> top > docs > PubMed:10233947 > annotations

PubMed:10233947 JSONTXT

Annnotations TAB JSON ListView MergeView

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 60-75 DiseaseOrPhenotypicFeature denotes T-cell leukemia 0005525
T2 154-169 DiseaseOrPhenotypicFeature denotes T-cell leukemia 0005525
T3 184-190 DiseaseOrPhenotypicFeature denotes HTLV-1 0005801
T4 946-952 DiseaseOrPhenotypicFeature denotes HTLV-1 0005801
T5 1385-1391 DiseaseOrPhenotypicFeature denotes HTLV-1 0005801

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 19-50 cell_type denotes CD4(+) and CD8(+) T lymphocytes
T2 89-100 protein denotes Tax mutants
T3 116-142 cell_line denotes functional molecular clone
T4 148-223 protein denotes human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator
T5 224-227 protein denotes Tax
T6 283-304 cell_line denotes multiple cell culture
T7 383-409 DNA denotes viral long terminal repeat
T8 411-414 DNA denotes LTR
T9 428-521 protein denotes cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family
T10 525-546 protein denotes transcription factors
T11 548-551 protein denotes Tax
T12 580-607 DNA denotes multiple cellular promoters
T13 620-629 protein denotes NF-kappaB
T14 673-684 protein denotes Tax mutants
T15 685-688 protein denotes M22
T16 693-696 protein denotes M47
T17 770-773 protein denotes Tax
T18 896-904 DNA denotes tax gene
T19 912-942 DNA denotes ACH functional molecular clone
T20 982-999 DNA denotes mutant ACH clones
T21 1058-1083 cell_type denotes primary human lymphocytes
T22 1135-1138 protein denotes M47
T23 1184-1197 cell_type denotes T lymphocytes
T24 1203-1206 protein denotes M22
T25 1246-1260 cell_type denotes infected cells
T26 1308-1316 protein denotes CREB/ATF
T27 1328-1331 protein denotes Tax
T28 1374-1381 cell_type denotes T cells
T29 1419-1428 protein denotes NF-kappaB

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-143 Sentence denotes Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.
S2 144-333 Sentence denotes The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax has been demonstrated to have transforming activity in multiple cell culture and transgenic-mouse models.
S3 334-668 Sentence denotes In addition to activating transcription from the viral long terminal repeat (LTR) through the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors, Tax activates the expression of multiple cellular promoters through the NF-kappaB pathway of transcriptional activation.
S4 669-856 Sentence denotes The Tax mutants M22 and M47 have previously been demonstrated to selectively abrogate the ability of Tax to activate transcription through the NF-kappaB or CREB/ATF pathway, respectively.
S5 857-1084 Sentence denotes These mutations were introduced in the tax gene of the ACH functional molecular clone of HTLV-1, and virus produced from the mutant ACH clones was examined for the ability to replicate and immortalize primary human lymphocytes.
S6 1085-1261 Sentence denotes While virus derived from the clone containing the M47 mutation retained the ability to immortalize T lymphocytes, the M22 mutant lost the ability to immortalize infected cells.
S7 1262-1453 Sentence denotes These results indicate that activation of the CREB/ATF pathway by Tax is dispensable for the immortalization of T cells by HTLV-1, whereas activation of the NF-kappaB pathway may be critical.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 144-227 NP denotes The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax
C2 548-551 NP denotes Tax
C3 770-773 NP denotes Tax
C4 946-952 NP denotes HTLV-1
C5 1184-1197 NP denotes T lymphocytes
C6 1328-1331 NP denotes Tax
C7 1374-1381 NP denotes T cells
C8 1385-1391 NP denotes HTLV-1
R1 C2 C1 coref-ident Tax,The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax
R2 C3 C2 coref-ident Tax,Tax
R3 C6 C3 coref-ident Tax,Tax
R4 C7 C5 coref-ident T cells,T lymphocytes
R5 C8 C4 coref-ident HTLV-1,HTLV-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-15 other_name denotes Immortalization
T2 54-88 virus denotes human T-cell leukemia virus type 1
T3 89-100 protein_family_or_group denotes Tax mutants
T4 116-142 cell_line denotes functional molecular clone
T5 148-182 virus denotes human T-cell leukemia virus type 1
T6 184-190 virus denotes HTLV-1
T7 224-227 protein_molecule denotes Tax
T8 283-304 cell_line denotes multiple cell culture
T9 309-332 other_artificial_source denotes transgenic-mouse models
T10 383-409 DNA_domain_or_region denotes viral long terminal repeat
T11 411-414 DNA_domain_or_region denotes LTR
T12 428-482 protein_family_or_group denotes cyclic AMP response element binding protein/activating
T13 483-503 protein_family_or_group denotes transcription factor
T14 525-546 protein_family_or_group denotes transcription factors
T15 548-551 protein_molecule denotes Tax
T16 580-607 DNA_family_or_group denotes multiple cellular promoters
T17 620-629 protein_complex denotes NF-kappaB
T18 641-667 other_name denotes transcriptional activation
T19 673-676 protein_molecule denotes Tax
T20 685-688 protein_molecule denotes M22
T21 693-696 protein_molecule denotes M47
T22 770-773 protein_molecule denotes Tax
T23 896-904 DNA_domain_or_region denotes tax gene
T24 912-942 DNA_molecule denotes ACH functional molecular clone
T25 946-952 virus denotes HTLV-1
T26 982-999 DNA_family_or_group denotes mutant ACH clones
T27 1058-1083 cell_type denotes primary human lymphocytes
T28 1135-1138 protein_molecule denotes M47
T29 1184-1197 cell_type denotes T lymphocytes
T30 1203-1206 protein_molecule denotes M22
T31 1246-1260 cell_type denotes infected cells
T32 1308-1316 protein_molecule denotes CREB/ATF
T33 1328-1331 protein_molecule denotes Tax
T34 1374-1381 cell_type denotes T cells
T35 1385-1391 virus denotes HTLV-1
T36 1419-1428 protein_molecule denotes NF-kappaB

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 161-169 HP_0001909 denotes leukemia