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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-185 Sentence denotes Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
T2 186-316 Sentence denotes The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy.
T3 317-582 Sentence denotes We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected.
T4 583-852 Sentence denotes We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist.
T5 853-1009 Sentence denotes Of even more interest, IkappaBalpha overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor.
T6 1010-1156 Sentence denotes Blocking NF-kappaB in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction.
T7 1157-1376 Sentence denotes The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.
T1 0-185 Sentence denotes Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
T2 186-316 Sentence denotes The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy.
T3 317-582 Sentence denotes We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected.
T4 583-852 Sentence denotes We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist.
T5 853-1009 Sentence denotes Of even more interest, IkappaBalpha overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor.
T6 1010-1156 Sentence denotes Blocking NF-kappaB in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction.
T7 1157-1376 Sentence denotes The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 256-276 DiseaseOrPhenotypicFeature denotes rheumatoid arthritis 0008383
T2 466-469 DiseaseOrPhenotypicFeature denotes can 0012833
T3 627-632 DiseaseOrPhenotypicFeature denotes tumor 0005070

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 59-68 protein denotes NF-kappaB
T2 157-184 protein denotes anti-inflammatory mediators
T3 202-222 protein denotes transcription factor
T4 223-232 protein denotes NF-kappaB
T5 361-370 protein denotes NF-kappaB
T6 401-419 protein denotes inhibitory subunit
T7 420-432 protein denotes IkappaBalpha
T8 526-546 cell_type denotes synovial macrophages
T9 548-559 cell_type denotes fibroblasts
T10 565-572 cell_type denotes T cells
T11 627-654 protein denotes tumor necrosis factor alpha
T12 665-691 protein denotes pro-inflammatory cytokines
T13 695-704 protein denotes NF-kappaB
T14 770-797 protein denotes anti-inflammatory mediators
T15 804-817 protein denotes IL-10 and -11
T16 827-851 protein denotes IL-1 receptor antagonist
T17 876-888 protein denotes IkappaBalpha
T18 932-965 protein denotes matrix metalloproteinases 1 and 3
T19 1019-1028 protein denotes NF-kappaB
T20 1330-1342 cell_type denotes normal cells

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 9-20 cui:C0302350 denotes therapeutic
E2-ti-1 21-28 cui:C1521840 denotes targets
E3-ti-1 38-48 cui:C0001483 denotes adenovirus
E4-ti-1 59-68 cui:C0079904 denotes NF-kappaB
E5-ti-1 83-95 cui:C0333348 denotes inflammatory
E6-ti-1 100-111 cui:C0233520 denotes destructive
E7-ti-1 112-122 cui:C0441712 denotes mechanisms
E8-ti-1 126-136 cui:C0035435 denotes rheumatoid
E9-ti-1 137-145 cui:C0039099 denotes synovium
E10-ti-1 162-184 cui:C0243042 denotes inflammatory mediators
T1 123-125 LOCATION_OF denotes in
E1-ab-1 190-194 cui:C0035820 denotes role
E2-ab-1 202-222 cui:C0040648 denotes transcription factor
E3-ab-1 223-232 cui:C0079904 denotes NF-kappaB
E4-ab-1 240-252 cui:C0699748 denotes pathogenesis
E5-ab-1 256-276 cui:C0003873 denotes rheumatoid arthritis
E6-ab-1 281-285 cui:C0205166 denotes long
E7-ab-1 293-300 cui:C1550501 denotes subject
E8-ab-1 304-315 cui:C0680243 denotes controversy
T2 190-194 ASSOCIATED_WITH denotes role
E1-ab-2 328-338 cui:C0001483 denotes adenoviral
E2-ab-2 339-348 cui:C0449851 denotes technique
E3-ab-2 352-360 cui:C0332206 denotes blocking
E4-ab-2 361-370 cui:C0079904 denotes NF-kappaB
E5-ab-2 401-411 cui:C0243077 denotes inhibitory
E6-ab-2 420-432 cui:C0126732 denotes IkappaBalpha
E7-ab-2 485-493 cui:C0012634 denotes diseased
E8-ab-2 515-518 cui:C0439083 denotes 90%
E9-ab-2 526-534 cui:C1550315 denotes synovial
E10-ab-2 535-546 cui:C0024432 denotes macrophages
E11-ab-2 548-559 cui:C0016030 denotes fibroblasts
E12-ab-2 565-572 cui:C0039194 denotes T cells
T3 526-546 PART_OF denotes synovial macrophages
E1-ab-3 601-612 cui:C0205359 denotes spontaneous
E2-ab-3 613-623 cui:C0033268 denotes production
E3-ab-3 627-654 cui:C1456820 denotes tumor necrosis factor alpha
E4-ab-3 665-669 cui:C0033382 denotes pro-
E5-ab-3 669-681 cui:C0333348 denotes inflammatory
E6-ab-3 682-691 cui:C0079189 denotes cytokines
E7-ab-3 695-704 cui:C0079904 denotes NF-kappaB
E8-ab-3 718-728 cui:C0035435 denotes rheumatoid
E9-ab-3 729-744 cui:C0039099 denotes synovial tissue
E10-ab-3 765-769 cui:C0205225 denotes main
E11-ab-3 775-797 cui:C0243042 denotes inflammatory mediators
E12-ab-3 804-809 cui:C0085295 denotes IL-10
E13-ab-3 827-840 cui:C0063710 denotes IL-1 receptor
T4 627-691 ISA denotes tumor necrosis factor alpha and other pro-inflammatory cytokines
T5 627-691 ISA denotes tumor necrosis factor alpha and other pro-inflammatory cytokines
T6 705-714 STIMULATES denotes dependent
T7 705-714 STIMULATES denotes dependent
T8 705-714 STIMULATES denotes dependent
T9 705-714 STIMULATES denotes dependent
T10 627-691 STIMULATES denotes tumor necrosis factor alpha and other pro-inflammatory cytokines
T11 627-691 STIMULATES denotes tumor necrosis factor alpha and other pro-inflammatory cytokines
T12 627-691 STIMULATES denotes tumor necrosis factor alpha and other pro-inflammatory cytokines
T13 627-691 STIMULATES denotes tumor necrosis factor alpha and other pro-inflammatory cytokines
E1-ab-4 876-888 cui:C0126732 denotes IkappaBalpha
E2-ab-4 918-928 cui:C0033268 denotes production
E3-ab-4 932-959 cui:C0127082 denotes matrix metalloproteinases 1
E4-ab-4 972-975 cui:C1518422 denotes not
E5-ab-4 999-1008 cui:C0243077 denotes inhibitor
T14 904-913 INHIBITS denotes inhibited
E1-ab-5 1010-1018 cui:C0332206 denotes Blocking
E2-ab-5 1019-1028 cui:C0079904 denotes NF-kappaB
E3-ab-5 1036-1046 cui:C0035435 denotes rheumatoid
E4-ab-5 1047-1052 cui:C0392905 denotes joint
E5-ab-5 1064-1068 cui:C0442824 denotes very
E6-ab-5 1107-1128 cui:C1155266 denotes inflammatory response
T15 1089-1097 DISRUPTS denotes reducing
E1-ab-6 1161-1171 cui:C0001483 denotes adenoviral
E2-ab-6 1172-1181 cui:C0449851 denotes technique
E3-ab-6 1201-1211 cui:C0205391 denotes widespread
E4-ab-6 1236-1241 cui:C0439831 denotes rapid
E5-ab-6 1242-1249 cui:C0039593 denotes testing
E6-ab-6 1257-1264 cui:C1280500 denotes effects
E7-ab-6 1268-1276 cui:C0332206 denotes blocking
E8-ab-6 1279-1288 cui:C0237399 denotes potential
E9-ab-6 1289-1300 cui:C0302350 denotes therapeutic
E10-ab-6 1330-1342 cui:C1268443 denotes normal cells
E11-ab-6 1353-1361 cui:C0012634 denotes diseased
R1 E9-ti-1 T1 subjectOf synovium,in
R2 E4-ti-1 T1 objectOf NF-kappaB,in
R3 E3-ab-1 T2 subjectOf NF-kappaB,role
R4 E4-ab-1 T2 objectOf pathogenesis,role
R5 E10-ab-2 T3 subjectOf macrophages,synovial macrophages
R6 E9-ab-2 T3 objectOf synovial,synovial macrophages
R7 E3-ab-3 T4 subjectOf tumor necrosis factor alpha,tumor necrosis factor alpha and other pro-inflammatory cytokines
R8 E6-ab-3 T4 objectOf cytokines,tumor necrosis factor alpha and other pro-inflammatory cytokines
R9 E6-ab-3 T5 subjectOf cytokines,tumor necrosis factor alpha and other pro-inflammatory cytokines
R10 E3-ab-3 T5 objectOf tumor necrosis factor alpha,tumor necrosis factor alpha and other pro-inflammatory cytokines
R11 E6-ab-3 T6 subjectOf cytokines,dependent
R12 E11-ab-3 T6 objectOf inflammatory mediators,dependent
R13 E6-ab-3 T7 subjectOf cytokines,dependent
R14 E13-ab-3 T7 objectOf IL-1 receptor,dependent
R15 E3-ab-3 T8 subjectOf tumor necrosis factor alpha,dependent
R16 E11-ab-3 T8 objectOf inflammatory mediators,dependent
R17 E3-ab-3 T9 subjectOf tumor necrosis factor alpha,dependent
R18 E13-ab-3 T9 objectOf IL-1 receptor,dependent
R19 E3-ab-3 T10 subjectOf tumor necrosis factor alpha,tumor necrosis factor alpha and other pro-inflammatory cytokines
R20 E11-ab-3 T10 objectOf inflammatory mediators,tumor necrosis factor alpha and other pro-inflammatory cytokines
R21 E3-ab-3 T11 subjectOf tumor necrosis factor alpha,tumor necrosis factor alpha and other pro-inflammatory cytokines
R22 E13-ab-3 T11 objectOf IL-1 receptor,tumor necrosis factor alpha and other pro-inflammatory cytokines
R23 E6-ab-3 T12 subjectOf cytokines,tumor necrosis factor alpha and other pro-inflammatory cytokines
R24 E11-ab-3 T12 objectOf inflammatory mediators,tumor necrosis factor alpha and other pro-inflammatory cytokines
R25 E6-ab-3 T13 subjectOf cytokines,tumor necrosis factor alpha and other pro-inflammatory cytokines
R26 E13-ab-3 T13 objectOf IL-1 receptor,tumor necrosis factor alpha and other pro-inflammatory cytokines
R27 E1-ab-4 T14 subjectOf IkappaBalpha,inhibited
R28 E3-ab-4 T14 objectOf matrix metalloproteinases 1,inhibited
R29 E2-ab-5 T15 subjectOf NF-kappaB,reducing
R30 E6-ab-5 T15 objectOf inflammatory response,reducing

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-185 Sentence denotes Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
S2 186-316 Sentence denotes The role of the transcription factor NF-kappaB in the pathogenesis of rheumatoid arthritis has long been a subject of controversy.
S3 317-582 Sentence denotes We used an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha, which has the advantage that it can be used in the diseased tissue itself, with >90% of the synovial macrophages, fibroblasts, and T cells infected.
S4 583-852 Sentence denotes We found that the spontaneous production of tumor necrosis factor alpha and other pro-inflammatory cytokines is NF-kappaB-dependent in rheumatoid synovial tissue, in contrast to the main anti-inflammatory mediators, like IL-10 and -11, and the IL-1 receptor antagonist.
S5 853-1009 Sentence denotes Of even more interest, IkappaBalpha overexpression inhibited the production of matrix metalloproteinases 1 and 3 while not affecting their tissue inhibitor.
S6 1010-1156 Sentence denotes Blocking NF-kappaB in the rheumatoid joint thus has a very beneficial profile, reducing both the inflammatory response and the tissue destruction.
S7 1157-1376 Sentence denotes The adenoviral technique described here has widespread applicability, allowing rapid testing of the effects of blocking a potential therapeutic target in either cultures of normal cells or in the diseased tissue itself.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 198-232 NP denotes the transcription factor NF-kappaB
C3 361-370 NP denotes NF-kappaB
C5 397-432 NP denotes the inhibitory subunit IkappaBalpha
C4 379-432 NP denotes overexpression of the inhibitory subunit IkappaBalpha
C2 325-432 NP denotes an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha
C6 434-439 NP denotes which
C7 444-457 NP denotes the advantage
C8 458-462 NP denotes that
C9 463-465 NP denotes it
C10 481-507 NP denotes the diseased tissue itself
C11 876-903 NP denotes IkappaBalpha overexpression
C12 932-965 NP denotes matrix metalloproteinases 1 and 3
C13 986-991 NP denotes their
C14 1157-1196 NP denotes The adenoviral technique described here
C15 1349-1375 NP denotes the diseased tissue itself
R1 C3 C1 coref-ident NF-kappaB,the transcription factor NF-kappaB
R2 C6 C5 coref-relat which,the inhibitory subunit IkappaBalpha
R3 C8 C7 coref-relat that,the advantage
R4 C9 C5 coref-pron it,the inhibitory subunit IkappaBalpha
R5 C11 C4 coref-ident IkappaBalpha overexpression,overexpression of the inhibitory subunit IkappaBalpha
R6 C13 C12 coref-pron their,matrix metalloproteinases 1 and 3
R7 C14 C2 coref-ident The adenoviral technique described here,an adenoviral technique of blocking NF-kappaB through overexpression of the inhibitory subunit IkappaBalpha
R8 C15 C10 coref-ident the diseased tissue itself,the diseased tissue itself

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 38-48 virus denotes adenovirus
T2 59-68 protein_complex denotes NF-kappaB
T3 83-95 other_name denotes inflammatory
T4 100-122 other_name denotes destructive mechanisms
T5 126-145 other_name denotes rheumatoid synovium
T6 157-184 protein_family_or_group denotes anti-inflammatory mediators
T7 202-222 protein_family_or_group denotes transcription factor
T8 223-232 protein_complex denotes NF-kappaB
T9 256-276 other_name denotes rheumatoid arthritis
T10 328-348 other_name denotes adenoviral technique
T11 361-370 protein_complex denotes NF-kappaB
T12 379-393 other_name denotes overexpression
T13 401-419 protein_subunit denotes inhibitory subunit
T14 420-432 protein_subunit denotes IkappaBalpha
T15 526-546 cell_type denotes synovial macrophages
T16 548-559 cell_type denotes fibroblasts
T17 565-572 cell_type denotes T cells
T18 601-623 other_name denotes spontaneous production
T19 627-654 protein_molecule denotes tumor necrosis factor alpha
T20 665-681 protein_family_or_group denotes pro-inflammatory
T21 682-691 protein_family_or_group denotes cytokines
T22 695-704 protein_complex denotes NF-kappaB
T23 718-744 tissue denotes rheumatoid synovial tissue
T24 770-797 protein_family_or_group denotes anti-inflammatory mediators
T25 827-851 protein_molecule denotes IL-1 receptor antagonist
T26 876-888 protein_subunit denotes IkappaBalpha
T27 992-1008 other_name denotes tissue inhibitor
T28 1019-1028 protein_complex denotes NF-kappaB
T29 1036-1052 body_part denotes rheumatoid joint
T30 1107-1128 other_name denotes inflammatory response
T31 1137-1155 other_name denotes tissue destruction
T32 1161-1181 other_name denotes adenoviral technique
T33 1279-1307 other_name denotes potential therapeutic target
T34 1330-1342 cell_type denotes normal cells
T35 1353-1368 tissue denotes diseased tissue

metamap-sample

Id Subject Object Predicate Lexical cue
T1 39-49 C1552907 denotes denovirus:
T2 730-745 C0039099 denotes ynovial tissue,
T3 138-146 C0039099 denotes ynovium
T4 1020-1029 C0079904 denotes F-kappaB
T5 696-705 C0079904 denotes F-kappaB-
T6 362-371 C0079904 denotes F-kappaB
T7 224-233 C0079904 denotes F-kappaB
T8 60-69 C0079904 denotes F-kappaB
T9 70-77 C0018790 denotes nhibits
T10 33-38 C1524063 denotes sing
T11 670-682 C0333348 denotes nflammatory
T12 84-96 C0333348 denotes nflammatory
T13 789-798 C0127400 denotes ediators,
T14 176-185 C0127400 denotes ediators.
T15 113-123 C0441712 denotes echanisms
T16 1302-1308 C1521840 denotes arget
T17 22-29 C1521840 denotes argets
T18 1269-1277 C0332206 denotes locking
T19 1011-1019 C0332206 denotes locking
T20 51-59 C0332206 denotes locking
T21 771-788 C1515999 denotes nti-inflammatory
T22 158-175 C1515999 denotes nti-inflammatory
T23 1290-1301 C0039796 denotes herapeutic
T24 10-21 C0039796 denotes herapeutic
T25 101-112 C0233520 denotes estructive
T26 933-960 C0127082 denotes atrix metalloproteinases 1
T27 877-889 C0126732 denotes kappaBalpha
T28 421-433 C0126732 denotes kappaBalpha,
T29 1162-1172 C0001483 denotes denoviral
T30 329-339 C0001483 denotes denoviral
T31 566-573 C0039194 denotes cells
T32 805-810 C0085295 denotes L-10
T33 828-832 C0021755 denotes L-1
T34 666-669 C0033382 denotes ro-
T35 683-692 C0079189 denotes ytokines
T36 536-547 C0024432 denotes acrophages,
T37 402-412 C3463820 denotes nhibitory
T38 549-560 C0016030 denotes ibroblasts,
T39 1363-1368 C0040300 denotes issue
T40 1138-1143 C0040300 denotes issue
T41 993-999 C0040300 denotes issue
T42 203-223 C0040648 denotes ranscription factor
T43 1048-1053 C0022417 denotes oint
T44 890-903 C1514559 denotes verexpression
T45 380-394 C1514559 denotes verexpression
T46 965-966 C2827736 denotes
T47 977-985 C0392760 denotes ffecting
T48 574-582 C0439663 denotes nfected.
T49 1108-1129 C1155266 denotes nflammatory response
T50 905-914 C0311403 denotes nhibited
T51 867-875 C0543488 denotes nterest,
T52 282-286 C0205166 denotes ong
T53 973-976 C1518422 denotes ot
T54 241-253 C0699748 denotes athogenesis
T55 587-592 C0150312 denotes ound
T56 1090-1098 C0392756 denotes educing
T57 321-325 C1273517 denotes sed
T58 1228-1236 C0683607 denotes llowing
T59 1183-1192 C1552738 denotes escribed
T60 1145-1156 C1261381 denotes estruction.
T61 1000-1009 C1999216 denotes nhibitor.
T62 1173-1182 C0449851 denotes echnique
T63 1081-1088 C1979963 denotes rofile,
T64 842-852 C0231491 denotes ntagonist.
T65 1213-1226 C1706839 denotes pplicability,
T66 1331-1337 C0439166 denotes ormal
T67 294-301 C1706203 denotes ubject
T68 516-518 C0439087 denotes 0%
T69 527-535 C1550315 denotes ynovial
T70 919-929 C0033268 denotes roduction
T71 706-715 C0851827 denotes ependent
T72 1243-1250 C0039593 denotes esting
T73 191-195 C1705810 denotes ole
T74 1202-1211 C0205391 denotes idespread
T75 413-419 C1711351 denotes ubunit
T76 1065-1069 C0442824 denotes ery
T77 766-770 C1542147 denotes ain
T78 833-841 C0597357 denotes eceptor
T79 305-316 C0680243 denotes ontroversy.
T80 1280-1288 C3245505 denotes otential
T81 1258-1265 C1280500 denotes ffects
T82 1237-1242 C0439831 denotes apid
T83 602-613 C0205359 denotes pontaneous

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 256-276 HP_0001370 denotes rheumatoid arthritis
T2 267-276 HP_0001369 denotes arthritis
T3 627-632 HP_0002664 denotes tumor