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PubMed:10330189 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 546-549 DiseaseOrPhenotypicFeature denotes can 0012833
T2 1117-1120 DiseaseOrPhenotypicFeature denotes can 0012833
T3 1398-1401 DiseaseOrPhenotypicFeature denotes can 0012833

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 38-87 protein denotes beta-catenin-lymphoid enhancer factor 1 complexes
T2 198-210 protein denotes beta-catenin
T3 264-271 protein denotes LEF/TCF
T4 277-319 protein denotes lymphoid enhancer factor and T-cell factor
T5 321-342 protein denotes transcription factors
T6 396-408 protein denotes beta-catenin
T7 533-545 protein denotes beta-catenin
T8 596-603 protein denotes LEF/TCF
T9 697-709 protein denotes beta-catenin
T10 711-718 DNA denotes Delta19
T11 745-750 protein denotes LEF-1
T12 752-762 protein denotes E-cadherin
T13 768-771 protein denotes APC
T14 780-784 protein denotes axin
T15 791-818 protein denotes Delta19 beta-catenin mutant
T16 936-943 DNA denotes Delta19
T17 999-1011 protein denotes beta-catenin
T18 1067-1082 protein denotes LEF/TCF factors
T19 1084-1096 protein denotes beta-Catenin
T20 1101-1116 protein denotes LEF-1 complexes
T21 1160-1194 cell_line denotes transformed T-lymphocyte cell line
T22 1196-1202 cell_line denotes Jurkat
T23 1215-1235 cell_type denotes normal T lymphocytes
T24 1385-1397 protein denotes beta-catenin
T25 1438-1466 protein denotes LEF-1-beta-catenin complexes
T26 1493-1513 protein denotes transcription factor
T27 1514-1518 protein denotes VP16

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-141 Sentence denotes Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression.
S2 142-371 Sentence denotes In response to activation of the Wnt signaling pathway, beta-catenin accumulates in the nucleus, where it cooperates with LEF/TCF (for lymphoid enhancer factor and T-cell factor) transcription factors to activate gene expression.
S3 372-507 Sentence denotes The mechanisms by which beta-catenin undergoes this shift in location and participates in activation of gene transcription are unknown.
S4 508-653 Sentence denotes We demonstrate here that beta-catenin can be imported into the nucleus independently of LEF/TCF binding, and it may also be exported from nuclei.
S5 654-785 Sentence denotes We have introduced a small deletion within beta-catenin (Delta19) that disrupts binding to LEF-1, E-cadherin, and APC but not axin.
S6 786-907 Sentence denotes This Delta19 beta-catenin mutant localizes to the nucleus because it may not be efficiently sequestered in the cytoplasm.
S7 908-1083 Sentence denotes The nuclear localization of Delta19 definitively demonstrates that the mechanisms by which beta-catenin localizes in the nucleus are completely independent of LEF/TCF factors.
S8 1084-1274 Sentence denotes beta-Catenin and LEF-1 complexes can activate reporter gene expression in a transformed T-lymphocyte cell line (Jurkat) but not in normal T lymphocytes, even though both factors are nuclear.
S9 1275-1377 Sentence denotes Thus, localization of both factors to the nucleus is not sufficient for activation of gene expression.
S10 1378-1519 Sentence denotes Excess beta-catenin can squelch reporter gene activation by LEF-1-beta-catenin complexes but not activation by the transcription factor VP16.
S11 1520-1665 Sentence denotes Taken together, these data suggest that a third component is necessary for gene activation and that this third component may vary with cell type.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 38-87 NP denotes beta-catenin-lymphoid enhancer factor 1 complexes
C3 125-140 NP denotes gene expression
C2 111-140 NP denotes activation of gene expression
C4 198-210 NP denotes beta-catenin
C5 226-237 NP denotes the nucleus
C6 239-244 NP denotes where
C7 245-247 NP denotes it
C8 264-342 NP denotes LEF/TCF (for lymphoid enhancer factor and T-cell factor) transcription factors
C9 355-370 NP denotes gene expression
C10 372-386 NP denotes The mechanisms
C11 390-395 NP denotes which
C12 396-408 NP denotes beta-catenin
C13 533-545 NP denotes beta-catenin
C14 567-578 NP denotes the nucleus
C15 617-619 NP denotes it
C17 697-709 NP denotes beta-catenin
C16 673-719 NP denotes a small deletion within beta-catenin (Delta19)
C18 720-724 NP denotes that
C19 786-818 NP denotes This Delta19 beta-catenin mutant
C20 832-843 NP denotes the nucleus
C21 852-854 NP denotes it
C22 975-989 NP denotes the mechanisms
C23 993-998 NP denotes which
C24 999-1011 NP denotes beta-catenin
C25 1025-1036 NP denotes the nucleus
C26 1067-1082 NP denotes LEF/TCF factors
C27 1084-1116 NP denotes beta-Catenin and LEF-1 complexes
C28 1249-1261 NP denotes both factors
C29 1297-1309 NP denotes both factors
C30 1313-1324 NP denotes the nucleus
C32 1361-1376 NP denotes gene expression
C31 1347-1376 NP denotes activation of gene expression
C33 1438-1466 NP denotes LEF-1-beta-catenin complexes
C34 1560-1577 NP denotes a third component
C35 1620-1640 NP denotes this third component
R1 C6 C5 coref-relat where,the nucleus
R2 C7 C4 coref-pron it,beta-catenin
R3 C9 C3 coref-ident gene expression,gene expression
R4 C11 C10 coref-relat which,The mechanisms
R5 C12 C4 coref-ident beta-catenin,beta-catenin
R6 C13 C12 coref-ident beta-catenin,beta-catenin
R7 C14 C5 coref-ident the nucleus,the nucleus
R8 C15 C13 coref-pron it,beta-catenin
R9 C17 C13 coref-ident beta-catenin,beta-catenin
R10 C18 C16 coref-relat that,a small deletion within beta-catenin (Delta19)
R11 C20 C14 coref-ident the nucleus,the nucleus
R12 C21 C19 coref-pron it,This Delta19 beta-catenin mutant
R13 C23 C22 coref-relat which,the mechanisms
R14 C24 C17 coref-ident beta-catenin,beta-catenin
R15 C25 C20 coref-ident the nucleus,the nucleus
R16 C26 C8 coref-ident LEF/TCF factors,LEF/TCF (for lymphoid enhancer factor and T-cell factor) transcription factors
R17 C27 C1 coref-ident beta-Catenin and LEF-1 complexes,beta-catenin-lymphoid enhancer factor 1 complexes
R18 C28 C27 coref-ident both factors,beta-Catenin and LEF-1 complexes
R19 C29 C28 coref-ident both factors,both factors
R20 C30 C25 coref-ident the nucleus,the nucleus
R21 C32 C9 coref-ident gene expression,gene expression
R22 C31 C2 coref-ident activation of gene expression,activation of gene expression
R23 C33 C29 coref-ident LEF-1-beta-catenin complexes,both factors
R24 C35 C34 coref-ident this third component,a third component

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 38-50 protein_molecule denotes beta-catenin
T2 125-140 other_name denotes gene expression
T3 175-196 other_name denotes Wnt signaling pathway
T4 198-210 protein_molecule denotes beta-catenin
T5 230-237 cell_component denotes nucleus
T6 264-271 protein_family_or_group denotes LEF/TCF
T7 277-319 protein_family_or_group denotes lymphoid enhancer factor and T-cell factor
T8 321-342 protein_family_or_group denotes transcription factors
T9 355-370 other_name denotes gene expression
T10 396-408 protein_molecule denotes beta-catenin
T11 476-494 other_name denotes gene transcription
T12 533-545 protein_molecule denotes beta-catenin
T13 571-578 cell_component denotes nucleus
T14 596-603 protein_family_or_group denotes LEF/TCF
T15 646-652 cell_component denotes nuclei
T16 697-709 protein_molecule denotes beta-catenin
T17 711-718 DNA_domain_or_region denotes Delta19
T18 745-750 protein_molecule denotes LEF-1
T19 752-762 protein_molecule denotes E-cadherin
T20 768-771 protein_molecule denotes APC
T21 780-784 protein_molecule denotes axin
T22 791-798 DNA_domain_or_region denotes Delta19
T23 799-811 protein_molecule denotes beta-catenin
T24 836-843 cell_component denotes nucleus
T25 897-906 cell_component denotes cytoplasm
T26 936-943 DNA_domain_or_region denotes Delta19
T27 999-1011 protein_molecule denotes beta-catenin
T28 1029-1036 cell_component denotes nucleus
T29 1067-1074 protein_molecule denotes LEF/TCF
T30 1084-1096 protein_molecule denotes beta-Catenin
T31 1101-1106 protein_molecule denotes LEF-1
T32 1139-1154 other_name denotes gene expression
T33 1160-1194 cell_line denotes transformed T-lymphocyte cell line
T34 1196-1202 cell_line denotes Jurkat
T35 1215-1221 cell_type denotes normal
T36 1222-1235 cell_type denotes T lymphocytes
T37 1317-1324 cell_component denotes nucleus
T38 1361-1376 other_name denotes gene expression
T39 1385-1397 protein_molecule denotes beta-catenin
T40 1438-1443 protein_molecule denotes LEF-1
T41 1443-1456 protein_molecule denotes -beta-catenin
T42 1493-1513 protein_family_or_group denotes transcription factor
T43 1514-1518 protein_molecule denotes VP16
T44 1595-1610 other_name denotes gene activation