PubMed:10233927 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	91-100	DiseaseOrPhenotypicFeature	denotes	Infection	0005550
T2	390-403	DiseaseOrPhenotypicFeature	denotes	EBV infection	0005111
T3	1006-1009	DiseaseOrPhenotypicFeature	denotes	can	0012833
T4	1259-1268	DiseaseOrPhenotypicFeature	denotes	infection	0005550

Id	Subject	Object	Predicate	Lexical cue
T1	45-58	cell_type	denotes	B lymphocytes
T2	104-117	cell_type	denotes	human B cells
T3	458-467	protein	denotes	cyclin D2
T4	500-509	DNA	denotes	EBV genes
T5	536-541	protein	denotes	E2F-4
T6	703-707	protein	denotes	CD21
T7	817-829	protein	denotes	BCL-2 family
T8	876-905	cell_line	denotes	EBV-immortalized B-cell lines
T9	987-992	protein	denotes	BCL-2
T10	997-1000	protein	denotes	A20
T11	1030-1039	protein	denotes	NF-kappaB
T12	1040-1060	protein	denotes	transcription factor
T13	1100-1117	protein	denotes	EBV LMP-1 protein
T14	1191-1204	protein	denotes	LMP-1 protein
T15	1223-1232	protein	denotes	NF-kappaB

Id	Subject	Object	Predicate	Lexical cue
S1	0-90	Sentence	denotes	Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.
S2	91-204	Sentence	denotes	Infection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and cell growth.
S3	205-386	Sentence	denotes	To interpret the mechanisms by which EBV activates the cell, we have assayed many proteins involved in control of the G0 and G1 phases of the cell cycle and regulation of apoptosis.
S4	387-708	Sentence	denotes	In EBV infection most of the changes, including the early induction of cyclin D2, are dependent on expression of EBV genes, but an alteration in the E2F-4 profile was partly independent of viral gene expression, presumably occurring in response to signal transduction activated when the virus binds to its receptor, CD21.
S5	709-1001	Sentence	denotes	By comparing the expression of genes controlling apoptosis, including those encoding several members of the BCL-2 family of proteins, the known relative resistance of EBV-immortalized B-cell lines to apoptosis induced by low serum was found to correlate with expression of both BCL-2 and A20.
S6	1002-1118	Sentence	denotes	A20 can be regulated by the NF-kappaB transcription factor, which is known to be activated by the EBV LMP-1 protein.
S7	1119-1269	Sentence	denotes	Quantitative assays demonstrated a direct temporal relationship between LMP-1 protein levels and active NF-kappaB during the time course of infection.

Id	Subject	Object	Predicate	Lexical cue
C1	32-41	NP	denotes	apoptosis
C2	71-89	NP	denotes	Epstein-Barr virus
C3	123-147	NP	denotes	Epstein-Barr virus (EBV)
C4	173-187	NP	denotes	the cell cycle
C5	218-232	NP	denotes	the mechanisms
C6	236-241	NP	denotes	which
C7	242-245	NP	denotes	EBV
C8	343-357	NP	denotes	the cell cycle
C9	376-385	NP	denotes	apoptosis
C10	670-679	NP	denotes	the virus
C12	689-692	NP	denotes	its
C11	689-701	NP	denotes	its receptor
C13	703-707	NP	denotes	CD21
C15	758-767	NP	denotes	apoptosis
C14	740-767	NP	denotes	genes controlling apoptosis
C16	779-784	NP	denotes	those
C17	909-918	NP	denotes	apoptosis
C18	1026-1060	NP	denotes	the NF-kappaB transcription factor
C19	1062-1067	NP	denotes	which
R1	C3	C2	coref-ident	Epstein-Barr virus (EBV),Epstein-Barr virus
R2	C6	C5	coref-relat	which,the mechanisms
R3	C7	C3	coref-ident	EBV,Epstein-Barr virus (EBV)
R4	C8	C4	coref-ident	the cell cycle,the cell cycle
R5	C9	C1	coref-ident	apoptosis,apoptosis
R6	C10	C7	coref-ident	the virus,EBV
R7	C12	C10	coref-pron	its,the virus
R8	C13	C11	coref-appos	CD21,its receptor
R9	C15	C9	coref-ident	apoptosis,apoptosis
R10	C16	C14	coref-pron	those,genes controlling apoptosis
R11	C17	C15	coref-ident	apoptosis,apoptosis
R12	C19	C18	coref-relat	which,the NF-kappaB transcription factor

Id	Subject	Object	Predicate	Lexical cue
T1	11-27	other_name	denotes	cell cycle entry
T2	32-41	other_name	denotes	apoptosis
T3	45-58	cell_type	denotes	B lymphocytes
T4	71-89	virus	denotes	Epstein-Barr virus
T5	104-117	cell_type	denotes	human B cells
T6	123-141	virus	denotes	Epstein-Barr virus
T7	143-146	virus	denotes	EBV
T8	177-187	other_name	denotes	cell cycle
T9	192-203	other_name	denotes	cell growth
T10	242-245	virus	denotes	EBV
T11	347-357	other_name	denotes	cell cycle
T12	376-385	other_name	denotes	apoptosis
T13	390-393	virus	denotes	EBV
T14	458-467	protein_molecule	denotes	cyclin D2
T15	500-503	virus	denotes	EBV
T16	536-541	protein_molecule	denotes	E2F-4
T17	576-597	other_name	denotes	viral gene expression
T18	703-707	protein_molecule	denotes	CD21
T19	758-767	other_name	denotes	apoptosis
T20	817-829	protein_family_or_group	denotes	BCL-2 family
T21	876-879	virus	denotes	EBV
T22	909-918	other_name	denotes	apoptosis
T23	987-992	protein_molecule	denotes	BCL-2
T24	997-1000	protein_molecule	denotes	A20
T25	1030-1039	protein_complex	denotes	NF-kappaB
T26	1040-1060	protein_family_or_group	denotes	transcription factor
T27	1100-1103	virus	denotes	EBV
T28	1119-1138	other_name	denotes	Quantitative assays
T29	1191-1204	protein_molecule	denotes	LMP-1 protein
T30	1223-1232	protein_complex	denotes	NF-kappaB