PubMed:10327050 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	36-65	DNA	denotes	mammalian MCM5 and MCM6 genes
T2	82-102	protein	denotes	transcription factor
T3	103-106	protein	denotes	E2F
T4	163-180	protein	denotes	MCM gene products
T5	287-302	DNA	denotes	mammalian genes
T6	310-320	DNA	denotes	MCM family
T7	473-506	DNA	denotes	isolated human MCM gene promoters
T8	508-537	DNA	denotes	Human MCM5 and MCM6 promoters
T9	559-568	DNA	denotes	E2F sites
T10	641-644	protein	denotes	E2F
T11	692-709	DNA	denotes	E2F-like sequence
T12	713-732	DNA	denotes	human MCM6 promoter
T13	769-778	DNA	denotes	E2F sites
T14	782-785	protein	denotes	E2F
T15	829-833	protein	denotes	E2F1
T16	880-900	DNA	denotes	endogenous MCM genes
T17	904-940	cell_line	denotes	rat embryonal fibroblast REF52 cells
T18	1007-1036	DNA	denotes	mammalian MCM5 and MCM6 genes
T19	1098-1101	protein	denotes	E2F
T20	1121-1139	DNA	denotes	multiple E2F sites
T21	1147-1156	DNA	denotes	promoters

Id	Subject	Object	Predicate	Lexical cue
S1	0-107	Sentence	denotes	Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.
S2	108-268	Sentence	denotes	Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle.
S3	269-411	Sentence	denotes	Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary.
S4	412-507	Sentence	denotes	In this study, we examined the transcriptional activities of isolated human MCM gene promoters.
S5	508-656	Sentence	denotes	Human MCM5 and MCM6 promoters with mutation in the E2F sites failed in promoter regulation following serum stimulation and exogenous E2F expression.
S6	657-807	Sentence	denotes	In addition, we identified a novel E2F-like sequence in human MCM6 promoter which cooperates with the authentic E2F sites in E2F-dependent regulation.
S7	808-941	Sentence	denotes	Forced expression of E2F1 could induce expression of all members of the endogenous MCM genes in rat embryonal fibroblast REF52 cells.
S8	942-1157	Sentence	denotes	Our results demonstrated that the growth-regulated expression of mammalian MCM5 and MCM6 genes, and presumably other MCM members, is primarily regulated by E2F through binding to multiple E2F sites in the promoters.

Id	Subject	Object	Predicate	Lexical cue
C1	36-65	NP	denotes	mammalian MCM5 and MCM6 genes
C2	78-106	NP	denotes	the transcription factor E2F
C3	122-137	NP	denotes	DNA replication
C4	163-180	NP	denotes	MCM gene products
C5	182-187	NP	denotes	which
C6	217-232	NP	denotes	DNA replication
C7	684-732	NP	denotes	a novel E2F-like sequence in human MCM6 promoter
C8	733-738	NP	denotes	which
C9	1007-1036	NP	denotes	mammalian MCM5 and MCM6 genes
C10	1098-1101	NP	denotes	E2F
R1	C5	C4	coref-relat	which,MCM gene products
R2	C6	C3	coref-ident	DNA replication,DNA replication
R3	C8	C7	coref-relat	which,a novel E2F-like sequence in human MCM6 promoter
R4	C9	C1	coref-ident	mammalian MCM5 and MCM6 genes,mammalian MCM5 and MCM6 genes
R5	C10	C2	coref-ident	E2F,the transcription factor E2F

Id	Subject	Object	Predicate	Lexical cue
T1	82-102	protein_family_or_group	denotes	transcription factor
T2	103-106	protein_molecule	denotes	E2F
T3	122-137	other_name	denotes	DNA replication
T4	163-180	protein_family_or_group	denotes	MCM gene products
T5	217-232	other_name	denotes	DNA replication
T6	257-267	other_name	denotes	cell cycle
T7	287-302	DNA_family_or_group	denotes	mammalian genes
T8	310-320	DNA_family_or_group	denotes	MCM family
T9	335-353	other_name	denotes	growth stimulation
T10	362-367	mono_cell	denotes	yeast
T11	377-388	other_name	denotes	mRNA levels
T12	397-410	other_name	denotes	G1/S boundary
T13	473-506	DNA_domain_or_region	denotes	isolated human MCM gene promoters
T14	559-562	protein_molecule	denotes	E2F
T15	579-598	other_name	denotes	promoter regulation
T16	631-640	other_name	denotes	exogenous
T17	641-644	protein_molecule	denotes	E2F
T18	692-695	protein_molecule	denotes	E2F
T19	713-732	DNA_domain_or_region	denotes	human MCM6 promoter
T20	769-772	protein_molecule	denotes	E2F
T21	782-785	protein_molecule	denotes	E2F
T22	829-833	protein_molecule	denotes	E2F1
T23	880-900	DNA_family_or_group	denotes	endogenous MCM genes
T24	904-940	cell_line	denotes	rat embryonal fibroblast REF52 cells
T25	976-1003	other_name	denotes	growth-regulated expression
T26	1098-1101	protein_molecule	denotes	E2F
T27	1121-1129	DNA_domain_or_region	denotes	multiple
T28	1130-1133	protein_molecule	denotes	E2F
T29	1147-1156	DNA_domain_or_region	denotes	promoters