ident | PKB/Akt,PKB/Akt |
| R6 | C17 | C14 | coref-ident | PKB/Akt;,PKB/Akt |
| R7 | C18 | C16 | coref-ident | PKB/Akt activity alone,the activity of PKB/Akt; |
| R8 | C19 | C15 | coref-ident | these cells,both HCD57-SREI and HCD57 cells |
| R9 | C20 | C10 | coref-ident | apoptosis,apoptosis |
| R10 | C21 | C2 | coref-ident | HCD57 cells,HCD57 erythroid cells |
| R11 | C22 | C5 | coref-ident | SCF,stem cell factor (SCF) |
| R12 | C23 | C17 | coref-ident | PKB/Akt,PKB/Akt; |
| R13 | C24 | C20 | coref-ident | apoptosis,apoptosis |
| R14 | C25 | C7 | coref-ident | viability,viability |
| R15 | C26 | C6 | coref-ident | proliferation,proliferation |
| R16 | C27 | C13 | coref-ident | the EPO-independent HCD57-SREI cells,these EPO-independent cells |
| R17 | C28 | C24 | coref-ident | apoptosis,apoptosis |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-16 | protein_molecule | denotes | Protein kinase B |
| T2 | 18-23 | protein_molecule | denotes | c-Akt |
| T3 | 26-55 | protein_molecule | denotes | phosphatidylinositol 3-kinase |
| T4 | 61-66 | protein_molecule | denotes | STAT5 |
| T5 | 84-98 | protein_family_or_group | denotes | erythropoietin |
| T6 | 100-103 | protein_family_or_group | denotes | EPO |
| T7 | 108-129 | cell_line | denotes | HCD57 erythroid cells |
| T8 | 166-169 | protein_family_or_group | denotes | EPO |
| T9 | 183-192 | other_name | denotes | apoptosis |
| T10 | 213-229 | cell_line | denotes | HCD57-SREI cells |
| T11 | 246-260 | protein_molecule | denotes | erythropoietin |
| T12 | 262-265 | protein_family_or_group | denotes | EPO |
| T13 | 271-287 | protein_molecule | denotes | stem cell factor |
| T14 | 289-292 | protein_molecule | denotes | SCF |
| T15 | 294-320 | protein_molecule | denotes | activated protein kinase B |
| T16 | 322-329 | protein_molecule | denotes | PKB/Akt |
| T17 | 334-337 | protein_family_or_group | denotes | EPO |
| T18 | 412-425 | other_name | denotes | proliferation |
| T19 | 469-478 | other_name | denotes | apoptosis |
| T20 | 497-500 | protein_family_or_group | denotes | EPO |
| T21 | 535-551 | cell_line | denotes | HCD57-SREI cells |
| T22 | 582-589 | protein_molecule | denotes | PKB/Akt |
| T23 | 591-597 | protein_molecule | denotes | STAT5a |
| T24 | 603-609 | protein_molecule | denotes | STAT5b |
| T25 | 630-633 | protein_family_or_group | denotes | EPO |
| T26 | 653-663 | protein_molecule | denotes | PI3-kinase |
| T27 | 702-709 | protein_molecule | denotes | PKB/Akt |
| T28 | 722-732 | protein_molecule | denotes | PI3-kinase |
| T29 | 743-751 | other_organic_compound | denotes | LY294002 |
| T30 | 765-777 | other_name | denotes | constitutive |
| T31 | 778-785 | protein_molecule | denotes | PKB/Akt |
| T32 | 790-806 | other_name | denotes | factor-dependent |
| T33 | 807-814 | protein_molecule | denotes | PKB/Akt |
| T34 | 829-843 | other_name | denotes | LY294002 study |
| T35 | 892-902 | cell_line | denotes | HCD57-SREI |
| T36 | 907-918 | cell_line | denotes | HCD57 cells |
| T37 | 951-958 | protein_molecule | denotes | PKB/Akt |
| T38 | 969-976 | protein_molecule | denotes | PKB/Akt |
| T39 | 1025-1034 | other_name | denotes | apoptosis |
| T40 | 1049-1060 | cell_line | denotes | HCD57 cells |
| T41 | 1066-1069 | protein_family_or_group | denotes | SCF |
| T42 | 1085-1092 | protein_molecule | denotes | PKB/Akt |
| T43 | 1119-1128 | other_name | denotes | apoptosis |
| T44 | 1157-1171 | protein_molecule | denotes | PKB/PI3-kinase |
| T45 | 1256-1268 | other_name | denotes | Constitutive |
| T46 | 1269-1274 | protein_molecule | denotes | STAT5 |
| T47 | 1336-1340 | protein_molecule | denotes | JAK2 |
| T48 | 1344-1348 | protein_family_or_group | denotes | EPOR |
| T49 | 1378-1390 | other_name | denotes | constitutive |
| T50 | 1391-1401 | protein_molecule | denotes | PI3-kinase |
| T51 | 1401-1409 | protein_molecule | denotes | /PKB/Akt |
| T52 | 1433-1436 | protein_family_or_group | denotes | EPO |
| T53 | 1449-1465 | cell_line | denotes | HCD57-SREI cells |
| T54 | 1471-1480 | other_name | denotes | apoptosis |
| T55 | 1501-1514 | other_name | denotes | proliferation |