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PubMed:10235509 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-64 cell_type denotes resting peripheral blood mononuclear cells
T2 98-101 protein denotes CD4
T3 134-143 protein denotes CDR2-loop
T4 147-169 protein denotes extracellular domain 1
T5 185-227 cell_type denotes resting peripheral blood mononuclear cells
T6 229-234 cell_type denotes PBMCs
T7 344-360 protein denotes cell surface CD4
T8 364-397 protein denotes gp120-anti-gp120 immune complexes
T9 547-556 protein denotes NF-kappaB
T10 671-685 protein denotes viral proteins
T11 826-829 protein denotes CD4
T12 855-860 cell_type denotes PBMCs
T13 973-982 protein denotes NF-kappaB
T14 1018-1023 cell_type denotes PBMCs
T15 1061-1074 cell_type denotes resting PBMCs
T16 1159-1168 protein denotes CDR2-loop
T17 1172-1180 protein denotes domain 1
T18 1182-1184 protein denotes D1
T19 1189-1192 protein denotes CD4
T20 1194-1243 protein denotes virus envelope and anti-CD4 monoclonal antibodies
T21 1305-1308 protein denotes CD4
T22 1328-1338 protein denotes antibodies
T23 1367-1369 protein denotes D1
T24 1385-1397 protein denotes D1/CDR3-loop
T25 1408-1419 protein denotes soluble CD4
T26 1421-1425 protein denotes sCD4
T27 1459-1479 protein denotes D1/CDR2-loop ligands
T28 1541-1546 cell_type denotes PBMCs
T29 1569-1572 protein denotes CD4
T30 1580-1592 protein denotes D1/CDR2-loop

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-170 Sentence denotes HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.
S2 171-296 Sentence denotes HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation.
S3 297-511 Sentence denotes We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to virus reactivation (9).
S4 512-712 Sentence denotes In this study, we demonstrate that NF-kappaB nuclear translocation and stimulation of virus production by iHIV-1 were strictly linked to the concentrations of viral proteins used as exogenous stimuli.
S5 713-795 Sentence denotes Moreover, we further investigated the physiologic relevance of these observations.
S6 796-918 Sentence denotes When submitted to an in vitro CD4 cross-linking by iHIV-1, PBMCs from HIV-1-infected patients were found to produce virus.
S7 919-1024 Sentence denotes This viral reactivation was associated with increased NF-kappaB nuclear translocation in patients' PBMCs.
S8 1025-1245 Sentence denotes Additionally, virus reactivation in resting PBMCs infected in vitro with HIV-1 was found to be specifically induced by ligands of the CDR2-loop in domain 1 (D1) of CD4 (virus envelope and anti-CD4 monoclonal antibodies).
S9 1246-1398 Sentence denotes In contrast, virus reactivation was not observed following CD4 oligomerization by antibodies that bind other epitopes in D1, including the D1/CDR3-loop.
S10 1399-1480 Sentence denotes Finally, soluble CD4 (sCD4) prevented virus reactivation by D1/CDR2-loop ligands.
S11 1481-1648 Sentence denotes Our results indicate that the signaling events initiated in PBMCs by oligomerization of CD4 at the D1/CDR2-loop can trigger HIV-1 upregulation in infected individuals.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 130-143 NP denotes the CDR2-loop
C2 147-169 NP denotes extracellular domain 1
C3 171-176 NP denotes HIV-1
C4 401-432 NP denotes heat-inactivated HIV-1 (iHIV-1)
C5 488-510 NP denotes virus reactivation (9)
C6 618-624 NP denotes iHIV-1
C7 847-853 NP denotes iHIV-1
C8 855-889 NP denotes PBMCs from HIV-1-infected patients
C9 919-942 NP denotes This viral reactivation
C10 1008-1023 NP denotes patients' PBMCs
C11 1098-1103 NP denotes HIV-1
C12 1155-1168 NP denotes the CDR2-loop
C13 1189-1192 NP denotes CD4
C14 1328-1338 NP denotes antibodies
C15 1339-1343 NP denotes that
C16 1367-1369 NP denotes D1
C17 1569-1572 NP denotes CD4
R1 C6 C4 coref-ident iHIV-1,heat-inactivated HIV-1 (iHIV-1)
R2 C7 C6 coref-ident iHIV-1,iHIV-1
R3 C9 C5 coref-ident This viral reactivation,virus reactivation (9)
R4 C10 C8 coref-ident patients' PBMCs,PBMCs from HIV-1-infected patients
R5 C11 C3 coref-ident HIV-1,HIV-1
R6 C12 C1 coref-ident the CDR2-loop,the CDR2-loop
R7 C15 C14 coref-relat that,antibodies
R8 C16 C2 coref-ident D1,extracellular domain 1
R9 C17 C13 coref-ident CD4,CD4

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-5 virus denotes HIV-1
T2 22-64 cell_type denotes resting peripheral blood mononuclear cells
T3 98-101 protein_molecule denotes CD4
T4 134-143 protein_domain_or_region denotes CDR2-loop
T5 147-169 protein_domain_or_region denotes extracellular domain 1
T6 171-176 virus denotes HIV-1
T7 185-227 cell_type denotes resting peripheral blood mononuclear cells
T8 229-234 cell_type denotes PBMCs
T9 280-295 other_name denotes cell activation
T10 344-356 protein_molecule denotes cell surface
T11 357-360 protein_molecule denotes CD4
T12 364-397 protein_complex denotes gp120-anti-gp120 immune complexes
T13 401-417 virus denotes heat-inactivated
T14 418-423 virus denotes HIV-1
T15 425-431 virus denotes iHIV-1
T16 488-506 other_name denotes virus reactivation
T17 547-556 protein_complex denotes NF-kappaB
T18 557-578 other_name denotes nuclear translocation
T19 618-624 virus denotes iHIV-1
T20 671-685 protein_family_or_group denotes viral proteins
T21 817-825 other_name denotes in vitro
T22 826-829 protein_molecule denotes CD4
T23 847-853 virus denotes iHIV-1
T24 855-860 cell_type denotes PBMCs
T25 866-871 virus denotes HIV-1
T26 881-889 multi_cell denotes patients
T27 924-942 other_name denotes viral reactivation
T28 973-982 protein_complex denotes NF-kappaB
T29 983-1004 other_name denotes nuclear translocation
T30 1008-1016 multi_cell denotes patients
T31 1018-1023 cell_type denotes PBMCs
T32 1061-1068 cell_type denotes resting
T33 1069-1074 cell_type denotes PBMCs
T34 1098-1103 virus denotes HIV-1
T35 1159-1168 protein_domain_or_region denotes CDR2-loop
T36 1172-1180 protein_domain_or_region denotes domain 1
T37 1182-1184 protein_domain_or_region denotes D1
T38 1189-1192 protein_molecule denotes CD4
T39 1194-1218 protein_family_or_group denotes virus envelope and anti-
T40 1218-1221 protein_molecule denotes CD4
T41 1259-1277 other_name denotes virus reactivation
T42 1305-1308 protein_molecule denotes CD4
T43 1328-1338 protein_family_or_group denotes antibodies
T44 1367-1369 protein_domain_or_region denotes D1
T45 1385-1397 protein_domain_or_region denotes D1/CDR3-loop
T46 1408-1415 protein_molecule denotes soluble
T47 1416-1419 protein_molecule denotes CD4
T48 1421-1425 protein_molecule denotes sCD4
T49 1437-1455 other_name denotes virus reactivation
T50 1459-1479 protein_family_or_group denotes D1/CDR2-loop ligands
T51 1541-1546 cell_type denotes PBMCs
T52 1569-1572 protein_molecule denotes CD4
T53 1580-1583 protein_domain_or_region denotes D1/
T54 1583-1592 protein_domain_or_region denotes CDR2-loop
T55 1605-1623 other_name denotes HIV-1 upregulation
T56 1627-1647 multi_cell denotes infected individuals

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1159-1163 gene:101060399 denotes CDR2
T1 1098-1101 disease:C0019693 denotes HIV
T2 1159-1163 gene:1039 denotes CDR2
T3 1098-1101 disease:C0019693 denotes HIV
R1 T0 T1 associated_with CDR2,HIV
R2 T2 T3 associated_with CDR2,HIV