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PubMed:10329958 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 37-41 cell_line denotes HAEC
T2 42-48 protein denotes VCAM-1
T3 131-161 cell_type denotes human aortic endothelial cells
T4 163-167 cell_line denotes HAEC
T5 298-319 protein denotes nuclear factor-kappaB
T6 321-330 protein denotes NF-kappaB
T7 405-414 protein denotes NF-kappaB
T8 457-488 protein denotes vascular cell adhesion molecule
T9 490-496 protein denotes VCAM-1
T10 687-691 cell_line denotes HAEC
T11 864-873 protein denotes NF-kappaB
T12 889-895 protein denotes VCAM-1
T13 983-989 protein denotes VCAM-1
T14 1052-1061 protein denotes NF-kappaB
T15 1100-1109 protein denotes NF-kappaB
T16 1125-1131 protein denotes VCAM-1
T17 1201-1210 protein denotes NF-kappaB
T18 1249-1255 protein denotes VCAM-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-82 Sentence denotes Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion.
S2 83-332 Sentence denotes We recently reported that prolonged exposure of human aortic endothelial cells (HAEC) to low shear stress flow patterns is associated with a sustained increase in the activated form of the transcriptional regulator nuclear factor-kappaB (NF-kappaB).
S3 333-636 Sentence denotes Here we investigate the hypothesis that low shear-induced activation of NF-kappaB is responsible for enhanced expression of vascular cell adhesion molecule (VCAM-1) resulting in augmented endothelial cell-monocyte (EC-Mn) adhesion and that this activation is dependent on intracellular oxidant activity.
S4 637-807 Sentence denotes Before exposure to low shear (2 dyn/cm2) for 6 h, HAEC were preincubated with or without the antioxidants pyrrolidine dithiocarbamate (PDTC) or N-acetyl-L-cysteine (NAC).
S5 808-916 Sentence denotes PDTC strongly inhibited low shear-induced activation of NF-kappaB, expression of VCAM-1, and EC-Mn adhesion.
S6 917-1073 Sentence denotes Paradoxically, NAC exerted a positive effect on low shear-induced VCAM-1 expression and EC-Mn adhesion and only slightly downregulated NF-kappaB activation.
S7 1074-1176 Sentence denotes However, cytokine-induced NF-kappaB activation and VCAM-1 expression are blocked by both PDTC and NAC.
S8 1177-1374 Sentence denotes These data suggest that NF-kappaB plays a key role in low shear-induced VCAM-1 expression and that pathways mediating low shear- and cytokine-induced EC-Mn adhesion may be differentially regulated.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 131-168 NP denotes human aortic endothelial cells (HAEC)
C2 268-331 NP denotes the transcriptional regulator nuclear factor-kappaB (NF-kappaB)
C3 353-367 NP denotes the hypothesis
C4 368-372 NP denotes that
C6 405-414 NP denotes NF-kappaB
C5 373-414 NP denotes low shear-induced activation of NF-kappaB
C7 457-497 NP denotes vascular cell adhesion molecule (VCAM-1)
C8 568-572 NP denotes that
C9 573-588 NP denotes this activation
C10 687-691 NP denotes HAEC
C11 864-873 NP denotes NF-kappaB
C12 889-895 NP denotes VCAM-1
C13 1201-1210 NP denotes NF-kappaB
R1 C4 C3 coref-relat that,the hypothesis
R2 C6 C2 coref-ident NF-kappaB,the transcriptional regulator nuclear factor-kappaB (NF-kappaB)
R3 C8 C3 coref-relat that,the hypothesis
R4 C9 C5 coref-ident this activation,low shear-induced activation of NF-kappaB
R5 C10 C1 coref-ident HAEC,human aortic endothelial cells (HAEC)
R6 C11 C6 coref-ident NF-kappaB,NF-kappaB
R7 C12 C7 coref-ident VCAM-1,vascular cell adhesion molecule (VCAM-1)
R8 C13 C11 coref-ident NF-kappaB,NF-kappaB

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 37-41 cell_line denotes HAEC
T2 42-48 protein_molecule denotes VCAM-1
T3 131-161 cell_type denotes human aortic endothelial cells
T4 163-167 cell_line denotes HAEC
T5 176-202 other_name denotes shear stress flow patterns
T6 298-319 protein_complex denotes nuclear factor-kappaB
T7 321-330 protein_complex denotes NF-kappaB
T8 405-414 protein_complex denotes NF-kappaB
T9 457-488 protein_family_or_group denotes vascular cell adhesion molecule
T10 490-496 protein_molecule denotes VCAM-1
T11 521-563 other_name denotes endothelial cell-monocyte (EC-Mn) adhesion
T12 687-691 cell_line denotes HAEC
T13 730-770 other_organic_compound denotes antioxidants pyrrolidine dithiocarbamate
T14 772-776 other_organic_compound denotes PDTC
T15 781-800 amino_acid_monomer denotes N-acetyl-L-cysteine
T16 802-805 amino_acid_monomer denotes NAC
T17 808-812 other_organic_compound denotes PDTC
T18 864-873 protein_complex denotes NF-kappaB
T19 889-895 protein_molecule denotes VCAM-1
T20 901-915 other_name denotes EC-Mn adhesion
T21 932-935 amino_acid_monomer denotes NAC
T22 983-989 protein_molecule denotes VCAM-1
T23 1005-1019 other_name denotes EC-Mn adhesion
T24 1052-1061 protein_complex denotes NF-kappaB
T25 1083-1099 other_name denotes cytokine-induced
T26 1100-1109 protein_complex denotes NF-kappaB
T27 1125-1131 protein_molecule denotes VCAM-1
T28 1163-1167 other_organic_compound denotes PDTC
T29 1172-1175 amino_acid_monomer denotes NAC
T30 1201-1210 protein_complex denotes NF-kappaB
T31 1249-1255 protein_molecule denotes VCAM-1
T32 1299-1326 other_name denotes shear- and cytokine-induced
T33 1327-1341 other_name denotes EC-Mn adhesion