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PubMed:10330423 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 220-228 DiseaseOrPhenotypicFeature denotes fracture 0005315
T2 239-242 DiseaseOrPhenotypicFeature denotes can 0012833

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells.
TextSentencer_T2 117-287 Sentence denotes Declining estrogen levels during the first postmenopausal decade lead to rapid bone loss and increased fracture risk that can be reversed by estrogen replacement therapy.
TextSentencer_T3 288-465 Sentence denotes The bone-protective effects of estrogen may involve suppression of inflammatory cytokines that promote osteoclastogenesis and bone resorption, such as IL-1, TNF-alpha, and IL-6.
TextSentencer_T4 466-575 Sentence denotes We investigated whether estrogen modulates IL-1 actions on human osteoclasts (OCs) and other bone cell types.
TextSentencer_T5 576-763 Sentence denotes Isolated human OCs and primary bone marrow-derived OC-like cells expressed both the signaling (IL-1RI) and decoy (IL-1RII) IL-1 receptors, whereas only IL-1RI was detected in osteoblasts.
TextSentencer_T6 764-1067 Sentence denotes IL-1RII/IL-1RI mRNA ratios and release of soluble IL-1RII (sIL-1RII) were lower in OC-like cells derived from women in the late postmenopausal period compared with younger women, but were unrelated to male donor age, suggesting that estrogen might play a role in regulating IL-1 receptor levels in vivo.
TextSentencer_T7 1068-1193 Sentence denotes Estrogen directly reduced in vitro OC-like cell IL-1RI mRNA levels while increasing IL-1RII mRNA levels and sIL-1RII release.
TextSentencer_T8 1194-1339 Sentence denotes These estrogenic events were associated with inhibited IL-1-mediated cytokine (IL-8) mRNA induction and cell survival, i.e., increased apoptosis.
TextSentencer_T9 1340-1470 Sentence denotes In contrast, estrogen did not alter IL-1R levels or IL-1 responsiveness in primary human osteoblasts or bone marrow stromal cells.
TextSentencer_T10 1471-1701 Sentence denotes We conclude that one novel mechanism by which estrogen exerts bone-protective effects may include a selective modulation of IL-1R isoform levels in OC or OC-like cells, thereby reducing their IL-1 responsiveness and cell survival.
TextSentencer_T11 1702-1865 Sentence denotes Conversely, this restraint on IL-1 actions may be lost as estrogen levels decline in aging women, contributing to an enhanced OC-mediated postmenopausal bone loss.
T1 0-116 Sentence denotes Estrogen's bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells.
T2 117-287 Sentence denotes Declining estrogen levels during the first postmenopausal decade lead to rapid bone loss and increased fracture risk that can be reversed by estrogen replacement therapy.
T3 288-465 Sentence denotes The bone-protective effects of estrogen may involve suppression of inflammatory cytokines that promote osteoclastogenesis and bone resorption, such as IL-1, TNF-alpha, and IL-6.
T4 466-575 Sentence denotes We investigated whether estrogen modulates IL-1 actions on human osteoclasts (OCs) and other bone cell types.
T5 576-763 Sentence denotes Isolated human OCs and primary bone marrow-derived OC-like cells expressed both the signaling (IL-1RI) and decoy (IL-1RII) IL-1 receptors, whereas only IL-1RI was detected in osteoblasts.
T6 764-1067 Sentence denotes IL-1RII/IL-1RI mRNA ratios and release of soluble IL-1RII (sIL-1RII) were lower in OC-like cells derived from women in the late postmenopausal period compared with younger women, but were unrelated to male donor age, suggesting that estrogen might play a role in regulating IL-1 receptor levels in vivo.
T7 1068-1193 Sentence denotes Estrogen directly reduced in vitro OC-like cell IL-1RI mRNA levels while increasing IL-1RII mRNA levels and sIL-1RII release.
T8 1194-1339 Sentence denotes These estrogenic events were associated with inhibited IL-1-mediated cytokine (IL-8) mRNA induction and cell survival, i.e., increased apoptosis.
T9 1340-1470 Sentence denotes In contrast, estrogen did not alter IL-1R levels or IL-1 responsiveness in primary human osteoblasts or bone marrow stromal cells.
T10 1471-1701 Sentence denotes We conclude that one novel mechanism by which estrogen exerts bone-protective effects may include a selective modulation of IL-1R isoform levels in OC or OC-like cells, thereby reducing their IL-1 responsiveness and cell survival.
T11 1702-1865 Sentence denotes Conversely, this restraint on IL-1 actions may be lost as estrogen levels decline in aging women, contributing to an enhanced OC-mediated postmenopausal bone loss.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10330423-10#30#34#gene3552 1732-1736 gene3552 denotes IL-1
10330423-10#30#34#gene3553 1732-1736 gene3553 denotes IL-1
10330423-10#138#162#diseaseC0029458 1840-1864 diseaseC0029458 denotes postmenopausal bone loss
30#34#gene3552138#162#diseaseC0029458 10330423-10#30#34#gene3552 10330423-10#138#162#diseaseC0029458 associated_with IL-1,postmenopausal bone loss
30#34#gene3553138#162#diseaseC0029458 10330423-10#30#34#gene3553 10330423-10#138#162#diseaseC0029458 associated_with IL-1,postmenopausal bone loss

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 607-618 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T2 1444-1455 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2222 1732-1736 gene:3552 denotes IL-1
T2223 1840-1864 disease:C0029458 denotes postmenopausal bone loss
R1 T2222 T2223 associated_with IL-1,postmenopausal bone loss
R2 T2222 T2223 associated_with IL-1,postmenopausal bone loss

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 607-618 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T2 1444-1455 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1732-1736 gene:3553 denotes IL-1
T1 1840-1864 disease:C0029458 denotes postmenopausal bone loss
T2 1732-1736 gene:3552 denotes IL-1
T3 1840-1864 disease:C0029458 denotes postmenopausal bone loss
R1 T0 T1 associated_with IL-1,postmenopausal bone loss
R2 T2 T3 associated_with IL-1,postmenopausal bone loss

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 751-762 HP_0011846 denotes osteoblasts
T2 1429-1440 HP_0011846 denotes osteoblasts