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PubMed:10331989 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 50-84 cell_type denotes erythroid and megakaryocytic cells
T2 94-112 DNA denotes regulatory element
T3 129-140 DNA denotes GATA-1 gene
T4 146-185 protein denotes lineage-restricted transcription factor
T5 186-192 protein denotes GATA-1
T6 228-262 cell_type denotes erythroid and megakaryocytic cells
T7 298-327 DNA denotes cis-acting regulatory element
T8 329-333 DNA denotes HS I
T9 353-403 DNA denotes hematopoietic-specific DNase I hypersensitive site
T10 454-502 DNA denotes murine hematopoietic-specific GATA-1 IE promoter
T11 504-508 DNA denotes HS I
T12 551-568 DNA denotes GATA-1/lacZ genes
T13 572-612 cell_type denotes primitive and definitive erythroid cells
T14 617-631 cell_type denotes megakaryocytes
T15 685-689 DNA denotes HS I
T16 782-796 DNA denotes 169 base pairs
T17 834-843 DNA denotes GATA site
T18 879-890 DNA denotes E-box motif
T19 896-911 DNA denotes composite motif
T20 920-985 protein denotes multi-protein hematopoietic-specific transcription factor complex
T21 1001-1007 protein denotes GATA-1
T22 1009-1019 protein denotes SCL/tal-1,
T23 1020-1023 protein denotes E2A
T24 1025-1029 protein denotes Lmo2
T25 1034-1039 protein denotes Ldb-1
T26 1064-1073 DNA denotes GATA site
T27 1084-1088 DNA denotes HS I
T28 1123-1134 DNA denotes E-box motif
T29 1212-1216 DNA denotes HS I
T30 1231-1240 DNA denotes GATA site
T31 1297-1308 protein denotes GATA-factor
T32 1321-1327 protein denotes GATA-1
T33 1331-1337 protein denotes GATA-2
T34 1420-1440 DNA denotes 317 base pair region
T35 1472-1486 DNA denotes 317 base pairs
T36 1518-1532 cell_type denotes megakaryocytes
T37 1543-1559 DNA denotes 5' 62 base pairs
T38 1702-1714 DNA denotes HS I element

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-141 Sentence denotes Different sequence requirements for expression in erythroid and megakaryocytic cells within a regulatory element upstream of the GATA-1 gene.
S2 142-263 Sentence denotes The lineage-restricted transcription factor GATA-1 is required for differentiation of erythroid and megakaryocytic cells.
S3 264-503 Sentence denotes We have localized a 317 base pair cis-acting regulatory element, HS I, associated with a hematopoietic-specific DNase I hypersensitive site, which lies approx. 3.7 kilobases upstream of the murine hematopoietic-specific GATA-1 IE promoter.
S4 504-651 Sentence denotes HS I directs high-level expression of reporter GATA-1/lacZ genes to primitive and definitive erythroid cells and megakaryocytes in transgenic mice.
S5 652-812 Sentence denotes Comparative sequence analysis of HS I between human and mouse shows approx. 63% nucleotide identity with a more conserved core of 169 base pairs (86% identity).
S6 813-891 Sentence denotes This core contains a GATA site separated by 10 base pairs from an E-box motif.
S7 892-1040 Sentence denotes The composite motif binds a multi-protein hematopoietic-specific transcription factor complex which includes GATA-1, SCL/tal-1, E2A, Lmo2 and Ldb-1.
S8 1041-1190 Sentence denotes Point mutations of the GATA site abolishes HS I function, whereas mutation of the E-box motif still allows reporter gene expression in both lineages.
S9 1191-1393 Sentence denotes Strict dependence of HS I activity on a GATA site implies that assembly of a protein complex containing a GATA-factor, presumably GATA-1 or GATA-2, is critical to activating or maintaining its function.
S10 1394-1614 Sentence denotes Further dissection of the 317 base pair region demonstrates that, whereas all 317 base pairs are required for expression in megakaryocytes, only the 5' 62 base pairs are needed for erythroid-specific reporter expression.
S11 1615-1715 Sentence denotes These findings demonstrate differential lineage requirements for expression within the HS I element.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 50-84 NP denotes erythroid and megakaryocytic cells
C2 142-192 NP denotes The lineage-restricted transcription factor GATA-1
C3 228-262 NP denotes erythroid and megakaryocytic cells
C4 282-327 NP denotes a 317 base pair cis-acting regulatory element
C5 329-333 NP denotes HS I
C6 351-403 NP denotes a hematopoietic-specific DNase I hypersensitive site
C7 405-410 NP denotes which
C8 416-422 NP denotes approx
C9 504-508 NP denotes HS I
C10 685-689 NP denotes HS I
C11 720-726 NP denotes approx
C12 757-811 NP denotes a more conserved core of 169 base pairs (86% identity)
C13 813-822 NP denotes This core
C15 876-890 NP denotes an E-box motif
C14 832-890 NP denotes a GATA site separated by 10 base pairs from an E-box motif
C16 892-911 NP denotes The composite motif
C17 918-985 NP denotes a multi-protein hematopoietic-specific transcription factor complex
C18 986-991 NP denotes which
C19 1001-1007 NP denotes GATA-1
C20 1060-1073 NP denotes the GATA site
C21 1119-1134 NP denotes the E-box motif
C22 1295-1308 NP denotes a GATA-factor
C23 1321-1327 NP denotes GATA-1
C24 1380-1383 NP denotes its
C25 1698-1714 NP denotes the HS I element
R1 C3 C1 coref-ident erythroid and megakaryocytic cells,erythroid and megakaryocytic cells
R2 C5 C4 coref-appos HS I,a 317 base pair cis-acting regulatory element
R3 C7 C6 coref-relat which,a hematopoietic-specific DNase I hypersensitive site
R4 C9 C4 coref-ident HS I,a 317 base pair cis-acting regulatory element
R5 C10 C9 coref-ident HS I,HS I
R6 C11 C8 coref-ident approx,approx
R7 C13 C12 coref-ident This core,a more conserved core of 169 base pairs (86% identity)
R8 C16 C15 coref-ident The composite motif,an E-box motif
R9 C18 C17 coref-relat which,a multi-protein hematopoietic-specific transcription factor complex
R10 C19 C2 coref-ident GATA-1,The lineage-restricted transcription factor GATA-1
R11 C20 C14 coref-ident the GATA site,a GATA site separated by 10 base pairs from an E-box motif
R12 C21 C16 coref-ident the E-box motif,The composite motif
R13 C23 C19 coref-ident GATA-1,GATA-1
R14 C24 C22 coref-pron its,a GATA-factor
R15 C25 C10 coref-ident the HS I element,HS I

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 94-112 DNA_family_or_group denotes regulatory element
T2 129-140 DNA_domain_or_region denotes GATA-1 gene
T3 146-164 protein_family_or_group denotes lineage-restricted
T4 165-185 protein_family_or_group denotes transcription factor
T5 186-192 protein_molecule denotes GATA-1
T6 298-308 DNA_domain_or_region denotes cis-acting
T7 309-327 DNA_family_or_group denotes regulatory element
T8 329-333 DNA_domain_or_region denotes HS I
T9 353-375 DNA_domain_or_region denotes hematopoietic-specific
T10 376-383 protein_molecule denotes DNase I
T11 454-483 DNA_domain_or_region denotes murine hematopoietic-specific
T12 484-490 protein_molecule denotes GATA-1
T13 504-508 DNA_domain_or_region denotes HS I
T14 551-568 DNA_domain_or_region denotes GATA-1/lacZ genes
T15 617-631 cell_type denotes megakaryocytes
T16 635-650 other_artificial_source denotes transgenic mice
T17 685-689 DNA_domain_or_region denotes HS I
T18 732-751 other_name denotes nucleotide identity
T19 782-796 DNA_domain_or_region denotes 169 base pairs
T20 834-843 DNA_domain_or_region denotes GATA site
T21 879-890 DNA_domain_or_region denotes E-box motif
T22 896-911 DNA_domain_or_region denotes composite motif
T23 920-956 protein_complex denotes multi-protein hematopoietic-specific
T24 957-977 protein_family_or_group denotes transcription factor
T25 1001-1007 protein_molecule denotes GATA-1
T26 1009-1019 protein_molecule denotes SCL/tal-1,
T27 1020-1023 protein_molecule denotes E2A
T28 1025-1029 protein_molecule denotes Lmo2
T29 1034-1039 protein_molecule denotes Ldb-1
T30 1064-1073 DNA_domain_or_region denotes GATA site
T31 1084-1088 DNA_domain_or_region denotes HS I
T32 1123-1134 DNA_domain_or_region denotes E-box motif
T33 1157-1172 other_name denotes gene expression
T34 1212-1216 DNA_domain_or_region denotes HS I
T35 1231-1240 DNA_domain_or_region denotes GATA site
T36 1297-1308 protein_family_or_group denotes GATA-factor
T37 1321-1327 protein_molecule denotes GATA-1
T38 1331-1337 protein_molecule denotes GATA-2
T39 1420-1440 DNA_domain_or_region denotes 317 base pair region
T40 1472-1486 DNA_domain_or_region denotes 317 base pairs
T41 1518-1532 cell_type denotes megakaryocytes
T42 1543-1559 DNA_domain_or_region denotes 5' 62 base pairs
T43 1575-1613 other_name denotes erythroid-specific reporter expression
T44 1702-1706 DNA_domain_or_region denotes HS I