PubMed:10318803
Annnotations
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-24 | https://acgg.asia/db/ggdb/info/gg158 | denotes | EXT |
| T2 | 35-40 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| T3 | 812-817 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| T4 | 818-823 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTR2 |
| T5 | 872-875 | https://acgg.asia/db/ggdb/info/gg158 | denotes | EXT |
| T6 | 1634-1639 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| T7 | 1640-1645 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTR2 |
| T8 | 1658-1697 | https://acgg.asia/db/ggdb/info/gg161 | denotes | alpha1,4-N-acetylhexosaminyltransferase |
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-24 | https://acgg.asia/db/ggdb/info/gg158 | denotes | EXT |
| T2 | 35-40 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| T3 | 812-817 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| T4 | 818-823 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTR2 |
| T5 | 872-875 | https://acgg.asia/db/ggdb/info/gg158 | denotes | EXT |
| T6 | 1634-1639 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| T7 | 1640-1645 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTR2 |
| T8 | 1658-1697 | https://acgg.asia/db/ggdb/info/gg161 | denotes | alpha1,4-N-acetylhexosaminyltransferase |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 108-129 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T2 | 134-153 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
| T3 | 363-384 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T4 | 1194-1213 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
| T5 | 1893-1900 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T7 | 1951-1962 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-209 | Sentence | denotes | The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. |
| T2 | 210-269 | Sentence | denotes | The key enzyme for the chain initiation of heparan sulfate. |
| T3 | 270-600 | Sentence | denotes | We previously demonstrated a unique alpha-N-acetylgalactosaminyltransferase that transferred N-acetylgalactosamine (GalNAc) to the tetrasaccharide-serine, GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser (GlcA represents glucuronic acid), derived from the common glycosaminoglycan-protein linkage region, through an alpha1,4-linkage. |
| T4 | 601-703 | Sentence | denotes | In this study, we purified the enzyme from the serum-free culture medium of a human sarcoma cell line. |
| T5 | 704-910 | Sentence | denotes | Peptide sequence analysis of the purified enzyme revealed 100% identity to the multiple exostoses-like gene EXTL2/EXTR2, a member of the hereditary multiple exostoses (EXT) gene family of tumor suppressors. |
| T6 | 911-1136 | Sentence | denotes | The expression of a soluble recombinant form of the protein produced an active enzyme, which transferred alpha-GalNAc from UDP-[3H]GalNAc to various acceptor substrates including GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser. |
| T7 | 1137-1431 | Sentence | denotes | Interestingly, the enzyme also catalyzed the transfer of N-acetylglucosamine (GlcNAc) from UDP-[3H]GlcNAc to GlcAbeta1-3Galbeta1-O-naphthalenemethanol, which was the acceptor substrate for the previously described GlcNAc transferase I involved in the biosynthetic initiation of heparan sulfate. |
| T8 | 1432-1594 | Sentence | denotes | The GlcNAc transferase reaction product was sensitive to the action of heparitinase I, establishing the identity of the enzyme to be alpha1, 4-GlcNAc transferase. |
| T9 | 1595-1998 | Sentence | denotes | These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 108-129 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T2 | 134-153 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
| T3 | 363-384 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T4 | 1194-1213 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
| T5 | 1893-1900 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T6 | 1893-1900 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T7 | 1951-1962 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 253-268 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 1415-1430 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 1901-1916 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T4 | 1951-1962 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 21-24 | https://acgg.asia/db/ggdb/info/gg158 | denotes | EXT |
| PD-GlycoGenes20190927-B_T2 | 35-40 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| PD-GlycoGenes20190927-B_T3 | 812-817 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| PD-GlycoGenes20190927-B_T4 | 818-823 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTR2 |
| PD-GlycoGenes20190927-B_T5 | 872-875 | https://acgg.asia/db/ggdb/info/gg158 | denotes | EXT |
| PD-GlycoGenes20190927-B_T6 | 1634-1639 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTL2 |
| PD-GlycoGenes20190927-B_T7 | 1640-1645 | https://acgg.asia/db/ggdb/info/gg161 | denotes | EXTR2 |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 134-153 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T2 | 1194-1213 | chem:24139 | denotes | N-acetylglucosamine |
| PD-NGLY1-deficiency-B_T3 | 1215-1221 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T4 | 1236-1242 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T5 | 1351-1357 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T6 | 1436-1442 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T7 | 1575-1581 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T8 | 1720-1726 | chem:24139 | denotes | GlcNAc |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 685-692 | HP_0100242 | denotes | sarcoma |
| T2 | 783-801 | HP_0002762 | denotes | multiple exostoses |
| T3 | 792-801 | HP_0100777 | denotes | exostoses |
| T4 | 852-870 | HP_0002762 | denotes | multiple exostoses |
| T5 | 861-870 | HP_0100777 | denotes | exostoses |
| T6 | 892-897 | HP_0002664 | denotes | tumor |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 4-9 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 685-692 | Disease | denotes | sarcoma | http://purl.obolibrary.org/obo/MONDO_0005089 |
| T3 | 783-801 | Disease | denotes | multiple exostoses | http://purl.obolibrary.org/obo/MONDO_0005508 |
| T4 | 841-870 | Disease | denotes | hereditary multiple exostoses | http://purl.obolibrary.org/obo/MONDO_0005508 |
| T5 | 892-897 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 4-9 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 21-24 | Phenotype | denotes | EXT | HP:0100777 |
| T3 | 685-692 | Phenotype | denotes | sarcoma | HP:0100242 |
| T4 | 783-801 | Phenotype | denotes | multiple exostoses | HP:0002762 |
| T5 | 852-870 | Phenotype | denotes | multiple exostoses | HP:0002762 |
| T6 | 872-875 | Phenotype | denotes | EXT | HP:0100777 |
| T7 | 892-897 | Phenotype | denotes | tumor | HP:0002664 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 386-392 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 1022-1028 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 1042-1048 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 1713-1719 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 1951-1962 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T12 | 253-268 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T16 | 1415-1430 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T7 | 1901-1916 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 4-9 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 21-24 | Phenotype | denotes | EXT | HP:0100777 |
| T3 | 685-692 | Phenotype | denotes | sarcoma | HP:0100242 |
| T4 | 783-801 | Phenotype | denotes | multiple exostoses | HP:0002762 |
| T5 | 852-870 | Phenotype | denotes | multiple exostoses | HP:0002762 |
| T6 | 872-875 | Phenotype | denotes | EXT | HP:0100777 |
| T7 | 892-897 | Phenotype | denotes | tumor | HP:0002664 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 4-9 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 685-692 | Disease | denotes | sarcoma | http://purl.obolibrary.org/obo/MONDO_0005089 |
| T3 | 783-801 | Disease | denotes | multiple exostoses | http://purl.obolibrary.org/obo/MONDO_0005508 |
| T4 | 841-870 | Disease | denotes | hereditary multiple exostoses | http://purl.obolibrary.org/obo/MONDO_0005508 |
| T5 | 892-897 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 679-684 | OrganismTaxon | denotes | human | 9606 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-209 | Sentence | denotes | The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. |
| T2 | 210-269 | Sentence | denotes | The key enzyme for the chain initiation of heparan sulfate. |
| T3 | 270-600 | Sentence | denotes | We previously demonstrated a unique alpha-N-acetylgalactosaminyltransferase that transferred N-acetylgalactosamine (GalNAc) to the tetrasaccharide-serine, GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser (GlcA represents glucuronic acid), derived from the common glycosaminoglycan-protein linkage region, through an alpha1,4-linkage. |
| T4 | 601-703 | Sentence | denotes | In this study, we purified the enzyme from the serum-free culture medium of a human sarcoma cell line. |
| T5 | 704-910 | Sentence | denotes | Peptide sequence analysis of the purified enzyme revealed 100% identity to the multiple exostoses-like gene EXTL2/EXTR2, a member of the hereditary multiple exostoses (EXT) gene family of tumor suppressors. |
| T6 | 911-1136 | Sentence | denotes | The expression of a soluble recombinant form of the protein produced an active enzyme, which transferred alpha-GalNAc from UDP-[3H]GalNAc to various acceptor substrates including GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser. |
| T7 | 1137-1431 | Sentence | denotes | Interestingly, the enzyme also catalyzed the transfer of N-acetylglucosamine (GlcNAc) from UDP-[3H]GlcNAc to GlcAbeta1-3Galbeta1-O-naphthalenemethanol, which was the acceptor substrate for the previously described GlcNAc transferase I involved in the biosynthetic initiation of heparan sulfate. |
| T8 | 1432-1594 | Sentence | denotes | The GlcNAc transferase reaction product was sensitive to the action of heparitinase I, establishing the identity of the enzyme to be alpha1, 4-GlcNAc transferase. |
| T9 | 1595-1998 | Sentence | denotes | These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-209 | Sentence | denotes | The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. |
| T2 | 210-269 | Sentence | denotes | The key enzyme for the chain initiation of heparan sulfate. |
| T3 | 270-600 | Sentence | denotes | We previously demonstrated a unique alpha-N-acetylgalactosaminyltransferase that transferred N-acetylgalactosamine (GalNAc) to the tetrasaccharide-serine, GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser (GlcA represents glucuronic acid), derived from the common glycosaminoglycan-protein linkage region, through an alpha1,4-linkage. |
| T4 | 601-703 | Sentence | denotes | In this study, we purified the enzyme from the serum-free culture medium of a human sarcoma cell line. |
| T5 | 704-910 | Sentence | denotes | Peptide sequence analysis of the purified enzyme revealed 100% identity to the multiple exostoses-like gene EXTL2/EXTR2, a member of the hereditary multiple exostoses (EXT) gene family of tumor suppressors. |
| T6 | 911-1431 | Sentence | denotes | The expression of a soluble recombinant form of the protein produced an active enzyme, which transferred alpha-GalNAc from UDP-[3H]GalNAc to various acceptor substrates including GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser. Interestingly, the enzyme also catalyzed the transfer of N-acetylglucosamine (GlcNAc) from UDP-[3H]GlcNAc to GlcAbeta1-3Galbeta1-O-naphthalenemethanol, which was the acceptor substrate for the previously described GlcNAc transferase I involved in the biosynthetic initiation of heparan sulfate. |
| T7 | 1432-1594 | Sentence | denotes | The GlcNAc transferase reaction product was sensitive to the action of heparitinase I, establishing the identity of the enzyme to be alpha1, 4-GlcNAc transferase. |
| T8 | 1595-1998 | Sentence | denotes | These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 386-392 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T2 | 1022-1028 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 1042-1048 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 1713-1719 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T5 | 1951-1962 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T12 | 253-268 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T16 | 1415-1430 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
| T7 | 1901-1916 | Glycan | denotes | heparan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G17927IW |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 253-268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 1415-1430 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 1901-1916 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 1951-1962 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 679-684 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 253-268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T2 | 1415-1430 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T3 | 1901-1916 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 1951-1962 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |