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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 55-77 cell_type denotes erythroblastic progeny
T2 81-116 cell_line denotes transduced hematopoietic stem cells
T3 334-379 cell_type denotes genetically modified hematopoietic stem cells
T4 426-453 DNA denotes constitutive viral enhancer
T5 461-470 DNA denotes U3 region
T6 478-484 DNA denotes 3' LTR
T7 503-526 DNA denotes autoregulatory enhancer
T8 534-585 DNA denotes erythroid-specific GATA-1 transcription factor gene
T9 591-608 DNA denotes replaced enhancer
T10 630-636 DNA denotes 5' LTR
T11 663-681 DNA denotes target cell genome
T12 727-757 cell_line denotes human hematopoietic cell lines
T13 759-807 cell_type denotes cord blood-derived CD34(+) stem/progenitor cells
T14 813-855 cell_line denotes murine bone marrow repopulating stem cells
T15 887-901 DNA denotes reporter genes
T16 903-919 DNA denotes triangle upLNGFR
T17 921-925 DNA denotes EGFP
T18 973-994 cell_line denotes transduced stem cells
T19 1135-1165 DNA denotes GATA-1 autoregulatory enhancer
T20 1210-1248 DNA denotes LTR-driven proviral transcription unit
T21 1256-1278 cell_type denotes erythroblastic progeny
T22 1287-1304 cell_type denotes human progenitors
T23 1309-1338 cell_line denotes mouse-repopulating stem cells
T24 1471-1474 DNA denotes LTR
T25 1571-1591 DNA denotes retroviral transgene
T26 1617-1652 cell_line denotes transduced hematopoietic stem cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-117 Sentence denotes Transcriptional targeting of retroviral vectors to the erythroblastic progeny of transduced hematopoietic stem cells.
S2 118-380 Sentence denotes Targeted expression to specific tissues or cell lineages is a necessary feature of a gene therapy vector for many clinical applications, such as correction of hemoglobinopathies or thalassemias by transplantation of genetically modified hematopoietic stem cells.
S3 381-586 Sentence denotes We developed retroviral vectors in which the constitutive viral enhancer in the U3 region of the 3' LTR is replaced by an autoregulatory enhancer of the erythroid-specific GATA-1 transcription factor gene.
S4 587-682 Sentence denotes The replaced enhancer is propagated to the 5' LTR upon integration into the target cell genome.
S5 683-856 Sentence denotes The modified vectors were used to transduce human hematopoietic cell lines, cord blood-derived CD34(+) stem/progenitor cells, and murine bone marrow repopulating stem cells.
S6 857-1130 Sentence denotes The expression of appropriate reporter genes (triangle upLNGFR, EGFP) was analyzed in the differentiated progeny of transduced stem cells in vitro, in liquid culture as well as in clonogenic assay, and in vivo, after bone marrow transplantation in lethally irradiated mice.
S7 1131-1339 Sentence denotes The GATA-1 autoregulatory enhancer effectively restricts the expression of the LTR-driven proviral transcription unit to the erythroblastic progeny of both human progenitors and mouse-repopulating stem cells.
S8 1340-1488 Sentence denotes Packaging of viral particles, integration into the target genome, and stability of the integrated provirus are not affected by the LTR modification.
S9 1489-1653 Sentence denotes Enhancer replacement is therefore an effective strategy to target expression of a retroviral transgene to a specific progeny of transduced hematopoietic stem cells.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 29-47 NP denotes retroviral vectors
C2 81-116 NP denotes transduced hematopoietic stem cells
C3 394-412 NP denotes retroviral vectors
C4 416-421 NP denotes which
C5 500-585 NP denotes an autoregulatory enhancer of the erythroid-specific GATA-1 transcription factor gene
C6 587-608 NP denotes The replaced enhancer
C7 1131-1165 NP denotes The GATA-1 autoregulatory enhancer
C8 1617-1652 NP denotes transduced hematopoietic stem cells
R1 C3 C1 coref-ident retroviral vectors,retroviral vectors
R2 C4 C3 coref-relat which,retroviral vectors
R3 C6 C5 coref-ident The replaced enhancer,an autoregulatory enhancer of the erythroid-specific GATA-1 transcription factor gene
R4 C7 C6 coref-ident The GATA-1 autoregulatory enhancer,The replaced enhancer
R5 C8 C2 coref-ident transduced hematopoietic stem cells,transduced hematopoietic stem cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-25 other_name denotes Transcriptional targeting
T2 29-47 virus denotes retroviral vectors
T3 55-77 cell_type denotes erythroblastic progeny
T4 81-116 cell_line denotes transduced hematopoietic stem cells
T5 118-137 other_name denotes Targeted expression
T6 203-222 virus denotes gene therapy vector
T7 232-253 other_name denotes clinical applications
T8 277-295 other_name denotes hemoglobinopathies
T9 299-311 other_name denotes thalassemias
T10 334-379 cell_type denotes genetically modified hematopoietic stem cells
T11 394-412 virus denotes retroviral vectors
T12 426-453 DNA_domain_or_region denotes constitutive viral enhancer
T13 461-470 DNA_domain_or_region denotes U3 region
T14 478-484 DNA_domain_or_region denotes 3' LTR
T15 503-526 DNA_domain_or_region denotes autoregulatory enhancer
T16 534-559 DNA_domain_or_region denotes erythroid-specific GATA-1
T17 560-580 protein_family_or_group denotes transcription factor
T18 591-608 DNA_domain_or_region denotes replaced enhancer
T19 630-636 DNA_domain_or_region denotes 5' LTR
T20 663-681 DNA_family_or_group denotes target cell genome
T21 687-703 virus denotes modified vectors
T22 727-757 cell_line denotes human hematopoietic cell lines
T23 759-807 cell_type denotes cord blood-derived CD34(+) stem/progenitor cells
T24 813-855 cell_line denotes murine bone marrow repopulating stem cells
T25 887-901 DNA_family_or_group denotes reporter genes
T26 903-919 DNA_domain_or_region denotes triangle upLNGFR
T27 921-925 DNA_domain_or_region denotes EGFP
T28 973-994 cell_line denotes transduced stem cells
T29 1008-1022 other_name denotes liquid culture
T30 1037-1053 other_name denotes clonogenic assay
T31 1074-1085 tissue denotes bone marrow
T32 1105-1129 multi_cell denotes lethally irradiated mice
T33 1135-1165 DNA_domain_or_region denotes GATA-1 autoregulatory enhancer
T34 1210-1248 DNA_domain_or_region denotes LTR-driven proviral transcription unit
T35 1256-1278 cell_type denotes erythroblastic progeny
T36 1287-1304 cell_type denotes human progenitors
T37 1309-1338 cell_line denotes mouse-repopulating stem cells
T38 1427-1446 virus denotes integrated provirus
T39 1471-1474 DNA_domain_or_region denotes LTR
T40 1571-1591 DNA_family_or_group denotes retroviral transgene
T41 1617-1652 cell_line denotes transduced hematopoietic stem cells