PubMed:10329147
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-44 | DNA | denotes | NFATp/AP-1 composite elements |
| T2 | 89-101 | cell_type | denotes | immune cells |
| T3 | 103-121 | DNA | denotes | Composite elements |
| T4 | 126-144 | DNA | denotes | regulatory modules |
| T5 | 148-157 | DNA | denotes | promoters |
| T6 | 161-170 | DNA | denotes | enhancers |
| T7 | 234-255 | protein | denotes | transcription factors |
| T8 | 283-331 | DNA | denotes | nuclear factors of activated T-cell (NFAT) sites |
| T9 | 366-421 | DNA | denotes | NFATp/c and an activating protein 1 (AP-1) binding site |
| T10 | 488-505 | DNA | denotes | NFAT target genes |
| T11 | 568-591 | DNA | denotes | NFAT composite elements |
| T12 | 638-663 | DNA | denotes | transcription start sites |
| T13 | 712-735 | DNA | denotes | NFAT composite elements |
| T14 | 792-826 | DNA | denotes | T-cell-specific promoter sequences |
| T15 | 841-859 | DNA | denotes | functional regions |
| T16 | 861-890 | DNA | denotes | coding and intronic sequences |
| T17 | 919-928 | DNA | denotes | promoters |
| T18 | 932-953 | DNA | denotes | muscle-specific genes |
| T19 | 965-981 | DNA | denotes | random sequences |
| T20 | 1028-1051 | DNA | denotes | NFAT composite elements |
| T21 | 1055-1064 | DNA | denotes | promoters |
| T22 | 1068-1082 | DNA | denotes | cytokine genes |
| T23 | 1117-1126 | DNA | denotes | promoters |
| T24 | 1140-1159 | protein | denotes | AP-1 family members |
| T25 | 1161-1182 | protein | denotes | Ca2+-binding proteins |
| T26 | 1248-1265 | cell_type | denotes | activated T-cells |
| T27 | 1276-1288 | cell_type | denotes | immune cells |
| T28 | 1361-1379 | DNA | denotes | composite elements |
| T29 | 1417-1440 | DNA | denotes | NFAT composite elements |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-102 | Sentence | denotes | Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells. |
| S2 | 103-256 | Sentence | denotes | Composite elements are regulatory modules of promoters or enhancers that consist of binding sites of two different but synergizing transcription factors. |
| S3 | 257-422 | Sentence | denotes | A well-studied example is nuclear factors of activated T-cell (NFAT) sites which are composite elements of a NFATp/c and an activating protein 1 (AP-1) binding site. |
| S4 | 423-736 | Sentence | denotes | We have developed a computational approach to identify potential NFAT target genes which (a) comprises an improved method to scan for individual NFAT composite elements; (b) considers positional effects relative to transcription start sites; and (c) involves cluster analysis of potential NFAT composite elements. |
| S5 | 737-982 | Sentence | denotes | All three steps progressively helpX?ed to discriminate T-cell-specific promoter sequences against other functional regions (coding and intronic sequences) of the same genes, against promoters of muscle-specific genes or against random sequences. |
| S6 | 983-1289 | Sentence | denotes | Using this approach, we identified potential NFAT composite elements in promoters of cytokine genes and their receptors as well as in promoters of genes for AP-1 family members, Ca2+-binding proteins and some other components of the regulatory network operating in activated T-cells and other immune cells. |
| S7 | 1290-1388 | Sentence | denotes | The method developed can be adapted to characterize and identify other composite elements as well. |
| S8 | 1389-1594 | Sentence | denotes | The program for recognition NFAT composite elements is available through the World Wide Web (http://compel.bionet.nsc.ru/FunSite/CompelScan. html and http://transfac.gbf.de/dbsearch/funsitep/s _comp.html). |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 126-170 | NP | denotes | regulatory modules of promoters or enhancers |
| C2 | 171-175 | NP | denotes | that |
| C3 | 283-331 | NP | denotes | nuclear factors of activated T-cell (NFAT) sites |
| C4 | 332-337 | NP | denotes | which |
| C5 | 441-465 | NP | denotes | a computational approach |
| C6 | 506-511 | NP | denotes | which |
| C7 | 989-1002 | NP | denotes | this approach |
| C8 | 1018-1082 | NP | denotes | potential NFAT composite elements in promoters of cytokine genes |
| C9 | 1087-1092 | NP | denotes | their |
| C10 | 1290-1310 | NP | denotes | The method developed |
| R1 | C2 | C1 | coref-relat | that,regulatory modules of promoters or enhancers |
| R2 | C4 | C3 | coref-relat | which,nuclear factors of activated T-cell (NFAT) sites |
| R3 | C6 | C5 | coref-relat | which,a computational approach |
| R4 | C7 | C5 | coref-ident | this approach,a computational approach |
| R5 | C9 | C8 | coref-pron | their,potential NFAT composite elements in promoters of cytokine genes |
| R6 | C10 | C7 | coref-ident | The method developed,this approach |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-44 | DNA_family_or_group | denotes | NFATp/AP-1 composite elements |
| T2 | 89-101 | cell_type | denotes | immune cells |
| T3 | 103-121 | DNA_family_or_group | denotes | Composite elements |
| T4 | 126-144 | DNA_family_or_group | denotes | regulatory modules |
| T5 | 148-157 | DNA_family_or_group | denotes | promoters |
| T6 | 161-170 | DNA_family_or_group | denotes | enhancers |
| T7 | 234-255 | protein_family_or_group | denotes | transcription factors |
| T8 | 283-331 | DNA_domain_or_region | denotes | nuclear factors of activated T-cell (NFAT) sites |
| T9 | 488-505 | DNA_domain_or_region | denotes | NFAT target genes |
| T10 | 568-591 | DNA_family_or_group | denotes | NFAT composite elements |
| T11 | 638-663 | DNA_domain_or_region | denotes | transcription start sites |
| T12 | 712-735 | DNA_family_or_group | denotes | NFAT composite elements |
| T13 | 792-826 | DNA_domain_or_region | denotes | T-cell-specific promoter sequences |
| T14 | 841-859 | DNA_family_or_group | denotes | functional regions |
| T15 | 919-928 | DNA_domain_or_region | denotes | promoters |
| T16 | 932-953 | DNA_family_or_group | denotes | muscle-specific genes |
| T17 | 965-981 | DNA_family_or_group | denotes | random sequences |
| T18 | 1028-1051 | DNA_family_or_group | denotes | NFAT composite elements |
| T19 | 1055-1064 | DNA_family_or_group | denotes | promoters |
| T20 | 1068-1082 | DNA_family_or_group | denotes | cytokine genes |
| T21 | 1117-1126 | DNA_family_or_group | denotes | promoters |
| T22 | 1140-1144 | protein_molecule | denotes | AP-1 |
| T23 | 1161-1182 | protein_family_or_group | denotes | Ca2+-binding proteins |
| T24 | 1216-1234 | other_name | denotes | regulatory network |
| T25 | 1248-1265 | cell_type | denotes | activated T-cells |
| T26 | 1276-1288 | cell_type | denotes | immune cells |
| T27 | 1361-1379 | DNA_family_or_group | denotes | composite elements |
| T28 | 1417-1421 | DNA_family_or_group | denotes | NFAT |
| T29 | 1422-1440 | DNA_family_or_group | denotes | composite elements |