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PubMed:10318814 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 10-23 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T2 102-115 Glycan_Motif denotes Peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T3 117-120 Glycan_Motif denotes PGN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T4 489-492 Glycan_Motif denotes PGN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T5 580-583 Glycan_Motif denotes PGN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T6 823-826 Glycan_Motif denotes PGN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T7 1016-1019 Glycan_Motif denotes PGN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T8 1183-1186 Glycan_Motif denotes PGN https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.
T2 102-332 Sentence denotes Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, induces secretion of cytokines in macrophages through CD14, the pattern recognition receptor that binds lipopolysaccharide and other microbial products.
T3 333-544 Sentence denotes To begin to elucidate the mechanisms that regulate the transcription of cytokine genes, we wanted to determine which transcription factors are activated by PGN in mouse RAW264.7 and human THP-1 macrophage cells.
T4 545-1086 Sentence denotes Our results demonstrated that: (i) PGN induced phosphorylation of the transcription factors ATF-1 and CREB; (ii) ATF-1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid, which was inhibited by dominant negative CREB and ATF-1; (iii) PGN induced phosphorylation of c-Jun, protein synthesis of JunB and c-Fos, and transcriptional activation of the AP-1 reporter plasmid, which was inhibited by dominant negative c-Fos; and (iv) PGN-induced activation of CREB/ATF and AP-1 was mediated through CD14.
T5 1087-1239 Sentence denotes This is the first study to demonstrate activation of CREB/ATF and AP-1 transcription factors by PGN or by any other component of Gram-positive bacteria.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 10-23 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T2 102-115 https://glytoucan.org/Structures/Glycans/G00023MO denotes Peptidoglycan

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 32-36 protein denotes CD14
T2 61-82 protein denotes transcription factors
T3 83-91 protein denotes CREB/ATF
T4 96-100 protein denotes AP-1
T5 201-210 protein denotes cytokines
T6 214-225 cell_type denotes macrophages
T7 234-238 protein denotes CD14
T8 405-419 DNA denotes cytokine genes
T9 450-471 protein denotes transcription factors
T10 496-510 cell_line denotes mouse RAW264.7
T11 515-543 cell_line denotes human THP-1 macrophage cells
T12 615-636 protein denotes transcription factors
T13 637-642 protein denotes ATF-1
T14 647-651 protein denotes CREB
T15 658-663 protein denotes ATF-1
T16 668-672 protein denotes CREB
T17 738-758 DNA denotes CRE reporter plasmid
T18 801-805 protein denotes CREB
T19 810-815 protein denotes ATF-1
T20 854-859 protein denotes c-Jun
T21 882-886 protein denotes JunB
T22 891-896 protein denotes c-Fos
T23 936-957 DNA denotes AP-1 reporter plasmid
T24 1000-1005 protein denotes c-Fos
T25 1042-1050 protein denotes CREB/ATF
T26 1055-1059 protein denotes AP-1
T27 1081-1085 protein denotes CD14
T28 1140-1148 protein denotes CREB/ATF
T29 1153-1179 protein denotes AP-1 transcription factors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-101 Sentence denotes Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.
S2 102-332 Sentence denotes Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, induces secretion of cytokines in macrophages through CD14, the pattern recognition receptor that binds lipopolysaccharide and other microbial products.
S3 333-544 Sentence denotes To begin to elucidate the mechanisms that regulate the transcription of cytokine genes, we wanted to determine which transcription factors are activated by PGN in mouse RAW264.7 and human THP-1 macrophage cells.
S4 545-1086 Sentence denotes Our results demonstrated that: (i) PGN induced phosphorylation of the transcription factors ATF-1 and CREB; (ii) ATF-1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid, which was inhibited by dominant negative CREB and ATF-1; (iii) PGN induced phosphorylation of c-Jun, protein synthesis of JunB and c-Fos, and transcriptional activation of the AP-1 reporter plasmid, which was inhibited by dominant negative c-Fos; and (iv) PGN-induced activation of CREB/ATF and AP-1 was mediated through CD14.
S5 1087-1239 Sentence denotes This is the first study to demonstrate activation of CREB/ATF and AP-1 transcription factors by PGN or by any other component of Gram-positive bacteria.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 61-100 NP denotes transcription factors CREB/ATF and AP-1
C2 102-121 NP denotes Peptidoglycan (PGN)
C4 156-178 NP denotes Gram-positive bacteria
C3 123-178 NP denotes the major cell wall component of Gram-positive bacteria
C5 234-238 NP denotes CD14
C7 240-272 NP denotes the pattern recognition receptor
C8 273-277 NP denotes that
C6 240-331 NP denotes the pattern recognition receptor that binds lipopolysaccharide and other microbial products
C9 355-369 NP denotes the mechanisms
C10 370-374 NP denotes that
C11 489-492 NP denotes PGN
C12 580-583 NP denotes PGN
C13 611-652 NP denotes the transcription factors ATF-1 and CREB;
C14 658-672 NP denotes ATF-1 and CREB
C15 706-758 NP denotes transcriptional activation of a CRE reporter plasmid
C16 760-765 NP denotes which
C17 823-826 NP denotes PGN
C18 902-957 NP denotes transcriptional activation of the AP-1 reporter plasmid
C19 959-964 NP denotes which
C20 1042-1059 NP denotes CREB/ATF and AP-1
C21 1081-1085 NP denotes CD14
C22 1140-1179 NP denotes CREB/ATF and AP-1 transcription factors
C23 1183-1186 NP denotes PGN
C24 1216-1238 NP denotes Gram-positive bacteria
R1 C3 C2 coref-appos the major cell wall component of Gram-positive bacteria,Peptidoglycan (PGN)
R2 C8 C7 coref-relat that,the pattern recognition receptor
R3 C6 C5 coref-appos the pattern recognition receptor that binds lipopolysaccharide and other microbial products,CD14
R4 C10 C9 coref-relat that,the mechanisms
R5 C11 C2 coref-ident PGN,Peptidoglycan (PGN)
R6 C12 C11 coref-ident PGN,PGN
R7 C14 C13 coref-ident ATF-1 and CREB,the transcription factors ATF-1 and CREB;
R8 C16 C15 coref-relat which,transcriptional activation of a CRE reporter plasmid
R9 C17 C12 coref-ident PGN,PGN
R10 C19 C18 coref-relat which,transcriptional activation of the AP-1 reporter plasmid
R11 C20 C1 coref-ident CREB/ATF and AP-1,transcription factors CREB/ATF and AP-1
R12 C21 C5 coref-ident CD14,CD14
R13 C22 C20 coref-ident CREB/ATF and AP-1 transcription factors,CREB/ATF and AP-1
R14 C23 C17 coref-ident PGN,PGN
R15 C24 C4 coref-ident Gram-positive bacteria,Gram-positive bacteria

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-23 carbohydrate denotes Bacterial peptidoglycan
T2 32-36 protein_molecule denotes CD14
T3 61-82 protein_family_or_group denotes transcription factors
T4 83-91 protein_molecule denotes CREB/ATF
T5 96-100 protein_molecule denotes AP-1
T6 102-115 carbohydrate denotes Peptidoglycan
T7 117-120 carbohydrate denotes PGN
T8 127-152 carbohydrate denotes major cell wall component
T9 156-178 mono_cell denotes Gram-positive bacteria
T10 201-210 protein_family_or_group denotes cytokines
T11 214-225 cell_type denotes macrophages
T12 234-238 protein_molecule denotes CD14
T13 284-302 lipid denotes lipopolysaccharide
T14 313-331 other_organic_compound denotes microbial products
T15 405-419 DNA_family_or_group denotes cytokine genes
T16 450-471 protein_family_or_group denotes transcription factors
T17 489-492 carbohydrate denotes PGN
T18 496-510 cell_line denotes mouse RAW264.7
T19 515-543 cell_line denotes human THP-1 macrophage cells
T20 580-583 carbohydrate denotes PGN
T21 615-636 protein_family_or_group denotes transcription factors
T22 637-642 protein_molecule denotes ATF-1
T23 647-651 protein_molecule denotes CREB
T24 658-663 protein_molecule denotes ATF-1
T25 668-672 protein_molecule denotes CREB
T26 738-758 DNA_molecule denotes CRE reporter plasmid
T27 801-805 protein_molecule denotes CREB
T28 810-815 protein_molecule denotes ATF-1
T29 823-826 carbohydrate denotes PGN
T30 854-859 protein_molecule denotes c-Jun
T31 861-878 other_name denotes protein synthesis
T32 882-886 protein_molecule denotes JunB
T33 891-896 protein_molecule denotes c-Fos
T34 902-928 other_name denotes transcriptional activation
T35 936-940 protein_molecule denotes AP-1
T36 1000-1005 protein_molecule denotes c-Fos
T37 1016-1019 carbohydrate denotes PGN
T38 1042-1046 protein_molecule denotes CREB
T39 1055-1059 protein_molecule denotes AP-1
T40 1081-1085 protein_molecule denotes CD14
T41 1140-1144 protein_molecule denotes CREB
T42 1153-1157 protein_molecule denotes AP-1
T43 1158-1179 protein_family_or_group denotes transcription factors
T44 1183-1186 carbohydrate denotes PGN
T45 1216-1238 mono_cell denotes Gram-positive bacteria

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 170-178 OrganismTaxon denotes bacteria 2|629395
T3 496-501 OrganismTaxon denotes mouse 10088|10090
T5 515-520 OrganismTaxon denotes human 9606
T6 1230-1238 OrganismTaxon denotes bacteria 2|629395

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 138-142 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060
T2 214-225 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T3 527-537 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 214-225 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 527-537 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394