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PubMed:10329626 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 14-17 DiseaseOrPhenotypicFeature denotes can 0012833
T2 986-989 DiseaseOrPhenotypicFeature denotes HES 0011895|0015691
T4 1272-1275 DiseaseOrPhenotypicFeature denotes can 0012833

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-13 protein denotes Rel/NF-kappaB
T2 84-91 protein denotes Jagged1
T3 106-121 protein denotes Notch receptors
T4 123-130 protein denotes Jagged1
T5 146-167 protein denotes DSL family of ligands
T6 172-187 protein denotes Notch receptors
T7 250-263 cell_type denotes cell lineages
T8 300-321 protein denotes transcription factors
T9 371-378 protein denotes Jagged1
T10 384-413 DNA denotes Rel/NF-kappaB-responsive gene
T11 420-425 protein denotes c-Rel
T12 430-434 protein denotes RelA
T13 537-556 protein denotes jagged1 transcripts
T14 593-602 protein denotes NF-kappaB
T15 668-680 protein denotes IkappaBalpha
T16 711-720 protein denotes NF-kappaB
T17 749-756 protein denotes Jagged1
T18 760-792 cell_line denotes c-Rel-expressing cell monolayers
T19 830-841 cell_type denotes lymphocytes
T20 857-878 protein denotes Notch1/TAN-1 receptor
T21 986-1003 RNA denotes HES-1 transcripts
T22 1007-1028 cell_line denotes co-cultivated T cells
T23 1036-1052 RNA denotes CD23 transcripts
T24 1070-1077 cell_type denotes B cells
T25 1099-1112 protein denotes Rel/NF-kappaB
T26 1134-1141 protein denotes Jagged1
T27 1178-1193 cell_type denotes splenic B cells
T28 1200-1205 protein denotes c-Rel
T29 1266-1271 protein denotes c-Rel
T30 1393-1400 protein denotes Jagged1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-122 Sentence denotes Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.
S2 123-264 Sentence denotes Jagged1 belongs to the DSL family of ligands for Notch receptors that control the proliferation and differentiation of various cell lineages.
S3 265-351 Sentence denotes However, little is known about the transcription factors that regulate its expression.
S4 352-414 Sentence denotes Here, we show that Jagged1 is a Rel/NF-kappaB-responsive gene.
S5 415-523 Sentence denotes Both c-Rel and RelA induced jagged1 gene expression, whereas a mutant defective for transactivation did not.
S6 524-721 Sentence denotes Importantly, jagged1 transcripts were also upregulated by endogenous NF-kappaB activation and this effect was inhibited by a dominant mutant of IkappaBalpha, a physiological inhibitor of NF-kappaB.
S7 722-879 Sentence denotes Cell surface expression of Jagged1 in c-Rel-expressing cell monolayers led to a functional interaction with lymphocytes expressing the Notch1/TAN-1 receptor.
S8 880-1078 Sentence denotes This correlated with the initiation of signaling downstream of Notch, as evidenced by increased levels of HES-1 transcripts in co-cultivated T cells and of CD23 transcripts in co-cultivated B cells.
S9 1079-1234 Sentence denotes Consistent with its Rel/NF-kappaB-dependent induction, Jagged1 was found to be highly expressed in splenic B cells where c-Rel is expressed constitutively.
S10 1235-1451 Sentence denotes These results demonstrate that c-Rel can trigger the Notch signaling pathway in neighboring cells by inducing jagged1 gene expression, and suggest a role for Jagged1 in B-cell activation, differentiation or function.
S11 1452-1585 Sentence denotes These findings also highlight the potential for an interplay between the Notch and NF-kappaB signaling pathways in the immune system.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 26-53 NP denotes the Notch signaling pathway
C3 84-91 NP denotes Jagged1
C2 70-91 NP denotes expression of Jagged1
C5 106-121 NP denotes Notch receptors
C4 93-121 NP denotes a ligand for Notch receptors
C6 123-130 NP denotes Jagged1
C8 172-187 NP denotes Notch receptors
C7 142-187 NP denotes the DSL family of ligands for Notch receptors
C9 188-192 NP denotes that
C10 296-321 NP denotes the transcription factors
C11 322-326 NP denotes that
C13 336-339 NP denotes its
C12 336-350 NP denotes its expression
C14 371-378 NP denotes Jagged1
C15 443-466 NP denotes jagged1 gene expression
C16 647-680 NP denotes a dominant mutant of IkappaBalpha
C17 682-720 NP denotes a physiological inhibitor of NF-kappaB
C18 749-756 NP denotes Jagged1
C19 1134-1141 NP denotes Jagged1
C20 1200-1205 NP denotes c-Rel
C21 1235-1248 NP denotes These results
C22 1266-1271 NP denotes c-Rel
C23 1284-1311 NP denotes the Notch signaling pathway
C24 1345-1368 NP denotes jagged1 gene expression
C25 1393-1400 NP denotes Jagged1
C26 1452-1466 NP denotes These findings
R1 C4 C3 coref-appos a ligand for Notch receptors,Jagged1
R2 C6 C3 coref-ident Jagged1,Jagged1
R3 C8 C5 coref-ident Notch receptors,Notch receptors
R4 C9 C7 coref-relat that,the DSL family of ligands for Notch receptors
R5 C11 C10 coref-relat that,the transcription factors
R6 C13 C6 coref-pron its,Jagged1
R7 C12 C2 coref-ident its expression,expression of Jagged1
R8 C14 C6 coref-ident Jagged1,Jagged1
R9 C17 C16 coref-appos a physiological inhibitor of NF-kappaB,a dominant mutant of IkappaBalpha
R10 C18 C14 coref-ident Jagged1,Jagged1
R11 C19 C18 coref-ident Jagged1,Jagged1
R12 C22 C20 coref-ident c-Rel,c-Rel
R13 C23 C1 coref-ident the Notch signaling pathway,the Notch signaling pathway
R14 C24 C15 coref-ident jagged1 gene expression,jagged1 gene expression
R15 C25 C19 coref-ident Jagged1,Jagged1
R16 C26 C21 coref-ident These findings,These results

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-13 protein_molecule denotes Rel/NF-kappaB
T2 30-53 other_name denotes Notch signaling pathway
T3 84-91 protein_molecule denotes Jagged1
T4 106-121 protein_family_or_group denotes Notch receptors
T5 123-130 protein_molecule denotes Jagged1
T6 146-167 protein_family_or_group denotes DSL family of ligands
T7 172-187 protein_family_or_group denotes Notch receptors
T8 250-263 cell_type denotes cell lineages
T9 300-321 protein_family_or_group denotes transcription factors
T10 371-378 protein_molecule denotes Jagged1
T11 384-397 protein_molecule denotes Rel/NF-kappaB
T12 420-425 protein_molecule denotes c-Rel
T13 430-434 protein_molecule denotes RelA
T14 443-466 other_name denotes jagged1 gene expression
T15 537-556 protein_family_or_group denotes jagged1 transcripts
T16 593-602 protein_complex denotes NF-kappaB
T17 668-680 protein_molecule denotes IkappaBalpha
T18 711-720 protein_complex denotes NF-kappaB
T19 749-756 protein_molecule denotes Jagged1
T20 760-765 protein_molecule denotes c-Rel
T21 830-841 cell_type denotes lymphocytes
T22 857-878 protein_molecule denotes Notch1/TAN-1 receptor
T23 986-1003 RNA_family_or_group denotes HES-1 transcripts
T24 1007-1028 cell_line denotes co-cultivated T cells
T25 1036-1040 protein_molecule denotes CD23
T26 1070-1077 cell_type denotes B cells
T27 1099-1112 protein_molecule denotes Rel/NF-kappaB
T28 1134-1141 protein_molecule denotes Jagged1
T29 1178-1185 cell_type denotes splenic
T30 1186-1193 cell_type denotes B cells
T31 1200-1205 protein_molecule denotes c-Rel
T32 1266-1271 protein_molecule denotes c-Rel
T33 1288-1311 other_name denotes Notch signaling pathway
T34 1345-1368 other_name denotes jagged1 gene expression
T35 1393-1400 protein_molecule denotes Jagged1
T36 1571-1584 body_part denotes immune system

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 0-13 Protein denotes Rel/NF-kappaB
T3 30-35 Protein denotes Notch
T7 84-91 Ligand denotes Jagged1
T8 95-101 Ligand denotes ligand
T11 123-130 Ligand denotes Jagged1
T12 146-156 Ligand denotes DSL family
T13 160-167 Ligand denotes ligands
T19 250-263 Cell denotes cell lineages
T20 300-321 TranscriptionFactor denotes transcription factors
T23 371-378 Ligand denotes Jagged1
T24 384-397 Protein denotes Rel/NF-kappaB
T25 409-413 Gene denotes gene
T26 420-425 Protein denotes c-Rel
T27 430-434 Protein denotes RelA
T29 443-450 Ligand denotes jagged1
T31 537-544 Ligand denotes jagged1
T32 545-556 Transcript denotes transcripts
T34 593-602 Protein denotes NF-kappaB
T37 668-680 Protein denotes IkappaBalpha
T39 711-720 Protein denotes NF-kappaB
T40 722-734 CellComponent denotes Cell surface
T42 749-756 Ligand denotes Jagged1
T43 760-765 Protein denotes c-Rel
T45 777-781 Cell denotes cell
T47 830-841 Cell denotes lymphocytes
T53 943-948 Protein denotes Notch
T55 986-991 Protein denotes HES-1
T56 992-1003 Transcript denotes transcripts
T57 1021-1028 Cell denotes T cells
T58 1036-1040 Protein denotes CD23
T59 1041-1052 Transcript denotes transcripts
T60 1070-1077 Cell denotes B cells
T61 1099-1112 Protein denotes Rel/NF-kappaB
T63 1134-1141 Ligand denotes Jagged1
T65 1178-1185 Tissue denotes splenic
T66 1186-1193 Cell denotes B cells
T67 1200-1205 Protein denotes c-Rel
T69 1266-1271 Protein denotes c-Rel
T71 1288-1293 Protein denotes Notch
T74 1345-1352 Ligand denotes jagged1
T76 1393-1400 Ligand denotes Jagged1
T77 1404-1410 Cell denotes B-cell
T80 1525-1530 Protein denotes Notch
T81 1535-1544 Protein denotes NF-kappaB
T9 106-121 Protein denotes Notch receptors
T10 172-187 Protein denotes Notch receptors
T15 649-664 MutantProtein denotes dominant mutant
T49 857-878 Protein denotes Notch1/TAN-1 receptor
E1 18-25 PositiveRegulation denotes trigger
E2 36-53 SignalingPathway denotes signaling pathway
E3 57-65 Increase denotes inducing
E4 70-80 GeneExpression denotes expression
E5 193-200 RegulatoryProcess denotes control
E6 205-218 CellGrowth denotes proliferation
E7 223-238 CellDifferentiation denotes differentiation
E8 327-335 RegulatoryProcess denotes regulate
E9 340-350 GeneExpression denotes expression
E10 435-442 PositiveRegulation denotes induced
E11 451-466 GeneExpression denotes gene expression
E12 567-578 Increase denotes upregulated
E13 603-613 PositiveRegulation denotes activation
E14 634-643 NegativeRegulation denotes inhibited
E15 698-707 NegativeRegulation denotes inhibitor
E16 735-745 GeneExpression denotes expression
E17 766-776 GeneExpression denotes expressing
E18 813-824 CellularProcess denotes interaction
E19 842-852 GeneExpression denotes expressing
E20 905-915 PositiveRegulation denotes initiation
E21 919-928 SignalingPathway denotes signaling
E22 966-975 Increase denotes increased
E23 1123-1132 Increase denotes induction
E24 1165-1174 GeneExpression denotes expressed
E25 1209-1218 GeneExpression denotes expressed
E26 1276-1283 PositiveRegulation denotes trigger
E27 1294-1311 SignalingPathway denotes signaling pathway
E28 1336-1344 Increase denotes inducing
E29 1353-1368 GeneExpression denotes gene expression
E30 1411-1421 PositiveRegulation denotes activation
E31 1423-1438 CellDifferentiation denotes differentiation
E32 1545-1563 SignalingPathway denotes signaling pathways
E33 398-408 ResponseProcess denotes responsive
E34 193-200 RegulatoryProcess denotes control
E35 435-442 PositiveRegulation denotes induced
E36 966-975 Increase denotes increased
R2 E6 T19 locatedIn proliferation,cell lineages
R3 E7 T19 locatedIn differentiation,cell lineages
R4 T32 T31 encodes transcripts,jagged1
R5 E16 T40 locatedIn expression,Cell surface
R6 E16 T45 locatedIn expression,cell
R8 E17 T45 locatedIn expressing,cell
R10 E19 T47 locatedIn expressing,lymphocytes
R11 T56 T55 encodes transcripts,HES-1
R12 T56 T57 locatedIn transcripts,T cells
R13 T59 T58 encodes transcripts,CD23
R14 T59 T60 locatedIn transcripts,B cells
R15 E24 T66 locatedIn expressed,B cells
R16 T66 T65 locatedIn B cells,splenic
R17 E25 T66 locatedIn expressed,B cells
R19 T1 E1 hasAgent Rel/NF-kappaB,trigger
R20 E2 E1 hasPatient signaling pathway,trigger
R21 T1 E3 hasAgent Rel/NF-kappaB,inducing
R22 E4 E3 hasPatient expression,inducing
R23 T7 E4 hasPatient Jagged1,expression
R24 T12 E5 hasAgent DSL family,control
R25 E6 E5 hasPatient proliferation,control
R26 T20 E8 hasAgent transcription factors,regulate
R27 E9 E8 hasPatient expression,regulate
R28 T26 E10 hasAgent c-Rel,induced
R29 E11 E10 hasPatient gene expression,induced
R30 T29 E11 hasPatient jagged1,gene expression
R31 E13 E12 hasAgent activation,upregulated
R32 T32 E12 hasPatient transcripts,upregulated
R33 T34 E13 hasAgent NF-kappaB,activation
R34 T15 E14 hasAgent dominant mutant,inhibited
R35 E12 E14 hasPatient upregulated,inhibited
R36 T37 E15 hasAgent IkappaBalpha,inhibitor
R37 T39 E15 hasPatient NF-kappaB,inhibitor
R38 T42 E16 hasPatient Jagged1,expression
R39 T43 E17 hasPatient c-Rel,expressing
R40 E16 E18 hasAgent expression,interaction
R41 T47 E18 hasPatient lymphocytes,interaction
R42 T49 E19 hasPatient Notch1/TAN-1 receptor,expressing
R43 E21 E20 hasPatient signaling,initiation
R44 T53 E21 hasAgent Notch,signaling
R45 T56 E22 hasPatient transcripts,increased
R46 T61 E23 hasAgent Rel/NF-kappaB,induction
R47 T63 E24 hasPatient Jagged1,expressed
R48 T67 E25 hasPatient c-Rel,expressed
R49 T69 E26 hasAgent c-Rel,trigger
R50 E27 E26 hasPatient signaling pathway,trigger
R51 E29 E28 hasPatient gene expression,inducing
R52 T74 E29 hasPatient jagged1,gene expression
R53 T77 E30 hasPatient B-cell,activation
R54 T24 E33 hasAgent Rel/NF-kappaB,responsive
R55 T23 E33 hasPatient Jagged1,responsive
R56 T12 E34 hasAgent DSL family,control
R57 E7 E34 hasPatient differentiation,control
R58 T27 E35 hasAgent RelA,induced
R59 E11 E35 hasPatient gene expression,induced
R60 T59 E36 hasPatient transcripts,increased